Treasure Room (Greed Mode Item Pool)

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(except in Rebirth)

All of the items in this pool can be found in the gold Treasure RoomTreasure Room in Greed Mode. They can also occasionally be found in the Greed Mode ShopShop.

Activated Collectibles

Name ID Icon Weight Description
Anarchist Cookbook 5.100.65
Anarchist Cookbook
3 rooms
1
Spawns six Troll Bomb.pngTroll Bombs around the room.
The Bean 5.100.111
The Bean
1 room
1
Isaac farts, damaging and poisoning any enemy in close range.
Blood Rights 5.100.186
Blood Rights
Unlimited
1
Takes a full heart of health and deals 40 damage to all enemies in the room. (in Repentance) Repeated uses in the same room only take half a heart.
Bob's Rotten Head 5.100.42
Bob's Rotten Head
2 rooms
1
Upon use, Isaac holds a poison Bomb.pngBomb above his head which can be thrown in the cardinal directions and explodes on impact.
The Book of Belial 5.100.34
The Book of Belial
3 rooms
1
(in Rebirth) +2 damage for the current room. Passively guarantees a Devil RoomDevil Room or Angel RoomAngel Room will appear while held.
(except in Rebirth) +2 damage for the current room. Passively increases the chance of finding a Devil RoomDevil Room or Angel RoomAngel Room while held.
Book of Revelations 5.100.78
Book of Revelations
6 rooms
1
Increases the chance of a Devil RoomDevil Room / Angel RoomAngel Room appearing while held. Upon use, gives one Soul Heart.pngSoul Heart, and replaces the boss of the current floor with a Harbinger if possible.
The Book of Sin 5.100.97
The Book of Sin
4 rooms
1
Spawns a random coin, heart, bomb, key, battery, pill or card near Isaac.
Box of Friends 5.100.357
Box of Friends
3 rooms
1
Duplicates all of Isaac's familiars for the current room. If Isaac has no familiars, spawns a Collectible Demon Baby icon.pngDemon Baby for the room instead.
Box of Spiders 5.100.288
Box of Spiders
2 rooms
1
(except in Repentance) Spawns 1-4 Blue Spiders that deal 2.5× Isaac's damage to enemies.
(in Repentance) Spawns 4-8 Blue Spiders that deal 2× Isaac's damage to enemies.
Dad's Key 5.100.175
Dad's Key
2 rooms
1
Opens all doors in the current room in almost all circumstances, including doors which require a Key.pngKey to open, entrances to Secret RoomSecret Rooms, and the door to Mega Satan Head ingame.pngMega Satan.
Dead Sea Scrolls 5.100.124
Dead Sea Scrolls
2 rooms
1
Triggers the effect of a random activated item from a list of possible options (not every activated item is included).
Deck of Cards 5.100.85
Deck of Cards
6 rooms
1
Gives Isaac a random card.
Doctor's Remote 5.100.47
Doctor's Remote
2 rooms
1
Creates a crosshair on the ground that can be aimed with tear controls. A missile strikes the spot after 2 seconds, creating a heavy damage explosion.
Flush! 5.100.291
Flush!
4 rooms
1
Turns all non-boss monsters in the room into Poop.pngPoop. (except in Rebirth) Instantly kills poop-themed bosses. Floods the current room.
Friendly Ball 5.100.382
Friendly Ball
2 rooms
1
Throwing the ball at a monster instantly kills and captures it. The captured enemy can later be released and will be friendly, fighting for Isaac and persisting between rooms.
The Gamekid 5.100.93
The Gamekid
4 rooms
1
Transforms Isaac into a rainbow-colored chomping creature for 6.5 seconds. Grants invulnerability, inflicts fear on all enemies, and has a chance of replenishing a Half Red Heart.pngHalf Red Heart every time an enemy is killed.
Glass Cannon 5.100.352
Glass Cannon
4 seconds
1
(except in Repentance) Fires a high-damage piercing spectral tear, but lowers Isaac's health to half a heart.
(in Repentance) Fires a high-damage piercing spectral tear. If Isaac takes damage while holding this, he takes extra damage and it becomes Collectible Broken Glass Cannon icon.pngBroken Glass Cannon.
Jar of Flies 5.100.434
Jar of Flies
Unlimited
1
Killing an enemy adds a fly to the jar, up to a maximum of 20. On use, releases Blue Flies equal to the number of flies in the jar.
Kidney Bean 5.100.421
Kidney Bean
1 room
1
Isaac farts, charming all nearby enemies.
Lemon Mishap 5.100.56
Lemon Mishap
2 rooms
1
Creates a tiny pool of yellow creep, damaging enemies that cross it.
Mega Bean 5.100.351
Mega Bean
3 rooms
1
Petrifies all enemies in the current room for about 1.5 seconds, poisons any enemies near Isaac, and sends a rock wave across the room in the direction Isaac is facing.
Mom's Bottle of Pills 5.100.102
Mom's Bottle of Pills
6 rooms
1
Gives Isaac a random pill.
Mr. Boom 5.100.37
Mr. Boom
2 rooms
1
(except in Repentance) Places a Collectible Mr. Mega icon.pngMr. Mega Bomb.pngBomb that deals 110 damage.
(in Repentance) Places a Collectible Mr. Mega icon.pngMr. Mega Bomb.pngBomb that deals 185 damage.
My Little Unicorn 5.100.77
My Little Unicorn
4 rooms
1
Grants invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
The Necronomicon 5.100.35
The Necronomicon
4 rooms
1
Deals 40 damage to every enemy in the room.
The Pinking Shears 5.100.107
The Pinking Shears
4 rooms
1
Separates Isaac's head from his body for the current room, granting flight and turning the body into a familiar that chases enemies.
Prayer Card 5.100.146
Prayer Card
6 rooms
1
Gives Isaac an Eternal Heart.pngEternal Heart.
Remote Detonator 5.100.137
Remote Detonator
Unlimited
1
Bomb.pngBombs placed by Isaac only explode when Remote Detonator is used. Gives 5 bombs.
Scissors 5.100.325
Scissors
4 rooms
1
Turns Isaac's head into a stationary familiar for the current room which fires tears automatically. (in Repentance) Isaac's body also shoots a controllable fountain of blood shots for the room.
Tammy's Head 5.100.38
Tammy's Head
1 room
1
Shoots 10 tears in a circle around Isaac, which retain the damage, range, shot speed, and special effects (such as poison) of Isaac's tears. Tears from this item have a +25 flat damage bonus.
Tear Detonator 5.100.383
Tear Detonator
15 seconds
1
Splits all of Isaac's tears that are currently in the air into 6 tears that fire in all directions, which retain their damage and shot speed.
Telepathy For Dummies 5.100.192
Telepathy For Dummies
2 rooms
1
Gives homing tears for the current room. (in Repentance) Also gives +3 range.
Wooden Nickel 5.100.349
Wooden Nickel
1 room
1
Has a roughly 50% chance to drop a Penny.pngPenny, Nickel.pngNickel, or Dime.pngDime and a roughly 50% chance to do nothing.
Yum Heart 5.100.45
Yum Heart
4 rooms
1
Restores one full Red Heart.pngRed Heart.
(in Afterbirth † and Repentance) Book of the Dead 5.100.545
Book of the Dead
6 rooms
1
(except in Repentance) Creates a friendly Bony.pngBony, Black Bony.pngBlack Bony, or an orbital bone for each enemy killed in the current room.
(in Repentance)Creates a friendly Bony.pngBony, Black Bony.pngBlack Bony, Bone Fly.pngBone Fly, Revenant.pngRevenant, or an orbital bone for each enemy killed in the current room.
(in Afterbirth † and Repentance) Brown Nugget 5.100.504
Brown Nugget
8 seconds
1
Spawns a stationary fly turret that lasts for the current room and fires tears at nearby enemies.
(in Afterbirth † and Repentance) Sharp Straw 5.100.507
Sharp Straw
10 seconds
1
(except in Repentance) Damages all enemies in the room. Has a chance to drop a Half Red Heart.pngHalf Red Heart or Half Soul Heart.pngHalf Soul Heart if an enemy is hit.
(in Repentance) Damages all enemies in the room. Has a chance to drop a Half Red Heart.pngHalf Red Heart if an enemy is hit.
(in Afterbirth † and Repentance) Sprinkler 5.100.516
Sprinkler
4 rooms
1
Creates a stationary sprinkler for the current room that rotates and fires tears in 8 directions. The tears copy Isaac's stats and most tear effects.
(in Afterbirth † and Repentance) Telekinesis 5.100.522
Telekinesis
7 seconds
1
Any enemy shots that come near Isaac for the next three seconds are held in place then fired back.
(in Afterbirth †) Wait What? 5.100.484
Wait What?
10 seconds
1
Isaac farts, sending out a circular rock wave that destroys obstacles and hurts enemies.
(in Repentance) Bag of Crafting 5.100.710
Bag of Crafting
Unlimited
1
Swipes a bag that collects and holds up to 8 pickups, which can then be used to craft an item. The power level of the item is based on the quality of pickups used.
(in Repentance) Decap Attack 5.100.729
Decap Attack
4 seconds
1
Throws Isaac's head, which is still able to fire tears at the spot it lands. Reactivating the item or stepping on the head reattaches it.
(in Repentance) Everything Jar 5.100.720
Everything Jar
12 rooms
1
Spawns certain pickups based on how many charges it has. If fully charged, instead has one of many unique effects.
(in Repentance) Fortune Cookie 5.100.557
Fortune Cookie
2 rooms
1
Gives Isaac a fortune, Soul Heart.pngSoul Heart, Card, Rune, or trinket, similar to a Fortune Telling Machine.pngFortune Telling Machine. Fortunes are much more likely to be given than anything else.
(in Repentance) Free Lemonade 5.100.578
Free Lemonade
4 rooms
1
Creates a large pool of yellow creep beneath Isaac.
(in Repentance) Friend Finder 5.100.687
Friend Finder
4 rooms
1
Spawns a random friendly monster that mimics Isaac's movements and attacks.
(in Repentance) Glowing Hourglass 5.100.422
Glowing Hourglass
Unlimited
1
Rewinds time, putting Isaac back in the previous room and undoing anything that happened in the current room. (in Repentance) Can only be used three times per floor, after which it functions like Collectible The Hourglass icon.pngThe Hourglass until the next floor.
(in Repentance) Golden Razor 5.100.555
Golden Razor
Unlimited
1
Spends 5 Penny.pngpennies to grant +1.2 damage for the current room. Grants 5 pennies when picked up for the first time.
(in Repentance) Larynx 5.100.611
Larynx
12 rooms
1
Isaac shouts, damaging and pushing away nearby enemies. The shout gets stronger the more charges the item has. Larynx gains 1 charge whenever Isaac takes damage, in addition to charging normally.
(in Repentance) Meat Cleaver 5.100.631
Meat Cleaver
2 rooms
1
Upon use, splits all enemies in the room into two smaller versions of themselves with much less health.
(in Repentance) Razor Blade 5.100.126
Razor Blade
Unlimited
1
Damages Isaac for one heart and grants +1.2 damage for the current room. (in Repentance) Subsequent uses in the same room only take half a heart.
(in Repentance) The Scooper 5.100.605
The Scooper
3 rooms
1
Summons Collectible The Peeper icon.pngThe Peeper for the current room, which leaves a trail of red creep.
(in Repentance) Spin to Win 5.100.655
Spin to Win
3 seconds
1
Gives +0.5 speed and greatly increases the rotation speed and damage of orbitals for 3 seconds. Passively gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage.
(in Repentance) Stitches 5.100.635
Stitches
3 seconds
1
Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar.
(in Repentance) Sumptorium 5.100.713
Sumptorium
10 seconds
1
Removes half a heart and creates a Clot familiar that mimics Isaac's movements and tear effects. As Character Tainted Eve icon.pngTainted Eve, passively converts health into Clots while firing. Activating returns all Clots to health.
(in Repentance) Suplex! 5.100.709
Suplex!
7 seconds
1
Upon use, Isaac dashes forward and picks up the first enemy hit. After a moment, he jumps and slams them into the ground to deal damage and create a circular rock wave.
(in Repentance) Yuck Heart 5.100.639
Yuck Heart
4 rooms
1
Grants Isaac a Rotten Heart.pngRotten Heart.
(in Repentance) Esau Jr. 5.100.703
Esau Jr.
1 room
0.5
Swaps between the current character and Esau Jr., who has +2 flat damage and flight. Characters have independent items and health. Dying as either character ends the run.
(in Repentance) Eternal D6 5.100.609
Eternal D6
2 rooms
0.5
Re-rolls all items in the room. Each item has a 25% chance to disappear instead.
(in Repentance) Gello 5.100.728
Gello
2 rooms
0.5
Spawns a demon familiar for the current room attached to Isaac that moves and fires in the direction Isaac shoots, using Isaac's damage, tears, range, shot speed, and special tear effects.
(in Repentance) Mega Mush 5.100.625
Mega Mush
12 rooms
0.5
Gigantifies Isaac for 30 seconds, increasing damage and range while lowering tears, granting invulnerability, and allowing Isaac to crush enemies and obstacles he walks on. The effect persists between rooms.
(in Repentance) Plum Flute 5.100.650
Plum Flute
4 rooms
0.5
Upon use, summons the boss Boss Baby Plum ingame.pngBaby Plum to fight for Isaac in the current room.
(in Repentance) Keeper's Box 5.100.719
Keeper's Box
4 rooms
0.2
Spawns a random ShopShop item or pickup which can be bought for its normal price.
(in Repentance) Anima Sola 5.100.722
Anima Sola
15 seconds
0.1
Chains down the nearest enemy for 5 seconds, preventing them from moving or attacking.
(in Repentance) Spindown Dice 5.100.723
Spindown Dice
6 rooms
0.1
Upon use, reduces the internal ID number of all items in the room by one, turning them into the item with that number.

Passive Collectibles

Name ID Icon Weight Description
3 Dollar Bill 5.100.191 3 Dollar Bill
1
(in Rebirth) Gives Isaac a random tear effect every room.
(except in Rebirth) Gives Isaac a random tear effect every few seconds.
8 Inch Nails 5.100.359 8 Inch Nails
1
+1.5 damage. Replaces Isaac's tears with nails, which have increased knockback.
20/20 5.100.245 20/20
1
Isaac fires two tears at once, one from each eye. (in Repentance) 0.8× damage multiplier.
???'s Only Friend 5.100.320 ???'s Only Friend
1
Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys
Abel 5.100.188 Abel
1
(in Rebirth) Spawns a familiar that mirrors Isaac's movements and shoots in the opposite direction.
(except in Rebirth) Spawns a familiar that mirrors Isaac's movements and shoots towards him.
Anemic 5.100.214 Anemic
1
After Isaac is damaged, a trail of red creep will be left behind him until he leaves the current room. (except in Repentance) +5 range. (in Repentance) +1.5 range.
Ankh 5.100.161 Ankh
1
Upon death, Isaac will respawn as Character ??? (Character) icon.png??? in the previous room, with 3 Soul Heart.pngSoul Hearts.
Anti-Gravity 5.100.222 Anti-Gravity
1
Tears float in position until firing ceases, after which they will fly off in the direction they were shot in. (except in Repentance) -2 Tear Delay. (in Repentance) +1 Fire Rate.
Aquarius 5.100.308 Aquarius
1
A trail of blue creep is left behind Isaac, which damages enemies. (in Repentance) The creep scales with damage and inherits most tear effects.
Aries 5.100.300 Aries
1
+0.25 Speed. Running into enemies while at a high speed will deal damage. (in Repentance) Prevents Isaac from taking contact damage while moving at high speed.
Ball of Tar 5.100.231 Ball of Tar
1
Adds a chance to shoot slowing tears. Isaac leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Best Bud 5.100.274 Best Bud
1
When hit, spawns a quickly orbiting attack fly similar to Collectible Forever alone icon.pngForever alone for the current room that deals high damage.
Betrayal 5.100.391 Betrayal
1
(except in Repentance) Charms all enemies in the room when Isaac takes damage.
(in Repentance) Enemies are able to damage each other. If an enemy is damaged by another enemy, they will attack that enemy instead of Isaac.
Big Fan 5.100.279 Big Fan
1
Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies.
Black Lotus 5.100.226 Black Lotus
1
Grants one Red Heart Container, one Soul Heart.pngSoul Heart, and one Black Heart.pngBlack Heart.
Blood Clot 5.100.254 Blood Clot
1
(except in Repentance)Tears fired from the left eye have +1 flat damage, +5 range, and +0.5 tear falling speed.
(in Repentance)Tears fired from the left eye have +1 flat damage and +2.75 range.
Blood of the Martyr 5.100.7 Blood of the Martyr
1
+1 damage. Isaac shoots blood tears.
Bloody Lust 5.100.157 Bloody Lust
1
Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor.
Bob's Brain 5.100.273 Bob's Brain
1
Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Bob's Curse 5.100.140 Bob's Curse
1
+5 Bomb.pngBombs. Grants Isaac's bombs a poison effect. (in Repentance) They also leave a lingering poison cloud, and Isaac becomes immune to poison.
Bobby-Bomb 5.100.125 Bobby-Bomb
1
+5 Bomb.pngBombs. Bombs gain a homing effect, slowly moving towards the nearest enemy.
Bomb Bag 5.100.131 Bomb Bag
1
Spawns a familiar that drops a Bomb.pngBomb every 3 rooms.
Bomber Boy 5.100.353 Bomber Boy
1
+5 Bomb.pngBombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects player-spawned Troll Bomb.pngTroll Bombs.
Brother Bobby 5.100.8 Brother Bobby
1
Spawns a familiar that follows Isaac around shooting tears that deal 3.5 damage. (in Repentance) He shoots more frequently than most familiars.
Bursting Sack 5.100.377 Bursting Sack
1
Spider enemies no longer target or deal contact damage to Isaac.
Butt Bombs 5.100.209 Butt Bombs
1
+5 Bomb.pngBombs. Bombs now cloud up the screen, briefly damaging and confusing all enemies.
Cain's Other Eye 5.100.319 Cain's Other Eye
1
(except in Repentance) Spawns a familiar that slowly floats around the room on a zig-zag pattern and shoots normal tears in the same direction as Isaac.
(in Repentance) Spawns a familiar that follows Isaac and fires tears in random cardinal directions that copy Isaac's tears and tear effects and scale with damage.
Cancer 5.100.301 Cancer
1
Adds 3 Soul Heart.pngSoul Hearts. Grants Collectible The Wafer icon.pngThe Wafer effect for the current room after taking damage.
Capricorn 5.100.307 Capricorn
1
(except in Repentance) Adds 1 Red Heart Container, gives +0.5 Damage, +0.1 Speed, +1.5 Range, and -1.0 Tear Delay, and gives 1 Bomb.pngBomb, Penny.pngPenny, and Key.pngKey.
(in Repentance) Adds 1 Red Heart Container, gives +0.5 Damage, +0.1 Speed, +0.75 Range, and +0.5 Fire Rate, and gives 1 Bomb.pngBomb, Penny.pngPenny, and Key.pngKey.
Celtic Cross 5.100.162 Celtic Cross
1
Grants a chance to trigger the Collectible Book of Shadows icon.pngBook of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
Charm of the Vampire 5.100.62 Charm of the Vampire
1
Heals Isaac for a Half Red Heart.pngHalf Red Heart for every 13 enemies killed. (in Repentance) +0.3 damage.
Chemical Peel 5.100.154 Chemical Peel
1
Tears fired from the left eye have +2 flat damage.
Chocolate Milk 5.100.69 Chocolate Milk
1
Grants charged tears that deal greater damage when fully charged.
The Common Cold 5.100.103 The Common Cold
1
Adds a chance to shoot poison tears, dealing damage over time when inflicted.
Continuum 5.100.369 Continuum
1
Grants spectral tears and increases range. Tears travel through walls and appear at the opposite side of the room.
Cricket's Body 5.100.224 Cricket's Body
1
When tears hit an object or deplete their range, they spawn 4 smaller tears, whose range and damage scale with Isaac's. (except in Repentance) Grants -1 tear delay and reduces range. (in Repentance) Grants +0.5 fire rate and reduces range.
Cricket's Head 5.100.4 Cricket's Head
1
Increases Damage by 0.5, and increases damage multiplier by ×1.5.
Cupid's Arrow 5.100.48 Cupid's Arrow
1
Grants Isaac triangular piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
Cursed Eye 5.100.316 Cursed Eye
1
Grants charged tears that can be fired in a tight burst. Getting hit while charging will teleport Isaac to another room.
Curse of the Tower 5.100.371 Curse of the Tower
1
Upon taking damage, spawns six Troll Bomb.pngTroll Bombs around the room, similar to the effect of XVI - The TowerXVI - The Tower.
Daddy Longlegs 5.100.170 Daddy Longlegs
1
Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total.
Dead Bird 5.100.117 Dead Bird
1
After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~4 damage per second.
Dead Eye 5.100.373 Dead Eye
1
Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
Dead Onion 5.100.336 Dead Onion
1
Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.
Deep Pockets 5.100.416 Deep Pockets
1
(except in Repentance) Allows Isaac to carry two cards or pills (or a combination of both) at the same time.
(in Repentance) Increases the coin cap to 999. If a room would otherwise yield no reward, 1-3 coins will spawn.
Distant Admiration 5.100.57 Distant Admiration
1
Spawns an attack fly that circles further out than Collectible Halo of Flies icon.pngHalo of Flies, but closer than Collectible Forever alone icon.pngForever alone, dealing 75 damage per second.
Dr. Fetus 5.100.52 Dr. Fetus
1
Tears are replaced by Bomb.pngBombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired.
Dry Baby 5.100.265 Dry Baby
1
Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering Collectible The Necronomicon icon.pngThe Necronomicon effect.
E. Coli 5.100.236 E. Coli
1
Enemies that touch Isaac are transformed into Poop.pngPoop.
Epiphora 5.100.368 Epiphora
1
Shooting in one direction increases Isaac's rate of fire until the cap is reached. As soon as Isaac changes direction or stops shooting, rate of fire is reset to its normal amount.
Eve's Mascara 5.100.310 Eve's Mascara
1
(except in Repentance) Doubles damage, halves tears stat, and greatly reduces shot speed.
(in Repentance) Doubles damage, 0.66x tears multiplier, and greatly reduces shot speed.
Evil Eye 5.100.410 Evil Eye
1
Adds a chance to fire a slow-moving eye that fires tears in the same direction as Isaac. The eye is destroyed when it hits an enemy or obstacle.
Explosivo 5.100.401 Explosivo
1
Isaac's tears have a chance to stick to enemies and explode.
Fire Mind 5.100.257 Fire Mind
1
Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.
Forever alone 5.100.128 Forever alone
1
Spawns an attack fly that orbits a long distance from Isaac, dealing 30 damage per second.
Friend Zone 5.100.364 Friend Zone
1
Spawns a white attack fly that orbits somewhere between Collectible Distant Admiration icon.pngDistant Admiration and Collectible Forever alone icon.pngForever alone, dealing 45 damage per second.
Gemini 5.100.318 Gemini
1
Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~6.43 damage per second.
Ghost Baby 5.100.163 Ghost Baby
1
Spawns a familiar that follows Isaac around and fires spectral tears.
Glitter Bombs 5.100.432 Glitter Bombs
1
+5 Bomb.pngBombs. Bombs have a chance to drop random pickups or charm enemies when they explode.
Gnawed Leaf 5.100.210 Gnawed Leaf
1
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
God's Flesh 5.100.398 God's Flesh
1
Tears have a chance to shrink enemies, making them run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Guillotine 5.100.206 Guillotine
1
Isaac's head is removed from his body and floats around him as an orbital. (except in Repentance) Gives +1 damage and grants -1 tear delay. (in Repentance) Gives +1 damage and grants +0.5 fire rate.
Halo of Flies 5.100.10 Halo of Flies
1
Spawns two Pretty Flies that block enemy shots and deal contact damage to flies.
Harlequin Baby 5.100.167 Harlequin Baby
1
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Headless Baby 5.100.269 Headless Baby
1
Spawns a familiar that follows Isaac, leaving blood creep on the ground.
Host Hat 5.100.375 Host Hat
1
A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.
Hot Bombs 5.100.256 Hot Bombs
1
+5 Bomb.pngBombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Infamy 5.100.242 Infamy
1
Gives Isaac a 50% chance to block projectiles coming from any direction.
Infestation 5.100.148 Infestation
1
(except in Repentance) 1-3 Blue Flies randomly spawn every time Isaac gets hit.
(in Repentance) 2-6 Blue Flies randomly spawn every time Isaac gets hit.
Infestation 2 5.100.234 Infestation 2
1
Spawns allied Blue Spiders from killed enemies.
The Inner Eye 5.100.2 The Inner Eye
1
Isaac shoots three tears at once with lower fire rate.
Ipecac 5.100.149 Ipecac
1
Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Iron Bar 5.100.201 Iron Bar
1
+0.3 damage. Adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Juicy Sack 5.100.266 Juicy Sack
1
Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room.
Kidney Stone 5.100.440 Kidney Stone
1
Isaac is occasionally forced to stop firing and charge an attack that launches a massive piercing, spectral kidney stone and a barrage of tears. (except in Repentance) -0.2 speed, decreases range.
Lazarus' Rags 5.100.332 Lazarus' Rags
1
(except in Repentance) Upon dying, resurrect as Character Lazarus Risen icon.pngLazarus Risen in the current room with one Red Heart container and Collectible Anemic icon.pngAnemic.
(in Repentance) Upon dying, resurrect as Character Lazarus Risen icon.pngLazarus Risen in the current room with one less Red Heart container, Collectible Anemic icon.pngAnemic, and +0.5 Damage. Transform into Character Lazarus icon.pngLazarus when reaching the next floor.
Leo 5.100.302 Leo
1
Isaac can destroy rocks by walking into them.
Lil Chest 5.100.362 Lil Chest
1
Spawns a chest familiar that spawns a random pickup (25% chance) or trinket (10% chance) upon clearing a room.
Lil Gurdy 5.100.384 Lil Gurdy
1
A Boss Gurdy Jr. ingame.pngGurdy Jr. familiar that charges up while Isaac is firing, bouncing around the room when released and dealing contact damage based on its speed.
Lil Haunt 5.100.277 Lil Haunt
1
Spawns a familiar that chases down enemies, dealing 4 damage per second and inflicting fear.
Little C.H.A.D. 5.100.96 Little C.H.A.D.
1
Spawns a familiar who drops a Half Red Heart.pngHalf Red Heart every 3 rooms.
Little Chubby 5.100.88 Little Chubby
1
Spawns a Charger.pngCharger familiar that charges forward and deals contact damage to any enemies in its path.
Little Gish 5.100.99 Little Gish
1
Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Little Steven 5.100.100 Little Steven
1
Spawns a familiar who follows Isaac around and fires homing tears.
Loki's Horns 5.100.87 Loki's Horns
1
Gives a random chance for projectiles to fire in all 4 cardinal directions.
Lost Contact 5.100.213 Lost Contact
1
Isaac's tears can hit and destroy enemy projectiles. -0.15 shot speed.
Lost Fly 5.100.365 Lost Fly
1
Spawns a fly familiar that moves in a straight line and circles around the first wall or obstacle it hits. (except in Repentance) It deals 105 damage per second on contact. (in Repentance) It deals 56 damage per second and forces nearby enemies to attack it.
The Ludovico Technique 5.100.329 The Ludovico Technique
1
Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
A Lump of Coal 5.100.132 A Lump of Coal
1
The more distance tears travel, the more damage they will do.
Lusty Blood 5.100.411 Lusty Blood
1
Isaac's damage increases for the current room each time he kills an enemy.
Maggy's Bow 5.100.312 Maggy's Bow
1
Gives one Red Heart Container and doubles the healing provided by Red Heart.pngRed Hearts. (in Repentance) Also heals 1 Red Heart when obtained.
Marked 5.100.394 Marked
1
Isaac will automatically fire tears directed at a red target on the ground. The target can be moved with tear controls. +0.7 tears, increases range.
Milk! 5.100.436 Milk!
1
Spawns a glass familiar that spills on the floor upon taking damage. (except in Repentance) After the milk spills, Isaac's tear delay is decreased by 2 for the current room. (in Repentance) After the milk spills, Isaac's fire rate is increased by 1 for the current room.
Mom's Contacts 5.100.110 Mom's Contacts
1
Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. (except in Repentance) +0.25 range. (in Repentance) +1.5 range.
Mom's Eye 5.100.55 Mom's Eye
1
Gives Isaac a chance to fire tears from the back of his head.
Mom's Eyeshadow 5.100.200 Mom's Eyeshadow
1
Tears have a chance to charm enemies.
Mom's Perfume 5.100.228 Mom's Perfume
1
Adds a chance to shoot fear tears. (except in Repentance) Decreases tear delay by 1. (in Repentance) +0.5 fire rate.
Monstro's Lung 5.100.229 Monstro's Lung
1
Replaces normal tears with a charged shot that fires 14 tears in the same fashion as Boss Monstro ingame.pngMonstro.
Mr. Mega 5.100.106 Mr. Mega
1
+5 Bomb.pngBombs. Increases the size, blast radius, and damage of Isaac's bombs.
The Mulligan 5.100.151 The Mulligan
1
Tears have a 1/6 chance of spawning allied Blue Flies when they hit an enemy.
Multidimensional Baby 5.100.431 Multidimensional Baby
1
Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed.
Mutant Spider 5.100.153 Mutant Spider
1
Isaac shoots four tears at once with lower fire rate.
My Reflection 5.100.5 My Reflection
1
Gives Isaac's tears a boomerang effect. (except in Repentance) +1.5 range, +1 tear falling speed, x1.6 shot speed multiplier. (in Repentance) 2x + 1.5 range, +1.5 damage, -1 luck, 1.6x shot speed multiplier.
Mysterious Liquid 5.100.317 Mysterious Liquid
1
Tears leave a small, short lasting pool of creep on impact or when their range is depleted.
Mystery Sack 5.100.271 Mystery Sack
1
Spawns a familiar that drops a Heart, coin, Bomb.pngBomb, or Key.pngKey every 5-6 rooms.
Night Light 5.100.425 Night Light
1
A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.
Number One 5.100.6 Number One
1
Grants +1.5 tears, but severely reduces range.
Number Two 5.100.378 Number Two
1
Continuously firing tears for three seconds causes Isaac to drop a Butt Bomb, which damages and confuses all enemies in the room when it explodes.
Obsessed Fan 5.100.426 Obsessed Fan
1
Spawns a familiar that follows Isaac's movements on a delay and deals 30 contact damage per second to enemies.
Odd Mushroom 5.100.121 Odd Mushroom
1
(except in Repentance) Grants one empty Heart container, +0.3 damage, +0.25 range, +0.5 tear falling speed, and -0.1 speed.
(in Repentance) Grants one full Heart container, +1 damage, +1.5 range, and -0.2 speed
Odd Mushroom 5.100.120 Odd Mushroom
1
+1.7 tears, +0.3 speed, slightly reduces damage.
Ouija Board 5.100.115 Ouija Board
1
Grants spectral tears that travel through obstacles (but not enemies). (in Repentance) +0.5 tears.
Papa Fly 5.100.430 Papa Fly
1
Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies.
The Parasite 5.100.104 The Parasite
1
Isaac's tears split in two when they hit something.
Pay To Play 5.100.380 Pay To Play
1
(except in Repentance) +5 Penny.pngCoins. Most doors require one Penny.pngPenny to open instead of a Key.pngKey.
(in Repentance) +5 Penny.pngCoins. All locked doors, Locked Chest.pngLocked Chests, and Key Blocks must be opened with one Penny.pngPenny instead of Key.pngKeys.
The Peeper 5.100.155 The Peeper
1
Spawns a familiar that slowly floats around the room in a zig-zag pattern, damaging enemies it passes through. (in Repentance) Increases the damage of tears from Isaac's left eye by 35%.
Pisces 5.100.309 Pisces
1
(except in Repentance) -1 Tear Delay, adds knock-back shots and increases tear size.
(in Repentance) +0.5 Fire Rate, adds knock-back shots and increases tear size.
Polyphemus 5.100.169 Polyphemus
1
Isaac fires huge tears that deal massive damage, but fire rate is greatly decreased. If a tear kills an enemy, it travels on with any leftover damage.
Proptosis 5.100.261 Proptosis
1
Tears start out massive with high damage, and then shrink down and become weaker over a short range.
Punching Bag 5.100.281 Punching Bag
1
Spawns a Mulligan.pngMulligan familiar that wanders randomly. Enemies will attack the Mulligan if it's closer.
Pupula Duplex 5.100.379 Pupula Duplex
1
Gives Isaac spectral tears and gives his tears a wide arc shape, increasing their size.
Purity 5.100.407 Purity
1
Boosts one of Isaac's stats depending on the color of the aura around him. The aura disappears upon taking damage and reappears with a random color upon entering a new room. Red boosts damage, blue boosts tears, yellow boosts speed, and orange boosts range.
Pyromaniac 5.100.223 Pyromaniac
1
+5 bombs. Grants immunity to explosion damage and causes explosions to heal Isaac. (in Repentance) Also grants immunity to fire.
Rotten Baby 5.100.268 Rotten Baby
1
Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time.
Rubber Cement 5.100.221 Rubber Cement
1
Tears bounce off walls, enemies, and environmental objects.
Rune Bag 5.100.389 Rune Bag
1
Spawns a familiar that drops a random rune after clearing enough rooms.
Sack of Pennies 5.100.94 Sack of Pennies
1
Spawns a familiar that drops a Penny.pngcoin every 2 rooms.
Sacrificial Dagger 5.100.172 Sacrificial Dagger
1
Spawns a dagger orbital familiar, blocking enemy shots and dealing a high amount of damage to enemies in contact.
Sad Bombs 5.100.220 Sad Bombs
1
+5 Bomb.pngBombs. Upon exploding, bombs shoot 10 tears around them, affected by tear modifiers.
The Sad Onion 5.100.1 The Sad Onion
1
+0.7 tears.
Sagittarius 5.100.306 Sagittarius
1
Increases speed by +0.2 and grants piercing tears.
Samson's Chains 5.100.321 Samson's Chains
1
Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most Obstacles.
Scapular 5.100.142 Scapular
1
Once per room, when Isaac is reduced to his last half heart, he is granted one Soul Heart.pngSoul Heart.
Scatter Bombs 5.100.366 Scatter Bombs
1
+5 Bomb.pngBombs. Isaac's bombs explode into 2-4 tiny bombs.
Scorpio 5.100.305 Scorpio
1
Grants poison tears, which deal damage over time when inflicted.
Serpent's Kiss 5.100.393 Serpent's Kiss
1
Tears have a chance to apply a poison effect to enemies. Isaac poisons enemies on contact. Poisoned enemies have a chance to drop a Black Heart.pngBlack Heart when killed.
Sissy Longlegs 5.100.280 Sissy Longlegs
1
Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. (in Repentance) Briefly charms enemies on contact.
Sister Maggy 5.100.67 Sister Maggy
1
(except in Repentance) Spawns a familiar that follows Isaac around shooting tears that deal 3.5 damage.
(in Repentance) Spawns a familiar that follows Isaac around shooting tears that deal 6 damage.
Smart Fly 5.100.264 Smart Fly
1
Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second.
SMB Super Fan 5.100.189 SMB Super Fan
1
(except in Repentance) +1 Red Heart container, +0.3 damage, +0.2 tears, +0.2 speed, +0.5 range, +1 tear falling speed. Fully restores all red hearts.
(in Repentance) +1 Red Heart container, +0.3 damage, +0.2 tears, +0.2 speed, +2.5 range. Fully restores all red hearts.
Soy Milk 5.100.330 Soy Milk
1
Tears are smaller and do much less damage, but fire in very rapid succession.
Spider Bite 5.100.89 Spider Bite
1
Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Spoon Bender 5.100.3 Spoon Bender
1
Grants Isaac homing tears.
Steam Sale 5.100.64 Steam Sale
1
Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup.
Steven 5.100.50 Steven
1
+1 damage.
Sticky Bombs 5.100.367 Sticky Bombs
1
+5 Bomb.pngBombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy. (in Repentance) They also leave a long-lasting puddle of slowing white creep.
Stigmata 5.100.138 Stigmata
1
+0.3 damage, grants one full Red Heart container. (in Repentance) Heals 1 additional Red Heart.pngRed Heart.
Strange Attractor 5.100.315 Strange Attractor
1
Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Taurus 5.100.299 Taurus
1
-0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the Collectible My Little Unicorn icon.pngMy Little Unicorn effect for 5 seconds.
Tech.5 5.100.244 Tech.5
1
Isaac occasionally fires an unlimited range piercing laser alongside his normal tears. The laser can glitch, mimicking the effects of certain items and trinkets.
Technology 5.100.68 Technology
1
Replaces tears with a piercing laser with unlimited range.
Technology 2 5.100.152 Technology 2
1
Replaces the tears fired from Isaac's right eye with a rapid-firing low damage piercing laser. (except in Repentance) Damage down.
Tech X 5.100.395 Tech X
1
Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the effectiveness of the ring.
Tiny Planet 5.100.233 Tiny Planet
1
Massively increases Range and grants spectral tears. Tears orbit around Isaac at a fixed distance until they hit the ground.
Tough Love 5.100.150 Tough Love
1
Adds a chance to shoot a tooth instead of a tear, which deals x3.2 Isaac's damage.
Tractor Beam 5.100.397 Tractor Beam
1
Isaac's tears are bound to a beam emitting in the direction he's firing. (except in Repentance) +0.5 Tears, +5.25 Range, +0.16 Shot Speed. (in Repentance) +1 Fire Rate, +2.5 Range, +0.16 Shot Speed.
Virgo 5.100.303 Virgo
1
Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills.
The Virus 5.100.13 The Virus
1
Isaac poisons enemies on contact. (except in Repentance) -0.1 speed. (in Repentance) +0.2 speed. (in Afterbirth and Afterbirth †) Poisoned enemies have a chance to drop a black heart when killed.
The Wafer 5.100.108 The Wafer
1
Most sources of damage that would cause more than one-half heart of damage are reduced to one-half heart instead.
The Wiz 5.100.358 The Wiz
1
Grants spectral tears. Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U a Wizard? pill.
Zodiac 5.100.392 Zodiac
1
Gives Isaac a random zodiac item effect that changes every floor.
The Halo 5.100.101 The Halo
(except in Repentance)1
(in Repentance)0.5
(except in Repentance) Grants one full Red Heart container, +0.3 damage, +0.2 tears, +0.25 range, +0.3 speed, and +0.5 tear falling speed.
(in Repentance) Grants one full Red Heart container, +0.3 damage, +0.2 tears, +1.5 range, and +0.3 speed. Heals 1 additional Red Heart.pngRed Heart.
Magic Mushroom 5.100.12 Magic Mushroom
(except in Repentance)1
(in Repentance)0.5
(except in Repentance) Makes Isaac bigger. Adds one Red Heart Container, +0.3 Damage, x1.5 damage multiplier, +5.25 Range, +0.3 Speed, and restores all Health.
(in Repentance) Makes Isaac bigger. Adds one Red Heart Container, +0.3 Damage, x1.5 damage multiplier, +2.5 Range, +0.3 Speed, and restores all Health.
The Body 5.100.334 The Body
(except in Repentance)1
(in Repentance)0.2
Adds 3 Red Heart Containers.
Death's Touch 5.100.237 Death's Touch
(except in Repentance)1
(in Repentance)0.2
+1.5 damage, -0.3 tears. Tears are replaced with large piercing scythes.
Holy Light 5.100.374 Holy Light
(except in Repentance)1
(in Repentance)0.2
Adds a chance to fire holy tears, which will create a damaging light beam in the area if they hit an enemy.
The Mind 5.100.333 The Mind
(except in Repentance)1
(in Repentance)0.2
Reveals the entire map, including all special rooms and Secret RoomSecret Rooms.
Mom's Knife 5.100.114 Mom's Knife
(except in Repentance)1
(in Repentance)0.2
Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
The Soul 5.100.335 The Soul
(except in Repentance)1
(in Repentance)0.2
Grants two Soul Heart.pngSoul Hearts. Isaac gains a pulsing aura that repels enemies and projectiles.
Epic Fetus 5.100.168 Epic Fetus
(except in Repentance)1
(in Repentance)0.1
Instead of tears, firing creates a crosshair which can be moved freely. A missile is dropped in the location after 1.5 seconds, exploding for high damage.
Missing No. 5.100.258 Missing No.
(except in Repentance)1
(in Repentance)0.1
Randomizes all passive items and stats upon pickup and at the start of each succeeding floor.
(except in Repentance) Cube of Meat 5.100.73 Cube of Meat
1
Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage.
(except in Repentance) Godhead 5.100.331 Godhead
1
(except in Repentance) Grants homing tears with a damaging halo. +0.5 Damage, -0.3 Tears -0.3 Shot Speed, +0.8 Tear Falling Speed, and +1.2 Range.
(in Repentance) Grants homing tears with a damaging halo. +0.5 Damage, -0.3 Tears, and -0.3 Shot Speed.
(except in Repentance) Judas' Shadow 5.100.311 Judas' Shadow
1
Upon death, respawns Isaac as Character Dark Judas icon.pngDark Judas with two Black Heart.pngBlack Hearts in the previous room.
(except in Repentance) Pyro 5.100.190 Pyro
1
Grants 99 Bomb.pngBombs.
(in Afterbirth † and Repentance) Adrenaline 5.100.493 Adrenaline
1
Increases damage based on how many empty Red Heart containers Isaac has.
(in Afterbirth † and Repentance) Analog Stick 5.100.465 Analog Stick
1
+0.35 tears up. Allows Isaac to fire tears diagonally.
(in Afterbirth † and Repentance) Apple! 5.100.443 Apple!
1
+0.3 tears. Adds a chance to fire a razor blade that deals 4× Isaac's damage.
(in Afterbirth † and Repentance) Backstabber 5.100.506 Backstabber
1
Isaac's tears deal double damage and inflict bleeding on enemies if they're facing away from Isaac.
(in Afterbirth † and Repentance) Big Chubby 5.100.473 Big Chubby
1
Spawns a familiar that follows Isaac and charges across the room when Isaac fires, blocking shots and dealing 40.5 damage per second on contact.
(in Afterbirth † and Repentance) Bloodshot Eye 5.100.509 Bloodshot Eye
1
Spawns an orbital familiar that deals 30 damage per second and fires a randomly angled tear every 2 seconds.
(in Afterbirth † and Repentance) Bozo 5.100.513 Bozo
1
+0.1 flat damage, grants a Soul Heart.pngSoul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a Rainbow Poop.pngRainbow Poop.
(in Afterbirth † and Repentance) Brittle Bones 5.100.549 Brittle Bones
1
Replaces all Red Heart.pngRed Heart Containers with 6 empty Bone Heart.pngBone Hearts. (except in Repentance) Upon losing a Bone Heart, Isaac fires bones in 8 directions and permanently gains a tears up. (in Repentance) Upon losing a Bone Heart, Isaac fires bones in 8 directions and permanently gains a fire rate up.
(in Afterbirth † and Repentance) Broken Modem 5.100.514 Broken Modem
1
Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals. The reward from clearing a room will sometimes be duplicated.
(in Afterbirth † and Repentance) Camo Undies 5.100.497 Camo Undies
1
Isaac becomes camouflaged at the beginning of each room. Until he shoots, all non-boss enemies will be confused. (in Repentance) Isaac gains +0.5 Speed while camouflaged, and gains Tears and Damage upon breaking it.
(in Afterbirth † and Repentance) Compound Fracture 5.100.453 Compound Fracture
1
Increases Range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.
(in Afterbirth † and Repentance) Cone Head 5.100.457 Cone Head
1
Grants a Soul Heart.pngSoul Heart. Gives Isaac a chance to ignore any damage taken.
(in Afterbirth † and Repentance) Contagion 5.100.466 Contagion
1
The first enemy killed in a room releases a gas cloud that poisons nearby enemies. Affected enemies will also release gas upon death, spreading the effect.
(in Afterbirth † and Repentance) Dead Tooth 5.100.446 Dead Tooth
1
While firing, Isaac gains a green aura that poisons nearby enemies.
(in Afterbirth † and Repentance) Depression 5.100.469 Depression
1
Spawns a familiar that leaves a trail of creep that damages enemies at 6 damage per second. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.
(in Afterbirth † and Repentance) Dog Tooth 5.100.445 Dog Tooth
1
+0.3 damage, +0.1 speed. Plays a howl or bark sound when entering a room with undiscovered Secret RoomSecret Rooms or Crawl SpaceCrawl Spaces.
(in Afterbirth † and Repentance) Euthanasia 5.100.496 Euthanasia
1
Adds a luck-based chance to fire needles that instantly kill basic enemies and deal triple damage to bosses. If a needle kills an enemy, it bursts into more tears/needles.
(in Afterbirth † and Repentance) Eye of Greed 5.100.450 Eye of Greed
1
Every 20 tears, Isaac loses 1 Penny.pngPenny and shoots an additional gold tear that petrifies enemies and turns them into gold. Any enemy killed while in this state will drop coins.
(in Afterbirth † and Repentance) Finger! 5.100.467 Finger!
1
Spawns a finger familiar that faces in the same direction as Isaac, rapidly damaging enemies it points at for 10% of Isaac's damage.
(in Afterbirth † and Repentance) Flat Stone 5.100.540 Flat Stone
1
Tears bounce off the floor, creating splashes. Splashes deal 25% of Isaac's tear damage to all enemies in a small area.
(in Afterbirth † and Repentance) Ghost Pepper 5.100.495 Ghost Pepper
1
(except in Repentance)Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them.
(in Repentance)Gives a chance to shoot blue fires alongside tears that become smaller as they travel.
(in Afterbirth † and Repentance) Glaucoma 5.100.460 Glaucoma
1
Adds a chance to shoot tears that confuse enemies for an extremely long time.
(in Afterbirth † and Repentance) Haemolacria 5.100.531 Haemolacria
1
Turns Isaac's tears into large blood tears fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.
(in Afterbirth † and Repentance) Hallowed Ground 5.100.543 Hallowed Ground
1
Spawns a white poop familiar, which turns into a White Poop.pngWhite Poop when Isaac is hurt. White poop has an aura that increases tear fire rate and can block enemy shots. (in Repentance) The aura also increases damage by 20% and gives homing.
(in Afterbirth † and Repentance) Hushy 5.100.470 Hushy
1
Spawns a Boss Hush ingame.pngHush familiar that bounces diagonally around the room and deals contact damage. While firing tears, it stops moving.
(in Afterbirth † and Repentance) Jacob's Ladder 5.100.494 Jacob's Ladder
1
Tears fire sparks of electricity in random directions upon hitting an obstacle or enemy.
(in Afterbirth † and Repentance) Jaw Bone 5.100.548 Jaw Bone
1
Spawns a familiar that flies through the room while firing, dealing a flat 7 contact damage to enemies and retrieving pickups.
(in Afterbirth † and Repentance) Jumper Cables 5.100.520 Jumper Cables
1
Grants an active item charge every 15 enemies killed.
(in Afterbirth † and Repentance) Lachryphagy 5.100.532 Lachryphagy
1
Isaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.
(in Afterbirth † and Repentance) Large Zit 5.100.502 Large Zit
1
Adds a chance to fire a creep shot that deals double damage and leaves a trail of slowing white creep.
(in Afterbirth † and Repentance) Lead Pencil 5.100.444 Lead Pencil
1
After every 15 tears fired, Isaac will fire a high-damage cluster of tears.
(in Afterbirth † and Repentance) Leprosy 5.100.525 Leprosy
1
Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
(in Afterbirth † and Repentance) Lil Monstro 5.100.471 Lil Monstro
1
Spawns a familiar that fires clusters of tears. Must be charged before shooting.
(in Afterbirth † and Repentance) Lil Spewer 5.100.537 Lil Spewer
1
Drops a random pill, and spawns a familiar that charges up and fires creep. Using pills changes the creep type.
(in Afterbirth † and Repentance) Linger Bean 5.100.447 Linger Bean
1
Constantly shooting causes Isaac to release gas clouds that can be pushed by his tears and damage nearby enemies.
(in Afterbirth † and Repentance) Little Horn 5.100.503 Little Horn
1
(except in Repentance) Adds a chance to fire a piercing tear that instantly kills any enemy that it touches.
(in Repentance) Adds a chance to fire a tear that summons Big Horn's hand to crush the first enemy it hits, instantly killing monsters or greatly damaging bosses.
(in Afterbirth † and Repentance) Metal Plate 5.100.449 Metal Plate
1
Grants one Soul Heart.pngSoul Heart. Enemy shots have a chance to be reflected at the shooter as confusing tears.
(in Afterbirth † and Repentance) Mom's Razor 5.100.508 Mom's Razor
1
Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time.
(in Afterbirth † and Repentance) Mom's Wig 5.100.217 Mom's Wig
1
Adds a chance to spawn Blue Spiders when firing tears. Restores 1 Red Heart.pngRed Heart.
(in Afterbirth † and Repentance) Mongo Baby 5.100.322 Mongo Baby
1
Spawns a familiar that copies the tears of Isaac's other familiars.
(in Afterbirth † and Repentance) Mystery Egg 5.100.539 Mystery Egg
1
Spawns an egg familiar, which hatches a random friendly monster when Isaac is hurt once per room. The power of the monster improves for each consecutive room cleared without taking damage.
(in Afterbirth † and Repentance) Parasitoid 5.100.461 Parasitoid
1
Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy.
(in Afterbirth † and Repentance) Pointy Rib 5.100.544 Pointy Rib
1
Spawns a bone familiar that hovers back and forth in front of Isaac, dealing damage equal to Isaac's damage.
(in Afterbirth † and Repentance) Pop! 5.100.529 Pop!
1
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
(in Afterbirth † and Repentance) Rainbow Baby 5.100.174 Rainbow Baby
1
Spawns a familiar that follows Isaac around and fires tears with random effects.
(in Afterbirth † and Repentance) Robo-Baby 5.100.95 Robo-Baby
1
Spawns a familiar that shoots Collectible Technology icon.pngTechnology lasers.
(in Afterbirth † and Repentance) Robo-Baby 2.0 5.100.267 Robo-Baby 2.0
1
Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.
(in Afterbirth † and Repentance) Shard of Glass 5.100.448 Shard of Glass
1
(except in Repentance) Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
(in Repentance) Taking damage causes Isaac to bleed, spraying a volley of blood in the direction he fires. Bleeding will eventually damage him, but it can be stopped by picking up a Red Heart.pngRed Heart.
(in Afterbirth † and Repentance) Sinus Infection 5.100.459 Sinus Infection
1
Adds a chance to fire a booger that sticks to enemies and deals damage over time.
(in Afterbirth † and Repentance) Slipped Rib 5.100.542 Slipped Rib
1
Spawns a bone familiar that circles around Isaac and reflects enemy shots.
(in Afterbirth † and Repentance) Sulfuric Acid 5.100.463 Sulfuric Acid
1
+0.3 damage. Adds a chance to fire acidic tears which can destroy obstacles and open doors.
(in Afterbirth † and Repentance) Technology Zero 5.100.524 Technology Zero
1
Connects Isaac's tears with electricity that can damage enemies.
(in Afterbirth † and Repentance) Varicose Veins 5.100.452 Varicose Veins
1
Taking damage releases a ring of 10 high damage tears.
(in Afterbirth † and Repentance) The Relic 5.100.98 The Relic
(except in Repentance)1
(in Repentance)0.2
Spawns a cross familiar that drops a Soul Heart.pngSoul Heart after clearing enough rooms.
(in Repentance) 120 Volt 5.100.559 120 Volt
1
Repeatedly zaps enemies that are close to Isaac.
(in Repentance) Akeldama 5.100.641 Akeldama
1
While in an uncleared room, Isaac forms a trail of bloody tears that drags behind him, bursting and dealing damage upon contact with enemies.
(in Repentance) Almond Milk 5.100.561 Almond Milk
1
Quadruples fire rate, with ×0.3 damage multiplier. Each tear is given a random effect that alters its movement.
(in Repentance) Belly Button 5.100.458 Belly Button
1
Drops a random trinket. Grants a second trinket slot.
(in Repentance) Belly Jelly 5.100.690 Belly Jelly
1
Causes enemies to bounce off of Isaac, dealing damage to them if they hit an enemy or obstacle. Also gives Isaac the chance to deflect enemy shots.
(in Repentance) Bird's Eye 5.100.616 Bird's Eye
1
Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them.
(in Repentance) Bird Cage 5.100.610 Bird Cage
1
The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to Collectible Dead Bird icon.pngDead Bird.
(in Repentance) Blood Bombs 5.100.614 Blood Bombs
1
Grants a Red Heart container and restores 5 hearts. Bombs leave behind damaging red creep. Isaac can place Bomb.pngBombs at the cost of half a heart if he doesn't have any.
(in Repentance) Blood Puppy 5.100.565 Blood Puppy
1
Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac. Dealing enough damage to it returns it to normal.
(in Repentance) Bloody Gust 5.100.695 Bloody Gust
1
The first 6 times Isaac takes damage on a given floor, he gains Speed and Fire Rate for the rest of the floor, up to a maximum of +1.02 and +3.00, respectively.
(in Repentance) Boiled Baby 5.100.607 Boiled Baby
1
Gives Isaac a familiar that fires chaotic bursts of tears in all directions.
(in Repentance) Bone Spurs 5.100.683 Bone Spurs
1
Enemies spawn floating bones on death, which block shots and damage/repel enemies that touch them.
(in Repentance) Bot Fly 5.100.629 Bot Fly
1
Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles.
(in Repentance) Candy Heart 5.100.671 Candy Heart
1
Gives Isaac a permanent stat boost whenever he heals with Red Heart.pngRed Heart pickups.
(in Repentance) Cracked Orb 5.100.675 Cracked Orb
1
Unlocks doors and reveals a random room on the map when Isaac takes damage.
(in Repentance) C Section 5.100.678 C Section
1
Replaces tears with fetuses that chase down enemies and deal contact damage. Each shot requires a brief charge up.
(in Repentance) Cube Baby 5.100.652 Cube Baby
1
Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills.
(in Repentance) Dirty Mind 5.100.576 Dirty Mind
1
Destroying poop spawns Dip Familiars that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects.
(in Repentance) Empty Heart 5.100.676 Empty Heart
1
If Isaac has one red heart or fewer at the beginning of a floor, he gains an empty red heart container.
(in Repentance) Eye Sore 5.100.558 Eye Sore
1
Causes Isaac to occasionally fire extra tears in random directions while shooting.
(in Repentance) Freezer Baby 5.100.608 Freezer Baby
1
Spawns a shooting familiar that has a chance to petrify enemies, and freezes monsters upon killing them.
(in Repentance) Fruity Plum 5.100.649 Fruity Plum
1
Gives Isaac a miniature Boss Baby Plum ingame.pngBaby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels.
(in Repentance) Ghost Bombs 5.100.727 Ghost Bombs
1
+5 Bomb.pngBombs. Bombs become spectral and spawn ghosts that deal contact damage to enemies and explode after 10 seconds.
(in Repentance) Giant Cell 5.100.658 Giant Cell
1
Causes Isaac to spawn Minisaac familiars when he takes damage, which chase and shoot at nearby enemies.
(in Repentance) Hemoptysis 5.100.726 Hemoptysis
1
Double-tapping a fire button causes Isaac to sneeze blood, dealing damage to enemies in front of him. Affected enemies are cursed and take more damage from Collectible Brimstone icon.pngBrimstone-like attacks.
(in Repentance) Hypercoagulation 5.100.724 Hypercoagulation
1
After Isaac takes damage from an enemy or donates health, launches Red Heart.pngRed Hearts from Isaac that despawn after 1.5 seconds.
(in Repentance) IBS 5.100.725 IBS
1
Causes Isaac to throw poop, create buffing creep, or drop bombs while fighting enemies.
(in Repentance) The Intruder 5.100.575 The Intruder
1
A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room.
(in Repentance) It Hurts 5.100.560 It Hurts
1
Releases a ring of tears and increases fire rate for the current room when Isaac takes damage.
(in Repentance) Knockout Drops 5.100.637 Knockout Drops
1
Adds a chance to shoot a fist tear that has extremely high knockback and confuses enemies.
(in Repentance) Lil Dumpy 5.100.615 Lil Dumpy
1
Spawns a Dumpy familiar that pushes away nearby enemies and projectiles just before Isaac is about to be hit, then falls asleep. He can be awoken by walking to him.
(in Repentance) Lil Portal 5.100.681 Lil Portal
1
A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room.
(in Repentance) Lodestone 5.100.617 Lodestone
1
Gives Isaac the chance to fire tears that magnetize enemies they hit, causing them to attract nearby pickups and enemies, as well as tears/shots from all sources.
(in Repentance) Lost Soul 5.100.612 Lost Soul
1
Creates a ghostly familiar that closely follows behind Isaac. It dies in one hit, but respawns at the start of the next floor. Each time it survives until the next floor, it rewards Isaac with Soul Heart.pngSoul Hearts, Eternal Heart.pngEternal Hearts, or an Item.
(in Repentance) Montezuma's Revenge 5.100.680 Montezuma's Revenge
1
While firing, Isaac charges up a short-ranged Collectible Brimstone icon.pngBrimstone-like diarrhea beam that shoots behind him.
(in Repentance) Mucormycosis 5.100.553 Mucormycosis
1
Gives Isaac the chance to fire spore tears that stick to enemies and blow up after a few seconds, dealing damage and poisoning nearby enemies and releasing more spores.
(in Repentance) Nancy Bombs 5.100.563 Nancy Bombs
1
+5 Bomb.pngBombs. Each bomb gains 1-4 random bomb synergies.
(in Repentance) Playdough Cookie 5.100.570 Playdough Cookie
1
Grants multicolored tears. Each color comes with a different status or tear effect.
(in Repentance) Polydactyly 5.100.454 Polydactyly
1
Allows Isaac to carry two cards, pills, or any combination of both. Spawns one random card, rune, or pill.
(in Repentance) Psy Fly 5.100.581 Psy Fly
1
Spawns a fly orbital familiar that chases and blocks enemy shots.
(in Repentance) Quints 5.100.661 Quints
1
The first five enemies killed in a room will spawn stationary shooting familiars where they died.
(in Repentance) Rocket in a Jar 5.100.583 Rocket in a Jar
1
+5 Bomb.pngBombs. If Isaac is currently firing, placing a bomb will instead shoot a fast-moving, explosive rocket in the direction he's facing.
(in Repentance) Rotten Tomato 5.100.618 Rotten Tomato
1
Adds a chance to fire tears that mark enemies with the Bait status effect. Enemies marked as bait are attacked by other enemies.
(in Repentance) The Swarm 5.100.693 The Swarm
1
Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly.
(in Repentance) Tinytoma 5.100.645 Tinytoma
1
Gives Isaac a Boss Teratoma ingame.pngTeratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders.
(in Repentance) Tooth and Nail 5.100.663 Tooth and Nail
1
Isaac periodically turns into a spiked statue, briefly becoming invulnerable and dealing contact damage.
(in Repentance) Vasculitis 5.100.657 Vasculitis
1
Enemies explode into tears upon death, which inherit the effects of Isaac's tears.
(in Repentance) Worm Friend 5.100.682 Worm Friend
1
Gives Isaac a Nerve Ending.pngNerve Ending familiar that burrows out of the ground to grab and deal damage to enemies over time.
(in Repentance) Astral Projection 5.100.677 Astral Projection
0.5
Causes Isaac to turn into a ghost if he gets hit while in an uncleared room, giving him flight and spectral tears and blocking the next hit he takes.
(in Repentance) Keeper's Kin 5.100.717 Keeper's Kin
0.2
Rocks and other Obstacles spawn blue spiders over time while in a room with enemies, and spawn two blue spiders when destroyed.
(in Repentance) Keeper's Sack 5.100.716 Keeper's Sack
0.2
Gives range, speed, or damage when buying things from a shop. Spawns three coins and a Key.pngKey on pickup.
(in Repentance) Pyro 5.100.190 Pyro
0.1
Grants 99 Bomb.pngBombs.
(in Repentance) Skeleton Key 5.100.17 Skeleton Key
0.1
Gives Isaac 99 Key.pngKeys.
(in Repentance) TMTRAINER 5.100.721 TMTRAINER
0.1
Causes all future items to be "glitched", granting them completely random effects.