Despite appearing as Troll Bombs, the bombs are mechanically identical to player-placed bombs and will benefit from Isaac's bomb-enhancing items.
These bombs hurt the player as well as enemies.
Taking damage from the Troll Bombs spawned by Curse of the Tower or any other type of bomb, including Isaac's bombs, will not re-activate the effect.
Picking up this item will make all health transactions more difficult. Devil Beggars and Blood Donation Machines will be almost impossible to use because they will very likely be destroyed by bombs.
The Polaroid: If Isaac is damaged when he has half a Red Heart or less, the shield will activate and protect him from the Troll Bombs.
Pyromaniac: Troll Bombs will heal Isaac instead, allowing for essentially infinite health with proper usage.
Due to Pyromaniac being weakened to healing half a heart per explosion in Repentance, this synergy requires The Wafer to continue being effective past Chapter 3/Chapter 3.5.
Remote Detonator: The Troll Bombs generated will not explode until Remote Detonator is activated, unlike regular Troll Bombs.
Safety Scissors: The Troll Bombs generated will be converted into bomb pickups rather than exploding.
Interactions
Blind Rage: Normally, the invincibility frames will end before most of the explosions take place. However, if Isaac takes a full heart of damage (e. g. from a champion), the invincibility will protect him from all spawned Troll Bombs.
Damage sources that scale up from half a heart of damage to a full heart of damage starting on Chapter 4 don't provide enough invincibility frames to ignore the explosions.
Blood Oath: Not recommended. Spawns 6 Troll Bombs for each Half Red Heart removed, making death highly likely if Isaac does not leave the room immediately after being stabbed by Blood Oath, and leaving the starting room unsafe.
Sharp Plug: Not recommended. Spawns 6 Troll Bombs for each Half Red Heart removed, making extra damage highly likely if Isaac does not leave the room immediately after using Sharp Plug.
Bomber Boy: Not recommended. The cross pattern explosion makes it very hard to avoid taking damage.
Troll Bombs around the room, similar to the effect of 
XVI - The Tower.
Picking up this item will make all health transactions more difficult. 
Devil Beggars and 
Blood Donation Machines will be almost impossible to use because they will very likely be destroyed by bombs.
Taking damage from 
IV Bag, however, does trigger the effect.
Blasting Cap: Spawned Troll Bombs can drop extra bomb pickups.
Glitter Bombs: Each troll bomb has a chance to spawn a pickup or a trinket including hearts for repeated use.
The Polaroid: If Isaac is damaged when he has half a 
Red Heart or less, the shield will activate and protect him from the Troll Bombs.
Pyromaniac: Troll Bombs will heal Isaac instead, allowing for essentially infinite health with proper usage.
The Wafer to continue being effective past Chapter 3/Chapter 3.5.
Remote Detonator: The Troll Bombs generated will not explode until Remote Detonator is activated, unlike regular Troll Bombs.
Safety Scissors: The Troll Bombs generated will be converted into bomb pickups rather than exploding.
Blind Rage: Normally, the invincibility frames will end before most of the explosions take place. However, if Isaac takes a full heart of damage (e. g. from a champion), the invincibility will protect him from all spawned Troll Bombs.
Blood Oath: Not recommended. Spawns 6 Troll Bombs for each 
Half Red Heart removed, making death highly likely if Isaac does not leave the room immediately after being stabbed by Blood Oath, and leaving the starting room unsafe.
Sharp Plug: Not recommended. Spawns 6 Troll Bombs for each 
Bomber Boy: Not recommended. The cross pattern explosion makes it very hard to avoid taking damage.
Mr. Mega: No effect.
Scatter Bombs: Not recommended. Each Troll Bomb will spawn several smaller bombs upon exploding, making it very hard to avoid taking damage.
Bombs 
The Binding of Isaac: Rebirth
