When used, swaps between the current character and Esau Jr., who has three Black Hearts, +2 flat damage, and flight. When used as Esau Jr., swaps back to the original character.
Coins, Bombs, and Keys are shared between the two characters, but everything else (including hearts, items, cards/pills, and trinkets) are not shared and apply only to the character that collects them.
When used for the first time, Esau Jr. gains a random item for each item the original character had. Each new item comes from the same item pool the respective original item was taken from.
Quest items like The Polaroid are given to both characters, as is the Esau Jr. item.
Pickups that would normally be generated by the new items will not drop when Esau Jr. is first used.
If either character dies, they both die, regardless of whether the other character has any remaining health.
If multiple copies of Esau Jr. are used, starting from the fifth one, instead of activating its regular effect, the item is consumed and spawns a familiar that behaves like Abel but deals 7.5 damage per shot with higher fire rate.
Notes
Unlike Lazarus Risen and Dark Judas, Esau Jr. is not an actual character. He is merely a costume applied to the current character, and as such retains all of the special features of the character such as health mechanics, Lilith's blindfold, and pocket active items.
Despite starting with only black hearts, Esau Jr. is able to gain heart containers if the original character could.
Esau Jr. will not keep any passive starting items the original character had, and they won't count towards the number of items Esau Jr. will get.
If a character has an Eternal Heart, then that character must be active when going to a new floor for the eternal heart to turn into a heart container.
Using Esau Jr. removes the damage penalty on Daily Challenges while retaining the schwag bonus. Deep Pockets schwag only persists if you don't transition between rooms.
Synergies
Book of Virtues: Spawns a black wisp when used to turn into Esau Jr. that is otherwise identical to a normal one; turning back into the original character spawns a normal wisp. Each form will retain their own set of wisps.
Butter!: Puts Esau Jr. on a pedestal and generates an extra copy for the swapped character to hold, duplicating the item.
Interactions
Bethany: Esau Jr. will have one heart container, but can still gain heart containers up to the character's normal cap. Soul Hearts will still be used as soul charges instead of health.
In the case of Luna, the character that has the item must also be active going into Secret Rooms for them to spawn beams of light. However, either character can then enter the beam of light to gain tears and soul hearts.
Chaos / Sacred Orb / TMTRAINER: Will affect the items given to Esau Jr. when used for the first time, but will not affect subsequent uses. Item generation is only affected if the character that has it is currently active.
The Forgotten: Esau Jr. will have one empty bone heart and three black hearts if used as The Forgotten, and one additional empty bone heart if used as The Soul.
Genesis: Using Genesis as Esau Jr. will revert back to the original character.
Keeper / Tainted Keeper: Esau Jr. will have two coin heart containers, but only one is filled.
Lost Soul: The character that holds Lost Soul must be the one to enter a new floor to get its rewards.
Panic Button: Activates Esau Jr. before the active character takes damage, redirecting the damage to the inactive character. The item's charge is used in the process.
Schoolbag: The extra active item will continue to be held by the character that has Schoolbag. However, it cannot gain charges through any means until the character becomes active again.
Tainted Cain: Each item given to Esau Jr. on the first use is based on the item pool of the last spawned item pedestal before each item is crafted. Esau Jr. starts with a separate bag of crafting that has its own inventory and starts empty. The crafting inventories of both characters are saved. Other abilities are unchanged.
Tainted Eden: Taking damage will visually turn Esau Jr. back into Tainted Eden, but will maintain Esau Jr.'s flight and flat damage bonus.
Tainted Jacob: Tainted Jacob and Esau Jr. both become ghosts if any of them get touched by Dark Esau.
Tainted Magdalene: Esau Jr.'s starting black hearts will quickly drain down to half a heart; he must obtain heart containers while in this form to have any survivability.
The Esau Jr. familiar created by using 5 duplicates of the item.
Bugs
Bug!
If one character has Deep Pockets, swapping to the other character then collecting or spending coins will cap the number of coins at 99.
Bug!
Upon swapping to a character with Bone Hearts for the first time, bone hearts become half soul hearts. This is only cosmetic, and they become normal again if health is updated (obtaining HP up items, etc). The bone hearts must be obtained before the first swap to cause the bug.
Bug!
If at least one character has Spear Of Destiny or Trinity Shield, swapping to the other character causes these items to leave a stationary copy of themselves until Isaac leaves the room. The stationary spear is only a visual bug with no collision while the stationary shield still blocks tears.