This item belongs to the Fun Guy set. Collecting three items from this set will transform Isaac into a walking mushroom.
This item belongs to the Stompy set. Collecting three items from this set will transform Isaac into Stompy.
Notes
This item can rarely drop from destroying mushrooms.
The x1.5 damage multiplier does not stack with the x1.5 damage multiplier from Cricket's Head, from the combination of The Book of Belial and Blood of the Martyr, or itself (by using an item such as Diplopia, for example). However, it will stack with any other multipliers, such as Sacred Heart.
Interactions
Haemolacria: Both 1.5x damage multipliers stack as expected.
Magic Mushroom does not give a Tears, Luck, or Shot Speed increase despite its quote saying 'All Stats Up!'.
This item and its effects are a reference to the Super Mushroom from the Super Mario Brothers video game franchise.
This item's sprite resembles to the mushroom species Amanita muscaria, fly agaric.
'Magic mushrooms' is a colloquial term for hallucinogenic mushrooms containing psilocybin. Fly agaric is hallucinogenic, although it does not contain psilocybin and is not considered a "magic mushroom".
+5.25 Range.
+2.5 Range.
This item belongs to the 
Fun Guy set. Collecting three items from this set will transform Isaac into a walking mushroom.
This item belongs to the 
Stompy set. Collecting three items from this set will transform Isaac into Stompy.
Cricket's Head, from the combination of 
The Book of Belial and 
Blood of the Martyr, or itself (by using an item such as 
Diplopia, for example). However, it will stack with any other multipliers, such as 
Sacred Heart.
Haemolacria: Both 1.5x damage multipliers stack as expected.
Tainted Bethany: On pickup, grants 12 blood charges.
Magic Mushroom, "One makes you larger" pills, 
XI - Strength, etc..
This item is one of only two (
The Bible (
Hive Mind, 
Parasitoid, and 
Skatole).
1up!.
Super Bandage is one of the few items that make a unique sound upon pickup.
Mushrooms 
The Binding of Isaac: Rebirth
