Familiar
Familiars are small companions, usually generated by passive items, that follow and assist Isaac. Effects of familiars include (but are not limited to) pickup generation, shooting familiars that fire their own tears at enemies, and orbitals that act as projectile shields and/or deal contact damage.
Many of these familiars (especially pickup generation and shooting familiars) follow behind Isaac. When Isaac picks up multiple of these following familiars, they form a line behind him from oldest to newest (with closest familiar behind Isaac being the oldest one picked up) rather than constantly overlapping one another on the same spot behind Isaac.
- In addition to being chronologically ordered, certain familiars on the line take priority over others in how close their position is to Isaac. There are 6 priorities:
- The 1st priority is taken by King Baby, making it always the closest familiar to Isaac.
- The 2nd priority is taken by Incubus.
- The 3rd priority is taken by Lil Brimstone and Lil Monstro.
- The 4th priority is taken by Censer, Dry Baby, Lil Abaddon, and Mongo Baby.
- The 5th priority is taken by most shooting familiars and some throwable familiars.
- The 6th priority is taken by most pickup generation familiars and "
quest item
" familiars such as Key Piece 1. Boiled Baby also takes this priority.
Isaac cannot have more than 64 total familiars at once. This includes blue spiders and flies, familiar items such as Dry Baby, Tainted Eve's blood clots, etc. Gaining more than this will result in familiars being destroyed, with blue spiders and flies being destroyed first.
Temporary Familiars
Blue Flies
Blue Flies are familiars that will orbit around Isaac and rush towards nearby enemies, dealing damage and dying in the process. Blue Flies deal double Isaac's current tear damage.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Guppy's Head | 5.100.145 | Reusable fly hive | Spawns 2-4 friendly Blue Flies that damage enemies. | 2 | |
Mom's Pad | 5.100.41 | Mass fear | Inflicts fear to all enemies in the room for 4 seconds. Spawns a blue fly. | 0 | |
Jar of Flies | 5.100.434 | Bug catcher | Killing an enemy adds a fly to the jar, up to a maximum of 20. On use, releases Blue Flies equal to the number of flies in the jar. | 2 | |
Compost | 5.100.480 | Gain more friends! | Doubles Isaac's Blue Flies and Blue Spiders, or spawns one if Isaac has none. Converts pickups in the current room into Blue Flies or Blue Spiders. | 1 | |
Everything Jar | 5.100.720 | Anything is possible | Spawns certain pickups based on how many charges it has. If fully charged, instead has one of many unique effects. | 3 |
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Infestation | 5.100.148 | Fly revenge | 1-3 Blue Flies randomly spawn every time Isaac gets hit. 2-6 Blue Flies randomly spawn every time Isaac gets hit. |
0 | |
Mom's Underwear | 5.100.29 | Range up | +5.25 range, +0.5 tear falling speed. +2.5 range. Spawns 3-6 Blue Flies on pickup. |
1 | |
Rotten Baby | 5.100.268 | Infested friend | Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time. | 3 | |
The Mulligan | 5.100.151 | They grow inside | Tears have a 1/6 chance of spawning allied Blue Flies when they hit an enemy. | 3 | |
Parasitoid | 5.100.461 | Egg tears! | Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy. | 3 | |
Lil Portal | 5.100.681 | It hungers | A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room. | 1 | |
The Swarm | 5.100.693 | Infest | Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. | 2 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Fish Head | 5.350.29 | It stinks | Spawns a Blue Fly every time Isaac takes damage. | |
Lil Larva | 5.350.86 | The poop is moving... | Spawns a Blue Fly from every pile of Poop that Isaac destroys. | |
Fish Tail | 5.350.94 | It also stinks! | Items and trinkets that generate Blue Flies or Locusts will generate twice as many. | |
Rotten Penny | 5.350.126 | Wealth of flies | Spawns a Blue Fly every time a coin is picked up. |
Name | ID | Icon | Message | Description |
---|---|---|---|---|
Rune of Berkano | 5.300.38 | Companionship | Summons 3 friendly Blue Flies and 3 friendly Blue Spiders. | |
Black Rune | 5.300.41 | Void | Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades. |
Other sources of Blue Flies
- Red Chest: Has a chance to spawn 3 Blue Flies.
- Dark blue champion: Will create 3 Blue Flies when defeated.
- Guppy: Isaac will create Blue Flies whenever his tears or his familiars' tears hit enemies.
- Guppy: Isaac's tears have a 66% chance to create Blue Flies whenever they hit enemies.
- Beelzebub: Some types of enemy flies become Blue Flies.
- Friends Till The End! pill: Spawns 3 Blue Flies.
- As Keeper or Tainted Keeper, all heart pickups turn into Blue Flies.
- Rotten Heart: After clearing a room, a maximum of 2 Blue Flies spawn for each Rotten Heart in Isaac's life bar.
- Corny Poops created by Tainted ??? or IBS spawn a Blue Fly every two seconds, up to a maximum of 3.
- Rotten Beggars can spawn Blue Flies as a reward.
Locusts
Locusts are variants of Blue Flies that are spawned by Locust trinkets and 7 Seals. They behave like regular Blue Flies but have additional special effects. Red Locusts explode on contact with an enemy, dealing an extra 60 damage in the radius (explosions are affected by certain bomb modifiers). Green Locusts poison the enemy. Yellow Locusts slow the enemy. Black Locusts deal quadruple Isaac's damage instead of double. White Locusts are identical to Blue Flies, but are generally spawned in high quantities.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
7 Seals | 5.100.526 | Lil harbingers! | Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. | 2 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Fish Tail | 5.350.94 | It also stinks! | Items and trinkets that generate Blue Flies or Locusts will generate twice as many. | |
Locust of Conquest | 5.350.117 | I bring Conquest | Upon entering a room with enemies, spawns 1-4 White Locusts which damage enemies. | |
Locust of Death | 5.350.116 | I bring Death | Upon entering a room with enemies, spawns a Black Locust that does a very high amount of damage. | |
Locust of Famine | 5.350.115 | I bring Famine | Upon entering a room with enemies, spawns a Yellow Locust that damages and slows enemies. | |
Locust of Pestilence | 5.350.114 | I bring Pestilence | Upon entering a room with enemies, spawns a Green Locust which damages and poisons enemies. | |
Locust of War | 5.350.113 | I bring War | Upon entering a room with enemies for the first time, spawns a Red Locust which detonates upon impact with enemies. | |
Cricket Leg | 5.350.185 | Infested | Adds a chance to spawn a random locust when killing an enemy. |
Name | ID | Icon | Message | Description |
---|---|---|---|---|
Soul of Apollyon | 5.300.94 | Bringer of calamity | Spawns 15 random locusts. |
Blue Spiders
Blue Spiders are familiars similar to Blue Flies that crawl erratically and rush towards nearby enemies, dealing damage and dying in the process.
Blue Spiders deal 2.5 times Isaac's current tear damage. Blue Spiders deal twice Isaac's current tear damage.
Unlike Blue Flies, Blue Spiders cannot attack over obstacles such as rocks and pits.
Bug! | 3DS Exiting the game and re-entering will cause all Blue Spiders to disappear. |
---|
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Box of Spiders | 5.100.288 | It's a box of spiders | Spawns 1-4 Blue Spiders that deal 2.5× Isaac's damage to enemies. Spawns 4-8 Blue Spiders that deal 2× Isaac's damage to enemies. |
1 | |
Compost | 5.100.480 | Gain more friends! | Doubles Isaac's Blue Flies and Blue Spiders, or spawns one if Isaac has none. Converts pickups in the current room into Blue Flies or Blue Spiders. | 1 | |
Everything Jar | 5.100.720 | Anything is possible | Spawns certain pickups based on how many charges it has. If fully charged, instead has one of many unique effects. | 3 |
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Dark Bum | 5.100.278 | He wants to take your life | Spawns a familiar that follows Isaac around and collects Red Hearts. For every 1½ Red Hearts collected, Dark Bum will give a reward. | 3 | |
Infestation 2 | 5.100.234 | Infestation shot | Spawns allied Blue Spiders from killed enemies. | 3 | |
Juicy Sack | 5.100.266 | Sticky babies | Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. | 2 | |
Mom's Wig | 5.100.217 | You feel itchy... | Adds a chance to spawn Blue Spiders when firing tears. Restores 1 Red Heart. | 2 | |
Sissy Longlegs | 5.100.280 | She loves you | Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. Briefly charms enemies on contact. | 1 | |
Spiderbaby | 5.100.211 | Spider revenge | Spawns 1-2 Blue Spiders when Isaac takes damage. Spawns 3-5 Blue Spiders when Isaac takes damage. |
0 | |
Spider Mod | 5.100.403 | Mod buddy! | Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery/Blue spider upon clearing a room. | 1 | |
Sticky Bombs | 5.100.367 | Egg sack bombs! | +5 Bombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy. They also leave a long-lasting puddle of slowing white creep. | 2 | |
Parasitoid | 5.100.461 | Egg tears! | Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy. | 3 | |
Keeper's Kin | 5.100.717 | Under a rock | Rocks and other Obstacles spawn blue spiders over time while in a room with enemies, and spawn two blue spiders when destroyed. | 2 | |
Strawman | 5.100.667 | A helping hand | Spawns a controllable Keeper to fight enemies alongside Isaac, functioning similarly to Jacob and Esau. If Keeper dies, he spawns 5 blue spiders and Strawman is removed from Isaac's inventory. | 2 | |
The Intruder | 5.100.575 | Invasive friend | A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. | 3 | |
Tinytoma | 5.100.645 | Itching for revenge | Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. | 1 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Louse | 5.350.70 | Itchy, tasty... | Occasionally spawns a Blue Spider. | |
Apple of Sodom | 5.350.140 | It feels empty | Picking up Red Hearts, even while at full health, can convert them into blue spiders. The effect may consume hearts needed for healing. |
Name | ID | Icon | Message | Description |
---|---|---|---|---|
Rune of Berkano | 5.300.38 | Companionship | Summons 3 friendly Blue Flies and 3 friendly Blue Spiders. | |
Black Rune | 5.300.41 | Void | Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades. |
Other sources of Blue Spiders
- Infested? pill: Spawns Blue Spiders equal to the number of enemies in the room.
- Infested! pill: Spawns a Blue Spider under Isaac and every pile of poop in the room.
- Rotten Beggars and Hell Games can spawn Blue Spiders as a reward.
- Red Chest: Has a chance to spawn 3 Blue Spiders.
Dips
Dips are temporary familiars that are spawned when destroying poops. They move erratically around the room and behave similarly to their hostile counterpart dealing contact damage to enemies and blocking projectiles. There are a variety of Dips with unique effects that correlate to different types of Poops.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Dirty Mind | 5.100.576 | Filthy friends | Destroying poop spawns Dip Familiars that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects. | 1 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Dingle Berry | 5.350.163 | Oops! | Spawns a Dip Familiar upon clearing a room. |
Other sources of Dips
- Destroying a Charming Poop spawns a few Dip Familiars.
Wisps
Wisps are temporary orbital familiars that are mostly associated with Bethany. By default, they orbit Isaac, blocking shots and dealing contact damage. They also fire spectral tears that deal 1.6-2.4 damage. Normal wisps have 2 health. There are many variants of wisps, most of which can be spawned randomly or through combinations with Book of Virtues. See here for a full list of wisps.
Other unique variants of wisps include item wisps from Lemegeton which only mimic the effects of passive items while alive, and red wisps from Vengeful Spirit, which are invulnerable, but disappear upon entering a new floor.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Book of Virtues | 5.100.584 | Spiritual companionship | Spawns a destroyable orbiting wisp familiar that fires tears and deals contact damage. Also acts as a passive item that causes other active items to spawn themed wisps. | 3 | |
Jar of Wisps | 5.100.685 | Your faith grows | Spawns random wisps that shoot various tears, block shots, and deal contact damage. The number of wisps spawned increases every time the jar is used. | 2 | |
Lemegeton | 5.100.712 | Item summoner | Spawns a wisp representing a random passive item, which orbits Isaac but can be destroyed. While the wisp is alive, Isaac gains that item's effects. Generation uses the current room's item pool 25% of the time, otherwise a random pool. | 3 |
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Vengeful Spirit | 5.100.702 | Hot blooded | After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots. | 1 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Beth's Essence | 5.350.182 | Virtue's reward | Upon entering an Angel Room, spawns 5 wisp orbitals. Giving money to Beggars can spawn wisps. | |
Beth's Faith | 5.350.142 | My faith protects me | At the beginning of each floor, spawn 4-8 wisps that orbit Isaac and fires tears alongside him. |
Name | ID | Icon | Message | Description |
---|---|---|---|---|
Soul of Bethany | 5.300.96 | Friends from beyond | Spawns 6 Book of Virtues wisps with random properties. |
Other sources of Wisps
- Picking up Birthright as Tainted Bethany spawns 4 item wisps with increased health.
Ghosts
Ghosts are temporary familiars that are summoned by various items. Most ghosts (except those created by Vade Retro) will automatically attack enemies after being summoned, quickly homing in on nearby enemies. All ghosts attack enemies by exploding, though some also deal contact damage shortly before doing so. Explosions from ghosts do not damage terrain or hurt Isaac. Unlike other temporary familiars, ghosts do not persist across rooms.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Vade Retro | 5.100.653 | Begone! | While held, enemies leave behind ghosts on death. Stronger enemies leave bigger ghosts. Using the item causes the ghosts to explode and damage nearby enemies, and instantly kills all ghost enemies with less than 50% HP. | 2 |
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Ghost Bombs | 5.100.727 | Spooky blast +5 bombs | +5 Bombs. Bombs become spectral and spawn ghosts that deal contact damage to enemies and explode after 10 seconds. | 2 | |
Hungry Soul | 5.100.684 | Out for blood | Enemies have a chance to spawn ghosts on death, which chase and deal contact damage to enemies and explode after a short time. | 2 | |
Purgatory | 5.100.634 | Help from beyond | While in a room with enemies, spawns red cracks in the ground. Walking over these cracks summons ghosts that launch themselves at enemies and explode. | 2 |
Chasing Familiars
Familiars in this category actively chase enemies, dealing contact damage to them.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
The Pinking Shears | 5.100.107 | Cut and run | Separates Isaac's head from his body for the current room, granting flight and turning the body into a familiar that chases enemies. | 2 |
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Ball of Bandages | 5.100.207 | Gotta lick 'em all! | Creates an orbital familiar. Collecting additional copies gives it the ability to shoot Charm tears, then chase enemies to deal contact damage, then deal even more contact damage. | 2 | |
Cube of Meat | 5.100.73 | Gotta meat 'em all! | Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage. | 2 | |
Daddy Longlegs | 5.100.170 | Daddy's love | Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total. | 3 | |
Dead Bird | 5.100.117 | Protective buddy | After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~4 damage per second. | 0 | |
Gemini | 5.100.318 | Conjoined friend | Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~6.43 damage per second. | 1 | |
Leech | 5.100.270 | Blood sucker | Spawns a leech familiar that chases enemies, dealing ~3 damage per second. Heals a Half Red Heart whenever Leech kills an enemy. | 2 | |
Lil Haunt | 5.100.277 | Fear him | Spawns a familiar that chases down enemies, dealing 4 damage per second and inflicting fear. | 1 | |
Smart Fly | 5.100.264 | Revenge fly | Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second. | 2 | |
Bumbo | 5.100.385 | Bumbo want coin! | Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. | 1 | |
7 Seals | 5.100.526 | Lil harbingers! | Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. | 2 | |
Bird Cage | 5.100.610 | Fat buddy | The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to Dead Bird. | 1 | |
Blood Puppy | 5.100.565 | What a cute little thing! | Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac, it will also generate Half Red Hearts on enemy kills. It can increase in power one more stage after killing even more enemies. Dealing enough damage to it returns it to normal. | 1 | |
The Intruder | 5.100.575 | Invasive friend | A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. | 3 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Eve's Bird Foot | 5.350.60 | Revenge from beyond | 5% chance to spawn a Dead Bird familiar for the current room each time an enemy dies. | |
Umbilical Cord | 5.350.33 | Fetal Protection | When brought down to only a Half Red Heart, spawns a Little Steven familiar for the current room. Adds a high chance to spawn a Gemini familiar for the current room after taking damage. |
Name | ID | Icon | Message | Description |
---|---|---|---|---|
Soul of Eve | 5.300.86 | Your very own murder | 14 Dead Bird familiars fly in and attack enemies. They leave after all enemies are dead or Isaac leaves the room. |
Note: Only third and fourth stage Cube of Meat and Ball of Bandages chase enemies.
Note: Only fourth stage Bumbo chases enemies.
Note: Only War and Death in 7 Seals chase enemies.
Orbital Familiars
Familiars that orbit Isaac, absorbing enemy projectiles and/or dealing contact damage. Despite their different apparent sizes, most of them have the same effective size with regard of blocking shots or damaging enemies.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Book of the Dead | 5.100.545 | Rise from the grave | Creates a friendly Bony, Black Bony, or an orbital bone for each enemy killed in the current room. Creates a friendly Bony, Black Bony, Bone Fly, Revenant, or an orbital bone for each enemy killed in the current room. |
3 | |
Spin to Win | 5.100.655 | Let it rip! | Gives +0.5 speed and greatly increases the rotation speed and damage of orbitals for 3 seconds. Passively gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage. | 1 |
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Ball of Bandages | 5.100.207 | Gotta lick 'em all! | Creates an orbital familiar. Collecting additional copies gives it the ability to shoot Charm tears, then chase enemies to deal contact damage, then deal even more contact damage. | 2 | |
Best Bud | 5.100.274 | Sworn protector | When hit, spawns a quickly orbiting attack fly similar to Forever alone for the current room that deals high damage. | 0 | |
Big Fan | 5.100.279 | Fat protector | Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies. | 2 | |
Cube of Meat | 5.100.73 | Gotta meat 'em all! | Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage. | 2 | |
Distant Admiration | 5.100.57 | Attack fly | Spawns an attack fly that circles further out than Halo of Flies, but closer than Forever alone, dealing 75 damage per second. | 2 | |
Forever alone | 5.100.128 | Attack fly | Spawns an attack fly that orbits a long distance from Isaac, dealing 30 damage per second. | 1 | |
Guardian Angel | 5.100.112 | Extra protection | Spawns an orbital familiar that blocks enemy shots, deals 7 damage per tick on contact, and increases the speed of all orbital familiars. | 2 | |
Guillotine | 5.100.206 | DMG + tears up. An out-of-body experience! | Isaac's head is removed from his body and floats around him as an orbital. Gives +1 damage and grants -1 tear delay. Gives +1 damage and grants +0.5 fire rate. | 2 | |
Halo of Flies | 5.100.10 | Projectile protection | Spawns two Pretty Flies that block enemy shots and deal contact damage to flies. | 2 | |
Sacrificial Dagger | 5.100.172 | My fate protects me | Spawns a dagger orbital familiar, blocking enemy shots and dealing a high amount of damage to enemies in contact. | 2 | |
Smart Fly | 5.100.264 | Revenge fly | Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second. | 2 | |
Friend Zone | 5.100.364 | Friendly fly | Spawns a white attack fly that orbits somewhere between Distant Admiration and Forever alone, dealing 45 damage per second. | 1 | |
Sworn Protector | 5.100.363 | Protective friend | Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room, it drops an Eternal Heart. | 3 | |
Angelic Prism | 5.100.528 | Eclipsed by the moon | Spawns an orbital familiar with a large orbital radius. Tears that pass through the prism split into four multi-colored tears. | 3 | |
Bloodshot Eye | 5.100.509 | Bloody friend | Spawns an orbital familiar that deals 30 damage per second and fires a randomly angled tear every 2 seconds. | 1 | |
Leprosy | 5.100.525 | You're tearing me apart! | Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots. | 1 | |
Mom's Razor | 5.100.508 | It's sharp! | Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time. | 2 | |
Slipped Rib | 5.100.542 | Projectile shield | Spawns a bone familiar that circles around Isaac and reflects enemy shots. | 2 | |
Bot Fly | 5.100.629 | Defense drone | Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles. | 3 | |
Psy Fly | 5.100.581 | Flamboyant protector | Spawns a fly orbital familiar that chases and blocks enemy shots. | 4 | |
The Swarm | 5.100.693 | Infest | Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. | 2 | |
Tinytoma | 5.100.645 | Itching for revenge | Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. | 1 |
Name | Description |
---|---|
Pretty Fly | Grants 1 fly orbital that circles the player, blocking projectiles and damaging fly-type enemies on touch. |
- Notes
- A maximum of three Pretty Flies can orbit around Isaac.
- It is possible to have more than three orbitals if one has access to co-op mode. If a co-op baby or multiple co-op babies temporarily hold all but two orbitals while Isaac picks up another, and then the co-op baby or co-op babies sign out or die, Isaac will receive their orbitals as well.
- Cube of Meat, Ball of Bandages, and Sacrificial Dagger take up a Pretty Fly slot.
- For example, If Isaac has three Pretty Flies and picks up a Cube of Meat, the Cube of Meat will replace one of the flies.
- Only first and second stage Cube of Meat and Ball of Bandages are orbitals. Therefore, upgrading from level 2 to level 3 will free up a Pretty Fly slot.
- Duplicated orbitals, such as Forever alone being copied with the Box of Friends or Diplopia, will fly directly opposite the original (having three copies will cause them to fly 120 degrees apart, four will fly at 90 degrees and so on).
- Trivia
- Pretty Fly is a play on the phrase "pretty fly" as a descriptor.
Pickup Generation Familiars
Familiars that generate pickups when certain conditions are met.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Bomb Bag | 5.100.131 | Gives bombs | Spawns a familiar that drops a Bomb every 3 rooms. | 2 | |
Bum Friend | 5.100.144 | He's greedy | Spawns a familiar that picks up coins for himself, giving random pickups in return. Can spawn Items from the Beggar Item Pool. | 1 | |
Dark Bum | 5.100.278 | He wants to take your life | Spawns a familiar that follows Isaac around and collects Red Hearts. For every 1½ Red Hearts collected, Dark Bum will give a reward. | 3 | |
Little C.H.A.D. | 5.100.96 | Gives kisses | Spawns a familiar who drops a Half Red Heart every 3 rooms. | 2 | |
Mystery Sack | 5.100.271 | ? | Spawns a familiar that drops a Heart, coin, Bomb, or Key every 5-6 rooms. | 2 | |
Sack of Pennies | 5.100.94 | Gives money | Spawns a familiar that drops a coin every 2 rooms. | 1 | |
The Relic | 5.100.98 | Soul generator | Spawns a cross familiar that drops a Soul Heart after clearing enough rooms. | 3 | |
Bumbo | 5.100.385 | Bumbo want coin! | Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. | 1 | |
Charged Baby | 5.100.372 | Bbbzzzzzt! | Spawns a familiar that occasionally drops a Lil' Battery, gives an active item charge, or petrifies all enemies in the room. | 3 | |
Key Bum | 5.100.388 | He wants your keys! | Spawns a familiar that follows Isaac and collects Keys for himself, giving random Chests in return. | 0 | |
Lil Chest | 5.100.362 | What's in the box? | Spawns a chest familiar that spawns a random pickup (25% chance) or trinket (10% chance) upon clearing a room. | 2 | |
Rune Bag | 5.100.389 | Rune generator | Spawns a familiar that drops a random rune after clearing enough rooms. | 3 | |
Spider Mod | 5.100.403 | Mod buddy! | Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery/Blue spider upon clearing a room. | 1 | |
Sworn Protector | 5.100.363 | Protective friend | Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room, it drops an Eternal Heart. | 3 | |
Acid Baby | 5.100.491 | Pills pills pills! | Spawns a familiar that drops a random pill every 3 rooms. Upon using a pill, all enemies in the room are poisoned. | 2 | |
Sack of Sacks | 5.100.500 | Gives sacks | Spawns a familiar that drops a Grab Bag every 5-6 rooms cleared. | 3 | |
Blood Puppy | 5.100.565 | What a cute little thing! | Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac, it will also generate Half Red Hearts on enemy kills. It can increase in power one more stage after killing even more enemies. Dealing enough damage to it returns it to normal. | 1 | |
Lost Soul | 5.100.612 | Protect him | Creates a ghostly familiar that closely follows behind Isaac. It dies in one hit, but respawns at the start of the next floor. Each time it survives until the next floor, it rewards Isaac with Soul Hearts, Eternal Hearts, or an Item. | 2 |
Note: Only the second, third, and fourth stages of Bumbo generate pickups.
Note: Only the second and third stages of Blood Puppy generate pickups.
Shooting Familiars
Familiars that attack with their own tears or other ranged effects. Most shooting familiars only shoot as long as Isaac is attacking or charging a shot, though there are others that target and fire automatically.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Scissors | 5.100.325 | Lose your head | Turns Isaac's head into a stationary familiar for the current room which fires tears automatically. Isaac's body also shoots a controllable fountain of blood shots for the room. | 1 | |
Brown Nugget | 5.100.504 | Friendly fly | Spawns a stationary fly turret that lasts for the current room and fires tears at nearby enemies. | 0 | |
Gello | 5.100.728 | Demonic gestation | Spawns a demon familiar for the current room that's attached to Isaac and moves and fires in the direction Isaac shoots, using Isaac's damage, tears, range, shot speed, and special tear effects. | 3 | |
Sumptorium | 5.100.713 | Blood to blood | Removes half a heart and creates a Clot familiar that mimics Isaac's movements and tear effects. As Tainted Eve, passively converts health into Clots while firing. Activating returns all Clots to health. | 3 |
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Abel | 5.100.188 | Mirrored buddy | Spawns a familiar that mirrors Isaac's movements and shoots in the opposite direction. Spawns a familiar that mirrors Isaac's movements and shoots towards him. |
0 | |
Ball of Bandages | 5.100.207 | Gotta lick 'em all! | Creates an orbital familiar. Collecting additional copies gives it the ability to shoot Charm tears, then chase enemies to deal contact damage, then deal even more contact damage. | 2 | |
Brother Bobby | 5.100.8 | Friends 'till the end | Spawns a familiar that follows Isaac around shooting tears that deal 3.5 damage. He shoots more frequently than most familiars. | 1 | |
Cain's Other Eye | 5.100.319 | Near-sighted friend | Spawns a familiar that slowly floats around the room on a zig-zag pattern and shoots normal tears in the same direction as Isaac. Spawns a familiar that follows Isaac and fires tears in random cardinal directions that copy Isaac's tears and tear effects and scale with damage. |
2 | |
Cube of Meat | 5.100.73 | Gotta meat 'em all! | Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage. | 2 | |
Demon Baby | 5.100.113 | Auto-turret friend | Spawns a familiar that follows Isaac and automatically fires at enemies in its reach. | 2 | |
Ghost Baby | 5.100.163 | Spectral buddy | Spawns a familiar that follows Isaac around and fires spectral tears. | 1 | |
Harlequin Baby | 5.100.167 | Double shot buddy | Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern. | 1 | |
Isaac's Heart | 5.100.276 | Protect it | Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released. | 0 | |
Lil Brimstone | 5.100.275 | Evil friend | Grants a familiar that charges a thin Brimstone laser while Isaac is shooting. | 2 | |
Little Gish | 5.100.99 | Sticky friend | Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed. | 2 | |
Little Steven | 5.100.100 | Psychic friend | Spawns a familiar who follows Isaac around and fires homing tears. | 2 | |
Mongo Baby | 5.100.322 | Mongo friend | Spawns a familiar that copies the tears of Isaac's other familiars. | 2 | |
Rainbow Baby | 5.100.174 | Random buddy | Spawns a familiar that follows Isaac around and fires tears with random effects. | 1 | |
Robo-Baby | 5.100.95 | Friends 'till the bbbbzzzt | Spawns a familiar that shoots Technology lasers. | 1 | |
Robo-Baby 2.0 | 5.100.267 | We worked out all the kinks | Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears. | 1 | |
Rotten Baby | 5.100.268 | Infested friend | Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time. | 3 | |
Sister Maggy | 5.100.67 | Friends 'till the end | Spawns a familiar that follows Isaac around shooting tears that deal 3.5 damage. Spawns a familiar that follows Isaac around shooting tears that deal 6 damage. |
1 | |
Bumbo | 5.100.385 | Bumbo want coin! | Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. | 1 | |
Fate's Reward | 5.100.361 | Your fate beside you | A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage. | 2 | |
Incubus | 5.100.360 | Dark friend | Spawns a demonic familiar that shoots tears identical to Isaac's in terms of damage, tears, and tear effects. | 4 | |
Lil Loki | 5.100.435 | 4-way buddy! | Spawns a Loki familiar that follows Isaac and fires 4 tears in a cross pattern. | 1 | |
Papa Fly | 5.100.430 | Turret follower | Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies. | 1 | |
Seraphim | 5.100.390 | Sworn friend | Spawns an angel familiar who follows Isaac and fires homing tears which deal 10 damage and have 75% shot speed. | 3 | |
Buddy in a Box | 5.100.518 | What could it be?! | Spawns a familiar with a random tear effect. The familiar is randomized at the start of each floor. | 2 | |
Lil Monstro | 5.100.471 | Ain't he cute? | Spawns a familiar that fires clusters of tears. Must be charged before shooting. | 2 | |
Lil Spewer | 5.100.537 | Puking buddy | Drops a random pill, and spawns a familiar that charges up and fires creep. Using pills changes the creep type. | 1 | |
Boiled Baby | 5.100.607 | Messy friend | Gives Isaac a familiar that fires chaotic bursts of tears in all directions. | 1 | |
Freezer Baby | 5.100.608 | Iced iced baby | Spawns a shooting familiar that has a chance to petrify enemies, and freezes monsters upon killing them. | 2 | |
Giant Cell | 5.100.658 | Micro friends | Causes Isaac to spawn Minisaac familiars when he takes damage, which chase and shoot at nearby enemies. | 1 | |
Lil Abaddon | 5.100.679 | Abyssal friend | Spawns a familiar that charges a miniature Maw Of The Void attack while Isaac shoots. | 2 | |
Quints | 5.100.661 | They lurk inside | The first five enemies killed in a room will spawn stationary shooting familiars where they died. | 2 | |
The Intruder | 5.100.575 | Invasive friend | A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. | 3 | |
Twisted Pair | 5.100.698 | Double trouble! | Spawns two familiars that float on either side of Isaac and fire tears that use his tears, range, shot speed, and tear effects, and scale with damage. | 4 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
???'s Soul | 5.350.57 | Imaginary Friend | Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and fires spectral and homing tears. | |
Isaac's Head | 5.350.54 | Dead friend | Spawns Isaac's severed head as a tear-firing familiar. Fires piercing tears. | |
Umbilical Cord | 5.350.33 | Fetal Protection | When brought down to only a Half Red Heart, spawns a Little Steven familiar for the current room. Adds a high chance to spawn a Gemini familiar for the current room after taking damage. | |
Found Soul | 5.350.180 | Finally! | Spawns a familiar that copies Isaac's movements and scales with damage and tears. If it takes damage, it will die and respawn on the next floor. | |
Lil Clot | 5.350.176 | Mini friend | Spawns a clot familiar that mimics Isaac's movements and tears. It dies for the current room after taking too much damage. |
Note: Only second stage Cube of Meat and Ball of Bandages shoot tears.
Note: Only third stage Bumbo fires tears.
Note: Most shooting familiars that follow Isaac take 5th priority along the familiar line. This is the second to last priority with the last being non-combat familiars. There are some exceptions such as Incubus which has 2nd priority, Lil Brimstone and Lil Monstro which have 3rd priority, and Boiled Baby which has 6th priority.
Note: Using five or more different copies of Esau Jr. will destroy the item and spawn a familiar that behaves the same way as Abel.
Wandering Familiars
Familiars that move around the room sporadically.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Punching Bag | 5.100.281 | Scape goat | Spawns a Mulligan familiar that wanders randomly. Enemies will attack the Mulligan if it's closer. | 1 | |
Sissy Longlegs | 5.100.280 | She loves you | Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. Briefly charms enemies on contact. | 1 | |
Spider Mod | 5.100.403 | Mod buddy! | Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery/Blue spider upon clearing a room. | 1 | |
7 Seals | 5.100.526 | Lil harbingers! | Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. | 2 | |
YO LISTEN! | 5.100.492 | Yo listen! | +1 luck. Spawns a fairy familiar that points out Secret Rooms, Crawl Space entrances, and tinted rocks. | 2 |
Note: The Spider Baby transformation grants a familiar nearly identical to Spider Mod with the only difference being the lack of ability to see enemy HP bars.
Note: Only Famine, Pestilence, and Conquest in 7 Seals wander randomly.
Bouncing Familiars
Familiars that bounce around the room in a zig-zag pattern, changing directions when hitting a wall.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
The Scooper | 5.100.605 | Plop! | Summons The Peeper for the current room, which leaves a trail of red creep. | 1 |
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
BBF | 5.100.272 | Big Beautiful Fly | Spawns a familiar that flies around the room in a zig-zag pattern and explodes on contact with an enemy. Respawns after ten seconds. | 1 | |
Cain's Other Eye | 5.100.319 | Near-sighted friend | Spawns a familiar that slowly floats around the room on a zig-zag pattern and shoots normal tears in the same direction as Isaac. Spawns a familiar that follows Isaac and fires tears in random cardinal directions that copy Isaac's tears and tear effects and scale with damage. |
2 | |
The Peeper | 5.100.155 | Plop! | Spawns a familiar that slowly floats around the room in a zig-zag pattern, damaging enemies it passes through. Increases the damage of tears from Isaac's left eye by 35%. | 2 | |
GB Bug | 5.100.405 | Double tap glitch | Spawns a familiar that bounces diagonally around the room, applying a random status effect to enemies it hits and has a chance to re-roll pickups it passes over. Spawns a familiar that follows Isaac. Double tapping the fire button launches it forward, causing it to reroll the first monster or pickup it hits. |
1 | |
Succubus | 5.100.417 | Damage booster | Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5× tear damage multiplier. | 3 | |
Hushy | 5.100.470 | Lil hush! | Spawns a Hush familiar that bounces diagonally around the room and deals contact damage. While firing tears, it stops moving. | 0 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
???'s Soul | 5.350.57 | Imaginary Friend | Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and fires spectral and homing tears. |
Mimicking Familiars
Familiars that copy Isaac's movements after a certain delay.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Multidimensional Baby | 5.100.431 | ydduB Buddy | Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed. | 2 | |
My Shadow | 5.100.433 | Me! And my shaaaadow! | Inflicts fear on all enemies in the room upon taking damage and spawns black friendly Chargers that attack enemies. Spawns a shadow familiar that closely follows behind Isaac. It spawns a black friendly Charger whenever an enemy touches it. |
2 | |
Obsessed Fan | 5.100.426 | Follows my every move... | Spawns a familiar that follows Isaac's movements on a delay and deals 30 contact damage per second to enemies. | 0 | |
Papa Fly | 5.100.430 | Turret follower | Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies. | 1 | |
Shade | 5.100.468 | It follows | Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly Chargers. | 0 |
Throwable Familiars
Familiars that are thrown by Isaac by shooting and can return to him after awhile.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Abyss | 5.100.706 | Come forth from the depths | Destroys all items in the room and gives Isaac a unique locust familiar for each item destroyed. Some items generate locusts with special effects. | 4 |
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Bob's Brain | 5.100.273 | Explosive thoughts | Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds. | 1 | |
Holy Water | 5.100.178 | Splash! | Spawns a bottle familiar that breaks when Isaac takes damage, leaving a puddle of blue creep. A bottle familiar that flies forward when Isaac shoots. It breaks upon hitting an enemy, leaving a puddle of blue creep that petrifies enemies. |
3 | |
Little Chubby | 5.100.88 | Attack buddy | Spawns a Charger familiar that charges forward and deals contact damage to any enemies in its path. | 2 | |
GB Bug | 5.100.405 | Double tap glitch | Spawns a familiar that bounces diagonally around the room, applying a random status effect to enemies it hits and has a chance to re-roll pickups it passes over. Spawns a familiar that follows Isaac. Double tapping the fire button launches it forward, causing it to reroll the first monster or pickup it hits. |
1 | |
Big Chubby | 5.100.473 | Chub chub | Spawns a familiar that follows Isaac and charges across the room when Isaac fires, blocking shots and dealing 40.5 damage per second on contact. | 1 | |
Jaw Bone | 5.100.548 | Fetch! | Spawns a familiar that flies through the room while firing, dealing a flat 7 contact damage to enemies and retrieving pickups. | 1 | |
Knife Piece 1 | 5.100.626 | ??? | Combined with Knife Piece 2, creates a knife familiar that damages enemies and can open the door to the Corpse. | 0 | |
Knife Piece 2 | 5.100.627 | ??? | Combined with Knife Piece 1, creates a knife familiar that damages enemies and can open the door to the Corpse. | 0 | |
Lil Portal | 5.100.681 | It hungers | A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room. | 1 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Apollyon's Best Friend | 5.350.186 | Attack buddy | Spawns an attack locust familiar which will fly forward while Isaac shoots. |
Note: Knife Piece 1 and Knife Piece 2 are only throwable when combined.
Controlled Familiars
Familiars that move in the direction Isaac is shooting.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Stitches | 5.100.635 | Bait and switch | Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar. | 1 |
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
???'s Only Friend | 5.100.320 | Controlled friend | Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys | 1 | |
Robo-Baby 2.0 | 5.100.267 | We worked out all the kinks | Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears. | 1 |
Others
Familiars that don't fit into any of the above categories or that produce multiple effects.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Monster Manual | 5.100.123 | Temporary buddy generator | Spawns a familiar from a specific selection for the current room. Spawns a familiar from a specific selection for the current floor. |
1 | |
Sprinkler | 5.100.516 | Sprinkles. | Creates a stationary sprinkler for the current room that rotates and fires tears in 8 directions. The tears copy Isaac's stats and most tear effects. | 2 |
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
1up! | 5.100.11 | Extra life | Gives Isaac an extra life. Upon death, he will respawn in the previous room with full health, after which 1up! will disappear. | 2 | |
Dead Cat | 5.100.81 | 9 lives | Sets Isaac's Red Heart Containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container. | 3 | |
Dry Baby | 5.100.265 | Immortal friend | Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering The Necronomicon effect. | 3 | |
Guppy's Hairball | 5.100.187 | Swing it | Spawns a familiar that loosely follows behind Isaac, which blocks shots can be swung like a flail to damage enemies. Grows bigger by killing enemies. | 1 | |
Headless Baby | 5.100.269 | Bloody friend | Spawns a familiar that follows Isaac, leaving blood creep on the ground. | 1 | |
Holy Water | 5.100.178 | Splash! | Spawns a bottle familiar that breaks when Isaac takes damage, leaving a puddle of blue creep. A bottle familiar that flies forward when Isaac shoots. It breaks upon hitting an enemy, leaving a puddle of blue creep that petrifies enemies. |
3 | |
Isaac's Heart | 5.100.276 | Protect it | Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released. | 0 | |
Juicy Sack | 5.100.266 | Sticky babies | Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. | 2 | |
Key Piece 1 | 5.100.238 | ??? | Combined with Key Piece 2, unlocks the golden gate in the starting room of Chest and Dark Room to fight Mega Satan. | 0 | |
Key Piece 2 | 5.100.239 | ??? | Combined with Key Piece 1, unlocks the golden gate in the starting room of Chest and Dark Room to fight Mega Satan. | 0 | |
Samson's Chains | 5.100.321 | The ol' ball and chain | Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most Obstacles. | 1 | |
Cambion Conception | 5.100.412 | Feed them hate | After taking damage a certain amount of times, a permanent demonic familiar spawns. | 2 | |
Censer | 5.100.387 | Peace be with you | Spawns a familiar which creates a circular aura that slows down enemies and enemy shots inside. | 3 | |
Farting Baby | 5.100.404 | He farts! | Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which charms, poisons, or knocks back nearby enemies. | 1 | |
Immaculate Conception | 5.100.413 | Feed them love | Upon picking up a certain amount of health, spawn a permanent angelic familiar. | 1 | |
Lil Gurdy | 5.100.384 | A gurd of your own! | A Gurdy Jr. familiar that charges up while Isaac is firing, bouncing around the room when released and dealing contact damage based on its speed. | 2 | |
Lost Fly | 5.100.365 | Lost protector | Spawns a fly familiar that moves in a straight line and circles around the first wall or obstacle it hits. It deals 105 damage per second on contact. It deals 56 damage per second and forces nearby enemies to attack it. | 2 | |
Milk! | 5.100.436 | Don't cry over it... | Spawns a glass familiar that spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the current room. After the milk spills, Isaac's fire rate is increased by 1 for the current room. | 1 | |
Angry Fly | 5.100.511 | He's violent | Spawns a fly familiar that orbits around a random enemy and deals 30 damage per second to enemies it comes in contact with. | 1 | |
Depression | 5.100.469 | :( | Spawns a familiar that leaves a trail of creep that damages enemies at 6 damage per second. Has a chance to spawn damaging beams of light onto enemies that touch the cloud. | 1 | |
Finger! | 5.100.467 | Watch where you point that! | Spawns a finger familiar that faces in the same direction as Isaac, rapidly damaging enemies it points at for 10% of Isaac's damage. | 1 | |
Hallowed Ground | 5.100.543 | Portable sanctuary | Spawns a white poop familiar, which turns into a White Poop when Isaac is hurt. White poop has an aura that increases tear fire rate and can block enemy shots. The aura also increases damage by 20% and gives homing. | 1 | |
King Baby | 5.100.472 | Hail to the king baby | Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, other familiars stop moving. | 1 | |
Lil Delirium | 5.100.519 | Delirious friend | Grants a familiar that transforms into another random familiar every 10 seconds. | 2 | |
Mystery Egg | 5.100.539 | Sacrificial insemination | Spawns an egg familiar, which hatches a random friendly monster when Isaac is hurt once per room. The power of the monster improves for each consecutive room cleared without taking damage. | 1 | |
Pointy Rib | 5.100.544 | Stabbing time | Spawns a bone familiar that hovers back and forth in front of Isaac, dealing damage equal to Isaac's damage. | 2 | |
Blood Oath | 5.100.569 | Bleed me dry | Stabs Isaac at the beginning of each floor, draining his Red Hearts. Increases damage and speed for the floor based on the amount drained. | 1 | |
Cube Baby | 5.100.652 | Kick it! | Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills. | 1 | |
Fruity Plum | 5.100.649 | Bouncy friend | Gives Isaac a miniature Baby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels. | 1 | |
Giant Cell | 5.100.658 | Micro friends | Causes Isaac to spawn Minisaac familiars when he takes damage, which chase and shoot at nearby enemies. | 1 | |
Knife Piece 1 | 5.100.626 | ??? | Combined with Knife Piece 2, creates a knife familiar that damages enemies and can open the door to the Corpse. | 0 | |
Knife Piece 2 | 5.100.627 | ??? | Combined with Knife Piece 1, creates a knife familiar that damages enemies and can open the door to the Corpse. | 0 | |
Lil Dumpy | 5.100.615 | Puffy buddy | Spawns a Dumpy familiar that pushes away nearby enemies and projectiles just before Isaac is about to be hit, then falls asleep. He can be awoken by walking to him. | 3 | |
Paschal Candle | 5.100.567 | Keep the flame burning | Gives Isaac a familiar that grants +0.4 Fire Rate for each consecutive room he's cleared without taking damage. The bonus stacks up to five times. | 3 | |
Star of Bethlehem | 5.100.651 | Follow the light | Spawns a star familiar that slowly travels towards the Boss Room, giving an aura that increases damage and tears and grants homing tears. | 3 | |
Vanishing Twin | 5.100.697 | He wants revenge | Spawns a familiar that becomes a weaker clone of the floor's boss when entering the Boss Room. Defeating it drops an extra item. | 2 | |
Worm Friend | 5.100.682 | Clingy buddy | Gives Isaac a Nerve Ending familiar that burrows out of the ground to grab and deal damage to enemies over time. | 3 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Tonsil | 5.350.97 | Sick... | When hit, there is a small chance to spawn a permanent tonsil familiar that blocks enemy shots. This can happen twice, after which the trinket is destroyed. |
Name | ID | Icon | Message | Description |
---|---|---|---|---|
Soul of Lilith | 5.300.92 | Motherhood | Adds one permanent familiar from the Baby Shop pool, except Stitches. Can give familiars that Isaac already has. Unique familiars can be received only once. |
Unlockable Achievements
- Buddy in a Box - Pick up 5 familiars in a single run.
- Rotten Penny - Have 20 Blue Flies at the same time.
The Binding of Isaac: Rebirth |
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