Familiars that follow behind Isaac have a certain priority in how close their position is to him over other familiars, with Lil Chest having the lowest priority at 6th / 8th and thus being farther from Isaac than familiars of different priorities.
Synergies
BFFS!: The chance to spawn a pickup increases to 31.25%, and the chance to spawn a trinket increases to 12.5%.
Familiars that follow behind Isaac have a certain priority in how close their position is to him over other familiars, with Lil Chest having the lowest priority at 
6th / 
8th and thus being farther from Isaac than familiars of different priorities.
BFFS!: The chance to spawn a pickup increases to 31.25%, and the chance to spawn a trinket increases to 12.5%.
