Infamy
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Infamy is a passive item.
Effects
- Enemy shots that hit Isaac have a 50% chance to be blocked.
- After effectively blocking a projectile, Isaac will briefly flash blue. Isaac in this state can still take damage from another projectile.
- Can block:
- Fireballs (e.g. from
Crackle), but their lines of fire harm Isaac. - Fire projectiles (e.g. from
Mega Satan). - Obstacles thrown by
Polty or 
Kineti.
- Fireballs (e.g. from
- Does not block:
Notes
- Although the mask is seen only on Isaac's face, projectiles still have a 50% chance to be blocked from any direction.
Interactions
Cone Head: Blocking effect from either item can occur.
- This leaves Isaac 60% chance to negate tears.
Holy Card / 
Holy Mantle: Infamy's chance of blocking projectiles is applied before the shield, allowing the shield to be saved.
Host Hat: Infamy's blocking effect is applied first. Host Hat does not fire tears when a tear is blocked by Infamy.
- This leaves Isaac 60% chance to negate tears in any way.
- Infamy: Additional copies of this item, such as from
Diplopia / 
Crooked Penny, have no effect. 
Metal Plate: Infamy's blocking effect is applied first. Tears blocked by Infamy are not reflected by Metal Plate.
- This leaves Isaac 62.5% chance to negate tears in any way.
In-game Footage
Trivia
- This item is a reference to the
Mask of Infamy boss. - This item is used in The Tank (challenge #5).
- Prior to Repentance, Infamy's description was "Damage reduction".
 The Binding of Isaac: Rebirth
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