Signs of the Zodiac

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The 12 Signs of the Zodiac are featured as passive collectibles each with effects loosely based on their given namesake.

(except in Rebirth)Zodiac Grants the effect of a random Zodiac sign each floor.

(in Repentance and Repentance+) Collecting any three items with the stars item tag unlocks the PlanetariumPlanetarium.

Items

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
Aries 5.100.300 Aries
Ramming speed
+0.25 Speed. Running into enemies while at a high speed will deal damage. (in Repentance and Repentance+) Prevents Isaac from taking contact damage while moving at high speed.
2
Taurus 5.100.299 Taurus
Speed down + rage is building
-0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the My Little UnicornMy Little Unicorn effect for 5 seconds.
1
Gemini 5.100.318 Gemini
Conjoined friend
Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~6.43 damage per second.
1
Cancer 5.100.301 Cancer
HP up + you feel protected
Adds 3 Soul Heart.pngSoul Hearts. Grants The WaferThe Wafer effect for the current room after taking damage.
3
Leo 5.100.302 Leo
Stompy
Isaac can destroy rocks by walking into them.
1
Virgo 5.100.303 Virgo
You feel refreshed and protected
Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills.
2
Libra 5.100.304 Libra
You feel balanced
Gives 6 Penny.pngCoins, 6 Bomb.pngBombs, and 6 Key.pngKeys and balances out all attributes.
1
Scorpio 5.100.305 Scorpio
Poison tears
Grants poison tears, which deal damage over time when inflicted.
3
Sagittarius 5.100.306 Sagittarius
(except in Repentance and Repentance+)
Penetrative shot + speed up
(in Repentance and Repentance+)
Piercing shots + speed up
Increases speed by +0.2 and grants piercing tears.
3
Capricorn 5.100.307 Capricorn
All stats up
(except in Repentance and Repentance+) Adds 1 Red Heart container, gives +0.5 Damage, +0.1 Speed, +1.5 Range, and -1.0 Tear Delay, and gives 1 Bomb.pngBomb, Penny.pngPenny, and Key.pngKey.
(in Repentance and Repentance+) Adds 1 Red Heart container, gives +0.5 Damage, +0.1 Speed, +0.75 Range, and +0.5 Fire Rate, and gives 1 Bomb.pngBomb, Penny.pngPenny, and Key.pngKey.
3
Aquarius 5.100.308 Aquarius
Trail of tears
A trail of blue creep is left behind Isaac, which damages enemies. (in Repentance and Repentance+) The creep scales with damage and inherits most tear effects.
2
Pisces 5.100.309 Pisces
Tears up + knock-back shots
(except in Repentance and Repentance+) -1 Tear Delay, adds knock-back shots and increases tear size.
(in Repentance and Repentance+) +0.5 Fire Rate, adds knock-back shots and increases tear size.
2
(except in Rebirth) Zodiac 5.100.392 Zodiac
The heavens will change you
Gives Isaac a random zodiac item effect that changes every floor.
1

Unlockable Achievements

Trivia

  • Some of the effects caused by the items in-game are directly related to their astrological significance or symbol. For example, Aquarius is portrayed as a man (Ganymede) bearing water, and in game the item causes Isaac to leave a trail of tears behind him while walking; Libra, which represents weighing scales, balances Isaac's stats.