Signs of the Zodiac

The 12 Signs of the Zodiac are featured as passive collectibles each with effects loosely based on their given namesake.

Zodiac Grants the effect of a random Zodiac sign each floor.

Collecting any three items with the stars item tag unlocks the Planetarium.

Items

Name	ID	Quote	Description	Quality
Aquarius	5.100.308	Trail of tears	A trail of blue creep is left behind Isaac, which damages enemies. The creep scales with damage and inherits most tear effects.	2
Aries	5.100.300	Ramming speed	+0.25 Speed. Running into enemies while at a high speed will deal damage. Prevents Isaac from taking contact damage while moving at high speed.	2
Cancer	5.100.301	HP up + you feel protected	Adds 3 Soul Hearts. Grants The Wafer effect for the current room after taking damage.	3
Capricorn	5.100.307	All stats up	Adds 1 Red Heart container, gives +0.5 Damage, +0.1 Speed, +1.5 Range, and -1.0 Tear Delay, and gives 1 Bomb, Penny, and Key. Adds 1 Red Heart container, gives +0.5 Damage, +0.1 Speed, +0.75 Range, and +0.5 Fire Rate, and gives 1 Bomb, Penny, and Key.	3
Gemini	5.100.318	Conjoined friend	Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~6.43 damage per second.	1
Leo	5.100.302	Stompy	Isaac can destroy rocks by walking into them.	1
Libra	5.100.304	You feel balanced	Gives 6 Coins, 6 Bombs, and 6 Keys and balances out all attributes.	1
Pisces	5.100.309	Tears up + knock-back shots	-1 Tear Delay, adds knock-back shots and increases tear size. +0.5 Fire Rate, adds knock-back shots and increases tear size.	2
Sagittarius	5.100.306	Piercing shots + speed up	Increases speed by +0.2 and grants piercing tears.	3
Scorpio	5.100.305	Poison tears	Grants poison tears, which deal damage over time when inflicted.	3
Taurus	5.100.299	Speed down + rage is building	-0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the My Little Unicorn effect for 5 seconds.	1
Virgo	5.100.303	You feel refreshed and protected	Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills.	2
Zodiac	5.100.392	The heavens will change you	Gives Isaac a random zodiac item effect that changes every floor.	1

Unlockable Achievements

The Planetarium - Collect any 3 items with the 'stars' item tag in a single run.

Trivia

Some of the effects caused by the items in-game are directly related to their astrological significance or symbol. For example, Aquarius is portrayed as a man (Ganymede) bearing water, and in game the item causes Isaac to leave a trail of tears behind him while walking; Libra, which represents weighing scales, balances Isaac's stats.

Zodiac Signs

Items