Creates a tiny / small pool of yellow creep, damaging enemies that cross it.
The pool lasts for the entire room, only disappearing when it is exited.
The puddle deals 8 damage per tick or 24 damage per second.
Synergies
Book of Virtues: Spawns yellow wisps in the middle ring. The wisps fire faster and have decreased range. The wisps themselves occasionally leave small puddles of yellow creep that last for 3 seconds and deal 7 damage per tick to enemies that walk over them (56 damage per second).
The Lemon Party Pill will drop a larger pool (almost the size of the room, if you stand in the middle) of Lemon Mishap.
In the original Binding of Isaac, Lemon Mishap was the only activated collectible to have an icon different to its item (the item was a lemon, but picked up it was a glass of lemonade).
In the original Binding of Isaac, Lemon Mishap was widely considered as one of the worst active items in the game, due to low damage and small creep size, making it both hard and unreliable at killing anything. In Rebirth, Lemon Mishap was buffed considerably.
tiny / 
small pool of yellow creep, damaging enemies that cross it.
Book of Virtues: Spawns yellow wisps in the middle ring. The wisps fire faster and have decreased range. The wisps themselves occasionally leave small puddles of yellow creep that last for 3 seconds and deal 7 damage per tick to enemies that walk over them (56 damage per second).
Lost Cork: Doubles puddle size.
Car Battery: No effect.
Free Lemonade is a reference to this.
The Binding of Isaac: Rebirth
