Polyphemus
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Polyphemus is a passive item.
Effects
- Greatly increased damage:
Tears down: 
Tears fired per second * 0.42.- If a tear kills an enemy and has left over damage, the tear travels on with the remaining damage.
Notes
- Polyphemus is a special item.
Synergies
Abyss: When Polyphemus is picked up instead of being converted into a locust, it grants all of Abyss's locusts the high damage up without suffering the tears down allowing Isaac to increase his damage rate substantially the more items he uses Abyss on.
Dr. Fetus: Increases tear delay, and after the first bomb explodes, a second bomb appears where the first one exploded, doing roughly half the damage of the first.
The Inner Eye/
Mutant Spider/
C Section: The tear rate is not lowered further, but the effect on damage becomes a flat +5 bonus instead.
The Forgotten: The Forgotten's bone club becomes massive. It deals very high damage but has a very low swing rate.
Rock Bottom: Allows Isaac to keep his previous fire rate in addition to the massive damage boost.
Shard of Glass: The rapidly spawning red tears do full damage.
Interactions
Haemolacria: The main tear retains the semi-piercing ability and may not burst when hitting a weaker enemy. Split tears do not semi-pierce.
Lachryphagy: Greatly increases how big the fed tear can grow.
Lost Contact: Isaac's tears will block enemy shots and continue, but lose 10 damage. If the tear had less than 10 damage left, it disappears.- Piercing tears: Semi-piercing is replaced by proper piercing, with no loss of damage on any enemy contact.
Polyphemus: No further effect when multiple copies are acquired.
In-game Footage
Trivia
- Much like other eye-altering passive items, Polyphemus has a unique appearance on The Forgotten, appearing as an empty eye socket.
- Polyphemus, ancient Greek for "The much vaunted", is a Cyclops. He is the son of Poseidon and the sea nymph Thoosa. This item is a reference to the cyclops named Polyphemus from the poem by Homer called "The Odyssey"
- This item is used in Slow Roll (challenge #15).
 The Binding of Isaac: Rebirth
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