Contagion
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This article is about Contagion, similar in appearance to Toxic Shock.
Contagion is a passive item added in The Binding of Isaac: Afterbirth †.
Effects
- In each room, the first enemy killed will release a gas explosion and poison nearby enemies.
- Poisoned enemies will also release gas upon death, spreading the effect.
- Poisoned enemies do not need to die while the poison is still active to spread the effect.
- The initial gas explosion deals 5 damage, and the poison deals Isaac's tear damage per tick, for 6 ticks.
- Poisoned enemies will also release gas upon death, spreading the effect.
Notes
- The effect will also activate if a
Shopkeeper is destroyed before killing any enemies.
- Re-entering a room and destroying another Shopkeeper inside it will trigger the effect for a second time.
- Re-entering a room and destroying another
- The gas explosion and poison can damage friendly enemies.
Synergies
Gigante Bean: Greatly increases the size of the gas explosions, making the poison spread much more effective.
Interactions
- Ace Cards: Enemies that are turned into pickups can't create a gas explosion.
Dr. Fetus/
Epic Fetus: Explosion damage does not apply to poison damage.
E. Coli/
Flush!: Enemies that are turned into poop can't create a gas explosion.- Freeze effects: Enemies that are frozen are still "alive" and can create a gas explosion when they are the first ice statue broken before any other enemy in the room dies.
Ipecac: Ipecac only applies a 2x multiplier as opposed to +40 to poison damage.- Poison tears: No effect. Gas explosions will only be triggered by poison caused by Contagion.
Second Hand: Poison duration is not affected.
In-game Footage
Trivia
- Contagion's sprite is a recolor of
Toxic Shock.
