User:Blcd/Item Tags no offensive

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Active Items

Name ID Icon Quote Description (in Repentance) Quality
Blood Rights 5.100.186
Blood Rights
Unlimited
Mass enemy damage at a cost Takes a full heart of health and deals 40 damage to all enemies in the room. (in Repentance) Repeated uses in the same room only take half a heart. 0
Book of Revelations 5.100.78
Book of Revelations
6 rooms
Reusable soul protection Increases the chance of a Devil RoomDevil Room / Angel RoomAngel Room appearing while held. Upon use, gives one Soul Heart.pngSoul Heart, and replaces the boss of the current floor with a Harbinger if possible. 3
Breath of Life 5.100.326
Breath of Life
3 seconds
Invincibility at a cost Grants a brief moment of invincibility when the charge bar hits zero. Isaac begins taking damage if the item is held any longer. (in Repentance) Isaac creates beams of light when touching enemies while invulnerable, and creates a powerful 4-way beam if blocking damage exactly as the invincibility starts. 1
Converter 5.100.296
Converter
3 rooms
Convert your soul (except in Repentance) Converts two Soul Heart.pngSoul Hearts or Black Heart.pngBlack Hearts into one filled Red Heart.pngRed Heart Container.
(in Repentance) Converts one Soul Heart.pngSoul Heart or Black Heart.pngBlack Heart into one filled Red Heart.pngRed Heart Container.
2
Guppy's Paw 5.100.133
Guppy's Paw
Unlimited
Soul converter Converts one Red Heart Container into three Soul Heart.pngSoul Hearts. 3
How to Jump 5.100.282
How to Jump
Unlimited
It's time you learned how Isaac jumps in the direction he is currently moving, allowing travel over obstacles and enemies. 1
IV Bag 5.100.135
IV Bag
Unlimited
Portable blood bank Damages Isaac and spawns a random amount of coins, similar to a Blood Donation Machine.pngBlood Donation Machine. 1
Kamikaze! 5.100.40
Kamikaze!
Unlimited
Become the bomb! Creates an explosion around Isaac, damaging him and nearby enemies as well as destroying obstacles. 0
Prayer Card 5.100.146
Prayer Card
6 rooms
Reusable eternity Gives Isaac an Eternal Heart.pngEternal Heart. 3
Razor Blade 5.100.126
Razor Blade
Unlimited
Feel my pain Takes one Red Heart.pngHeart of health and grants +1.2 damage for the current room. (in Repentance) Repeated uses in the same room only take half a heart. 0
Satanic Bible 5.100.292
Satanic Bible
6 rooms
Reusable evil... but at what cost? Gives one Black Heart.pngBlack Heart. (in Repentance) Replaces the boss room item on the current floor with a Devil Deal. 4
The Jar 5.100.290
The Jar
Unlimited
Save your life When at full health, up to 4 extra Red Heart.pngRed Hearts can be stored in The Jar. Activating drops the stored hearts on the ground. 0
The Nail 5.100.83
The Nail
6 rooms
Temporary demon form (except in Repentance) Gives one Soul Heart.pngSoul Heart. For the current room; +0.7 damage, -0.18 speed, Isaac breaks rocks and deals contact damage.
(in Repentance) Gives half a Black Heart.pngBlack Heart. For the current room; +2 damage, -0.18 speed, Isaac breaks rocks and deals contact damage.
2
The Poop 5.100.36
The Poop
1 room
Plop! Spawns a pile of Poop.pngPoop where Isaac is standing and knocks back nearby enemies. May yield pickups like regular poop. 0
Unicorn Stump 5.100.298
Unicorn Stump
1 room
You feel stumped Gives invulnerability and increased speed for six seconds, but removes the ability to shoot tears. 1
Yum Heart 5.100.45
Yum Heart
4 rooms
Reusable regeneration Restores one full Red Heart.pngRed Heart. 1
Clicker 5.100.482
Clicker
6 rooms
Change Transforms Isaac into a random character and removes the last item collected. 0
Dull Razor 5.100.486
Dull Razor
2 rooms
I feel numb... Hurts Isaac without depleting health, activating any items that trigger upon taking damage. 1
Potato Peeler 5.100.487
Potato Peeler
Unlimited
A pound of flesh Removes a Heart Container, increases damage and range, and grants a Collectible Cube of Meat icon.pngCube of Meat. 2
Broken Glass Cannon 5.100.474
Broken Glass Cannon
4 rooms
You broke it! Begins with no charges and turns into Collectible Glass Cannon icon.pngGlass Cannon when used. Only acquired by taking damage while holding Glass Cannon. 0
Hold 5.100.715
Hold
Unlimited
Saved for later Exclusive to Character Tainted ??? icon.pngTainted ???. Allows him to save one poop bomb for later, allowing him to gather more over time. 0
Recall 5.100.714
Recall
3 seconds
Come back Retrieves the Forgotten's body from any distance. Only available as the Collectible Birthright icon.pngBirthright effect for Character Tainted Forgotten icon.pngTainted Forgotten. 0
Spin to Win 5.100.655
Spin to Win
3 seconds
Let it rip! Gives +0.5 speed and greatly increases the rotation speed and damage of orbitals for 3 seconds. Passively gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage. 1
Sumptorium 5.100.713
Sumptorium
10 seconds
Blood to blood Removes half a heart and creates a Clot familiar that mimics Isaac's movements and tear effects. As Character Tainted Eve icon.pngTainted Eve, passively converts health into Clots while firing. Activating returns all Clots to health. 3
Yuck Heart 5.100.639
Yuck Heart
4 rooms
Gross! Gives Isaac a Rotten Heart.pngRotten Heart. 1

Passive Items

Name ID Icon Quote Description (in Repentance) Quality
<3 5.100.15 <3 HP up Grants Isaac one Red Heart container and fully restores Isaac's health. 2
1up! 5.100.11 1up! Extra life Gives Isaac an extra life. Upon death, he will respawn in the previous room with full health, after which 1up! will disappear. 2
A Snack 5.100.346 A Snack HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red Heart.pngRed Heart. 1
Anemic 5.100.214 Anemic Toxic blood After Isaac is damaged, a trail of red creep will be left behind him until he leaves the current room. (except in Repentance) +5 range. (in Repentance) +1.5 range. 1
Ankh 5.100.161 Ankh Eternal life? Upon death, Isaac will respawn as Character ??? (Character) icon.png??? in the previous room, with 3 Soul Heart.pngSoul Hearts. 1
Ball of Bandages 5.100.207 Ball of Bandages Gotta lick 'em all! Creates an orbital familiar. Collecting additional copies gives it the ability to shoot Charm tears, then chase enemies to deal contact damage, then deal even more contact damage. 2
Best Bud 5.100.274 Best Bud Sworn protector When hit, spawns a quickly orbiting attack fly similar to Collectible Forever alone icon.pngForever alone for the current room that deals high damage. 0
Big Fan 5.100.279 Big Fan Fat protector Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies. 2
Black Lotus 5.100.226 Black Lotus HP up x3! Grants one Red Heart Container, one Soul Heart.pngSoul Heart, and one Black Heart.pngBlack Heart. 2
Blood Bag 5.100.119 Blood Bag HP up Grants one filled Red Heart container, restores 4 Red Heart.pngRed Hearts, and increases speed by 0.3. 2
Bloody Lust 5.100.157 Bloody Lust RAGE! Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor. 2
Breakfast 5.100.25 Breakfast HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red Heart.pngRed Heart. 1
Broken Watch 5.100.337 Broken Watch I think it's broken Slows all enemies in every fourth newly-discovered room, with a small chance to speed them up instead. 1
Bucket of Lard 5.100.129 Bucket of Lard HP up (except in Repentance) Grants two empty Red Heart containers, heals Isaac for a Half Red Heart.pngHalf Red Heart, -0.2 speed.
(in Repentance) Grants two Red Heart containers, -0.2 speed.
1
Cancer 5.100.301 Cancer HP up + you feel protected Adds 3 Soul Heart.pngSoul Hearts. Grants Collectible The Wafer icon.pngThe Wafer effect for the current room after taking damage. 3
Celtic Cross 5.100.162 Celtic Cross Blessing of protection Grants a chance to trigger the Collectible Book of Shadows icon.pngBook of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds. 1
Charm of the Vampire 5.100.62 Charm of the Vampire DMG up + kills heal Heals Isaac for a Half Red Heart.pngHalf Red Heart for every 13 enemies killed. (in Repentance) +0.3 damage. 1
Cube of Meat 5.100.73 Cube of Meat Gotta meat 'em all! Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage. 2
Dark Bum 5.100.278 Dark Bum He wants to take your life Spawns a familiar that follows Isaac around and collects Red Heart.pngRed Hearts. For every 1½ Red Hearts collected, Dark Bum will give a reward. 3
Dead Bird 5.100.117 Dead Bird Protective buddy After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~4 damage per second. 0
Dead Cat 5.100.81 Dead Cat 9 lives Sets Isaac's Red Heart Containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container. 3
Dead Dove 5.100.185 Dead Dove Flight + spectral tears Grants spectral tears and flight. 3
Dessert 5.100.24 Dessert HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red Heart.pngRed Heart. 1
Dinner 5.100.23 Dinner HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red Heart.pngRed Heart. 1
Dry Baby 5.100.265 Dry Baby Immortal friend Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering Collectible The Necronomicon icon.pngThe Necronomicon effect. 3
E. Coli 5.100.236 E. Coli Turdy touch Enemies that touch Isaac are transformed into Poop.pngPoop. 1
Fanny Pack 5.100.204 Fanny Pack Filled with goodies Has a chance to drop a random pickup when Isaac takes damage. 1
Fate 5.100.179 Fate Flight eternal Grants flight and one Eternal Heart.pngEternal Heart. 3
Gimpy 5.100.225 Gimpy Sweet suffering Gives chance of spawning a Soul Heart.pngSoul Heart when taking damage. Enemies have a chance to drop a Half Red Heart.pngHalf Red Heart after being killed. 2
Gnawed Leaf 5.100.210 Gnawed Leaf Unbreakable After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots. 1
Guardian Angel 5.100.112 Guardian Angel Extra protection Spawns an orbital familiar that blocks enemy shots, deals 7 damage per tick on contact, and increases the speed of all orbital familiars. 2
Guppy's Collar 5.100.212 Guppy's Collar Eternal life? Grants a permanent 50% chance to respawn with 1/2 of a Red Heart.pngRed Heart after death. 1
Habit 5.100.156 Habit Item martyr When Isaac is hit, his active item gains 1 room's worth of charge. 2
Halo of Flies 5.100.10 Halo of Flies Projectile protection Spawns two Pretty Flies that block enemy shots and deal contact damage to flies. 2
Holy Grail 5.100.184 Holy Grail Flight + HP up Grants flight and one Red Heart container. (in Repentance) Heals 1 additional Red Heart.pngRed Heart. 3
Holy Mantle 5.100.313 Holy Mantle Holy shield Grants a shield that negates the first instance of damage taken from a hostile source once per room. 4
Infamy 5.100.242 Infamy Blocks damage... sometimes Gives Isaac a 50% chance to block projectiles coming from any direction. 2
Infestation 5.100.148 Infestation Fly revenge (except in Repentance) 1-3 Blue Flies randomly spawn every time Isaac gets hit.
(in Repentance) 2-6 Blue Flies randomly spawn every time Isaac gets hit.
0
Isaac's Heart 5.100.276 Isaac's Heart Protect it Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. (in Repentance) The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released. 0
Judas' Shadow 5.100.311 Judas' Shadow Sweet revenge Upon death, respawns Isaac as Character Dark Judas icon.pngDark Judas with two Black Heart.pngBlack Hearts in the previous room. 3
Lazarus' Rags 5.100.332 Lazarus' Rags Eternal life? (except in Repentance) Upon dying, resurrect as Character Lazarus Risen icon.pngLazarus Risen in the current room with one Red Heart container and Collectible Anemic icon.pngAnemic.
(in Repentance) Upon dying, resurrect as Character Lazarus Risen icon.pngLazarus Risen in the current room with one less Red Heart container, Collectible Anemic icon.pngAnemic, and +0.5 Damage. Transform into Character Lazarus icon.pngLazarus when reaching the next floor.
1
Leo 5.100.302 Leo Stompy Isaac can destroy rocks by walking into them. 1
Little C.H.A.D. 5.100.96 Little C.H.A.D. Gives kisses Spawns a familiar who drops a Half Red Heart.pngHalf Red Heart every 3 rooms. 2
Lord of the Pit 5.100.82 Lord of the Pit Demon wings Grants flight and +0.3 speed. 3
Lunch 5.100.22 Lunch HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red Heart.pngRed Heart. 1
Maggy's Bow 5.100.312 Maggy's Bow HP up + you feel healthy Gives one Red Heart Container and doubles the healing provided by Red Heart.pngRed Hearts. (in Repentance) Also heals 1 Red Heart when obtained. 2
Magic Scab 5.100.253 Magic Scab HP + luck up Grants one full Red Heart container, +1 luck. (in Repentance) Heals 1 additional Red Heart.pngRed Heart. 2
Magneto 5.100.53 Magneto Item snatcher Pulls pickups towards Isaac. 1
MEAT! 5.100.193 MEAT! DMG + HP up Grants one full Red Heart container, +0.3 damage. (in Repentance) Heals 1 additional Red Heart.pngRed Heart 2
Midas' Touch 5.100.202 Midas' Touch Golden touch Enemies that touch Isaac are temporarily petrified and turn to gold. Any enemy killed while in this state will drop Penny.pngPennies. 2
Missing Page 2 5.100.262 Missing Page 2 Evil up. Your enemies will pay! Grants one Black Heart.pngBlack Heart. Upon taking damage that reduces Isaac's health to one heart or less, deals damage to all enemies in the room. (in Repentance) Increases the damage of Black Heart.pngBlack Hearts and Collectible The Necronomicon icon.pngThe Necronomicon-like effects by 40. 0
Mitre 5.100.173 Mitre Blessing of purity Grants a chance of converting any Red Heart.pngRed Heart pickups that spawn into Soul Heart.pngSoul Hearts instead. 3
Old Bandage 5.100.219 Old Bandage HP up Grants an empty Red Heart container. Adds a chance of dropping a Red Heart.pngRed Heart after taking damage. 2
Ouija Board 5.100.115 Ouija Board Spectral tears + tears up Grants spectral tears that travel through obstacles (but not enemies). (in Repentance) +0.5 tears. 2
Piggy Bank 5.100.227 Piggy Bank My life savings Gives 3 Penny.pngPennies on pick-up. Every time Isaac is damaged, he will drop one or two additional pennies. 1
Placenta 5.100.218 Placenta Regeneration + HP up Grants one full Red Heart container, and a chance to regenerate a Half Red Heart.pngHalf Red Heart of health every minute of gameplay. 2
Punching Bag 5.100.281 Punching Bag Scape goat Spawns a Mulligan.pngMulligan familiar that wanders randomly. Enemies will attack the Mulligan if it's closer. 1
Pyromaniac 5.100.223 Pyromaniac It hurts so good +5 bombs +5 bombs. Grants immunity to explosion damage and causes explosions to heal Isaac. (in Repentance) Also grants immunity to fire. 4
Raw Liver 5.100.16 Raw Liver HP up Grants 2 Red Heart containers and completely restores health. 2
Rosary 5.100.72 Rosary Tears + faith up Grants 3 Soul Heart.pngSoul Hearts. Causes Collectible The Bible icon.pngThe Bible to appear in any item pool. (in Repentance) +0.5 tears. 2
Rotten Meat 5.100.26 Rotten Meat HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red Heart.pngRed Heart. 1
Sacrificial Dagger 5.100.172 Sacrificial Dagger My fate protects me Spawns a dagger orbital familiar, blocking enemy shots and dealing a high amount of damage to enemies in contact. 2
Samson's Chains 5.100.321 Samson's Chains The ol' ball and chain Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most Obstacles. 1
Scapular 5.100.142 Scapular Pray for a miracle Once per room, when Isaac is reduced to his last half heart, he is granted one Soul Heart.pngSoul Heart. 2
Sharp Plug 5.100.205 Sharp Plug Infinite charge... at a cost Damages Isaac in exchange for fully recharging Isaac's current activated item. 2
Skatole 5.100.9 Skatole Fly love Flies become harmless or less dangerous depending on the type. 0
Smart Fly 5.100.264 Smart Fly Revenge fly Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second. 2
Spiderbaby 5.100.211 Spiderbaby Spider revenge (except in Repentance) Spawns 1-2 Blue Spiders when Isaac takes damage.
(in Repentance) Spawns 3-5 Blue Spiders when Isaac takes damage.
0
Spirit of the Night 5.100.159 Spirit of the Night Scary Grants spectral tears and flight. 3
Stem Cells 5.100.176 Stem Cells HP + shot speed up Grants one full Red Heart container and +0.16 shot speed. (in Repentance) Heals 1 additional Red Heart.pngRed Heart 1
Stigmata 5.100.138 Stigmata DMG + HP up +0.3 damage, grants one full Red Heart container. (in Repentance) Heals 1 additional Red Heart.pngRed Heart. 2
Stop Watch 5.100.232 Stop Watch Let's slow this down a bit... (in Rebirth)+0.3 speed. Automatically inflicts slow to all enemies in every room.
(in Afterbirth and Afterbirth †)+0.3 speed. Upon taking damage, inflicts slow to all enemies for the current room.
(in Repentance)+0.3 speed. Slows all enemies in every room to 80% speed.
4
Super Bandage 5.100.92 Super Bandage +2 hearts Grants one full Red Heart container and 2 Soul Heart.pngSoul Hearts. 2
Taurus 5.100.299 Taurus Speed down + rage is building -0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the Collectible My Little Unicorn icon.pngMy Little Unicorn effect for 5 seconds. 1
The Black Bean 5.100.180 The Black Bean Toot on touch (except in Repentance) When taking damage, Isaac farts, poisoning enemies in range.
(in Repentance) When taking damage, Isaac farts five times, poisoning and knocking back nearby enemies and leaving lingering poison clouds.
0
The Body 5.100.334 The Body I feel all Adds 3 Red Heart Containers. 3
The Ladder 5.100.60 The Ladder Building bridges Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections. 1
The Relic 5.100.98 The Relic Soul generator Spawns a cross familiar that drops a Soul Heart.pngSoul Heart after clearing enough rooms. 3
The Soul 5.100.335 The Soul I am all Grants two Soul Heart.pngSoul Hearts. Isaac gains a pulsing aura that repels enemies and projectiles. 3
The Virus 5.100.13 The Virus Poison touch + speed up Isaac poisons enemies on contact. (except in Repentance) -0.1 speed. (in Repentance) +0.2 speed. (in Afterbirth and Afterbirth †) Poisoned enemies have a chance to drop a black heart when killed. 2
The Wafer 5.100.108 The Wafer Damage resistance Most sources of damage that would cause more than one-half heart of damage are reduced to one-half heart instead. 4
Thunder Thighs 5.100.314 Thunder Thighs HP up + speed down + you feel stompy Destroys rocks upon contact with Isaac. Adds one Red Heart container and lowers Speed. 1
Transcendence 5.100.20 Transcendence We all float down here... Grants flight. 3
Trinity Shield 5.100.243 Trinity Shield You feel guarded Isaac gains a shield that protects him from enemy shots. It aims in the direction Isaac fires from. 2
Virgo 5.100.303 Virgo You feel refreshed and protected Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills. 2
Cambion Conception 5.100.412 Cambion Conception Feed them hate After taking damage a certain amount of times, a permanent demonic familiar spawns. 2
Censer 5.100.387 Censer Peace be with you Spawns a familiar which creates a circular aura that slows down enemies and enemy shots inside. 3
Circle of Protection 5.100.423 Circle of Protection Protect me from myself Surrounds Isaac with a large white halo that occasionally deals Isaac's tear damage to enemies inside it, and can convert enemy shots into friendly homing tears. 2
Crack Jacks 5.100.354 Crack Jacks HP up. Don't swallow the prize! Grants one full Red Heart container and drops a random trinket. (in Repentance) Heals 1 additional Red Heart.pngRed Heart. 2
Curse of the Tower 5.100.371 Curse of the Tower Embrace chaos Upon taking damage, spawns six Troll Bomb.pngTroll Bombs around the room, similar to the effect of XVI - The TowerXVI - The Tower. 0
Empty Vessel 5.100.409 Empty Vessel I reward an empty vessel Grants two Black Heart.pngBlack Hearts. While Isaac has no red hearts, grants flight and periodically grants an invincibility shield for a few seconds. 2
Farting Baby 5.100.404 Farting Baby He farts! Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which charms, poisons, or knocks back nearby enemies. 1
Host Hat 5.100.375 Host Hat Blast resistance A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions. 3
Immaculate Conception 5.100.413 Immaculate Conception Feed them love Upon picking up a certain amount of health, spawn a permanent angelic familiar. 1
Milk! 5.100.436 Milk! Don't cry over it... Spawns a glass familiar that spills on the floor upon taking damage. (except in Repentance) After the milk spills, Isaac's tear delay is decreased by 2 for the current room. (in Repentance) After the milk spills, Isaac's fire rate is increased by 1 for the current room. 1
Night Light 5.100.425 Night Light Scared of the dark? A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots. 1
PJs 5.100.428 PJs You feel cozy Grants 4 Soul Heart.pngSoul Hearts and fully restores Isaac's health. 2
Sworn Protector 5.100.363 Sworn Protector Protective friend Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room, it drops an Eternal Heart.pngEternal Heart. 3
Adrenaline 5.100.493 Adrenaline Panic = power Increases damage based on how many empty Red Heart containers Isaac has. 2
Blanket 5.100.535 Blanket You feel Safe Grants one Soul Heart.pngSoul Heart. Upon entering a boss room, grants a shield that blocks one hit, then disappears. 2
Bloodshot Eye 5.100.509 Bloodshot Eye Bloody friend Spawns an orbital familiar that deals 30 damage per second and fires a randomly angled tear every 2 seconds. 1
Bozo 5.100.513 Bozo Party time! +0.1 flat damage, grants a Soul Heart.pngSoul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a Rainbow Poop.pngRainbow Poop. 2
Brittle Bones 5.100.549 Brittle Bones Everything hurts Replaces all Red Heart.pngRed Heart Containers with 6 empty Bone Heart.pngBone Hearts. (except in Repentance) Upon losing a Bone Heart, Isaac fires bones in 8 directions and permanently gains a tears up. (in Repentance) Upon losing a Bone Heart, Isaac fires bones in 8 directions and permanently gains a fire rate up. 3
Broken Modem 5.100.514 Broken Modem Lag! Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals. The reward from clearing a room will sometimes be duplicated. 3
Cone Head 5.100.457 Cone Head Hard headed! Grants a Soul Heart.pngSoul Heart. Gives Isaac a chance to ignore any damage taken. 2
Dad's Ring 5.100.546 Dad's Ring Father's blessing Creates a ring of light around Isaac that petrifies enemies in contact. 3
Dark Prince's Crown 5.100.442 Dark Prince's Crown Loss is power (except in Repentance) When at exactly one Red Heart.pngRed Heart, +0.75 tears, +1.5 range, and +0.2 shot speed.
(in Repentance) When at exactly one Red Heart.pngRed Heart, +2 fire rate, +1.5 range, and +0.2 shot speed.
1
Greed's Gullet 5.100.501 Greed's Gullet Money = health! Grants a Red Heart container for every 25 Penny.pngCoins Isaac has. 1
Hallowed Ground 5.100.543 Hallowed Ground Portable sanctuary Spawns a white poop familiar, which turns into a White Poop.pngWhite Poop when Isaac is hurt. White poop has an aura that increases tear fire rate and can block enemy shots. (in Repentance) The aura also increases damage by 20% and gives homing. 1
Leprosy 5.100.525 Leprosy You're tearing me apart! Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots. 1
Marbles 5.100.538 Marbles Choking hazard Spawns 3 random trinkets. Taking damage has a 5% chance to swallow Isaac's currently held trinket, gaining its effect permanently. 2
Marrow 5.100.541 Marrow HP up? Grants one Bone Heart.pngBone Heart and spawns three Red Heart.pngRed Hearts. 1
Metal Plate 5.100.449 Metal Plate It itches... Grants one Soul Heart.pngSoul Heart. Enemy shots have a chance to be reflected at the shooter as confusing tears. 1
Midnight Snack 5.100.456 Midnight Snack HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red Heart.pngRed Heart. 1
Mom's Razor 5.100.508 Mom's Razor It's sharp! Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time. 2
Mystery Egg 5.100.539 Mystery Egg Sacrificial insemination Spawns an egg familiar, which hatches a random friendly monster when Isaac is hurt once per room. The power of the monster improves for each consecutive room cleared without taking damage. 1
Shard of Glass 5.100.448 Shard of Glass Blood and guts! (except in Repentance) Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
(in Repentance) Taking damage causes Isaac to bleed, spraying a volley of blood in the direction he fires. Bleeding will eventually damage him, but it can be stopped by picking up a Red Heart.pngRed Heart.
1
Slipped Rib 5.100.542 Slipped Rib Projectile shield Spawns a bone familiar that circles around Isaac and reflects enemy shots. 2
Varicose Veins 5.100.452 Varicose Veins I'm leaking... Taking damage releases a ring of 10 high damage tears. 1
2Spooky 5.100.554 2Spooky 4me Enemies near Isaac are afflicted with fear. 1
A Pound of Flesh 5.100.672 A Pound of Flesh Blood money Devil deals now cost Penny.pngCoins, ShopShop items now cost health, and consumables in shops are free but surrounded by spikes. 1
Astral Projection 5.100.677 Astral Projection The true out-of-body experience! Causes Isaac to turn into a ghost if he gets hit while in an uncleared room, giving him flight and spectral tears and blocking the next hit he takes. 2
Belly Jelly 5.100.690 Belly Jelly Bounce away! Causes enemies to bounce off of Isaac, dealing damage to them if they hit an enemy or obstacle. Also gives Isaac the chance to deflect enemy shots. 3
Binge Eater 5.100.664 Binge Eater All you can eat +1 Red Heart Container and fully heals Isaac. Item pedestals also offer a random food item. Picking up a food item temporarily grants +3.6 damage and permanently boosts 2 stats. 4
Bird Cage 5.100.610 Bird Cage Fat buddy The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to Collectible Dead Bird icon.pngDead Bird. 1
Blood Bombs 5.100.614 Blood Bombs Bloody blast + HP up Grants a Red Heart container and restores 5 hearts. Bombs leave behind damaging red creep. Isaac can place Bomb.pngBombs at the cost of half a heart if he doesn't have any. 2
Blood Oath 5.100.569 Blood Oath Bleed me dry Stabs Isaac at the beginning of each floor, draining his Red Heart.pngRed Hearts. Increases damage and speed for the floor based on the amount drained. 1
Bloody Gust 5.100.695 Bloody Gust May your rage bring haste The first 6 times Isaac takes damage on a given floor, he gains Speed and Fire Rate for the rest of the floor, up to a maximum of +1.02 and +3.00, respectively. 2
Bot Fly 5.100.629 Bot Fly Defense drone Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles. 3
Candy Heart 5.100.671 Candy Heart Power of love Gives Isaac a permanent stat boost whenever he heals with Red Heart.pngRed Heart pickups. 1
Cracked Orb 5.100.675 Cracked Orb Shards of knowledge Unlocks doors and reveals a random room on the map when Isaac takes damage. 1
Cube Baby 5.100.652 Cube Baby Kick it! Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills. 1
Dad's Note 5.100.668 Dad's Note ... Sends Isaac on an Ascent toward HomeHome. 0
Divine Intervention 5.100.568 Divine Intervention Double tap shield Double tapping a fire key creates a shield that pushes away enemies and reflects enemy projectiles and lasers. 2
Dogma 5.100.633 Dogma Ascended Grants flight, +2 damage, and increases speed to 1.1. Grants enough health to have 6 full hearts, if possible. Grants the Collectible Holy Mantle icon.pngHoly Mantle effect for the room it was obtained in. Automatically given to Isaac after defeating Dogma. 3
Empty Heart 5.100.676 Empty Heart It multiplies If Isaac has one red heart or fewer at the beginning of a floor, he gains an empty red heart container. 1
Giant Cell 5.100.658 Giant Cell Micro friends Causes Isaac to spawn Minisaac familiars when he takes damage, which chase and shoot at nearby enemies. 1
Heartbreak 5.100.694 Heartbreak Eternal sorrow Grants 3 broken hearts and +0.25 damage for every broken heart Isaac has. Every otherwise fatal hit will add 2 more until Isaac has nothing but broken hearts. 3
Hypercoagulation 5.100.724 Hypercoagulation Thick blooded After Isaac takes damage from an enemy or donates health, launches Red Heart.pngRed Hearts from Isaac that despawn after 1.5 seconds. 2
Inner Child 5.100.688 Inner Child Let him free Upon death, Isaac respawns in the current room with half of a Red Heart.pngRed Heart, a massive size down, and +0.2 Speed. 2
It Hurts 5.100.560 It Hurts No it doesn't... Releases a ring of tears and increases fire rate for the current room when Isaac takes damage. 1
Knife Piece 1 5.100.626 Knife Piece 1 ??? Combined with Collectible Knife Piece 2 icon.pngKnife Piece 2, creates a knife familiar that damages enemies and can open the door to the CorpseCorpse. 0
Knife Piece 2 5.100.627 Knife Piece 2 ??? Combined with Collectible Knife Piece 1 icon.pngKnife Piece 1, creates a knife familiar that damages enemies and can open the door to the CorpseCorpse. 0
Lil Dumpy 5.100.615 Lil Dumpy Puffy buddy Spawns a Dumpy familiar that pushes away nearby enemies and projectiles just before Isaac is about to be hit, then falls asleep. He can be awoken by walking to him. 3
Lost Soul 5.100.612 Lost Soul Protect him Creates a ghostly familiar that closely follows behind Isaac. It dies in one hit, but respawns at the start of the next floor. Each time it survives until the next floor, it rewards Isaac with Soul Heart.pngSoul Hearts, Eternal Heart.pngEternal Hearts, or an Item. 2
Orphan Socks 5.100.571 Orphan Socks Speed up + your feet feel stronger Prevents creep and floor spikes from damaging Isaac. Also gives Isaac +0.3 speed and 2 Soul Heart.pngSoul Hearts. 2
Psy Fly 5.100.581 Psy Fly Flamboyant protector Spawns a fly orbital familiar that chases and blocks enemy shots. 4
Sanguine Bond 5.100.692 Sanguine Bond He awaits your offering Spawns a special set of spikes in the Devil RoomDevil Room. Taking damage from the spikes has a chance to grant a reward. 1
Spirit Shackles 5.100.674 Spirit Shackles Unfinished business On death, Isaac's ghost is chained to his dead body and he can continue to fight with 1/2 of a heart, returning to life after 10 seconds. After it activates, it must be recharged by picking up a Soul Heart.pngSoul Heart. 2
Supper 5.100.707 Supper HP up Grants one full Red Heart container. Heals 1 additional Red Heart.pngRed Heart. 1
The Swarm 5.100.693 The Swarm Infest Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. 2
Tinytoma 5.100.645 Tinytoma Itching for revenge Gives Isaac a Boss Teratoma ingame.pngTeratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. 1
Vengeful Spirit 5.100.702 Vengeful Spirit Hot blooded After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots. 1
Tonsil 5.100.474 Tonsil Gross... Grants a familiar that follows Isaac and blocks enemy shots. {{{quality}}}