Grants a passive ability that varies from character to character. The effect typically enhances/magnifies the character's special traits or helps mitigate some of their downsides.
+1 Luck. Every floor, except for ???, Chest, Dark Room, The Void, and Home, has a very high chance to contain an upgraded Arcade that generally contains more Machines. This includes odd-numbered floors, Cathedral, and Sheol. Arcades will appear even if Cain is not holding at least 5 Coins. Arcades will still not spawn in Greed Mode.
The Book of Belial becomes a passive item that can be held beneath other active items, similar to Book of Virtues. May stack with Book of Virtues. If Judas is not currently holding The Book of Belial, he receives it. The damage boost received from The Book of Belial scales with the amount of charges the active item above it has; may not work with one-time-use items, items with unlimited use, timed recharges, or items that do not follow normal room charge rules (Isaac's Tears, etc). Has special interactions with certain items — see The Book of Belial for more information.
Red Heart Clots now spawn temporary Half Red Hearts on death that last for two seconds before disappearing. Clots spawned from other types of hearts will not drop hearts.
The non-active form of Tainted Lazarus will appear in ghostly form, being completely immune to damage and dealing 25% damage (including tear effects such as Holy Light). Holding down the "drop" key allows the active form to move independently of the other form, similar to Jacob and Esau. Using Flip will cause the two characters to switch states while maintaining positions. Both characters receive the Birthright effect when one character collects it.
Creates 3 random items from random item pools. Only one can be taken. Ignores item weight and can spawn items that have already been taken during the run. Can also spawn multiples of the same item, if they exist in multiple item pools.
Items gained before Birthright will not be re-rolled, neither by taking damage, nor by items such as D4 and Missing No.. Items gained afterwards will still be affected.
Most familiars that normally follow Lilith, including Lilith's innate Incubus, will always be positioned in front of Lilith, creating a stack, facing whatever direction she was shooting. Non-attacking familiars (The Relic, Farting Baby, etc.) will follow Lilith's most recently acquired attacking familiar instead; if the most recent familiar is throwable like Holy Water, familiars following it will also be launched with it. If Lilith has King Baby, it will always be positioned directly in front of Lilith with all other affected familiars forming a semi-circle around it, and will behave normally otherwise. Dry Baby is considered an "attacking familiar" and will be within the stack. Lil Portal and Jaw Bone are exempt and behave normally.
Familiars that normally follow Tainted Lilith will instead act like and stack on top of her Gello familiar, disappearing inside of her while she's not firing and swinging out when she attacks. The melee attack gains a flat +3 damage bonus per familiar (regardless of damage multipliers) and if those familiars can shoot, they do so along with the Gello familiar. The Gello familiar gains the properties of King Baby, causing attached familiars to automatically aim and shoot at enemies. Familiars like Jaw Bone or Holy Water still function, but they are bound to the Gello familiar rather than their normal means of movement.
Using Void has a 10% chance to spawn one previously destroyed passive item (while keeping the bonus stats). Each absorbed passive item has an equal chance to be spawned. Spawned items can be spawned again even if they are not reabsorbed. Absorbing duplicates of the same item will make it more likely to be spawned, as each duplicate counts as a separate item and thus has its own chance to be spawned. Birthright has no effect if Void is not held.
The Soul is unchained and free to move. It can move to different rooms, leaving The Forgotten behind, and switching back teleports The Soul back to The Forgotten.
Tainted Soul is given Recall, an unlimited-use active item, in their pocket active slot. When used, Recall pulls Tainted Forgotten into Tainted Soul's hands automatically from a distance, dealing damage to enemies as it travels.
Dark Esau splits into two. Both Esaus will always charge at the same time, and one will not charge if the other is not in position. Using Anima Sola chains both Dark Esaus at once and forces them together into one spot. Subsequent uses release each Dark Esau one at a time. Anima Sola's recharge time is reduced to 10 seconds, and chain duration is increased to 6.67 seconds.
Each additional copy of Birthright for Magdalene, Tainted Magdalene, and Keeper will add another heart container; however, their respective health caps will not be raised any further. Cain will also gain +1 Luck for each copy of Birthright.
When Magdalene or Keeper enter the area in which Knife Piece 2 can be acquired, all hearts above the usual cap are removed and are not restored upon leaving the area. Additional hearts can be regained afterwards.
While playing as Tainted Cain in Greed Mode, purchasing an on-sale item over and over while having Birthright results in almost infinite consumables.
If The Soul enters a new floor with Birthright, swapping back to The Forgotten will cause him to appear at The Soul's current location.
Before Antibirth the item originated from the Binding of Isaac: Community Remix mod, where it was known as 'Soul Script'.
This item's name, description, and unlock requirement are a reference to the biblical story of Jacob and Esau, in which Esau trades his birthrights to Jacob in exchange for stew.
When Tainted Jacob picks up Birthright, Dark Esau, a representation of his own rage, seemingly becomes only angrier and doubles in power.
Birthright's effect doubling Dark Esau's power, instead of Tainted Jacob's, and the quote "it's not yours", further reflects the fact that it was originally his.
Prior to patch V1.7.6, Tainted Jacob's Birthright pickup quote was "There is no escape".
Tainted Keeper's pickup quote could be based off the song Money, Money, Money, by the band ABBA.
Eden's Birthright could be a reference to how Eden functions in the card game The Binding of Isaac: Four Souls, as Eden starts the game by drawing 3 treasure cards and selecting one to keep permanently while the other two are discarded.
Bugs
Bug!
Playing as Keeper, having more than 3 HP, and entering the area in which Knife Piece 2 can be acquired will remove the fourth HP (can be increased back to 4 HP after)
Bug!
Playing as Magdalene, having more than 12 hearts, and entering the area in which Knife Piece 2 can be acquired will completely remove all hearts above 12.
Bug!
Playing as Tainted Lazarus, Picking up Birthright and using Flip at the same time as the other form appears will cause the other form to be in a bugged state where he acts significantly faster than intended. Restarting the game will undo the effects.