View table: collectible

Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys

Repeatedly zaps enemies that are close to Isaac.

Gives Isaac an extra life. Upon death, he will respawn in the previous room with full health, after which 1up! will disappear.

Isaac fires two tears at once, one from each eye. 0.8× damage multiplier.

Enemies near Isaac are afflicted with fear.

Gives Isaac a random tear effect every room.
Gives Isaac a random tear effect every few seconds.

Active items don't charge when clearing rooms. Instead, they're charged by dealing damage to enemies.

Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts.

+1.5 damage. Replaces Isaac's tears with nails, which have increased knockback.

Reduces the charge of any activated item by 1. Any 1 charge items instead have timed recharges.

+0.5 Tears, +0.2 Shot Speed.

Gives Isaac 100 Pennies.

The more distance tears travel, the more damage they will do.

Passively grants flight and increases speed to 1.5. Upon use, Isaac charges in the direction the pony is facing, giving invulnerability during the charge and dealing damage to enemies hit.

Devil deals now cost Coins, Shop items now cost health, and consumables in shops are free but surrounded by spikes.

Gives Isaac 25 coins.

Grants one full Red Heart container. Heals 1 additional Red Heart.

+1.5 damage, +0.2 speed. Removes all Red Heart containers, grants six Black Hearts, and adds a chance to shoot fear tears.
+1.5 damage, +0.2 speed. Grants two Black Hearts, converts all Red Heart Containers into Black Hearts, and adds a chance to shoot fear tears.

Spawns a familiar that mirrors Isaac's movements and shoots in the opposite direction.
Spawns a familiar that mirrors Isaac's movements and shoots towards him.

Destroys all items in the room and gives Isaac a unique locust familiar for each item destroyed. Some items generate locusts with special effects.

Spawns a familiar that drops a random pill every 3 rooms. Upon using a pill, all enemies in the room are poisoned.

+0.7 tears, grants an Eternal Heart. Allows Angel Rooms to appear even if a Devil Deal has been taken before. Reduces the Devil/Angel room chance penalty for taking Red heart damage.

Increases damage based on how many empty Red Heart containers Isaac has.

While in an uncleared room, Isaac forms a trail of bloody tears that drags behind him, bursting and dealing damage upon contact with enemies.

Spawns three Soul Hearts and two Angel Room items and is consumed. Starts with no charges, and can only be charged by picking up 6 Soul Hearts.

Quadruples fire rate, with ×0.3 damage multiplier. Each tear is a given random effect that alters its movement.

+0.35 tears up. Allows Isaac to fire tears diagonally.

Spawns six Troll Bombs around the room.

After Isaac is damaged, a trail of red creep will be left behind him until he leaves the current room. +5 range. +1.5 range.

Spawns an orbital familiar with a large orbital radius. Tears that pass through the prism split into four multi-colored tears.

Spawns a fly familiar that orbits around a random enemy and deals 30 damage per second to enemies it comes in contact with.

Chains down the nearest enemy for 5 seconds, preventing them from acting.

Upon death, Isaac will respawn as ??? in the previous room, with 3 Soul Hearts.

Tears float in position until firing ceases, after which they will fly off in the direction they were shot in. -2 Tear Delay. +1 Fire Rate.

+0.3 tears. Adds a chance to fire a razor blade that deals 4× Isaac's damage.

A trail of blue creep is left behind Isaac, which damages enemies. The creep scales with damage and inherits most tear effects.

+0.25 Speed. Running into enemies while at a high speed will deal damage. Prevents Isaac from taking contact damage while moving at high speed.

Causes Isaac to turn into a ghost if he gets hit while in an uncleared room, giving him flight and spectral tears and blocking the next hit he takes.

When Isaac takes damage, a damaging black ring briefly appears around him. This ring can cause enemies to drop Black Hearts.
After Isaac kills an enemy, adds a luck-based chance to spawn a damaging black ring around them.

Isaac builds rage every time a room is cleared. After four rooms, fires a large Brimstone laser when entering the next room.

Isaac's tears deal double damage and inflict bleeding on enemies if they're facing away from Isaac.

Collects and holds up to 8 pickups, which can then be used to craft an item. The power level of the item is based on the quality of pickups used.

Creates an orbital familiar. Collecting additional copies gives it the ability to shoot Charm tears, then chase enemies to deal contact damage, then deal even more contact damage.

Adds a chance to shoot slowing tears. Isaac leaves a trail of slowing creep behind as he moves, impeding enemies' speed.

Recharges Isaac's currently held active item and drops 2-4 batteries.

Spawns a familiar that flies around the room in a zig-zag pattern and explodes on contact with an enemy. Respawns after ten seconds.

Drops a random trinket. Grants a second trinket slot.

Causes enemies to bounce off of Isaac, dealing damage to them if they hit an enemy or obstacle. Also gives Isaac the chance to deflect enemy shots.

Isaac goes berserk for 5 seconds, greatly increasing his speed, tears, and damage, but restricting him to using a melee weapon instead of his tears. This item charges by dealing damage to enemies instead of clearing rooms.

When hit, spawns a quickly orbiting attack fly similar to Forever alone for the current room that deals high damage.

Spawns a decoy Isaac that explodes after 5 seconds. Enemies will always target the decoy and ignore Isaac.

Charms all enemies in the room when Isaac takes damage.
Enemies are able to damage each other. If an enemy is damaged by another enemy, they will attack that enemy instead of Isaac.

Increases the size and effectiveness of most familiars.

Spawns a familiar that follows Isaac and charges across the room when Isaac fires, blocking shots and dealing 40.5 damage per second on contact.

Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies.

+1 Red Heart Container and fully heals Isaac. Item pedestals also offer a random food item. Picking up a food item temporarily grants +3.6 damage and permanently boosts 2 stats.

Grants one Soul Heart, +0.75 tears and decreases Isaac's size.

The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to Dead Bird.

Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them.

Grants a character-specific effect that enhances their special abilities.

Prevents curses. Grants one Black Heart. Increases the chance for a Devil Room or Angel Room to appear.

Throws a black hole on the ground which sucks in and damages enemies and destroys nearby obstacles.

Grants one Red Heart Container, one Soul Heart, and one Black Heart.

Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it.

Copies the effect of the card or rune currently held by Isaac.
Copies the effect of the card currently held by Isaac. The charge time is based on the power of the card.

Grants one Soul Heart. Upon entering a boss room, grants a shield that blocks one hit, then disappears.

Grants one filled Red Heart container, restores 4 Red Hearts, and increases speed by 0.3.

Grants a Red Heart container and restores 5 hearts. Bombs leave behind damaging red creep. Isaac can place Bombs at the cost of half a heart if he doesn't have any.

Tears fired from the left eye have +1 flat damage, +5 range, and +0.5 tear falling speed.
Tears fired from the left eye have +1 flat damage and +2.75 range.

Stabs Isaac at the beginning of each floor, draining his Red Hearts. Increases damage and speed for the floor based on the amount drained.

+1 damage. Isaac shoots blood tears.

Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac. Dealing enough damage to it returns it to normal.

Takes a full heart of health and deals 40 damage to all enemies in the room. Repeated uses in the same room only take half a heart.

Spawns an orbital familiar that deals 30 damage per second and fires a randomly angled tear every 2 seconds.

The first 6 times Isaac takes damage on a given floor, he gains Speed and Fire Rate for the rest of the floor, up to a maximum of +1.02 and +3.00, respectively.

Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor.

Gives one full Red Heart container, +0.7 tears, and -0.16 shot speed. Heals 1 additional Red Heart.

Reveals the locations of Secret Rooms and Super Secret Rooms on the map.

Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.

+5 Bombs. Grants Isaac's bombs a poison effect. They also leave a lingering poison cloud, and Isaac becomes immune to poison.

Isaac holds a poison Bomb which can be thrown in the cardinal directions and explodes on impact.

+5 Bombs. Bombs gain a homing effect, slowly moving towards the nearest enemy.

All normal Bombs become Double Bombs.

Gives Isaac a familiar that fires chaotic bursts of tears in all directions.

Spawns a familiar that drops a Bomb every 3 rooms.

+5 Bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects player-spawned Troll Bombs.

Enemies spawn floating bones on death, which block shots and damage/repel enemies that touch them.

Increases the chance of a Devil Room / Angel Room appearing while held. Upon use, gives one Soul Heart, and replaces the boss of the current floor with a Harbinger if possible.

Gives the effect of Treasure Map, The Compass, or Blue Map for the duration of the current floor. If all effects are active, X-Ray Vision is provided for the floor instead. Highlights any Tinted Rocks and rocks with Crawl Space in the room.

Creates a protective shield, nullifying all types of damage in the current room for 10 seconds.

Creates a friendly Bony, Black Bony, or an orbital bone for each enemy killed in the current room.
Creates a friendly Bony, Black Bony, Bone Fly, Revenant, or an orbital bone for each enemy killed in the current room.

Spawns a destroyable orbiting wisp familiar that fires tears and deals contact damage. Also acts as a passive item that causes other active items to spawn themed wisps.

Grants 10 Bombs.

Drops 5 random cards.

Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles.

Spawns various pickups: 1 coin, 1 Key, 1 Bomb, 1 Heart, 1 card/rune, 1 pill and 1 trinket.

Duplicates all of Isaac's familiars for the current room. If Isaac has no familiars, spawns a Demon Baby for the room instead.

Spawns 1-4 Blue Spiders that deal 2.5× Isaac's damage to enemies.
Spawns 4-8 Blue Spiders that deal 2× Isaac's damage to enemies.

+0.1 flat damage, grants a Soul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a Rainbow Poop.

Grants one full Red Heart container. Heals 1 additional Red Heart.