BFFS!
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BFFS! is a passive item.
Effects
- Visually increases the size of all familiars by 25%, and improves the effectiveness of most of them.
- Doubles the damage of Familiars that deal damage through tears and contact damage.
- Has no effect on Creep generated by familiars.
- For pickup-generating familiars, increases the frequency that they drop pickups.
- Familiars that require clearing a certain number of rooms will require one less room.
- Familiars that have a random chance to drop items have a higher chance.
- Familiars that pick up consumables require less, except
Dark Bum which is unaffected.
- Some familiars have unique synergies.
- Doubles the damage of Familiars that deal damage through tears and contact damage.
Notes
- The size change is only cosmetic: familiars' hitbox for blocking damage or attacking is not affected.
- Familiars summoned by a trinket or by
Monster Manual are also affected by BFFS!.
Wisps are also affected by BFFS!.
- Blue Flies and Blue Spiders are not affected, they instead benefit from
Hive Mind. - Does not increase the frequency or effectiveness of Status Effects applied by familiars.
Synergies
BBF/
Bob's Brain: Doubles impact damage and increases explosive damage by 25.
Bird Cage: Spawns 4 rock waves in an x pattern. Doubles the damage when the bird lands and doubles contact damage. Damage of waves unaffected.
Blood Oath: Adds 2 extra full hearts worth of bonuses if any health is drained.
Holy Water: Double water damage and spawns a blue flame at point of impact.
Incubus: Shoots tears that do 
2x Isaac's damage 1.5x Isaac's damage. Still deals 2x as 
Lilith.
Isaac's Heart: Fires additional shots in random directions and leaves a larger puddle of creep. Does not change the heart's size.
Juicy Sack: Spawns an extra Blue Spider.
Lil Spewer: Increases the creep pool's size, but not its damage.
Lost Soul: Gives the Lost Soul a 
Holy Mantle effect.
Mystery Egg: Spawns a champion variant of an enemy, even if the enemy normally can't be a champion.
Stitches: On use, fires eight tears from Isaac's original location. The tears synergize with Isaac's tear effects.
Succubus: The aura's radius increases, but the damage multiplier and damage to enemies remain the same.
Interactions
Blood Puppy: Only increases the damage and size while it isn't hostile.
Evil Eye: The eyes are not treated as familiars and therefore will not synergize with BFFS!
Guillotine/
Scissors: Doesn't change the head's size, but still improves its damage.- Hive Mind: Does not stack.
Shade: Retains the increased damage even after being absorbed.
No Effect
The following familiars will appear larger, but gain no actual benefits.
1up!
Angelic Prism
Brown Nugget
Censer- Dark Bum
Dead Cat
Depression
Dry Baby
Farting Baby
GB Bug
Hallowed Ground
Headless Baby- Holy Water
- Isaac's Heart
Key Piece 1
Key Piece 2
King Baby
Milk!
Multidimensional Baby
Paschal Candle
Punching Bag
Rotten Baby
Sissy Longlegs
Slipped Rib
Sprinkler
Star of Bethlehem
Trinity Shield
Vanishing Twin
YO LISTEN!
In-game Footage
Trivia
- BFF stands for Best Friends Forever.
- This item is used in The Family Man (challenge #19) and Scat Man (challenge #36).
 Familiar Modifiers
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| Items |
| Trinkets |
 The Binding of Isaac: Rebirth
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