Azazel's Rage
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Azazel's Rage is an unlockable passive item added in The Binding of Isaac: Repentance.
Effects
- Isaac builds up rage every time he clears a room, which is indicated by the patch of skin that spreads around his face, as well as the four sections of the horn lighting up red one at a time.
- After four rooms, Isaac's head will start to flash red; upon entering a room with enemies, he will fire a large
Brimstone laser for ~3.33 seconds.
- The laser deals Isaac's damage per tick (15x Isaac's damage per second).
Notes
- The counter for activation will go up during Greed Mode,
Challenge Rooms, 
Boss Challenge Rooms and 
Boss Rush waves, as well as the waves in the 
The Beast fight.
- If the Brimstone laser is ready, it will fire automatically after clearing a Greed Mode or Beast fight wave.
It will not fire in challenge rooms or boss rush.
In-game footage
Trivia
- This item is, most likely,
Azazel's severed right horn. - This item resembles one of the horns of The Beast.
Gallery
The five stages of Azazel's Rage as it slowly overtakes Isaac. The final stage slowly pulses red.
 Tainted Azazel Unlocks
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 The Beast Unlocks
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 The Binding of Isaac: Rebirth
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