The icon of the D infinity will change to resemble the corresponding die while being held. Putting it back on a pedestal will change its icon back to normal.
When in possession of more than one active item with the Schoolbag, all dice must be cycled through before the other active item can be used.
When playing as Tainted Isaac and holding D infinity as well as another active item via Schoolbag, if Schoolbag is replaced by another passive item in its slot while the other active item is held, D infinity will be dropped on the ground, reset to its original state. This could allow the player to use any dice item with only a 2-pip charge.
Synergies
Book of Virtues: Spawns a normal wisp in addition to having an extra effect based on the current die selected.
Interactions
Car Battery: Activates 2 dice. The second activation die cannot be predicted.
The second activation die is determined by the seed and never changes.
Void: When absorbed and Void is used, replicates the effect of a random die item.
Acts as a copy of one of the 10 dice D infinity can replicate. This die is randomly chosen and does not change.
Grants a random dice item that transforms into a different random die item upon use.
Acts as any die item except for 
Spindown Dice, and can be cycled through by pressing the drop key.
Schoolbag, all dice must be cycled through before the other active item can be used.
Tainted Isaac and holding 
D infinity as well as another active item via 
Book of Virtues: Spawns a normal wisp in addition to having an extra effect based on the current die selected.
Car Battery: Activates 2 dice. The second activation die cannot be predicted.
Void: When absorbed and Void is used, replicates the effect of a random die item.
Delirium.
D1, 
D4, 
The D6, 
Eternal D6, 
D7, 
D8, 
D10, 
D12, 
D20 and 
D100.
Dice 
Isaac Unlocks 
Delirium Unlocks 
The Binding of Isaac: Rebirth
