The Tears multiplier can cause Isaac's tear delay to decrease beyond the normal cap of 5.
The Speed multiplier cannot cause Isaac's speed to decrease or increase past the normal range of 0.1 to 2.0.
The multiplier overrides the Speed Up effect of A Pony or White Pony, which normally raise Isaac's Speed to 1.5 if it is below that value.
The hidden maximum Speed value also gets the same multiplier, which may further cap Isaac's Speed.
The multipliers are chosen in a way that keeps their total product roughly the same; the item will most often increase two and decrease two of Isaac's stats, although it can increase three and decrease one or increase one and decrease three. Larger increases are balanced by larger decreases.
Synergies
Rock Bottom: Allows affected stats to reach high multipliers, potentially doubling them if used enough.
Book of Virtues: Spawns a black glowing die wisp on the middle ring. Each wisp has a random damage and fire rate assigned to it. Wisp health is not randomized.
Interactions
Car Battery: Re-rolls twice instantly without any benefits.
Rock Bottom: Considers both sets of multipliers, allowing higher stats to be reached faster.
Jacob and Esau: Only the brother using D8 will get their stats rerolled with the exception of Speed, which is shared between both brothers.
Tear Falling Speed are unaffected.
A Pony or 
White Pony, which normally raise Isaac's Speed to 1.5 if it is below that value.
Rock Bottom: Allows affected stats to reach high multipliers, potentially doubling them if used enough.
Book of Virtues: Spawns a black glowing die wisp on the middle ring. Each wisp has a random damage and fire rate assigned to it. Wisp health is not randomized.
Car Battery: Re-rolls twice instantly without any benefits.
Jacob and Esau: Only the brother using D8 will get their stats rerolled with the exception of Speed, which is shared between both brothers.
Dice 
The Binding of Isaac: Rebirth
