While holding this trinket, if there's another familiar that follows Isaac's Head, dropping this trinket will move the familiar to the first familiar slot.
This resets upon quitting and re-entering the game.
This is useful with familiars that are more effective when closer to Isaac, such as Lil Brimstone and Incubus.
Familiars that follow behind Isaac have a certain priority in how close their position is to him over other familiars, with Isaac's Head having 5th / 7th priority.
Synergies
Golden Trinket / Mom's Box: Tears deal Isaac's damage. Having both raises the damage to Isaac's damage x 1.5.
Sacrificial Altar: Sacrifices the familiar, destroying the trinket and generating an item normally.