D100

D100 is an unlockable activated item.

Effects

Upon use, it:

Rerolls all passive items on Isaac (like the D4).
Rerolls all pedestal items in the room (like The D6).
Rerolls all pickups in the room (like the D20).
Restarts the room and respawns all enemies (like the D7).
Rerolls Isaac's damage, tears, range and speed (like the D8).
Rerolls all enemies in the room into weaker ones (like the D10).
- Doesn't go into effect in rooms the D7 works in.
Rerolls all rocks in the room (like the D12).
Duplicates 1 random pickup in the current room (like the D1).
- The pickup is rerolled by the D20 before being duplicated, essentially just granting a random extra pickup.

D100 is a special item.
See the D4, The D6, and the D20 to learn more about the respective individual effects.
- See the D1, D4, The D6, D7, D8, D10, D12, and the D20 to learn more about the respective individual effects.
If Missing No. is given to the player, it will activate and remove the D100, preventing further rerolls.
- Note that Missing No. can be re-rolled into, but can't be re-rolled out of.
D100's quality is treated as 2 for the purposes of Bag of Crafting.

Book of Virtues: Rerolls all of Isaac's wisps and gives him one random wisp. Book of Virtues will not be rerolled in the process.

Unlike the base game sprite, the D100 sprite on the lower part of the 3DS screen appears to have no edges and is a perfect sphere, which would make it more akin to the D infinity.