Curse Room

Curse Rooms feature teeth-like spikes on the door that hurt Isaac when entering and exiting the room.

Curse rooms can appear from Chapter 1 to 5.

Taking damage from the spikes doesn't reduce the odds of getting a Devil or Angel room.

Layouts

The following room maps were made using Basement Renovator for cleaner viewing.

In Downpour and Dross, Spiders will be replaced by Striders.

ID	Weight	Contents
0	1	A Red Chest.
1	1	Two Red Chests.
2	1	Two Red Chests.
3	1	An item and four Spiders.
4	1 0.25	Two Black Hearts.
5	1 0.75	Two Red Chests and a Bomb Chest.
6	1	A Big Spider and four Spiders.
7	1	A Red Chest.
8	1	A Red Chest and four Blue Fire Places.
9	1 0.5	A Black Heart and a Nulls.
10	1	A Red Chest and two Nulls.
11	1 0.5	A Reward Plate, four Fire Places, and two Nulls.
12	1 0.25	A random rune.
13	1 0.5	Two random cards and seven Red Fire Places.
14	1 0.5	Four spiders and a Devil Beggar.
15	1	Two Red Chests and an Imp.
16	1	A Red Chest.
17	1 0.5	A black heart and two spiders.
18	1	Two random pickups, a Nickel, and a Big Spider.
19	1	A Spiked Chest.
20	1	Three Red Chests, one surrounded by spikes.
21	0.25 0.1	A Satan statue, two Red Fire Places, and a pickup that has an equal chance to be : a random trinket, a random rune, a Black Rune, an item, a random pickup, and a red chest.
22	1 0.5	Two Black Globin's Heads and a Fire Place.
23	0.1	Three red chests and three black hearts.
24	0.1	A Black Globin's Head, and 6 urns (4 of them have 50% chance to be a Black Globin's Head instead).
25	0.5	An item and two Bulbs.
26	0.25	A red chest, two Reward Plates and four Fire Places.
27	0.25	An item and two Red Fire Places.
28	0.1	A Reward Plate, two red chests, four urns, and two Blue Fire Places.
29	0.25	Two Black Sacks, four urns, and a Blue Fire Place.
30	0.5	A random rune behind three urns that each have 50% chance to be a cobweb instead, two spiders, and two Fire Places.

ID	Weight	Contents
31	1	A coin and two red chests.
32	0.5	A coin, two red chests, four cobwebs, and spikes.
33	1	A coin, three red chests, and four Fire Places.
34	1	A coin, three red chests, and two Sacks.
35	0.5	A coin, two black hearts, an Imp, and four Blue Fire Places.
36	1	A coin, three red chests, and six Fire Places.
37	1	A coin, two red chests, and four Fire Places.
38	1	A coin, four red chests, and two Nulls.
39	1	A coin, four red chests, and spikes.
40	0.1	A coin, a Big Spider, and two items.

ID	Weight	Contents
0	1	A Red Chest and two Red Fire Places.
1	1	Two Red Chests.
2	1 0.5	A Locked Chest and two urns.
3	1 0.5	A Bomb Chest and two urns.
4	1 0.1	A Reward Plate.
5	1 0.25	Two Reward Plate and two random hearts.
6	1 0.5	Three random pills and two Fire Places.
7	1	A random card, four urns, and two cobwebs.
8	1	A random rune and two Fire Places.
9	1	A red chest and four rocks.
10	1 0.25	A bed and twelve rocks.
11	1 0.5	Two keys and two urns.
12	1 0.25	Four random hearts.
13	1 0.5	Three coins.
14	1	A red chest.
15	1	Two random pills.
16	1 0.5	Three random bombs.
17	1 0.5	Two random bombs.
18	1 0.5	A red chest and two spiders.
19	1 0.5	A Double Bomb, four urns, and two cobwebs.
20	1	A Black Heart.
21	0.5	Three red chests.
22	0.5	Two Black Sacks.
23	0.75	An item and four urns.
3	0.5	Duplicate of #23 with the weight of #3, a leftover.

Items that grant flight allow Isaac to avoid damage taken upon entering a Curse Room, but do not prevent damage taken upon leaving.
Any item that gives Isaac a shield or invulnerability will prevent damage taken when passing through a Curse Room Door, including Holy Mantle.
If a Secret Room is next to a Curse Room, it can be entered without taking any damage by bombing the wall between these rooms from the Secret Room.
The damage done by the Curse Room's door is applied when touching the door. This means that Isaac can be damaged by it without actually going through the door, and any effects that occur upon taking damage will occur in the current room and not the room that the door leads to.
During Cursed! (challenge #10), all doors except for special types turn into this type of door.
Damage taken from entering a Curse Room doesn't count for the purposes of score calculation.
Holding Flat File will remove the spikes from Curse Room doors, allowing them to be entered without taking damage.

Bug!	Isaac can pass through Curse Room doors without taking damage even when he should. This usually requires 2.0 speed, a long running start and careful positioning to cross the door before its damage effect kicks in, or alternatively several size downs and very careful nudging along the door's edge.