Boss Room

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Bossroom.png

Boss Rooms contain one of the many bosses, with victory granting Isaac an item from the Boss pool, hearts (depending on difficulty), and a trap door leading to the next level.

Notes

  • Double Trouble Boss Rooms contain 2 bosses of the same type from the previous chapter. Defeating them only gives one item. Double Trouble Boss Rooms only appear from chapter 2 onward.
    • (except in Rebirth) Double Trouble Boss Rooms can now contain 2 bosses of different types. Additionally, they can appear as early as chapter 1.
  • If the floor is affected by Curse of the Labyrinth, 2 separate Boss Rooms will appear in series. The trapdoor to the next floor will only appear after defeating the second boss.
  • When a boss is defeated, an entrance to a Devil RoomDevil Room or Angel RoomAngel Room can appear.
    • A Devil Room door can't appear on the first floor, unless JokerJoker is used. A Devil Room door can also appear in a boss room on the first floor if the floor is spawned with the Curse of the Labyrinth, in which the Devil Room door will appear after defeating the second boss.
    • Upon defeating Boss Mom's Heart ingame.pngMom's Heart, a Devil RoomDevil Room containing a trapdoor or an Angel RoomAngel Room containing a beam of light may appear. This allows Isaac to visit SheolSheol or CathedralCathedral respectively even if Boss It Lives ingame.pngIt Lives has not yet been unlocked. If one of these paths is taken instead of touching the large chest, the next Mom's Heart ending will not play but will be unlocked and it will count as a victory against Mom's Heart.
      • (except in Rebirth) Devil RoomDevil Rooms and Angel RoomAngel Rooms no longer contain a trapdoor or a beam after defeating It Lives. They instead have their normal contents.
  • Boss Mr. Fred ingame.pngMr. Fred, (in Repentance and Repentance+) Boss Tuff Twins ingame.pngTuff Twins, (in Repentance and Repentance+) Boss Great Gideon ingame.pngGreat Gideon, (in Repentance and Repentance+) Boss The Shell ingame.pngThe Shell, and Mega Satan Head ingame.pngMega Satan are always fought in a double-sized (2x1) room.
    • (except in Rebirth) Boss Hush ingame.pngHush is always fought in a 2x2 room and Boss Ultra Greed ingame.pngUltra Greed is fought in a double-sized one.
    • (except in Rebirth and Afterbirth) Boss Delirium ingame.pngDelirium is fought in a 2x2 room.
    • (in Repentance and Repentance+) Boss Mother secondphase ingame.pngMother is a fought in a regular room in her first phase, which expands to a double-sized room for her second.
  • Before the boss has been defeated, the eyes of the skull above the boss room's door are flashing.
  • Collectible Dad's Key icon.pngDad's Key, (except in Rebirth)Get out of Jail Free CardGet out of Jail Free Card, (except in Rebirth and Afterbirth)Collectible Mr. ME! icon.pngMr. ME!, (except in Rebirth and Afterbirth)Door StopDoor Stop can allow Isaac to flee the boss room by opening the door from the inside.
    • This won't work if the boss is Boss Mom ingame.pngMom.