Seraphim (Transformation)

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(except in Rebirth)

After obtaining 3 holy items listed below ((in Repentance and Repentance+) 3 items with the angel item tag), Isaac will gain 3 Soul Heart.pngSoul Hearts and permanent flight.

Activated Collectibles

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
The Bible 5.100.33
The Bible
4 rooms
Temporary flight Grants flight for the current room. Instantly kills Boss Mom ingame.pngMom, Boss Mom's Heart ingame.pngMom's Heart, and Boss It Lives ingame.pngIt Lives when activated, but kills Isaac when used on Boss Satan ingame.pngSatan.
1
The Bible 5.100.33
The Bible
4 rooms
Temporary flight Grants flight for the current room. Instantly kills Boss Mom ingame.pngMom, Boss Mom's Heart ingame.pngMom's Heart, and Boss It Lives ingame.pngIt Lives when activated, but kills Isaac when used on Boss Satan ingame.pngSatan.
1

Passive Collectibles

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
Dead Dove 5.100.185 Dead Dove Flight + spectral tears Grants spectral tears and flight.
3
Holy Grail 5.100.184 Holy Grail Flight + HP up Grants flight and one Red Heart container. (in Repentance and Repentance+) Heals 1 additional Red Heart.pngRed Heart.
3
Holy Mantle 5.100.313 Holy Mantle Holy shield Grants a shield that negates the first instance of damage taken from a hostile source once per room.
4
Mitre 5.100.173 Mitre Blessing of purity Grants a chance of converting any Red Heart.pngRed Heart pickups that spawn into Soul Heart.pngSoul Hearts instead.
3
Rosary 5.100.72 Rosary Tears + faith up Grants 3 Soul Heart.pngSoul Hearts. Causes Collectible The Bible icon.pngThe Bible to appear in any item pool. (in Repentance and Repentance+) +0.5 tears.
2
The Halo 5.100.101 The Halo All stats up (except in Repentance and Repentance+) Grants one full Red Heart container, +0.3 damage, +0.2 tears, +0.25 range, +0.3 speed, and +0.5 tear falling speed.
(in Repentance and Repentance+) Grants one full Red Heart container, +0.3 damage, +0.2 tears, +1.5 range, and +0.3 speed. Heals 1 additional Red Heart.pngRed Heart.
(in Repentance)2
(in Repentance+)3
(except in Repentance and Repentance+) Guardian Angel 5.100.112 Guardian Angel Extra protection Spawns an orbital familiar that blocks enemy shots, deals 7 damage per tick on contact, and increases the speed of all orbital familiars.
(except in Repentance and Repentance+) Sworn Protector 5.100.363 Sworn Protector Protective friend Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room, it drops an Eternal Heart.pngEternal Heart.
(in Repentance and Repentance+) Celtic Cross 5.100.162 Celtic Cross Blessing of protection Grants a chance to trigger the Collectible Book of Shadows icon.pngBook of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
1
(in Repentance and Repentance+) Divine Intervention 5.100.568 Divine Intervention Double tap shield Double tapping a fire key creates a shield that pushes away enemies and reflects enemy projectiles and lasers.
(except in Repentance+)2
(in Repentance+)1
(in Repentance and Repentance+) Godhead 5.100.331 Godhead God tears (except in Repentance and Repentance+) Grants homing tears with a damaging halo. +0.5 Damage, -0.3 Tears -0.3 Shot Speed, +0.8 Tear Falling Speed, and +1.2 Range.
(in Repentance and Repentance+) Grants homing tears with a damaging halo. +0.5 Damage, -0.3 Tears, and -0.3 Shot Speed.
4
(in Repentance and Repentance+) Holy Light 5.100.374 Holy Light Holy death shot Adds a chance to fire holy tears, which will create a damaging light beam in the area if they hit an enemy.
3
(in Repentance and Repentance+) Immaculate Heart 5.100.573 Immaculate Heart Halo of tears Adds one Red Heart Container and fully restores health. x1.2 damage multiplier. Isaac will occasionally fire extra tears that orbit around him.
3
(in Repentance and Repentance+) Revelation 5.100.643 Revelation Awaken your faith Grants flight and two Soul Heart.pngSoul Hearts. In addition to tears, Isaac can charge up and fire a powerful holy laser.
4
(in Repentance and Repentance+) Sacred Heart 5.100.182 Sacred Heart Homing shots + DMG up (except in Repentance and Repentance+) Adds a Red Heart Container. Grants homing tears, a x2.3 Damage multiplier, +1 flat Damage, -0.4 Tears, -0.25 Shot Speed, and +4.125 Range.
(in Repentance and Repentance+) Adds a Red Heart Container. Grants homing tears, a x2.3 Damage multiplier, +1 flat Damage, -0.4 Tears, and -0.25 Shot Speed.
4
(in Repentance and Repentance+) Sacred Orb 5.100.691 Sacred Orb Destined for greatness Prevents items of quality 0-1 from appearing, and items of quality 2 from appearing 33% of the time. Quest items are unaffected.
4
(in Repentance and Repentance+) Salvation 5.100.696 Salvation Divine protection Gives Isaac a halo that summons beams of light on enemies inside it. The halo grows larger the more times Isaac has taken damage this floor.
3
(in Repentance and Repentance+) Scapular 5.100.142 Scapular Pray for a miracle Once per room, when Isaac is reduced to his last half heart, he is granted one Soul Heart.pngSoul Heart.
2

Notes

  • Despite having the same name, the familiar Collectible Seraphim icon.pngSeraphim does not contribute to the Seraphim transformation.
  • Picking up and dropping multiple, distinct copies of Collectible The Bible icon.pngThe Bible will count each copy towards the transformation. This makes Collectible Rosary icon.pngRosary and to a lesser degree, Rosary BeadRosary Bead especially helpful in gaining the transformation.