This item belongs to the Seraphim set. Collecting three items from this set will transform Isaac into an angel.
Notes
Due to being quality 0, Skatole cannot be obtained from Shell Games after Sacred Orb has been picked up.
Interactions
Bag of Crafting: Sacred Orb prevents crafting quality 1 and 0 items, typically resulting in them being replaced by quality 2 items. If a recipe that can only result in a quality 0-1 item is put in the bag, it will replace the item with Breakfast instead.
The design of the Sacred Orb seems to be based upon a globus cruciger, lit. "cross-bearing orb", a Christian symbol of authority.
This item is a stronger version of Tainted Lost's "better items" mechanic. Its unlock method is unusual, as most other tainted characters have items based on their unique mechanics unlocked by defeating Delirium instead of The Beast.