Item Tags quest
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Items with this tag cannot be rerolled in most circumstances, and bypass character-specific limitations. Most items in this list are progression-related.
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Tainted Isaac: Items do not have a second option, and do not contribute to the 8-item limit. -
Tainted Cain: Items will not be decomposed into pickups, and can be picked up as normal. -
Tainted Eden: Items will not be rerolled upon hit.
Activated Collectibles
| Name | ID | Icon | Quote | Description | Quality |
|---|---|---|---|---|---|
| Broken Shovel | 5.100.550 |  
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It feels cursed | While held, causes Mom to continuously attempt to stomp on Isaac. Activating makes her stop for the current room or wave. One of two parts necessary to create  Mom's Shovel.
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| Mom's Shovel | 5.100.552 | 
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Lost but not forgotten | Creates a trapdoor that leads to the next floor. Unlocks  The Forgotten when used on a mound of dirt that appears in  Dark Room.
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Passive Collectibles
| Name | ID | Icon | Quote | Description | Quality |
|---|---|---|---|---|---|
| Broken Shovel | 5.100.551 | 
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It feels cursed | One of two parts necessary to create Mom's Shovel. No effect if somehow obtained on its own.
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| Dad's Note | 5.100.668 | 
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... | Sends Isaac on an Ascent toward  Home.
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| Dogma | 5.100.633 | 
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Ascended | Grants flight, +2 damage, and increases speed to 1.1. Grants enough health to have 6 full hearts, if possible. Grants the  Holy Mantle effect for the room it was obtained in. Automatically given to Isaac after defeating Dogma.
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| Key Piece 1 | 5.100.238 | 
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??? | Combined with  Key Piece 2, unlocks the golden gate in the starting room of  Chest and Dark Room to fight  Mega Satan.
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| Key Piece 2 | 5.100.239 | 
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??? | Combined with  Key Piece 1, unlocks the golden gate in the starting room of Chest and Dark Room to fight Mega Satan.
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| Knife Piece 1 | 5.100.626 | 
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??? | Combined with  Knife Piece 2, creates a knife familiar that damages enemies and can open the door to the  Corpse.
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| Knife Piece 2 | 5.100.627 | 
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??? | Combined with  Knife Piece 1, creates a knife familiar that damages enemies and can open the door to the Corpse.
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| The Negative | 5.100.328 | 
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Fate chosen | If Isaac has half a red heart or no red hearts after taking damage, all enemies in the room take significant damage. Allows entrance into the Dark Room. +1 Damage and also allows access to Home.
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| The Polaroid | 5.100.327 | 
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Fate chosen | If Isaac has half a red heart or no red hearts after taking damage, he gains a shield that nullifies all types of damage for 5 seconds. Allows entrance into Chest. Also allows access to Home.
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 The Binding of Isaac: Rebirth
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