This trinket allows Isaac to leave rooms, including boss rooms, if the fight goes poorly.
This becomes particularly useful in The Void, as it allows to escape the Delirium fight if encountered.
Leaving immediately after enemies have spawned gives the player information on the fight, potentially improving decision making.
If a Devil Room has a Krampus fight in it, Isaac may choose not to fight him and leave.
If Greed / Super Greed is found in a Shop, one can kill it and leave the room while summoned monsters are still alive to respawn the boss and farm its loot infinitely.
Does not affect Mom's and Mega Satan's boss room as the access door itself disappears.
If a room contained champion enemies, upon leaving and re-entering the room, all previous champion enemies will have turned to regular enemies.
Synergies
4.5 Volt / Jumper Cables: Provides infinite charges by clearing some enemies then leaving the room, and repeating.
Head of the Keeper: With enough patience, Coins can be gathered infinitely.
Holy Mantle: Can be used to reset the shield at will.
Tainted Keeper: Leaving and re-entering the room allows for limited coin farming; however, enemies in rooms Tainted Keeper has already visited will eventually stop dropping coins.
Challenge Room or awaking an Angel in an 
Angel Room.
Cannot spawn in Greed Mode.
Devil Room has a 
Krampus fight in it, Isaac may choose not to fight him and leave.
Greed / 
Super Greed is found in a 
Shop, one can kill it and leave the room while summoned monsters are still alive to respawn the boss and farm its loot infinitely.
Mom's and 
Mega Satan's boss room as the access door itself disappears.
If a room contained champion enemies, upon leaving and re-entering the room, all previous champion enemies will have turned to regular enemies.
4.5 Volt / 
Jumper Cables: Provides infinite charges by clearing some enemies then leaving the room, and repeating.
Charm of the Vampire / 
Gimpy: Allows the possibility to generate unlimited Hearts.
Head of the Keeper: With enough patience, Coins can be gathered infinitely.
Holy Mantle: Can be used to reset the shield at will.
Tainted Keeper: Leaving and re-entering the room allows for limited coin farming; however, enemies in rooms Tainted Keeper has already visited will eventually stop dropping coins.
The Binding of Isaac: Rebirth
