Item Tags uniquefamiliar

Items with this tag are familiars which are unique and cannot be duplicated by Box of Friends or The Twins, and Soul of Lilith can grant them only once. Note that this does not prevent getting multiple copies of the items through duplication effects such as Diplopia.

Activated Collectibles

Name	ID	Icon	Quote	Description	Quality
Stitches	5.100.635		Bait and switch	Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar.	1

Passive Collectibles

Name	ID	Quote	Description	Quality
Blood Oath	5.100.569	Bleed me dry	Stabs Isaac at the beginning of each floor, draining his Red Hearts. Increases damage and speed for the floor based on the amount drained.	1
Dead Cat	5.100.81	9 lives	Sets Isaac's Red Heart Containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container.	3
Isaac's Heart	5.100.276	Protect it	Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released.	0
Key Piece 1	5.100.238	???	Combined with Key Piece 2, unlocks the golden gate in the starting room of Chest and Dark Room to fight Mega Satan.	0
Key Piece 2	5.100.239	???	Combined with Key Piece 1, unlocks the golden gate in the starting room of Chest and Dark Room to fight Mega Satan.	0
Knife Piece 1	5.100.626	???	Combined with Knife Piece 2, creates a knife familiar that damages enemies and can open the door to the Corpse.	0
Knife Piece 2	5.100.627	???	Combined with Knife Piece 1, creates a knife familiar that damages enemies and can open the door to the Corpse.	0
Paschal Candle	5.100.567	Keep the flame burning	Gives Isaac a familiar that grants +0.4 Fire Rate for each consecutive room he's cleared without taking damage. The bonus stacks up to five times.	3
Vanishing Twin	5.100.697	He wants revenge	Spawns a familiar that becomes a weaker clone of the floor's boss when entering the Boss Room. Defeating it drops an extra item.	2 1
Milk!	5.100.436	Don't cry over it...	Spawns a glass familiar that follows Isaac. After Isaac takes damage, the milk spills, and he gains -2 tear delay ( +1.0 fire rate) until leaving the room Spawns a glass familiar that follows Isaac. The milk will block projectiles, and upon blocking 10, the milk spills, giving Isaac +1.0 fire rate for the rest of the floor.	1
1up!	5.100.11	Extra life	Gives Isaac an extra life. Upon death, he will respawn in the previous room with full health, after which 1up! will disappear.	2
Lost Soul	5.100.612	Protect him	Creates a ghostly familiar that closely follows behind Isaac. It dies in one hit, but respawns at the start of the next floor. Each time it survives until the next floor, it rewards Isaac with Soul Hearts, Eternal Hearts, or an Item.	1
Star of Bethlehem	5.100.651	Follow the light	Spawns a star familiar that slowly travels towards the Boss Room, giving an aura that increases damage and tears and grants homing tears.	3
Strawman	5.100.667	A helping hand	Spawns a controllable Keeper to fight enemies alongside Isaac, functioning similarly to Jacob and Esau. If Keeper dies, he spawns 5 blue spiders and Strawman is removed from Isaac's inventory.	1