Wisps

Wisps are orbital familiars that are created by the Book of Virtues. This article lays out the effects and stats of the wisps Isaac can create, mostly covering Book of Virtues synergies.

Unique Wisps

Descriptions for the following wisp stats:

Item: The item that spawns the following wisp. Everything Jar, Esau Jr., Mom's Box, Pandora's Box, R Key, and Death Certificate only spawn normal wisps, and have no unique effects.
Orbit: The ring around Isaac the wisp occupies. The Inner ring can hold 6 wisps, the Center ring can hold 8 wisps, and the Outer ring can hold 12 wisps. Wisps that don't orbit Isaac will count as “other” and have their unique behavior in the notes.
HP: The amount of hits the wisp can take before being destroyed. Contact damage and explosions count as two hits taken. Wisps are immune to damage if Isaac is Shielded/Invulnerable or under the effects of Gnawed Leaf. Invulnerability frames from taking damage do not count.
Tear Damage: The damage the wisp's tears do. All wisps deal an additional +0.1 tear damage for every floor deeper into the game Isaac is. Note that the contact damage the wisps deal is 2x Isaac's damage per tick (4x Isaac's damage per second) and is unaffected by the wisp type, with a few exceptions.
- BFFS! will double the base damage, contact damage, and damage scaling per floor of the wisps, and Forgotten Lullaby will double their fire rate.
Tear Delay: The number of frames the wisp has to wait between firing tears. 30 frames equals one second.
Tear Effects: Any special tear effects/modifiers the wisp's tears have, such as Homing or Poison, and the chance of that effect occurring if it is a chance.
Notes: Any other effects the wisp has that are worth noting.

Item	Orbit	HP	Damage	Tear Delay	Tear Effects	Notes
None	Center ring	2	3	30	None	These are the default wisps spawned by Book of Virtues and other things that spawn wisps, such as Jar of Wisps, Beth's Essence, Beth's Faith, and Soul of Bethany.
The Bible	Inner ring	3	6	30	Homing	Wisps' tears have 0.75 shot speed. The wisps' tears effectively act as though they have Sacred Heart.
The Book of Belial	Center ring	3	6	30	None	N/A
The Necronomicon	Inner ring	3	3.5	30	None	The wisps deal 40 damage to all enemies in the room when destroyed. This is not boosted by BFFS!, but is boosted by Missing Page 2.
The Poop	Outer ring	1	1.5	30	E. Coli (2.5%)	Also has a chance to spawn if Isaac destroys poop while holding Notched Axe.
Mr. Boom	Center ring	1	1.5	30	None	The wisps spawn miniature homing bombs when destroyed. These miniature bombs behave the same as ones created by Scatter Bombs, with the exception that they deal 100 blast damage instead of 50.
Tammy's Head	Outer ring	1	1.5	15	None	The wisps' tears are inaccurate, and fire in a spread.
Mom's Bra	Center ring	2	3	30	Petrification (5%)	N/A
Kamikaze!	Center ring	3	7	30	Explosive	The wisps explode when destroyed, dealing 30 damage to enemies that are close to it. This explosion is small enough to not hit Isaac. All explosions the wisps make are unaffected by BFFS! and bomb synergies.
Mom's Pad	Center ring	2	3	30	Fear (7.5%)	N/A
Bob's Rotten Head	Center ring	2	3	30	Poison + Explosive (7.5%)	The wisps' tears have decreased range and travel in an arc.
Teleport!	Center ring	3	4	30	Teleport (10%)	The teleport effect teleports non-boss enemies hit by the tear to a random location in the current room; it does not affect Isaac. The wisps also temporarily vanish every 5 seconds, preventing them from blocking shots or taking/dealing damage.
Yum Heart	Center ring	2	3	30	None	Enemies killed by the wisps' tears have a 20% chance to drop a full red heart.
Doctor's Remote	Center ring	1	1.5	30	None	When Doctor's Remote is used, the wisps fire two inaccurate, explosive tears at the crosshair in an arc that deal 14 damage (28 if Isaac has BFFS!).
Shoop da Whoop!	Outer ring	2.5	1.5	30	None	The wisps also fire lasers when Isaac uses Shoop da Whoop!. The lasers deal 7 damage per tick (BUG: 3.5 if Isaac has BFFS!), and can hit up to 10 times for a total of 70 damage. Multiple lasers can hit the same enemy.
Lemon Mishap	Center ring	1	1.5	10	None	The wisps' tears have decreased range. The wisps themselves occasionally leave small puddles of yellow creep that last for 3 seconds and deal 7 damage per tick to enemies that walk over them (56 damage per second).
Book of Shadows	Center ring	1	1.5	30	None	The wisps are immune to damage from blocking projectiles.
Anarchist Cookbook	Center ring	1	3	30	None	The wisps spawn troll bombs when destroyed. These troll bombs will use Isaac's bomb synergies.
The Hourglass	Center ring	1	1.5	30	None	The wisps slow all enemies in the room for 3 seconds when destroyed. If the Hourglass is used or extra wisps are destroyed while the slow is in effect, it's duration is extended.
My Little Unicorn	Center ring	3	4	30	None	The wisps orbit Isaac more quickly than normal wisps and change colors constantly, with both of these effects being boosted while My Little Unicorn is active. The wisps also deal an extra 8 contact damage.
Book of Revelations	Inner ring	5	No tears	No tears	None	The wisps give 7 Seals' harbinger familiars for the current room when destroyed.
The Nail	Inner ring	3	6	30	Blister	N/A
We Need To Go Deeper!	Center ring	5	3	30	None	N/A
Deck of Cards	Inner ring	3	3	30	None	The wisps spawn cards when destroyed.
Monstro's Tooth	Center ring	2	12	45	None	The wisps' tears look like teeth, similar to those created from Tough Love.
The Gamekid	Inner ring	4	3	25	Fear (chance unknown) + Anti-Gravity	The wisps look like little Pac-Men while shooting.
Mom's Bottle of Pills	Inner ring	4	3	30	Poison/Petrification/Confusion/Burn/Spawn a Troll Bomb (chances unknown)	The wisps spawn pills when destroyed. Each tear effect is assigned to one color of pill wisp based on the current seed. The only color pill wisp without a tear effect also spawns a hostile Spider when destroyed. For the troll bomb effect, the pill itself spawns the troll bomb instead of the tear, and the chance for it to do so is independent of whether or not its tears hit anything.
The D6	Center ring	4	3	30	None	An extra wisp is spawned per item rerolled.
The Pinking Shears	Inner ring	4	3.5	30	Piercing	N/A
The Bean	Outer ring	1	1.5	30	None	The wisps deal 5 damage to and poison nearby enemies when destroyed.
Monster Manual	Inner ring	3	2-4	15-30	Random	The wisps given function similarly to familiars given by Buddy in a Box.
Razor Blade	Center ring	8	3	30	None	N/A
Forget Me Now	Center ring	Infinite	10	30	None	The wisp only lasts for the floor Forget Me Now created.
A Pony	Center ring	2	Other	Other	None	The wisps charge in the direction Isaac shoots instead of firing tears. While charging, the wisps deal contact damage equal to 40% of Isaac's damage per tick (120% of Isaac's damage per second) and are immune to damage. Wisps must wait 2.5 seconds after hitting a wall before they can charge again. The wisps deal their normal contact damage while not charging.
Guppy's Paw	Center ring	20	3.5	30	None	Spawns 3 wisps for every heart container consumed in addition to granting soul hearts.
IV Bag	Outer ring	1	3	30	None	N/A
Best Friend	Center ring	2	3.5	30	Mark (7.5%)	N/A
Remote Detonator	Inner ring	0.5	2.5	30	None	The wisps are summoned when bombs placed by Isaac explode. Using Remote Detonator also causes the wisps' tears to explode, dealing 16.5 damage to enemies that are close to them (24 if Isaac has BFFS!).
Guppy's Head	Outer ring	1	1.5	30	None	Using Guppy's Head summons 2-4 wisps instead of Blue Flies; the wisps summon the Blue Flies when destroyed. One wisp contains one Blue Fly.
Prayer Card	Inner ring	3	6	30	Homing	Wisps' tears have 0.75 shot speed. The wisps' tears effectively act as though they have Sacred Heart.
Notched Axe (Coal)	Center ring	2	2.5	30	A Lump of Coal	Has a chance to spawn when Isaac destroys an obstacle with Notched Axe.
Notched Axe (Iron)	Center ring	3	4	30	Confusion (10%)	Has an uncommon chance to spawn when Isaac destroys an obstacle with Notched Axe.
Notched Axe (Gold)	Center ring	2	3.5	30	Head of the Keeper (10%)	Has a rare chance to spawn when Isaac destroys an obstacle with Notched Axe.
Notched Axe (Diamond)	Center ring	8	7	30	None	Has a very rare chance to spawn when Isaac destroys an obstacle with Notched Axe.
Notched Axe (Redstone)	Center ring	3	3.5	30	Technology	Has a rare chance to spawn when Isaac destroys an obstacle with Notched Axe.
Crystal Ball	Center ring	5	3.5	30	None	Wisps' tears have 1.2 shot speed. The wisps will automatically aim directly at nearby enemies.
Crack the Sky	Center ring	4	3	30	None	The wisps summon a beam of light when touched, dealing 12 damage to nearby enemies in addition to their normal contact damage.
The Candle	Other	1	2.5	30	None	The wisps do not persist between rooms.
D20	Center ring	4	4	30	None	In addition to summoning it's specific wisp, instead of rerolling pickups, it will destroy all pickups in the room and has a chance to give a random wisp for each pickup destroyed.
Spider Butt	Center ring	1	3	30	Slow (7.5%)	N/A
Dad's Key	Center ring	1.5	3	30	None	If the wisps touch locked Chests or special room doors, they will unlock them, destroying themselves in the process. These wisps can open ANY locked door they touch, including the ones to Mega Satan, the Ascent, and Corpse. Stone/Mega Chests are unaffected.
Portable Slot	Outer ring	2	1.5	30	None	This wisp is only given if Portable Slot spawns a coin; other effects are noted in the “other interactions” section below.
White Pony	Center ring	2	3	30	Holy Light (10%)	The beams of light the wisps' tears make deal extra damage to enemies in a small area equal to 3x the wisps' tear damage.
Blood Rights	Center ring	8	3	30	None	N/A
Telepathy For Dummies	Center ring	2	3	30	Homing	N/A
Clear Rune	Center ring	2	3	30	N/A	The wisps spawn Runes/Soul Stones when destroyed, and enemies killed by the wisps' tears have a 15% chance to drop a Rune/Soul Stone. The effect of the wisps and the types of runes they spawn are independent from Clear Rune's charge time and the most recently used rune.
How to Jump	Other	1	3	15	None	The wisps are stationary, and remain where Isaac was when he jumped. Up to 6 of these wisps can exist at a time. The wisps do not persist between rooms.
D10	Center ring	2	3	30	D10 (10%)	N/A
Blank Card	Center ring	2	3	30	None	The wisps spawn Cards when destroyed, and enemies killed by the wisps' tears have a 15% chance to drop a Card. The effect of the wisps and the types of cards they spawn are independent from Blank Card's charge time and the most recently used card.
Book of Secrets	Center ring	2	3	30	None	The wisps invoke the effect of Cracked Orb when destroyed.
Box of Spiders	Outer ring	1	2	30	None	Using Box of Spiders summons 5-6 wisps instead of Blue Spiders; the wisps summon the Blue Spiders when destroyed. One wisp contains one Blue Spider.
Red Candle	Center ring	1	5	75	None	The wisps shoot small flames instead of tears; flames last for 5 seconds or until they block 2 shots and/or deal 2 ticks of damage. The wisps do not persist between rooms, and the damage they deal does not increase with BFFS! or scale up on later floors.
The Jar	Center ring	1.5	2	30	None	When The Jar is used, any red hearts that would drop are instead turned into wisps. The health and damage of the wisps is unaffected by whether or not the hearts would be half hearts or full hearts. The wisps have a chance to drop half red hearts when destroyed.
Flush!	Center ring	2	1.5	30	None	An additional wisp is spawned for each enemy turned into poop.
Satanic Bible	Center ring	2	3	30	None	Each wisp gives Isaac +10% Devil Room chance.
Head of Krampus	Center ring	2	3	30	None	The wisps fire small Brimstone lasers in the cardinal directions when destroyed. The lasers deal the wisps' tear damage per tick, and can hit up to 20 times. BFFS! will not increase this damage, despite it scaling with the wisps' tear damage.
Butter Bean	Center ring	1	No tears	No tears	None	The wisps invoke the effect of Butter Bean when destroyed and do not persist between rooms.
Magic Fingers	Inner ring	1	1	30	None	The wisps have a chance to drop coins when destroyed.
Converter	Center ring	4	3	30	None	Wisps are only spawned when hearts are converted.
Unicorn Stump	Center ring	3	No tears	No tears	None	The wisps orbit Isaac more quickly and change colors constantly, and become much more vibrant while Isaac is invulnerable. The wisps do not take contact damage, but also don't deal contact damage if Unicorn Stump isn't active. If Unicorn Stump is active, the wisps deal contact damage equal to 2x Isaac's damage -5. If Isaac has less than 2.5 damage, the wisps will deal no damage even if Unicorn Stump is active.
Isaac's Tears	Center ring	0.5	1	30	None	Summons six wisps at a time. Using Isaac's Tears destroys the previous set of wisps. The wisps are automatically destroyed after three seconds.
Undefined	Center ring	2	3	30	Playdough Cookie	N/A
Scissors	Center ring	2	3	30	None	The wisps fire 2-3 tears at a time, which are inaccurate, travel in an arc, and have variable range.
The Boomerang	Center ring	1	3	30	My Reflection	The wisps do not persist between rooms.
Diplopia	Center ring	12	3	30	None	The wisp fires two tears at a time (similar to 20/20). Using Diplopia also duplicates all of Isaac's other wisps.
Placebo	Center ring	2	3	30	None	The wisps spawn Pills when destroyed. The effects of the wisps and types of pills they spawn is independent from Placebo's charge time and the most recently used pill. Unlike Blank Card and Clear Rune, enemies killed by these wisps' tears do not have a chance to drop pills.
Wooden Nickel	Center ring	2	2	30	None	The wisps have a 50% chance to drop coins when destroyed, much like Wooden Nickel itself.
Mega Bean	Center ring	2	3	30	None	The wisps send rock waves outward when Mega Bean is used. They also petrify and poison all enemies in a large radius when destroyed.
Glass Cannon	Center ring	0.5	8	30	None	If one of the wisps is destroyed, all the others are also destroyed. Does not affect wisps other than ones made by this item. Despite Glass Cannon having a timed charge, the wisps persist between rooms.
Box of Friends	Center ring	2	3	30	None	After creating a wisp, Box of Friends also gives temporary copies of all of Isaac's wisps, including any extra copies Box of Friends made.
Friendly Ball (Normal)	Center ring	2	3	30	None	Enemies captured by Friendly Ball spawn this wisp when they die if they wouldn't spawn any of the other variants listed below.
Friendly Ball (Homing)	Center ring	2	3	30	Homing	Enemies captured by Friendly Ball spawn this wisp when they die if they were psychic or had homing shots in some way.
Friendly Ball (Explosive)	Center ring	2	3	60	Explosive (33%)	Enemies captured by Friendly Ball spawn this wisp when they die if they created explosions in some way. Explosive tears deal no extra damage.
Friendly Ball (Brimstone)	Center ring	2	2.5	60	Brimstone	Enemies captured by Friendly Ball spawn this wisp when they die if they fired lasers in some way. The laser does not need to be charged to be fired, and can tick up to 8 times for a total of 20 damage.
Tear Detonator	Center ring	2	2	30	None	The wisps' tears burst into 6 of Isaac's tears when Tear Detonator is used. They also burst into 6 tears and invoke the effect of Tear Detonator when destroyed. Despite Tear Detonator having a timed recharge, the wisps persist between rooms.
D12	Center ring	2	2	30	D12 (obstacles only, 5%)	Poops and TNT cannot be rerolled by the wisps' tears.
Ventricle Razor	Other	2	No tears	No tears	None	One wisp orbits each portal; no wisps are given to Isaac.
D8	Center ring	2	3-4	25-35	None	Each wisp has a random damage and fire rate assigned to it. Wisp health is not randomised.
Teleport 2.0	Center ring	4	6	30	Teleport (20%)	The teleport effect teleports non-boss enemies hit by the tear to a random location in the current room; it does not affect Isaac. The wisps also temporarily vanish every 5 seconds, preventing them from blocking shots or taking/dealing damage.
Kidney Bean	Center ring	2	3	30	None	The wisps charm nearby enemies when destroyed.
Glowing Hourglass	Center ring	1	1.5	30	Petrification (30%)	N/A
Mine Crafter	Other	Other	No tears	No tears	None	The wisp cannot take or deal damage in any way, and bounces around the room in a random direction instead of following Isaac. If the wisp is shot by Isaac or his familiars, it explodes, dealing 100 damage to nearby enemies. The wisp does not persist between rooms. Explosions and enemy shots do not detonate it, and the wisps' explosions are unaffected by BFFS! and bomb synergies.
Jar of Flies	Center ring	2 * Blue Flies in the wisp	1 + 0.5 per Blue Fly in the wisp	30	None	Using Jar of Flies summons wisps instead of Blue Flies; the wisps do not summon the flies when destroyed. Up to five flies at a time are consumed to summon one wisp, with stacking health and damage. The damage of the wisps decreases as they take damage. Enemies killed by wisps’ tears will not add flies to the jar.
D7	Center ring	2	3	30	None	The wisps start gray; if the wisps get hit while they’re gray, they invoke the effect of the D7 in the current room and turn blue. Damage that turns the wisps from gray to blue is negated.
Mega Blast	Center ring	2 6	2.5	30	Lil Brimstone	Lasers can hit up to 8 times for a total of 20 damage. If Mega Blast is being used, the wisps will continuously fire their laser outward rather than in the direction Mega Blast is firing.
Plan C	Center ring	2	12	30	None	Spawns eight wisps on use. As Plan C will still kill Isaac after using it, he must have a respawn in order to use the wisps.
D1	Center ring	2	3	30	None	An extra wisp spawns if no pickups are duplicated.
Pause	Center ring	2	3	30	None	Wisps pause all enemies and enemy shots for 3 seconds when destroyed. This effect is not cancelled by shooting tears.
Smelter	Center ring	2	3	30	None	The wisps have a chance to spawn trinkets when destroyed.
Compost	Center ring	See notes	3	30	None	The wisp will only be summoned if Compost destroys at least one pickup, and the wisp's health will be equal to the number of pickups converted to Blue Flies/Spiders. If Isaac hits the blue fly cap of 64 as a result of using Compost, all but one of Isaac's wisps will despawn.
Dataminer	Center ring	2	3	30	Transform non-boss enemies into random wisps (5%)	The wisps are indistinguishable from normal ones outside of their unique tear effect.
Mama Mega!	Center ring	2	3	30	None	Summons 8 wisps on use. The wisps summon Golden Troll Bombs when destroyed.
Wait What?	Center ring	0.5	No tears	No tears	None	The wisps invoke the effect of Wait What? when destroyed and do not persist between rooms.
Crooked Penny	Center ring	See Notes	2	30	None	The wisps have a 50/50 chance to duplicate all their copies or destroy all their copies when one takes damage. Does not affect wisps other than ones made by this item. Using Crooked Penny always spawns one wisp, with no chance to affect the others.
Dull Razor	Center ring	2	No tears	No tears	None	Whenever Isaac takes damage, there is a chance that the damage is negated and one of the wisps is destroyed instead. "Damage" taken from using Dull Razor does not count for this effect.
Potato Peeler	Other	Infinite	3	30	None	The wisps do not orbit Isaac, block shots, or deal contact damage. Instead, they chase and constantly shoot at nearby enemies.
Brown Nugget	Center ring	2	1	10	None	The wisps automatically shoot at nearby enemies instead of in the direction Isaac shoots. The wisps do not persist between rooms.
Sharp Straw	Outer ring	0.5	3	30	None	Enemies have a chance to spawn wisps when they’re killed by Sharp Straw. Despite Sharp Straw having a timed charge, the wisps persist between rooms.
Delirious (Monstro)	Center ring	2 6	0.5 3	60	None	Fires an inaccurate spray of 6-10 tears at a time, similarly to Monstro's Lung but without the charge time. Can be one of the unique wisps created from using Delirious.
Delirious (Duke of Flies)	Center ring	2 6	Other	60	Rotten Baby	Each wisp can have up to 3 Blue Flies out at a time. Can be one of the unique wisps created from using Delirious.
Delirious (Loki)	Center ring	2 6	3	60 25	Loki's Horns	The direction the tears are fired alternates between the cardinal and ordinal directions. Can be one of the unique wisps created from using Delirious.
Delirious (Haunt)	Center ring	2 6	1	60	Brimstone	The laser does not need to be charged to be fired, and can tick up to 8 times for a total of 8 damage. Can be one of the unique wisps created from using Delirious.
Black Hole	Center ring	2	3	30	Strange Attractor	N/A
Sprinkler	Center ring	2	2	10	None	The wisps fire tears in a spiral pattern, similarly to Sprinkler itself.
Coupon	Center ring	2	3	30	None	The wisps fire three tears at a time, similarly to The Inner Eye. However, all of these wisps are destroyed if Isaac buys something using money. Does not affect wisps other than ones made by this item.
Telekinesis	Outer ring	2	2	30	None	Tears caught by Telekinesis become wisps. The wisps are outside the range of Telekinesis, making them vulnerable to shots before they can be converted to Wisps.
Moving Box	Center ring	2	3	30	None	Moving Box must drop a pickup/item in order for it to spawn wisps. The wisps invoke the effect of The Book of Sin when destroyed.
Mr. ME!	Center ring	2	No tears	No tears	None	If the current room is cleared, the wisps automatically move toward and unlock chests and special room doors, destroying themselves in the process. The wisps can open ANY locked doors, including the ones to Mega Satan, the Ascent, and Corpse. Stone/Mega Chests are unaffected.
Sacrificial Altar	Center ring	12	6	30	None	All other wisps are turned into half red hearts in the process. Lemegeton's wisps instead become half soul hearts.
Book of the Dead	Inner ring	3	4	30	None	The wisps spawn friendly Bonys when destroyed. The book will summon wisps regardless of whether or not there were enemies killed in the current room, and the ring of wisps is close enough to Isaac to be inside the ring of bone orbitals Book of the Dead makes.
Broken Shovel (Soul)	Center ring	2	3	30	II - The High Priestess (10%)	This wisp is also spawned when Mom's Shovel is used, alongside it's unique wisp.
Mom's Shovel (Forgotten)	Center ring	10	No tears	No tears	None	A Forgotten and Soul wisp are spawned each use.
Golden Razor	Center ring	2	3	30	Midas' Touch (15%)	N/A
Sulfur	Center ring	2	2.5	90	Brimstone	The lasers fired are small and reach only one tile out, but do not need to be charged. Each laser can hit an enemy up to 8 times for a total of 20 damage. Range, using Sulfur, having Brimstone, and playing as Azazel/ Tainted Azazel does not affect the wisp.
Fortune Cookie	Center ring	1	2	30	None	Each wisp gives Isaac +0.2 luck. If wisps are lost, luck is only updated after Isaac's luck changes through any means. This mechanic also causes the first wisp given to not increase luck.
Damocles	Center ring	2	3	30	None	The wisp's tears look like Spirit Sword's beams, but there are no other effects. Likely not fully implemented.
Free Lemonade	Center ring	2	3	30	None	The wisps make small puddles of yellow creep every other shot, which last for 3 seconds and deal 7 damage per tick to enemies that walk over them (56 damage per second).
Red Key	Center ring	1.5	3	30	None	The wisps have a chance to unlock red rooms when Isaac enters an unexplored room.
Wavy Cap	Center ring	2	1.5	30	None	Only one of this wisp can exist at a time.
Mom's Bracelet	Other	2	3	30	Confusion (10%)	Three wisps are created where thrown obstacles land; these wisps rotate around where the obstacle was thrown and fire tears in the same direction Isaac does. The wisps do not persist between rooms. Isaac cannot have more than 8 of these wisps at one time, and wisps in Isaac's Center ring count against this limit.
The Scooper	Center ring	2	3	30	None	Despite the fact that the wisps look like they’re spinning, the angle they fire shots doesn’t rotate.
Eternal D6	Center ring	Infinite	3	30	None	Every use has a 50% chance to destroy all the wisps instead of spawn another. Does not affect wisps other than ones made by this item. Rerolling items does not affect this chance.
Larynx	Center ring	1 * Charges Used	1.5 * Charges Used	30	None	The wisps deals contact damage equal to 30% of Isaac's damage * Charges Used. Charges Used equals the number of charges Larynx had at the time it was used.
Lemegeton	Inner Ring, moves to other rings as they’re filled	4	No tears	No tears	None	The wisps take the appearance of an Item from the Item Pool of the room Lemegeton was used in. While Isaac has the wisp, he gains the effect of its associated item. Lemegeton's interaction with Book of Virtues is noted in the "Other Interactions" section below.
Sharp Key	Center ring	2	3	30	None	Despite the wisps' appearance, they cannot unlock anything. Due to a bug, Sharp Key can spawn wisps even if Isaac has no keys.
Meat Cleaver	Center ring	4	3	30	None	Before spawning wisps, Meat Cleaver divides all of Isaac's wisps into two wisps that have half health and deal half tear damage. Wisps will be destroyed if they try to divide a third time.
Stitches	Other	2	1.5	30	None	When Isaac teleports, he leaves behind a stationary wisp that fires tears in the same direction Isaac does. Up to 6 of these wisps can exist at a time. The wisps do not persist between rooms.
Eraser	Center ring	Infinite	3	30	None	If a non-boss enemy touches the wisp, it is erased and the wisp is destroyed. The wisp cannot erase bosses, regardless of how much health they have left.
Yuck Heart	Center ring	2	No tears	No tears	None	Every wisp spawns an additional Blue Fly when a room is cleared. The wisps also create a small green cloud when destroyed; this is purely cosmetic.
Urn of Souls	Center ring	2	3	30	The Candle (Chance unknown)	A wisp spawns for every consecutive second Urn of Souls is fired (BUG: and whenever the urn is activated/deactivated). The occasional fires shot by the wisps block enemy shots, deal contact damage to enemies, and last for 3 seconds before dissipating. The flames deal 10 damage per tick for the first second they're out, scale down to 5 damage over the next second, and then stay at 5 damage until they dissipate (60-30 damage per second). The damage these fires deal does not increase with BFFS! or scale up on later floors.
Magic Skin	Center ring	4	3	30	Poison	N/A
Plum Flute	Center ring	2	3.5	30	None	When the Baby Plum spawned from using Plum Flute bounces diagonally around the room, all the wisps will bounce around the room and fire tears behind themselves as well. The wisps are invulnerable while bouncing around the room.
Spin to Win	Center ring	0.5	3	5	None	Generates wisps once every 0.25 seconds while in use; all wisps are destroyed when the item stops being used. Wisps other than ones made by Spin to Win will not be destroyed, but they will spin faster while it's active.
Vengeful Spirit	Center ring	Infinite	3	30	None	The wisps are summoned when Isaac takes damage, and Isaac can have up to 6 of them at a time. They cannot be destroyed and last for the entire floor, but do not block shots. They also deal damage equal to half of Isaac's damage per tick (7.5x Isaac's damage per second, doubled if Isaac has BFFS!).
Berserk!	Center ring	10	No tears	No tears	None	N/A
Dark Arts	Center ring	2	3	30	None	The wisps are summoned when Isaac kills enemies with Dark Arts, and do not persist between rooms.
Abyss	Center ring	10	No tears	No tears	None	The number of items destroyed does not change the wisps given.
Suplex!	Other	2	3	30	None	3 wisps are summoned where Isaac lands after using Suplex; the wisps rotate around the spot Isaac landed and fire tears in the same direction Isaac does. The wisps do not persist between rooms.
Keeper's Box	Center ring	2	3	30	None	Enemies killed by the wisps' tears have a 20% chance to drop a penny.
Anima Sola	Other	2	3	30	None	The wisps orbit the enemy that was chained and constantly shoot at them. When the enemy dies, the wisps despawn.
Gello	Center ring	2	3	30	None	The wisps will orbit Gello instead of Isaac while it's active.
Decap Attack	Other	2	3	30	None	A stationary wisp spawns where Isaac was when he threw his head that fires tears in the same direction Isaac does. The wisps do not persist between rooms.

Other Interactions

The following items don't have unique wisps when used with Book of Virtues, and instead have other effects:

Alabaster Box: Spawns 8 normal wisps when used.
The Book of Sin: Spawns the wisp of Yum Heart, Mom's Bottle of Pills, Deck of Cards, Mr. Boom, Portable Slot (Coin wisp, x3), Bob's Rotten Head, Anarchist Cookbook, or Shoop da Whoop!. Shoop Da Whoop wisps will not fire lasers when Book of Sin is used. The wisp given is independent of the pickup generated.
Breath of Life: Spawns a normal wisp if Isaac takes damage from using it.
Clicker/Friend Finder: Spawns a random wisp.
D infinity: Spawns a normal wisp, along with the appropriate extra wisp of the die it's mimicking if the conditions for it are met.
D4/D100: Removes all of Isaac's wisps and gives him one random wisp for every two items rerolled. Book of Virtues will not be rerolled in the process.
Dead Sea Scrolls/Metronome: The wisp spawned will be based on the item it mimicked.
Eden's Soul/Mystery Gift: Spawns a random wisp. For the rest of the run, a random wisp spawns after clearing a room if the one given by the item was destroyed, including the replacement wisps given by this effect.
Genesis: Replaces all of Isaac's wisps with 3 normal wisps, in addition to its other effects.
Jar of Wisps: The number of wisps spawned is doubled and then increased by 1.
Lemegeton: Lets Lemegeton's wisps shoot homing tears once per second that deal 3 damage.
Portable Slot: Gives the wisps of the following items depending on the reward:
- Coin: Portable Slot (see wisps section above)
  - Two wisps are spawned if Portable Slot gives 2 coins.
- Heart: Yum Heart
- Bomb:Mr. Boom
- Key: Dad's Key
- Pill: Mom's Bottle of Pills
- Black Fly: Nothing
- Pretty Fly: Guppy's Head (x2-4)
Spindown Dice: Spawns an extra wisp and rerolls all of Isaac's wisps. All of the wisps will reroll into the same type of wisp.
Vade Retro: Ghosts created by enemies very slowly move and shoot tears in the same direction Isaac is shooting. The ghosts' tears deal 3.5 damage, and are fired once every second. No wisps are created when using Vade Retro. The wisps' damage are unaffected by the enemy they spawned from.
Void: Spawns the wisps of all the active items it's absorbed. Spawns no wisps by itself. Using Void on Book of Virtues will give stat upgrades instead of its normal effect, as Book of Virtues is considered a passive item.