Status Effects

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This article is about effects which can be inflicted on monsters. For the different kinds of effects which Isaac's primary weapon can have, see Tear Effects.

Status effects are special effects that can be inflicted on an enemy from a variety of sources, such as tears, Bomb.pngBombs, and items. Each status effect has a color and/or symbol/effect associated with them for easy identification. These colorations are not to be confused with champions.

Effects

Effect Appearance Description
Burn Burn Effect.png (in Rebirth) Afflicted enemies take 4 to 6 fire damage over time. Afflicted enemies will be tinted orange for the duration and have a fire symbol above them.
(except in Rebirth) Afflicted enemies will sustain double Isaac's tear damage over time. Afflicted enemies will be tinted orange for the duration and have a fire symbol above them.
Charm Charm Effect.png Afflicted enemies will temporarily fight on Isaac's side, running toward and/or shooting at other enemies and damaging them for 25% of their maximum HP per touch, 5 damage with half-heart-dealing projectiles, and 10 with full-heart-dealing projectiles. If no other enemies are in the room, a charmed enemy will instead run towards Isaac. (Charmed enemies can still hurt Isaac.) Afflicted enemies will be tinted pink for the duration and have a heart symbol above them. Most enemies with ranged attacks will not fire them (but can damage other enemies with them if they do — see the above "monster infighting" damage description).
(except in Rebirth and Afterbirth) Charmed enemies will prioritize non-charmed enemies and won't target invincible enemies. Charmed (except in Rebirth and Afterbirth) Portal.pngPortals will also spawn friendly enemies.
Confusion/Concussion[Details 1] Confusion Effect.png Afflicted enemies are slowed and walk around randomly. While confused, most non-boss enemies will be unable to attack. Bosses will have randomized movement, but will still be able to fire projectiles at Isaac. Afflicted enemies will be tinted pale gray and have stars above them.
Fear Fear Effect.png Afflicted enemies are scared of Isaac and will run away from him. While scared, most non-boss enemies will be unable to attack or charge towards Isaac. Bosses will run away from Isaac, but will still be able to shoot projectiles at him. Afflicted enemies will be tinted purple and have a skull symbol above them.
Petrified Petrified Effect.pngGold Petrified Effect.png Afflicted enemies are stopped in place. They cannot move or attack, but will still deal contact damage. Afflicted enemies will be shaded brown-gray as if turned to stone (unless petrified by Midas' TouchMidas' Touch, in which case they will be shaded gold).[Details 2]
Poison Poison Effect.png (in Rebirth) Afflicted enemies sustain 4 to 6 damage over time. Afflicted enemies will be tinted green and have a bubbly effect surrounding them.
(except in Rebirth) Afflicted enemies will sustain double Isaac's tear damage over time. Afflicted enemies will be tinted green and have a bubbly effect surrounding them.
Slow Slow Effect.pngTar Slow Effect.png Afflicted enemies are slowed down to approximately 51.3% of their original speed. Any projectiles they shoot will also be slowed down to the same amount. Attacks that end when the enemy runs out of momentum, such as the charging attacks of Boss Gurdy Jr. ingame.pngGurdy Jr. and Boss Dingle ingame.pngDingle, will be vastly shortened in duration. Depending on the item that triggers the slow effect, afflicted enemies will be tinted black or white with a snail icon above them.
(except in Repentance and Repentance+) Slowed projectiles will lose momentum much more quickly, greatly reducing their total range.
(except in Rebirth)
Friendly 		Friendly Effect.png Afflicted enemies are permanently charmed[Details 3] and will fight on Isaac's side until they die.[Details 4] Most enemies under this effect will follow Isaac across rooms, like a familiar.[Details 5] Friendly enemies cannot hurt Isaac, but many of them will still chase and "attack" Isaac in a room with no enemies. Enemies spawned from afflicted enemies will also be friendly. Friendly enemies are slightly tinted gray, and have heart symbols above their head.
(except in Rebirth)
Shrink 		Shrink Effect.png Afflicted enemies are shrunken and will run away from Isaac. Isaac can walk over shrunken enemies to kill them.
(except in Rebirth and Afterbirth)
Bleed 		Bleed Effect.png (except in Repentance and Repentance+) Afflicted enemies take damage equal to 10% of their maximum health every 5 seconds.
(in Repentance and Repentance+) Afflicted enemies take damage based on how quickly they move; the faster the enemy, the more damage they take. While moving, a bleeding enemy leaves behind red creep that can damage other enemies.
(in Repentance and Repentance+)
Bait 		Mark Effect.png Afflicted enemies will be attacked by other enemies, functioning like a reverse charm effect. Afflicted enemies are tinted red.
(in Repentance and Repentance+)
Chained 		Chained Effect.png Afflicted enemies are chained in place, preventing them from taking any action.
(in Repentance and Repentance+)
Frozen 		Frozen Effect.png Enemies that are killed by items that can inflict Frozen [Details 6] become ice statues on death that block both Isaac's tears and enemy shots. Ice statues can also be pushed by Isaac, causing them to slide, leaving damaging blue creep (which deals 22 damage per second), until they hit an obstacle or enemy, dealing 35 damage to enemies they collide with. After an ice statue blocks 10 shots or collides with something while sliding, it shatters into a ring of 10 icicles which slow and deal 8 + (floor − 1) damage to enemies they hit. Enemies that are killed by these icicles also become ice statues. Frozen enemies will not trigger any of their on-death effects, such as exploding or splitting.

(except in Repentance+) On-kill effects from items such as Charm of the VampireCharm of the Vampire and Lusty BloodLusty Blood are not triggered when enemies are frozen. (in Repentance+) On-kill effects do trigger.

(in Repentance and Repentance+)
Magnetized 		Magnetized Effect.png Afflicted enemies attract tears/projectiles, pickups, and other enemies. Enemy shots attracted by this effect can damage other enemies.
(in Repentance and Repentance+)
Brimstone Curse 		Brimstone Curse Effect.png Effect exclusively applied by (in Repentance and Repentance+) Character Tainted Azazel icon.pngTainted Azazel and HemoptysisHemoptysis. Cursed enemies take more damage from BrimstoneBrimstone and Brimstone-like effects. On death, cursed enemies explode, spreading the effect to nearby enemies. Enemies spawned/created from cursed enemies will also be cursed.
(in Repentance and Repentance+)
Weaken 		Weaken Effect.png Effect exclusively applied by (in Repentance and Repentance+) XI - Strength?XI - Strength?. Afficted enemies are slowed slightly and take 2x damage from all sources. Enemies also have their damage reduced to half a heart, even on the WombWomb stages and beyond.

Notes

  1. ↑ "Confusion" is the proper name of this status effect, but it is sometimes referred to as "Concussion" in certain item and effect descriptions (such as Iron BarIron Bar).
  2. ↑ Enemies that are petrified by Midas' Touch or an analogous effect (e.g. (except in Rebirth and Afterbirth) Eye of GreedEye of Greed and (except in Rebirth) Gold Heart.pngGold Heart) will drop coins on death. This does not happen with other petrification effects, even if Isaac is able to inflict both kinds in the same build, which is why Midas' Touch applies different shading. (in Repentance+) if a violet champion monster is killed while it is gold-petrified, the trinket it drops is guaranteed to be a golden one. Rainbow champions still drop normal trinkets.
  3. ↑ While most friendly enemies are spawned with the condition, it is possible for a non-friendly enemy to become friendly without being killed. In this scenario, the enemy in question will still be treated as though it was dead for purposes such as whether or not a room counts as cleared.
  4. ↑ Friendly enemies can take damage, including contact and projectile damage, from non-friendly enemies (blocking most enemy projectiles in the process), which works like how charmed enemies deal damage to other enemies. (Friendly and non-friendly enemies making contact with each other generally damage each other more-or-less at the same time if both enemies can cause contact damage.) Some charmed or friendly enemies can also take damage in different ways (such as (in Repentance and Repentance+) Bishop.pngBishops taking damage when they prevent damage being dealt to Isaac).
  5. ↑ Some friendly-inducing effects cause affected enemies to despawn when Isaac leaves the room.
  6. ↑ If a non-boss enemy dies within 10 ticks (0.33 seconds) after being hit by a freezing tear, it will be frozen regardless of what killed it.
  • Host.pngHost-type enemies will take burn and poison damage even if their skull is down, and all status effects can be applied by tears even if their skulls are down.
    • If a Host-type enemy is petrified, they will take damage regardless of if they are vulnerable or not.
  • After a boss or mini-boss has had a status effect applied on them, they will receive immunity against all status effects for 8 seconds. This means that no other status effect can be applied to that enemy during this period.
    • Slow effects and (in Repentance and Repentance+) Brimstone Curse are the exceptions to this rule.
  • (in Repentance+) AbyssAbyss can create locusts that apply various status effects on enemies depending on the item consumed.

Burn

Passive items that cause burning

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
Fire Mind 5.100.257 Fire Mind Flaming tears Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.
2

Trinkets that cause burning

Name ID Icon Quote Description
(in Repentance and Repentance+) A Lighter 5.350.135 A Lighter Watch the world burn Adds a chance for enemies to burn upon entering a room.

Other sources that burn enemies

  • (in Repentance and Repentance+) Character Judas icon.pngJudas' BirthrightBirthright effect will inflict Burn on nearby enemies when using an active item.
  • (in Repentance and Repentance+) When playing as Character Tainted Jacob icon.pngTainted Jacob, Dark Esau.pngDark Esau inflicts Burn on enemies he passes through whilst dashing.

Charm

Activated items that cause charming

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
(except in Rebirth) Kidney Bean 5.100.421
Kidney Bean
4 seconds
 Love toots! Isaac farts, charming all nearby enemies.
(except in Repentance+) 1
(in Repentance+) 0

Passive items that cause charming

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
Ball of Bandages 5.100.207 Ball of Bandages Gotta lick 'em all! Creates an orbital familiar. Collecting additional copies gives it the ability to shoot Charm tears, then chase enemies to deal contact damage, then deal even more contact damage.
(except in Repentance+) 2
(in Repentance+) 1
Mom's Eyeshadow 5.100.200 Mom's Eyeshadow Charm tears Tears have a chance to charm enemies.
1
(except in Rebirth) Farting Baby 5.100.404 Farting Baby He farts! Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which charms, poisons, or knocks back nearby enemies.
1
(except in Rebirth) Glitter Bombs 5.100.432 Glitter Bombs Prize bombs! +5 Bomb.pngBombs. Bombs have a chance to drop random pickups or charm enemies when they explode.
2
(except in Rebirth and Afterbirth) Bozo 5.100.513 Bozo Party time! +0.1 flat damage, grants a Soul Heart.pngSoul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a Rainbow Poop.pngRainbow Poop.
2
(in Repentance and Repentance+) Venus 5.100.591 Venus HP up + you feel pretty Adds one red Heart container. Heals 1 additional Red Heart.pngRed Heart. Enemies near Isaac become charmed.
2
(in Repentance and Repentance+) Sissy Longlegs 5.100.280 Sissy Longlegs She loves you Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. (in Repentance and Repentance+) Briefly charms enemies on contact.
1
(in Afterbirth and Afterbirth †) Betrayal 5.100.391 Betrayal Turn your enemy (except in Repentance and Repentance+) Charms all enemies in the room when Isaac takes damage.
(in Repentance and Repentance+) Enemies are able to damage each other. If an enemy is damaged by another enemy, they will attack that enemy instead of Isaac.

Pills that cause charming

Pill Effect
Pheromones Charms all enemies in the room for a short period of time.

Notes

  • First stage of Ball of Bandages cannot charm enemies. See Ball of BandagesBall of Bandages for details.
  • Charmed enemies will still target Isaac if they are the only enemy in the room.

Confusion

Passive items that cause confusion

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
Butt Bombs 5.100.209 Butt Bombs Toxic blast +5 bombs +5 Bomb.pngBombs. Bombs now cloud up the screen, briefly damaging and confusing all enemies.
(except in Repentance+) 2
(in Repentance+) 1
Iron Bar 5.100.201 Iron Bar DMG up + concussive tears +0.3 damage. Adds a chance to shoot concussive tears, causing enemies to walk around randomly.
2
(except in Rebirth) Number Two 5.100.378 Number Two Uh oh... Continuously firing tears for three seconds causes Isaac to drop a Butt BombsButt Bombs bomb, which damages and confuses all enemies in the room when it explodes.
2
(except in Rebirth and Afterbirth) Camo Undies 5.100.497 Camo Undies Camo kid Isaac becomes camouflaged at the beginning of each room. Until he shoots, all non-boss enemies will be confused. (in Repentance and Repentance+) Isaac gains +0.5 Speed while camouflaged, and gains Tears and Damage upon breaking it.
3
(except in Rebirth and Afterbirth) Glaucoma 5.100.460 Glaucoma Blind tears! Adds a chance to shoot tears that confuse enemies for an extremely long time.
1
(except in Rebirth and Afterbirth) Metal Plate 5.100.449 Metal Plate It itches... Grants one Soul Heart.pngSoul Heart. Enemy shots have a chance to be reflected at the shooter as confusing tears.
1
(in Repentance and Repentance+) Knockout Drops 5.100.637 Knockout Drops They pack a punch! Adds a chance to shoot a fist tear that has extremely high knockback and confuses enemies.
(except in Repentance+) 3
(in Repentance+) 2

Trinkets that cause confusion

Name ID Icon Quote Description
(except in Rebirth) Faded Polaroid 5.350.69 Faded Polaroid You feel faded Occasionally causes Isaac to blend into the ground, which briefly confuses all enemies in the room. (in Repentance and Repentance+) Can be used to open the Strange Door in The Depths.

Other sources of confusion

  • Destroying a (except in Rebirth) Black Poop.pngBlack Poop briefly confuses all enemies in the room.

Fear

Activated items that cause fear

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
Mom's Pad 5.100.41
Mom's Pad
2 rooms
 Mass fear Inflicts fear to all enemies in the room for 4 seconds. (in Repentance and Repentance+) Spawns a blue fly.
0
The Gamekid 5.100.93
The Gamekid
4 rooms
 Temporary Man-Pac Transforms Isaac into a rainbow-colored chomping creature for 6.5 seconds. Grants invulnerability, inflicts fear on all enemies, and has a chance of replenishing a Half Red Heart.pngHalf Red Heart every time an enemy is killed.
1

Passive Items that cause fear

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
Abaddon 5.100.230 Abaddon Evil + DMG up + fear shot (except in Repentance and Repentance+) +1.5 damage, +0.2 speed. Removes all Red Heart containers, grants six Black Heart.pngBlack Hearts, and adds a chance to shoot fear tears.
(in Repentance and Repentance+) +1.5 damage, +0.2 speed. Grants two Black Heart.pngBlack Hearts, converts all Red Heart Containers into Black Hearts, and adds a chance to shoot fear tears.
3
Dark Matter 5.100.259 Dark Matter DMG up + fear shot +1 damage, adds a chance to shoot fear tears.
3
Lil Haunt 5.100.277 Lil Haunt Fear him Spawns a familiar that chases down enemies, dealing 4 damage per second and inflicting fear.
1
Mom's Perfume 5.100.228 Mom's Perfume Fear shot + tears up Adds a chance to shoot fear tears. (except in Repentance and Repentance+) Decreases tear delay by 1. (in Repentance and Repentance+) +0.5 fire rate.
2
(except in Rebirth) Spear Of Destiny 5.100.400 Spear Of Destiny Your destiny In addition to tears, Isaac holds a spear in front of him which deals contact damage equal to 2× his tear damage, and occasionally inflicts fear.
(except in Repentance+) 2
(in Repentance+) 1
(except in Rebirth and Afterbirth) Bozo 5.100.513 Bozo Party time! +0.1 flat damage, grants a Soul Heart.pngSoul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a Rainbow Poop.pngRainbow Poop.
2
(in Repentance and Repentance+) 2Spooky 5.100.554 2Spooky 4me Enemies near Isaac are afflicted with fear.
1
(in Afterbirth and Afterbirth †) My Shadow 5.100.433 My Shadow Me! And my shaaaadow! (except in Repentance and Repentance+) Inflicts fear on all enemies in the room upon taking damage and spawns black friendly Charger.pngChargers that attack enemies.
(in Repentance and Repentance+) Spawns a shadow familiar that closely follows behind Isaac. It spawns a black friendly Charger.pngCharger whenever an enemy touches it.

Pills that cause fear

Pill Effect
(except in Rebirth) Power Pill! Temporarily grants invulnerability, inflicts fear on enemies in the room, and lets Isaac deal contact damage, similar to The GamekidThe Gamekid.

Other sources of fear

  • (in Repentance and Repentance+) If Little HornLittle Horn kills an enemy, it will be feared briefly before being crushed.

Petrification

Activated items that petrify enemies

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
Mom's Bra 5.100.39
Mom's Bra
3 rooms
 Mass paralysis Petrifies all enemies in the current room for 4 seconds.
(except in Repentance+) 1
(in Repentance+) 0
The Boomerang 5.100.338
The Boomerang
2 seconds
 It will never leave you Throws a boomerang which retrieves pickups, as well as damages and petrifies enemies hit for 2 seconds. (in Repentance and Repentance+) Pierces through enemies.
1
(except in Rebirth) Mega Bean 5.100.351
Mega Bean
6 rooms
 Giga fart! Petrifies all enemies in the current room for about 1.5 seconds, poisons any enemies near Isaac. (except in Repentance+) The fart also sends a rock wave across the room in the direction Isaac is facing. (in Repentance+) The fart also creates a Mama Mega!Mama Mega! explosion.
1

Passive items that petrify enemies

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
Midas' Touch 5.100.202 Midas' Touch Golden touch Enemies that touch Isaac are temporarily petrified and turn to gold. Any enemy killed while in this state will drop Penny.pngPennies.
(except in Repentance+) 2
(in Repentance+) 1
Mom's Contacts 5.100.110 Mom's Contacts Freeze effect Adds a chance to shoot petrifying tears. (except in Repentance and Repentance+) +0.25 range. (in Repentance and Repentance+) +1.5 range.
3
(except in Rebirth) Charged Baby 5.100.372 Charged Baby Bbbzzzzzt! Spawns a familiar that occasionally drops a Lil' Battery.pngLil' Battery, gives an active item charge, or petrifies all enemies in the room.
(except in Repentance+) 3
(in Repentance+) 2
(except in Rebirth and Afterbirth) Dad's Ring 5.100.546 Dad's Ring Father's blessing Creates a ring of light around Isaac that petrifies enemies in contact.
(except in Repentance+) 3
(in Repentance+) 2
(except in Rebirth and Afterbirth) Eye of Greed 5.100.450 Eye of Greed Gold tears! Every 20 tears, Isaac loses 1 Penny.pngPenny and shoots an additional gold tear that petrifies enemies and turns them into gold. Any enemy killed while in this state will drop coins.
2
(in Repentance and Repentance+) Freezer Baby 5.100.608 Freezer Baby Iced iced baby Spawns a shooting familiar that has a chance to petrify enemies, and freezes monsters upon killing them.
2
(in Repentance and Repentance+) Holy Water 5.100.178 Holy Water Splash! (except in Repentance and Repentance+) Spawns a bottle familiar that breaks when Isaac takes damage, leaving a puddle of blue creep.
(in Repentance and Repentance+) A bottle familiar that flies forward when Isaac shoots. It breaks upon hitting an enemy, leaving a puddle of blue creep that petrifies enemies.
3
(in Repentance+) Uranus 5.100.596 Uranus Ice tears Isaac shoots ice tears, which slow enemies and freeze monsters they kill. Frozen enemies slide away and explode into ice shards when touched.
3

Trinkets that petrify enemies

Name ID Icon Quote Description
(in Repentance and Repentance+) Ice Cube 5.350.188 Ice Cube Stay frosty Adds a chance to petrify enemies when entering the room. Killing the petrified enemy freezes it.

Other sources that petrify enemies

  • (except in Rebirth and Afterbirth) Losing a Gold Heart.pngGold Heart briefly turns all nearby enemies into gold.

Poison

Activated items that poison enemies

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
Bob's Rotten Head 5.100.42
Bob's Rotten Head
2 rooms
 Reusable ranged bomb Isaac holds a poison Bomb.pngBomb which can be thrown in a cardinal direction and explodes on impact.
1
The Bean 5.100.111
The Bean
4 seconds
 Toot on command Isaac farts, damaging and poisoning any enemy in close range.
0
(except in Rebirth) Mega Bean 5.100.351
Mega Bean
6 rooms
 Giga fart! Petrifies all enemies in the current room for about 1.5 seconds, poisons any enemies near Isaac. (except in Repentance+) The fart also sends a rock wave across the room in the direction Isaac is facing. (in Repentance+) The fart also creates a Mama Mega!Mama Mega! explosion.
1

Passive items that poison enemies

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
Bob's Brain 5.100.273 Bob's Brain Explosive thoughts Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
(except in Repentance+) 1
(in Repentance+) 0
Bob's Curse 5.100.140 Bob's Curse +5 poison bombs +5 Bomb.pngBombs. Grants Isaac's bombs a poison effect. (in Repentance and Repentance+) They also leave a lingering poison cloud, and Isaac becomes immune to poison.
1
Ipecac 5.100.149 Ipecac Explosive shots Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
4
Scorpio 5.100.305 Scorpio Poison tears Grants poison tears, which deal damage over time when inflicted.
3
The Black Bean 5.100.180 The Black Bean Toot on touch (except in Repentance and Repentance+) When taking damage, Isaac farts, poisoning enemies in range.
(in Repentance and Repentance+) When taking damage, Isaac farts five times, poisoning and knocking back nearby enemies and leaving lingering poison clouds.
0
The Common Cold 5.100.103 The Common Cold Poison damage Adds a chance to shoot poison tears, dealing damage over time when inflicted.
1
The Virus 5.100.13 The Virus Poison touch + speed up Isaac poisons enemies on contact. (except in Repentance and Repentance+) -0.1 speed. (in Repentance and Repentance+) +0.2 speed. (in Afterbirth and Afterbirth †) Poisoned enemies have a chance to drop a black heart when killed.
2
(except in Rebirth) Farting Baby 5.100.404 Farting Baby He farts! Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which charms, poisons, or knocks back nearby enemies.
1
(except in Rebirth) Serpent's Kiss 5.100.393 Serpent's Kiss The kiss of death Tears have a chance to apply a poison effect to enemies. Isaac poisons enemies on contact. Poisoned enemies have a chance to drop a Black Heart.pngBlack Heart when killed.
2
(except in Rebirth) Toxic Shock 5.100.350 Toxic Shock Mass poison Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short-lasting pool of green creep on the ground.
3
(except in Rebirth and Afterbirth) Acid Baby 5.100.491 Acid Baby Pills pills pills! Spawns a familiar that drops a random pill every 3 rooms. Upon using a pill, all enemies in the room are poisoned.
2
(except in Rebirth and Afterbirth) Contagion 5.100.466 Contagion Outbreak! The first enemy killed in a room releases a gas cloud that poisons nearby enemies. Affected enemies will also release gas upon death, spreading the effect.
2
(except in Rebirth and Afterbirth) Dead Tooth 5.100.446 Dead Tooth Toxic breath While firing, Isaac gains a green aura that poisons nearby enemies.
1
(in Repentance and Repentance+) Jupiter 5.100.594 Jupiter You're a gas giant! +2 red Heart containers, -0.3 speed. Isaac builds speed while standing still, and releases poison gas clouds when he moves afterwards.
2
(in Repentance and Repentance+) Mucormycosis 5.100.553 Mucormycosis Spore shot Gives Isaac the chance to fire spore tears that stick to enemies and blow up after a few seconds, dealing damage and poisoning nearby enemies and releasing more spores.
3

Trinkets that poison enemies

Name ID Icon Quote Description
Pinky Eye 5.350.30 Pinky Eye Poison shots Adds a 10% chance to shoot a poison tear, dealing damage over time when inflicted.
(except in Rebirth and Afterbirth) Black Tooth 5.350.95 Black Tooth It looks dead Adds a chance to fire a black tooth that deals double damage and poisons enemies.
(except in Rebirth and Afterbirth) Locust of Pestilence 5.350.114 Locust of Pestilence I bring Pestilence Upon entering a room with enemies, spawns a Green Locust which damages and poisons enemies.
(in Repentance and Repentance+) Torn Card 5.350.157 Torn Card Death awaits Every 15 shots, Isaac shoots an IpecacIpecac + My ReflectionMy Reflection tear.

Pills that poison enemies

Pill Effect
Bad Gas Isaac farts, poisoning enemies around him.

Slow

Activated items that slow enemies

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
Spider Butt 5.100.171
Spider Butt
2 rooms
 Mass enemy slowdown + damage Deals 10 damage to all enemies in the room and slows them for 4 seconds. (in Repentance and Repentance+) Enemies killed by Spider Butt spawn Blue Spiders.
1
The Hourglass 5.100.66
The Hourglass
2 rooms
 Temporary enemy slowdown All enemies in the room are slowed for 8 seconds.
(except in Repentance+) 1
(in Repentance+) 0

Passive items that slow enemies

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
Ball of Tar 5.100.231 Ball of Tar Sticky feet... Adds a chance to shoot slowing tears. Isaac leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
2
Broken Watch 5.100.337 Broken Watch I think it's broken Slows all enemies in every fourth newly-discovered room, with a small chance to speed them up instead.
1
Juicy Sack 5.100.266 Juicy Sack Sticky babies Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room.
2
Little Gish 5.100.99 Little Gish Sticky friend Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
(except in Repentance+) 2
(in Repentance+) 1
Spider Bite 5.100.89 Spider Bite Slow effect Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
2
(except in Rebirth) Censer 5.100.387 Censer Peace be with you Spawns a familiar which creates a circular aura that slows down enemies and enemy shots inside.
(except in Repentance+) 3
(in Repentance+) 2
(except in Rebirth) Night Light 5.100.425 Night Light Scared of the dark? A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.
1
(except in Rebirth and Afterbirth) Large Zit 5.100.502 Large Zit Creep shots Adds a chance to fire a creep shot that deals double damage and leaves a trail of slowing white creep.
1
(except in Rebirth and Afterbirth) Lil Spewer 5.100.537 Lil Spewer Puking buddy Drops a random pill, and spawns a familiar that charges up and fires creep. Using pills changes the creep type.
1
(except in Rebirth and Afterbirth) Parasitoid 5.100.461 Parasitoid Egg tears! Adds a chance to fire an egg sack which creates slowing creep and spawns 1-2 Blue Flies or Blue Spiders upon hitting an enemy.
3
(in Repentance and Repentance+) Cube Baby 5.100.652 Cube Baby Kick it! Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills.
1
(in Repentance and Repentance+) The Intruder 5.100.575 The Intruder Invasive friend A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room.
(except in Repentance+) 3
(in Repentance+) 2
(in Repentance and Repentance+) Uranus 5.100.596 Uranus Ice tears Isaac shoots ice tears, which slow enemies and freeze monsters they kill. Frozen enemies slide away and explode into ice shards when touched.
3
(in Repentance and Repentance+) Worm Friend 5.100.682 Worm Friend Clingy buddy Gives Isaac a Nerve Ending.pngNerve Ending familiar that burrows out of the ground to grab and deal damage to enemies over time.
3
(in Repentance and Repentance+) Sticky Bombs 5.100.367 Sticky Bombs Egg sack bombs! +5 Bomb.pngBombs. Bombs stick to enemies and spawn 2-5 Blue Spiders on kill. (in Repentance and Repentance+) Bombs leave a long-lasting puddle of slowing creep. (in Repentance+) Spawns 1-2 Blue Spiders or Blue Flies when bombs damage enemies.
(except in Repentance+) 2
(in Repentance+) 1
(except in Repentance and Repentance+) Stop Watch 5.100.232 Stop Watch Let's slow this down a bit... (in Rebirth) +0.3 speed. Automatically inflicts slow to all enemies in every room.
(in Afterbirth and Afterbirth †) +0.3 speed. Upon taking damage, inflicts slow to all enemies for the current room.
(in Repentance and Repentance+) +0.3 speed. Slows all enemies in every room to 80% speed.

Trinkets that slow enemies

Name ID Icon Quote Description
(except in Rebirth and Afterbirth) Locust of Famine 5.350.115 Locust of Famine I bring Famine Upon entering a room with enemies, spawns a Yellow Locust that damages and slows enemies.
(in Repentance and Repentance+) Chewed Pen 5.350.130 Chewed Pen It's leaking Adds a chance to fire tears that slow enemies.

Cards that slow enemies

Name ID Icon Message Description
(except in Rebirth and Afterbirth) Era Walk 5.300.54 Era Walk Savor the moment For the current room, enemies are slowed, Isaac's speed is increased by 0.50, and his shot speed is decreased by 1.00.

Pills that slow enemies

Pill Effect
I'm Drowsy... (except in Repentance and Repentance+) Slows all enemies for the duration of the room.

(in Repentance and Repentance+) Slows all enemies, Isaac, and the background music for the duration of the room.

Notes

  • The creep from items like Ball of TarBall of Tar and Juicy SackJuicy Sack only slow enemies for as long as they remain in the creep.
  • The Mask Heart.pngMask + Heart enemy is not affected by the slow effect.
  • (in Repentance and Repentance+) Stop Watch's slowdown effect is classified as a separate effect from the slow status and fully stacks with the status. See Stop WatchStop Watch for more details.

Friendly (except in Rebirth)

Activated items that create friendly enemies

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
Friendly Ball 5.100.382
Friendly Ball
2 rooms
 Gotta fetch 'em all! Throwing the ball at a monster instantly kills and captures it. The captured enemy can later be released and will be friendly, fighting for Isaac and persisting between rooms.
1
(except in Rebirth and Afterbirth) Book of the Dead 5.100.545
Book of the Dead
6 rooms
 Rise from the grave (except in Repentance and Repentance+) Creates a friendly Bony.pngBony, Black Bony.pngBlack Bony, or an orbital bone for each enemy killed in the current room.
(in Repentance and Repentance+) Creates a friendly Bony.pngBony, Black Bony.pngBlack Bony, Bone Fly.pngBone Fly, Revenant.pngRevenant, Big Bony.pngBig Bony, or an orbital bone for each enemy killed in the current room.
(except in Repentance+) 3
(in Repentance+) 2
(except in Rebirth and Afterbirth) Delirious 5.100.510
Delirious
12 rooms
 Unleash the power! Spawns Boss Delirium ingame.pngDelirium as a random friendly boss that fights for Isaac. (except in Repentance+) The boss lasts the for the current room. (in Repentance+) The boss persists between rooms. The charge time is based on the power of the boss summoned.
1
(in Repentance and Repentance+) Friend Finder 5.100.687
Friend Finder
4 rooms
 Best friends forever! Spawns a random friendly monster that mimics Isaac's movements and attacks.
(except in Repentance+) 3
(in Repentance+) 2

Passive items that create friendly enemies

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
My Shadow 5.100.433 My Shadow Me! And my shaaaadow! (except in Repentance and Repentance+) Inflicts fear on all enemies in the room upon taking damage and spawns black friendly Charger.pngChargers that attack enemies.
(in Repentance and Repentance+) Spawns a shadow familiar that closely follows behind Isaac. It spawns a black friendly Charger.pngCharger whenever an enemy touches it.
(except in Repentance+) 2
(in Repentance+) 1
(except in Rebirth and Afterbirth) Mystery Egg 5.100.539 Mystery Egg Sacrificial insemination Spawns an egg familiar, which hatches a random friendly monster when Isaac is hurt once per room. The power of the monster improves for each consecutive room cleared without taking damage.
(except in Repentance+) 1
(in Repentance+) 0
(except in Rebirth and Afterbirth) Poke Go 5.100.505 Poke Go Gotta catch em... Upon entering a room with enemies in it, has a chance to spawn a random friendly enemy that persists across rooms.
2
(except in Rebirth and Afterbirth) Shade 5.100.468 Shade It follows Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly My Shadow.pngChargers.
0

Trinkets that create friendly enemies

Name ID Icon Quote Description
(in Repentance and Repentance+) Polished Bone 5.350.167 Polished Bone Friends from beyond After clearing a room, adds a 25% chance to spawn a friendly Bony.pngBony.

Cards that create friendly enemies

Name ID Icon Message Description
(in Repentance and Repentance+) XIII - Death? 5.300.69 XIII - Death? May life spring forth from the fallen Creates a friendly Bony.pngBony, Black Bony.pngBlack Bony, Bone Fly.pngBone Fly, Revenant.pngRevenant, Big Bony.pngBig Bony, or an orbital bone for each enemy killed in the current room.

Other sources to create friendly enemies

Shrink (except in Rebirth)

Passive items that grant shrinking tears

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
God's Flesh 5.100.398 God's Flesh Shrink shot! Tears have a chance to shrink enemies, making them run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
1

Bleed (except in Rebirth and Afterbirth)

Passive items that inflict bleed

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
Backstabber 5.100.506 Backstabber Watch your back! Isaac's tears deal double damage and inflict bleeding on enemies if they're facing away from Isaac.
3
Mom's Razor 5.100.508 Mom's Razor It's sharp! Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time.
(except in Repentance+) 2
(in Repentance+) 1

Bait (in Repentance and Repentance+)

Passive items that inflict bait

Name ID Icon Quote Description Quality
Rotten Tomato 5.100.618 Rotten Tomato Delicious! Adds a chance to fire tears that mark enemies with the Bait status effect. Enemies marked as bait are attacked by other enemies.
2

Chained (in Repentance and Repentance+)

Activated items that inflict chained

Name ID Icon Quote Description Quality
Anima Sola 5.100.722
Anima Sola
15 seconds
 Repent Chains down the nearest enemy for 5 seconds, preventing them from moving or attacking.
(except in Repentance+) 3
(in Repentance+) 2

Frozen (in Repentance and Repentance+)

Passive items that freeze enemies

Name ID Icon Quote Description Quality
Cube Baby 5.100.652 Cube Baby Kick it! Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills.
1
Freezer Baby 5.100.608 Freezer Baby Iced iced baby Spawns a shooting familiar that has a chance to petrify enemies, and freezes monsters upon killing them.
2
Uranus 5.100.596 Uranus Ice tears Isaac shoots ice tears, which slow enemies and freeze monsters they kill. Frozen enemies slide away and explode into ice shards when touched.
3

Trinkets that freeze enemies

Name ID Icon Quote Description
Ice Cube 5.350.188 Ice Cube Stay frosty Adds a chance to petrify enemies when entering the room. Killing the petrified enemy freezes it.

Magnetized (in Repentance and Repentance+)

Passive items that magnetize enemies

Name ID Icon Quote Description Quality
Lodestone 5.100.617 Lodestone Magnetizing tears Gives Isaac the chance to fire tears that magnetize enemies they hit, causing them to attract nearby pickups and enemies, as well as tears/shots from all sources.
(except in Repentance+) 3
(in Repentance+) 2

Brimstone Curse (in Repentance and Repentance+)

Passive items that inflict brimstone curse

Name ID Icon Quote Description Quality
Hemoptysis 5.100.726 Hemoptysis Double tap sneeze Double-tapping a fire button causes Isaac to sneeze blood, dealing damage to enemies in front of him. Affected enemies are cursed and take more damage from BrimstoneBrimstone-like attacks.
1

Other sources that inflict brimstone curse

Weaken (in Repentance and Repentance+)

Cards that weaken enemies

Name ID Icon Message Description
XI - Strength? 5.300.67 XI - Strength? May you break their resolve All enemies in the room are weakened, becoming slightly slower and taking double damage from all sources. Affected enemies also have their damage reduced to half a heart. The effect lasts up to one minute, or until the room is left.

Random

These items inflict random status effects on enemies.

Passive items that inflict random effects

Name ID Icon Quote Description (in Repentance and Repentance+) Quality
3 Dollar Bill 5.100.191 3 Dollar Bill Rainbow tears (in Rebirth) Gives Isaac a random tear effect every room.
(except in Rebirth) Gives Isaac a random tear effect every few seconds.
2
(except in Rebirth) Fruit Cake 5.100.418 Fruit Cake Rainbow effects! Isaac's tears gain a random effect that changes every shot.
2
(except in Rebirth) Spider Mod 5.100.403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery.pngLil' Battery / Blue spider upon clearing a room.
1
(in Repentance and Repentance+) Playdough Cookie 5.100.570 Playdough Cookie Tasty rainbow Grants multicolored tears. Each color comes with a different status or tear effect.
2
(in Afterbirth and Afterbirth †) GB Bug 5.100.405 GB Bug Double tap glitch (except in Repentance and Repentance+) Spawns a familiar that bounces diagonally around the room, applying a random status effect to enemies it hits and has a chance to re-roll pickups it passes over.
(in Repentance and Repentance+) Spawns a familiar that follows Isaac. Double tapping the fire button launches it forward, causing it to reroll the first monster or pickup it hits.

Other sources that inflict random effects

  • (except in Rebirth and Afterbirth) Spider BabySpider Baby creates a spider familiar that applies random status effects to enemies that come in contact with it.


SmallIsaac.pngThe Binding of Isaac: RebirthSmallIsaac.png
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