Spawns Esau as a temporary secondary character, controlled at the same time as Isaac. He dies with no consequences if his health runs out, and disappears when Isaac leaves the room.
Esau is given random items equal to the number of items Isaac has, each based on the pools of the items Isaac's were obtained from.
He cannot leave a room, so he can't be used to negate damage from exiting a Curse Room.
He also cannot pick up items, nor can he pick up things such as pills/cards/soul stones.
He can pick up all other pickups and can replenish his health by picking up hearts.
When the Soul of Jacob and Esau is used, some items given to Esau will also apply to Isaac for the floor. This happens with Black Candle and mapping items such as The Compass, for example.
If Esau is given PHD / False PHD, pills will remain identified for the rest of the run, even if negative pills aren't converted into positive ones.
If Esau is given Eden's Blessing, an extra item will be given to Isaac at the start of the next run.
If multiple Souls of Jacob and Esau are used in the same room, only one Esau will be removed after leaving the room. For every room that is left, one copy of Esau will disappear.
Bug!
Items granted to Esau will remove those items from their respective pools as if they were obtained. This also prevents future uses of the soul stone from giving that item to Esau.
Esau as a temporary secondary character, controlled at the same time as Isaac. He dies with no consequences if his health runs out, and disappears when Isaac leaves the room.
Blood Donation Machines, 
Devil Beggars, 
Hell Games, and 
Sacrifice Room allowing 
The Lost and 
Tainted Lost to safely use them without dying, or a form of invulnerability.
Curse Room.
Black Candle and mapping items such as 
The Compass, for example.
PHD / 
False PHD, pills will remain identified for the rest of the run, even if negative pills aren't converted into positive ones.
Eden's Blessing, an extra item will be given to Isaac at the start of the next run.
Bug!
Items granted to Esau will remove those items from their respective pools as if they were obtained. This also prevents future uses of the soul stone from giving that item to Esau.
