Soul of Apollyon

Soul Stones

• Soul of Isaac
• Soul of Magdalene
• Soul of Cain
• Soul of Judas
• Soul of ???
• Soul of Eve
• Soul of Samson
• Soul of Azazel
• Soul of Lazarus
• Soul of Eden
• Soul of the Lost
• Soul of Lilith
• Soul of the Keeper
• Soul of Apollyon
• Soul of the Forgotten
• Soul of Bethany
• Soul of Jacob and Esau

Soul of Apollyon is an unlockable rune added in The Binding of Isaac: Repentance.

Effects

• Spawns 15 random locusts.

Notes

• All locusts have an equal chance to be any of the 5 types.

Strategy

• Using the Soul of Apollyon near an enemy can be dangerous: an explosive locust may spawn on it and immediately explode, damaging Isaac.

Synergies

• Hive Mind: Doubles the damage dealt by locusts.

The Binding of Isaac: Rebirth
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