NO!
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This article is about NO!, similar in appearance to Nuh Uh!.
NO! is a trinket added in The Binding of Isaac: Afterbirth.
Effect
- Prevents activated collectibles from being generated, if possible, from all item pools while this trinket is being held.
Notes
- Activated items will start appearing again once the item pool's non-activated items are exhausted or become scarce.
- When the trinket is dropped, the item generation mechanics go back to normal, and active items will be generated normally again.
- In runs where many items have been collected/rerolled, the trinket can function as a sort of warning to the player that an item pool will soon be exhausted if activated items begin to show up.
Fixed boss drops and machines are not affected by NO!:
Anarchist Cookbook from 
Pride
Bob's Rotten Head from 
Sloth
Crystal Ball from a 
Fortune Telling Machine
Head of Krampus from 
Krampus
IV Bag from a 
Blood Donation Machine
Mr. Boom from 
Wrath
A Pony from 
Headless Horseman
Shoop da Whoop! from 
Envy
White Pony from 
Conquest
Yum Heart from 
Super Lust
Most fixed active item drops are prevented:
- Pride drops a
Key - Sloth drops a card
- Krampus always drops
A Lump of Coal - Blood Donation Machines drop a
Blood Bag if unlocked, still IV Bag otherwise - Wrath drops
Bombs - Headless Horseman and Conquest drop either
Ball of Bandages or 
Cube of Meat - Envy drops a
Troll Bomb - Super Lust drops a pill
Baby Plum will spawn a regular boss room item if spared.
- Some active items that are hard-coded to appear in certain rooms will still spawn, such as Grave Rooms that contain
We Need To Go Deeper! or 
Dross rooms that contain 
The Poop. 
Bumbino will still drop active items from his item pool, if he collects enough coins.
Mystery Gift can still give The Poop.
Shopkeepers can still drop 
Coupon.
Synergies
Golden Trinket / 
Mom's Box: Items with 0 quality are rerolled.
Interactions
Book of Virtues: Will not be prevented from spawning, since it's treated as a passive item. Is nigh-guaranteed to spawn in a 
Library.
Death Certificate: Death Certificate's item generation ignores NO!'s changes to item availability.
Magic Skin: Additional copies of Magic Skin can still replace other items.
TMTRAINER: Active items generated by TMTRAINER will not be prevented from spawning.
In-game Footage
Trivia
- NO!'s sprite was changed for Booster Pack #5.
