Mom's Box
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Mom's Box is an activated item added in The Binding of Isaac: Afterbirth.
Effects
- Increases luck by 1 and doubles the effects of certain trinkets while held. When used, drops a random trinket on the ground.
This item belongs to the 
Yes Mother? set. Collecting three items from this set will transform Isaac into his mother.
Notes
- Most trinkets are not affected. Of the 188 trinkets in Repentance, only 72 have a doubled effect.
- This effect stacks additively with
Golden Trinkets; holding one with Mom's Box will cause applicable trinkets to have triple the regular effect. - Holding a second Mom's Box by using
Schoolbag only increases luck, the effects of trinkets are not affected further.
Synergies
Book of Virtues: Spawns a normal wisp with no unique effect.- Gulp! Pill /
Marbles / 
Smelter: Trinket effects are still doubled when permanently applied to Isaac. 
Broken Remote: Triggers the 
Teleport 2.0 effect whenever an activated item is used.
Crystal Key: Increases the chance of red rooms spawning.
NO!: Prevents items with quality 0 from appearing.
Rosary Bead: Adds 4 Rosaries to all item pools. Upon picking up a Rosary, the effect will end.
Tick: Boss' health will be reduced by 30%. Having the Tick also be golden does not further decrease boss' health.
Hook Worm / 
Ring Worm / 
Wiggle Worm: In addition to the further stats increase, they have an increased effect on your tear trajectory.
Interactions
Mother's Kiss: Grants double the heart containers but only one of them is filled.
Void: Passive effects of Mom's Box are lost if absorbed.
No Effect
These trinkets are not affected by Mom's Box.
'M
???'s Soul
AAA Battery
Ace of Spades
Adoption Papers
Apple of Sodom
Baby-Bender
Bag Lunch
Bat Wing
Beth's Essence
Black Tooth
Blessed Penny
Blister
Bloody Crown
Bloody Penny
Blue Key
Bob's Bladder
Brain Worm
Broken Ankh
Broken Magnet
Broken Padlock- Broken Remote
Burnt Penny
Butter!
Cain's Eye
Callus
Cartridge
Charged Penny
Chewed Pen
Child's Heart
Child Leash
Counterfeit Penny
Cracked Dice
Crow Heart
Cursed Penny
Cursed Skull
Daemon's Tail
Devil's Crown
Dim Bulb
Door Stop
Duct Tape
Endless Nameless
Equality!
Eve's Bird Foot
Expansion Pack
Extension Cord
Faded Polaroid
Filigree Feather
Finger Bone
Fish Head
Fish Tail
Flat File
Flat Penny
Flat Worm
Forgotten Lullaby
Found Soul
Fragmented Card
Friendship Necklace
Gigante Bean
Gilded Key
Hairpin
Holy Crown
Ice Cube
Isaac's Head
Jawbreaker
Judas' Tongue
Keeper's Bargain
Kid's Drawing
The Left Hand
Liberty Cap
Locust of Conquest
Locust of Death
Locust of Famine
Locust of Pestilence
Locust of War
Lost Cork
Louse
Lucky Rock
Match Stick
Meconium
A Missing Page
Missing Poster
Mom's Locket
Mom's Toenail
Monkey Paw
Myosotis
Mysterious Candy
Mysterious Paper
Nose Goblin
Nuh Uh!
Number Magnet
Panic Button
Paper Clip
Pay to Win
Pinky Eye
Poker Chip
Pulse Worm
Rainbow Worm
RC Remote
Red Patch
Rib of Greed- Ring Worm
- Rosary Bead
Rotten Penny
Rusted Key
Safety Cap
Safety Scissors
Samson's Lock
Shiny Rock
Short Fuse
Sigil of Baphomet
Silver Dollar
Stem Cell
Store Credit
Store Key
Strange Key
Super Ball
Super Magnet
Telescope Lens
Temporary Tattoo
Tonsil
Torn Card
Torn Pocket
Umbilical Cord
Vibrant Bulb
Walnut
Wicked Crown- Wiggle Worm
Wish Bone
Wooden Cross
Your Soul
Unlockable Achievements
Mom's Contact - Obtain three Yes Mother? items in one run.
Trivia
- The item description possibly is a reference to the film Seven (1995) where the climax of the film involves the protagonist asking the question over and over again "What's in the box?".
- The item strongly resembles the chest found in Mom's room in
Home. - This item is used in Pica Run (challenge #41).
 Trinket Modifiers
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| Items |
| Pills |
 The Binding of Isaac: Rebirth
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