List of curated daily challenges

The following table is a list of curated daily runs for Daily Challenges:

Date	Event, if any	Peculiarities
January 1	New Year's	Magdalene to It Lives! / and Lazarus to The Lamb; blindfolded; starts with 99 Bombs. The Treasure Room item pool is replaced with explosive Items: Mr. Boom, Bob's Rotten Head, Remote Detonator, Anarchist Cookbook, Boom!, Pyro, Mr. Mega, Butt Bombs, Glitter Bombs, Sticky Bombs, Scatter Bombs, Sad Bombs, Hot Bombs, Bomber Boy, Bob's Curse, Bobby-Bomb, Pyromaniac, Match Book, BOGO Bombs, Bomb Bag, Curse of the Tower, Dr. Fetus, Nancy Bombs, Rocket in a Jar, Blood Bombs, Ghost Bombs. Once all of these have been encountered once, the item pool will turn back to normal.
January 14	National Dress Up Your Pet Day	Isaac to a random goal; starts with Guppy's Head, Guppy's Collar, and Guppy's Tail; no Treasure Rooms.
January 16	National Nothing Day	Apollyon to a random goal; no Treasure Rooms or Shops.
January 27	Thomas Crapper Day	??? to a random goal; starts with Flush!, Number Two, Number One and Butt Bombs; no Treasure Rooms or Shops.
February 2	Groundhog Day	Same character, goal and seed as the previous day. However, if either day is a Sunday or Monday, slight variations will occur. NOTE: This run is never available in Afterbirth. Only the results of previous days can be seen and you can't participate in the run, unless you haven't played the previous day. Leaderboards for Feb 2nd on the AB version of the run still don't exist no matter what, however.
February 9	National Toothache Day	Cain to a random goal; starts with Monstro's Tooth, Tough Love, Dead Tooth and 50 Luck; no Treasure Rooms.
February 11	National "Don't Cry Over Spilled Milk" Day	Magdalene to a random goal; starts with Soy Milk and Milk!.
February 14	Valentine's Day	Magdalene to It Lives!; starts with Friendly Ball, Mom's Eyeshadow, The Battery and 7 Luck.
February 18	National Battery Day	Isaac to a random goal; starts with Charged Baby, 9 Volt, The Battery, Car Battery, Mom's Purse, AAA Battery and Watch Battery.
March 2	Edmund's birthday	Isaac to Mega Satan; starts with The Left Hand. The drop function is disabled, however Trinkets and Cards/Pills/Runes can still be swapped.
March 4	Holy Experiment Day	Magdalene to a random goal; starts with Immaculate Conception, Seraphim and Eucharist; no Treasure Rooms.
March 17	St. Patrick's day	Cain to Mega Satan; starts with 18 Luck.
March 20	National Alien Abduction Day	Isaac to a random goal; starts with The Parasite, Tractor Beam and Cone Head; no Treasure Rooms.
March 22	National "Goof off" day	Isaac to a random goal; starts with an inherent effect of most worm Trinkets: Flat Worm, Hook Worm, Lazy Worm, Ouroboros Worm, Pulse Worm, Ring Worm, Tape Worm, Whip Worm, Wiggle Worm.
Easter (ranges from late March through May)	Easter	Lazarus to Isaac; starts with The Nail, Stigmata and Blood of the Martyr; no Treasure Rooms.
April 1	April fools	Keeper ( with the Old Man Keeper costume) to Mega Satan; random Items and Trinkets upon pickup. The actual Items will be from the current room's item pool and ignore the touch-removal rule. The advertised Items' weights are decremented on sight and are removed from all item pools upon pickup. Every Nickel is a Sticky Nickel. Chests are more likely to spawn Chests.
April 10	National siblings day	Lilith to a random goal; starts with Sister Maggy, Brother Bobby, Ghost Baby, Little Gish, Little Steven and Mongo Baby.
April 15	National That Sucks day	Lazarus to a random goal; starts with Bob's Brain, Cursed Eye, Curse of the Tower, Dead Cat, Bucket of Lard and Tick; no Treasure Rooms.
April 22	National Jelly Bean day	Magdalene to a random goal; starts with Wait What?, The Black Bean, Linger Bean and 9 Volt; no Treasure Rooms.
May 4	May the 4th be with you!	Isaac to a random goal; starts with Technology and Spear Of Destiny / Spirit Sword.
May 8	Mothers' day	Isaac to It Lives!; starts with Mom's Pad, Mom's Lipstick and Mom's Eye; no Treasure Rooms.
May 13	National "Stamp Out Hunger" and Frog Jump day	Magdalene to a random goal; starts with How to Jump and Thunder Thighs. Using How to Jump will send out rock waves similar to Wait What?. No Treasure Rooms.
May 17	National "Pack Rat Day"	Isaac to a random goal; starts with D20 and Sack Head.
May 30	Memorial day	The Lost to ???; blindfolded; starts with Ghost Baby, Sister Maggy, Brother Bobby, Rotten Baby, Dry Baby and BFFS!.
June 2		Magdalene to It Lives! / The Lamb; starts with Blank Card, Mom's Toenail and II - The High Priestess in addition to her starting Pill. Mom's Toenail can't be dropped or swapped, however other Trinkets can. No Treasure Rooms.
June 5	World Environment Day	??? to a random goal; starts with Gnawed Leaf and Restock.
June 18	Fathers' day	Cain to a random goal; starts with A Dollar.
June 19	Fathers' day	Cain to It Lives!; starts with Dad's Key, Daddy Longlegs and 9 Volt; no Treasure Rooms. Trapdoors can't be spawned on Womb II.
June 25	Pride day	The Lost to Mom; starts with 3 Dollar Bill, Fruit Cake and Rainbow Baby.
July 2	I Forgot Day	??? / The Forgotten to a random goal; starts with Forget Me Now. Permanent Curse of the Lost, Curse of the Blind, and Curse of the Unknown. Curse removal only lasts for the current floor.
July 4	American Independence day	Samson to Mega Satan; starts with Dr. Fetus, Scatter Bombs, Soy Milk and Rocket in a Jar. Bombs/Rockets fired by Dr. Fetus have a cosmetic firework effect.
July 11		??? to a random goal; starts with Compost, The Mulligan, and Rotten Baby; no Treasure Rooms.
July 13	Embrace Your Geekness Day	Lazarus to a random goal; starts with Monster Manual, 20/20, Robo-Baby and Dice Shard in addition to his starting Pill; no Treasure Rooms.
August 15	National Relaxation day	Magdalene to a random goal; starts with Tammy's Head, Brimstone, Rubber Cement, Holy Mantle and Spoon Bender; no Treasure Rooms.
August 16	National Tell a Joke day	Keeper to a random goal; firing tears sometimes causes farts; every pill is Explosive Diarrhea.
August 22	National Be an Angel day	Isaac to a random goal; starts with Sacred Heart, Fate and Holy Light.
September 5	National Be Late for Something day	Magdalene to a random goal; starts with Stop Watch, Broken Watch and 0.15 Speed.
September 17	National Apple Dumpling day	Cain to a random goal; every Boss Item is Apple!.
September 22	Elephant Appreciation Day	Magdalene to a random goal; starts with Thunder Thighs and Bucket of Lard.
October 6	National Mad Hatter day	Judas to a random goal; starts with Dr. Fetus and Scatter Bombs. The Treasure Room item pool is replaced with explosive Items: Mr. Boom, Remote Detonator, Boom!, Mr. Mega, Butt Bombs, Glitter Bombs, Sticky Bombs, Scatter Bombs, Sad Bombs, Bomber Boy, Bob's Curse, Bobby-Bomb, Bomb Bag, Number Two, Curse of the Tower, Explosivo, Nancy Bombs, Rocket in a Jar.
October 7	World Smile Day	Isaac to a random goal; starts with Chaos.
October 31	Halloween	Eve to Satan; starts with Sack Head.
November 1	Day of the Dead	The Lost to The Lamb on Hard mode; starts with Dead Cat, without D4 and Holy Mantle. Eternal D6 is removed, but the inherent Holy Mantle effect is available.
November 11	Veterans' day	The Lost to Mega Satan on Hard mode; no Treasure Rooms.
November 13	World Kindness day	Isaac to a random goal; starts with Blank Card, Habit, A Quarter, PHD and XX - Judgement; no Treasure Rooms.
November 19	National "Have a Bad Day" day	??? to a random goal; starts with Cursed Eye, Curse of the Tower, Scatter Bombs, Bob's Brain and Tick; no Treasure Rooms.
4th Thursday of November	Thanksgiving	Magdalene to Mega Satan; starts with Cupid's Arrow. The Boss Room item pool is replaced with Rotten Meat. (This only applies to the initial Item. Rerolls can be other Items)
December 5	Krampusnacht	Isaac to Satan; starts with A Lump of Coal and Mitre. A Devil Room spawns on the first floor. Isaac has an inherent Goat Head effect until Krampus ( or Greed) is encountered.
December 6	Satoru Iwata's birthday	Isaac (with the Satoru Iwata costume) to Isaac; starts with The Gamekid and Cartridge. The Treasure Room item pool is replaced with Nintendo-themed Items: How to Jump, Friendly Ball, The Boomerang, The Candle, Red Candle, Odd Mushroom, Odd Mushroom, Magic Mushroom, Mini Mush, Gnawed Leaf, The Ladder, Treasure Map, The Compass, Crown Of Light, Trinity Shield, Spirit Sword, Mom's Bracelet. Once all of these have been encountered once, the item pool will turn back to normal.
December 23	National Festivus day	Judas to a random goal; starts with Blank Card, PHD, Habit and XI - Strength. The Treasure Room item pool is replaced with: The Body, The Soul, The Mind and Godhead.
December 25	Christmas	Isaac (with a Christmas Hat) to Mega Satan; starts with A Lump of Coal and A Quarter. Isaac has an inherent More Options effect.
December 31	New Year's Eve	Isaac to a random goal; starts with There's Options and More Options.

Removed dailies

Date	Event, if any	Peculiarities
November 4, 2022 & March 24, 2023	G FUEL \| Brimstone & Isaac's Tears launch	Isaac to ???; starts without The D6; GFVE LLLL special seed is enabled. The item blacklist from the seed is expanded with: Cupid's Arrow, The D6, Death's Touch, D100, D4, Taurus, Cursed Eye, Dead Onion, D7, Eye of Belial, D infinity, Eye of the Occult, Eternal D6, Death Certificate, Berserk!. Score-specific changes: Having atleast one G FUEL! multiplies Exploration Bonus from enemies killed by 10. G FUEL! awards an independent base value of 1833 Schwag Bonus; every subsequent can gives around 17% less; every floor increases the base value of a can by around 17%; maximum G FUEL! Schwag Bonus is 10289.

Notes

Only the listed peculiarities are predetermined. Everything else is randomly generated by the game.
If a curated daily with a set goal lands on a Monday, it will be on Normal mode instead.
If a curated daily with a set goal lands on a Sunday, the set goal will take priority over Mega Satan. This may not always hold true across different DLC run versions, however.
Starting Items can be removed with D4 effects, Clicker or 0 - The Fool? with Tarot Cloth.
Soul of the Forgotten or Soul of Jacob and Esau will copy all starting items (including Active Items), grant the same amount of starting pickups and drop a copy of the starting Trinket/Card/Pill/Rune.
Curated item pools work slightly differently: Encountering one of the Items in a Treasure Room will not decrement its weight, allowing it to reappear again. Picking them up or encountering them in a different item pool will decrement them as usual. Once all of the listed Items have been removed, the item pool will turn back to normal.