Familiar
Familiars are small companions, usually generated by passive items, that follow and assist Isaac. Effects of familiars include (but are not limited to) pickup generation, shooting familiars that fire their own tears at enemies, and orbitals that act as projectile shields and/or deal contact damage.
Many of these familiars (especially pickup generation and shooting familiars) follow behind Isaac. When Isaac picks up multiple of these following familiars, they form a line behind him from oldest to newest (with closest familiar behind Isaac being the oldest one picked up) rather than constantly overlapping one another on the same spot behind Isaac.
In addition to being chronologically ordered, certain familiars on the line take priority over others in how close their position is to Isaac. There are the following priorities, in order:
King Baby, making it always the closest familiar to Isaac.
Milk!.
Incubus.
Lil Portal.
Lil Brimstone and
Lil Monstro.
Censer,
Dry Baby,
Lil Abaddon, and
Mongo Baby.
- Most shooting familiars and some throwable familiars.
- Most pickup generation familiars and "
quest item
" familiars such asKey Piece 1.
Boiled Baby also takes this priority.
Isaac cannot have more than 64 total familiars at once. This includes blue spiders and flies, familiar items such as Dry Baby,
Tainted Eve's blood clots, etc. Gaining more than this will result in familiars being destroyed, with blue spiders and flies being destroyed first.
Temporary Familiars
Blue Flies
Blue Flies are familiars that will orbit around Isaac and rush towards nearby enemies, dealing damage and dying in the process. Blue Flies deal double Isaac's current tear damage.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Guppy's Head | 5.100.145 | ![]() |
Reusable fly hive | Spawns 2-4 friendly Blue Flies that damage enemies. | 2 |
![]() |
5.100.434 | ![]() |
Bug catcher | Killing an enemy adds a fly to the jar, up to a maximum of 20. On use, releases Blue Flies equal to the number of flies in the jar. | 2 |
![]() |
5.100.480 | ![]() |
Gain more friends! | Doubles Isaac's Blue Flies and Blue Spiders, or spawns one if Isaac has none. Converts pickups in the current room into Blue Flies or Blue Spiders. | ![]() ![]() |
![]() |
5.100.720 | ![]() |
Anything is possible | Spawns certain pickups based on how many charges it has. If fully charged, instead has one of many unique effects. | ![]() ![]() |
![]() |
5.100.41 | ![]() |
Mass fear | Inflicts fear to all enemies in the room for 4 seconds. ![]() |
0 |
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Infestation | 5.100.148 | ![]() |
Fly revenge | ![]() ![]() |
0 |
Rotten Baby | 5.100.268 | ![]() |
Infested friend | Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time. | 3 |
The Mulligan | 5.100.151 | ![]() |
They grow inside | Tears have a 1/6 chance of spawning allied Blue Flies when they hit an enemy. | 3 |
![]() |
5.100.461 | ![]() |
Egg tears! | Adds a chance to fire an egg sack which creates slowing creep and spawns 1-2 Blue Flies or Blue Spiders upon hitting an enemy. | 3 |
![]() |
5.100.681 | ![]() |
It hungers | Spawns a familiar that flies forward, consuming pickups in its path and dealing damage to enemies. Each pickup increases its size and damage and spawns a Blue Fly. ![]() ![]() 1 + (stage number) pickups, opens a portal which leads to a special room with contents that persist between floors.
|
![]() ![]() |
![]() |
5.100.693 | ![]() |
Infest | Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. | 2 |
![]() |
5.100.29 | ![]() |
Range up | ![]() ![]() |
1 |
![]() |
5.100.367 | ![]() |
Egg sack bombs! | +5 ![]() ![]() ![]() |
1 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Fish Head | 5.350.29 | ![]() |
It stinks | Spawns a Blue Fly every time Isaac takes damage. |
![]() |
5.350.86 | ![]() |
The poop is moving... | Spawns a Blue Fly from every pile of ![]() |
![]() |
5.350.94 | ![]() |
It also stinks! | Items and trinkets that generate Blue Flies or Locusts will generate twice as many. |
![]() |
5.350.126 | ![]() |
Wealth of flies | Spawns a Blue Fly every time a coin is picked up. |
Name | ID | Icon | Message | Description |
---|---|---|---|---|
Berkano | 5.300.38 | ![]() |
Companionship | Spawns 3 friendly Blue Flies and 3 friendly Blue Spiders. |
![]() |
5.300.41 | ![]() |
Void | Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades. |
Other sources of Blue Flies
-
Red Chest: Has a chance to spawn 3 Blue Flies.
- Dark blue champion: Will create 3 Blue Flies when defeated.
Guppy: Isaac will create Blue Flies whenever his tears or his familiars' tears hit enemies.
Guppy: Isaac's tears have a 66% chance to create Blue Flies whenever they hit enemies.
Beelzebub: Some types of enemy flies become Blue Flies.
Friends Till The End! pill: Spawns 3 Blue Flies.
- As
Keeper or
Tainted Keeper, all heart pickups turn into Blue Flies.
Rotten Heart: After clearing a room, a maximum of 2 Blue Flies spawn for each Rotten Heart in Isaac's life bar.
Corny Poops created by
Tainted ??? or
IBS spawn a Blue Fly every two seconds, up to a maximum of 3.
Rotten Beggars can spawn Blue Flies as a reward.
Locusts 
Locusts are variants of Blue Flies that are spawned by Locust trinkets and 7 Seals. They behave like regular Blue Flies but have additional special effects. Red Locusts explode on contact with an enemy, dealing an extra 60 damage in the radius (
explosions are affected by certain bomb modifiers). Green Locusts poison the enemy. Yellow Locusts slow the enemy. Black Locusts deal quadruple Isaac's damage instead of double. White Locusts are identical to Blue Flies, but are generally spawned in high quantities.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
7 Seals | 5.100.526 | ![]() |
Lil harbingers! | Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. | 2 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Fish Tail | 5.350.94 | ![]() |
It also stinks! | Items and trinkets that generate Blue Flies or Locusts will generate twice as many. |
Locust of Conquest | 5.350.117 | ![]() |
I bring Conquest | Upon entering a room with enemies, spawns 1-4 White Locusts which damage enemies. |
Locust of Death | 5.350.116 | ![]() |
I bring Death | Upon entering a room with enemies, spawns a Black Locust that does a very high amount of damage. |
Locust of Famine | 5.350.115 | ![]() |
I bring Famine | Upon entering a room with enemies, spawns a Yellow Locust that damages and slows enemies. |
Locust of Pestilence | 5.350.114 | ![]() |
I bring Pestilence | Upon entering a room with enemies, spawns a Green Locust which damages and poisons enemies. |
Locust of War | 5.350.113 | ![]() |
I bring War | Upon entering a room with enemies for the first time, spawns a Red Locust which detonates upon impact with enemies. |
![]() |
5.350.185 | ![]() |
Infested | Adds a 1/6 chance to spawn a random locust when killing an enemy. |
Name | ID | Icon | Message | Description |
---|---|---|---|---|
![]() |
5.300.94 | ![]() |
Bringer of calamity | Spawns 15 random locusts. |
Blue Spiders
Blue Spiders are familiars similar to Blue Flies that crawl erratically and rush towards nearby enemies, dealing damage and dying in the process.
Blue Spiders deal 2.5 times Isaac's current tear damage.
Blue Spiders deal twice Isaac's current tear damage.
Unlike Blue Flies, Blue Spiders cannot attack over obstacles such as rocks and pits.
![]() |
3DS Exiting the game and re-entering will cause all Blue Spiders to disappear. |
---|
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Box of Spiders | 5.100.288 | ![]() |
It's a box of spiders | ![]() ![]() |
1 |
![]() |
5.100.480 | ![]() |
Gain more friends! | Doubles Isaac's Blue Flies and Blue Spiders, or spawns one if Isaac has none. Converts pickups in the current room into Blue Flies or Blue Spiders. | ![]() ![]() |
![]() |
5.100.720 | ![]() |
Anything is possible | Spawns certain pickups based on how many charges it has. If fully charged, instead has one of many unique effects. | ![]() ![]() |
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Dark Bum | 5.100.278 | ![]() |
He wants to take your life | Spawns a familiar that follows Isaac around and collects ![]() |
3 |
Infestation 2 | 5.100.234 | ![]() |
Infestation shot | Spawns allied Blue Spiders from killed enemies. | 3 |
Juicy Sack | 5.100.266 | ![]() |
Sticky babies | Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. | 2 |
Mom's Wig | 5.100.217 | ![]() |
You feel itchy... | Adds a chance to spawn Blue Spiders when firing tears. Restores 1 ![]() |
2 |
Sissy Longlegs | 5.100.280 | ![]() |
She loves you | Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. ![]() |
1 |
Spiderbaby | 5.100.211 | ![]() |
Spider revenge | ![]() ![]() |
0 |
![]() |
5.100.403 | ![]() |
Mod buddy! | Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a ![]() |
1 |
![]() |
5.100.367 | ![]() |
Egg sack bombs! | +5 ![]() ![]() ![]() |
![]() ![]() |
![]() |
5.100.461 | ![]() |
Egg tears! | Adds a chance to fire an egg sack which creates slowing creep and spawns 1-2 Blue Flies or Blue Spiders upon hitting an enemy. | 3 |
![]() |
5.100.717 | ![]() |
Under a rock | Rocks and other Obstacles spawn blue spiders over time while in a room with enemies, and spawn two blue spiders when destroyed. | 2 |
![]() |
5.100.667 | ![]() |
A helping hand | Spawns a controllable ![]() ![]() |
![]() ![]() |
![]() |
5.100.575 | ![]() |
Invasive friend | A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. | ![]() ![]() |
![]() |
5.100.645 | ![]() |
Itching for revenge | Gives Isaac a ![]() |
1 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
![]() |
5.350.70 | ![]() |
Itchy, tasty... | Occasionally spawns a Blue Spider. |
![]() |
5.350.140 | ![]() |
It feels empty | Picking up ![]() |
Name | ID | Icon | Message | Description |
---|---|---|---|---|
Berkano | 5.300.38 | ![]() |
Companionship | Spawns 3 friendly Blue Flies and 3 friendly Blue Spiders. |
![]() |
5.300.41 | ![]() |
Void | Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades. |
Other sources of Blue Spiders
Infested? pill: Spawns Blue Spiders equal to the number of enemies in the room.
Infested! pill: Spawns a Blue Spider under Isaac and every pile of poop in the room.
Rotten Beggars and
Hell Games can spawn Blue Spiders as a reward.
-
Red Chest: Has a chance to spawn 3 Blue Spiders.
Dips 
Dips are temporary familiars that are spawned when destroying poops. They move erratically around the room and behave similarly to their hostile counterpart dealing contact damage to enemies and blocking projectiles. There are a variety of Dips with unique effects that correlate to different types of Poops.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Dirty Mind | 5.100.576 | ![]() |
Filthy friends | Destroying poop spawns Dip Familiars that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects. | 1 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Dingle Berry | 5.350.163 | ![]() |
Oops! | Spawns a Dip Familiar upon clearing a room. |
Other sources of Dips
- Destroying a
Charming Poop spawns a few Dip Familiars.
Wisps 
Wisps are temporary orbital familiars that are mostly associated with Bethany. By default, they orbit Isaac, blocking shots and dealing contact damage. They also fire spectral tears that deal 1.6-2.4 damage. Normal wisps have 2 health. There are many variants of wisps, most of which can be spawned randomly or through combinations with
Book of Virtues. See here for a full list of wisps.
Other unique variants of wisps include item wisps from Lemegeton which only mimic the effects of passive items while alive, and red wisps from
Vengeful Spirit, which are invulnerable, but disappear upon entering a new floor.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Book of Virtues | 5.100.584 | ![]() |
Spiritual companionship | Passively causes active items to spawn themed orbital wisp familiars on use, which fire tears and block shots. Can be activated to spawn a basic wisp if Isaac has no other active item. | 3 |
Jar of Wisps | 5.100.685 | ![]() |
Your faith grows | Spawns random wisps that shoot various tears, block shots, and deal contact damage. The number of wisps spawned increases every time the jar is used. | ![]() ![]() |
Lemegeton | 5.100.712 | ![]() |
Item summoner | Spawns a destructible orbital familiar representing a random passive item, which blocks shots and deals contact damage. While the wisp is alive, Isaac gains that item's effects. | 3 |
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Vengeful Spirit | 5.100.702 | ![]() |
Hot blooded | After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots. | 1 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Beth's Essence | 5.350.182 | ![]() |
Virtue's reward | Upon entering an ![]() ![]() |
Beth's Faith | 5.350.142 | ![]() |
My faith protects me | At the beginning of each floor, spawn 4-8 wisps that orbit Isaac and fires tears alongside him. |
Name | ID | Icon | Message | Description |
---|---|---|---|---|
Soul of Bethany | 5.300.96 | ![]() |
Friends from beyond | Spawns 6 ![]() |
Other sources of Wisps
- Picking up
Birthright as
Tainted Bethany spawns 4 item wisps with increased health.
Ghosts 
Ghosts are temporary familiars that are summoned by various items. Most ghosts (except those created by Vade Retro) will automatically attack enemies after being summoned, quickly homing in on nearby enemies. All ghosts attack enemies by exploding, though some also deal contact damage shortly before doing so. Explosions from ghosts do not damage terrain or hurt Isaac. Unlike other temporary familiars, ghosts do not persist across rooms.
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Vade Retro | 5.100.653 | ![]() |
Begone! | While held, enemies leave behind ghosts on death. Stronger enemies leave bigger ghosts. Using the item causes the ghosts to explode and damage nearby enemies, and instantly kills all ghost enemies with less than 50% HP. | ![]() ![]() |
Name | ID | Icon | Quote | Description | Quality |
---|---|---|---|---|---|
Ghost Bombs | 5.100.727 | ![]() |
Spooky blast +5 bombs | +5 ![]() |
![]() ![]() |
Hungry Soul | 5.100.684 | ![]() |
Out for blood | Enemies have a chance to spawn ghosts on death, which chase and deal contact damage to enemies and explode after a short time. | 2 |
Purgatory | 5.100.634 | ![]() |
Help from beyond | While in a room with enemies, spawns red cracks in the ground. Walking over these cracks summons ghosts that launch themselves at enemies and explode. | ![]() ![]() |
Chasing Familiars
Familiars in this category actively chase enemies, dealing contact damage to them.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
The Pinking Shears | 5.100.107 | ![]() |
Cut and run | Separates Isaac's head from his body for the current room, granting flight and turning the body into a familiar that chases enemies. | 2 |
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Ball of Bandages | 5.100.207 | ![]() |
Gotta lick 'em all! | Creates an orbital familiar. Collecting additional copies gives it the ability to shoot Charm tears, then chase enemies to deal contact damage, then deal even more contact damage. | ![]() ![]() |
Cube of Meat | 5.100.73 | ![]() |
Gotta meat 'em all! | Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage. | ![]() ![]() |
Daddy Longlegs | 5.100.170 | ![]() |
Daddy's love | Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total. | 3 |
Dead Bird | 5.100.117 | ![]() |
Protective buddy | After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~4 damage per second. ![]() |
0 |
Gemini | 5.100.318 | ![]() |
Conjoined friend | Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~6.43 damage per second. | 1 |
Leech | 5.100.270 | ![]() |
Blood sucker | Spawns a leech familiar that chases enemies, dealing ~3 damage per second. Heals a ![]() |
2 |
Lil Haunt | 5.100.277 | ![]() |
Fear him | Spawns a familiar that chases down enemies, dealing 4 damage per second and inflicting fear. | 1 |
Smart Fly | 5.100.264 | ![]() |
Revenge fly | Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing damage. | ![]() ![]() |
![]() |
5.100.385 | ![]() |
Bumbo want coin! | Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. | 1 |
![]() |
5.100.526 | ![]() |
Lil harbingers! | Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. | 2 |
![]() |
5.100.610 | ![]() |
Fat buddy | The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to ![]() |
![]() ![]() |
![]() |
5.100.565 | ![]() |
What a cute little thing! | Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac. Dealing enough damage to it returns it to normal. | 1 |
![]() |
5.100.575 | ![]() |
Invasive friend | A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. | ![]() ![]() |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Eve's Bird Foot | 5.350.60 | ![]() |
Revenge from beyond | 5% chance to spawn a ![]() |
![]() |
5.350.33 | ![]() |
Fetal Protection | When brought down to only a ![]() ![]() ![]() ![]() |
Name | ID | Icon | Message | Description |
---|---|---|---|---|
![]() |
5.300.86 | ![]() |
Your very own murder | 14 ![]() |
Note: Only third and fourth stage Cube of Meat and
Ball of Bandages chase enemies.
Note: Only fourth stage
Bumbo chases enemies.
Note: Only
War and
Death in
7 Seals chase enemies.
Orbital Familiars
Familiars that orbit Isaac, absorbing enemy projectiles and/or dealing contact damage. Despite their different apparent sizes, most of them have the same effective size with regard of blocking shots or damaging enemies.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
![]() |
5.100.545 | ![]() |
Rise from the grave | ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
![]() ![]() |
![]() |
5.100.655 | ![]() |
Let it rip! | Gives +0.5 speed and greatly increases the rotation speed and damage of orbitals for 3 seconds. Passively gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage. | ![]() ![]() |
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Ball of Bandages | 5.100.207 | ![]() |
Gotta lick 'em all! | Creates an orbital familiar. Collecting additional copies gives it the ability to shoot Charm tears, then chase enemies to deal contact damage, then deal even more contact damage. | ![]() ![]() |
Best Bud | 5.100.274 | ![]() |
Sworn protector | When hit, spawns a quickly orbiting attack fly similar to ![]() |
0 |
Big Fan | 5.100.279 | ![]() |
Fat protector | Spawns a large, slow-moving orbital familiar that blocks enemy shots and deals 30 damage per second to enemies. Reduces the speed other orbitals rotate at. | ![]() ![]() |
Cube of Meat | 5.100.73 | ![]() |
Gotta meat 'em all! | Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage. | ![]() ![]() |
Distant Admiration | 5.100.57 | ![]() |
Attack fly | Spawns an attack fly that circles further out than ![]() ![]() |
![]() ![]() |
Forever alone | 5.100.128 | ![]() |
Attack fly | Spawns an attack fly that orbits a long distance from Isaac, dealing 30 damage per second. | 1 |
Guardian Angel | 5.100.112 | ![]() |
Extra protection | Spawns an orbital familiar that blocks enemy shots, deals 7 damage per tick on contact, and increases the speed of all orbital familiars. | ![]() ![]() |
Guillotine | 5.100.206 | ![]() |
DMG + tears up. An out-of-body experience! | Isaac's head becomes an orbital familiar that blocks shots and deals contact damage. Tears are still fired from the rotating head. ![]() ![]() |
![]() ![]() |
Halo of Flies | 5.100.10 | ![]() |
Projectile protection | Spawns two Pretty Flies that block enemy shots and deal contact damage to flies. | 2 |
Sacrificial Dagger | 5.100.172 | ![]() |
My fate protects me | Spawns a dagger orbital familiar, blocking enemy shots and dealing a high amount of damage to enemies in contact. | 2 |
Smart Fly | 5.100.264 | ![]() |
Revenge fly | Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing damage. | ![]() ![]() |
![]() |
5.100.364 | ![]() |
Friendly fly | Spawns a white attack fly that orbits somewhere between ![]() ![]() |
1 |
![]() |
5.100.363 | ![]() |
Protective friend | Spawns an orbital familiar which does ![]() ![]() ![]() |
![]() ![]() |
![]() |
5.100.528 | ![]() |
Eclipsed by the moon | Spawns an orbital familiar with a large orbital radius. Tears that pass through the prism split into four multi-colored tears. | 3 |
![]() |
5.100.511 | ![]() |
He's violent | Spawns a fly familiar that orbits around a random enemy and deals 30 damage per second to enemies it comes in contact with. | 1 |
![]() |
5.100.509 | ![]() |
Bloody friend | ![]() ![]() |
1 |
![]() |
5.100.525 | ![]() |
You're tearing me apart! | Taking damage grants a body part orbital that blocks shots and deals contact damage, up to a maximum of three. The body parts are destroyed after blocking enough damage. | ![]() ![]() |
![]() |
5.100.508 | ![]() |
It's sharp! | Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time. | ![]() ![]() |
![]() |
5.100.542 | ![]() |
Projectile shield | Spawns a bone familiar that circles around Isaac and reflects enemy shots. | ![]() ![]() |
![]() |
5.100.629 | ![]() |
Defense drone | Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles. | 3 |
![]() |
5.100.581 | ![]() |
Flamboyant protector | Spawns a fly orbital familiar that seeks out incoming enemy shots and destroys them. | 4 |
![]() |
5.100.693 | ![]() |
Infest | Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. | 2 |
![]() |
5.100.645 | ![]() |
Itching for revenge | Gives Isaac a ![]() |
1 |
Name | Description |
---|---|
Pretty Fly | Grants 1 fly orbital that circles the player, blocking projectiles and damaging fly-type enemies on touch. |
Pretty Fly
- A maximum of three Pretty Flies can orbit around Isaac.
Cube of Meat,
Ball of Bandages,
Sworn Protector,
Guardian Angel,
Smart Fly,
Sacrificial Dagger, and
Slipped Rib take up a Pretty Fly slot. These familiars are not affected by the Pretty Fly cap of 3.
- If Isaac has three Pretty Flies and picks up a
Cube of Meat, the Cube of Meat will replace one of the flies.
- The amount of Pretty Flies Isaac has is stored. If a Pretty Fly is replaced by a Cube of Meat but then that Cube of Meat is removed, the replaced Pretty Fly will return. If Isaac has more than 3 Pretty Flies and one of his current Pretty Flies is removed through
Sacrificial Altar, then another will replace it.
Orbital Rings
- There are set orbit rings that have specific rotations and distance from Isaac.
If two orbitals share a same orbit ring they will be positioned opposite each other (three will cause them to fly 120 degrees apart, four will fly at 90 degrees etc.).
- Ring 1 flies counter-clockwise and is the closest to Isaac.
- It consists of Pretty Flies and familiars that can replace Pretty Flies.
Guardian Angel will increase the rotation speed of all familiars in this ring.
- It consists of Pretty Flies and familiars that can replace Pretty Flies.
- Ring 2 flies counter-clockwise and is second closest.
- It consists of
Bloodshot Eye,
Big Fan,
Guillotine,
Leprosy, and
Mom's Razor
Big Fan will decrease the rotation speed of all familiars in this ring and ring 1. It will also override
Guardian Angel's speed boost.
A Pretty Fly Horse Pill will spawn a unique
Big Fan that will not orbit slower or affect the speed of other orbitals.
- It consists of
- Ring 3 flies counter-clockwise and orbits slightly slower than ring 2.
- Ring 4 flies clockwise at the speed of ring 3.
- It consists of
Distant Admiration and
Bot Fly.
- It consists of
- Ring 5 flies counter-clockwise even slower than ring 4.
- It consists of
Friend Zone and
Angelic Prism.
- It consists of
- Ring 6 flies counter-clockwise at the speed of ring 5.
- It consists of
Forever alone and
Best Bud.
Best Bud will orbit much faster than
Forever alone but not affect the speed of the ring. However it will impact the orbiting position of other
Forever alones.
- It consists of
The Swarm has a unique orbit ring between 2 and 3, it orbits counter-clockwise much slower.
Angry Fly has a unique orbit ring between 3 and 4, it orbits clockwise much faster.
- Familiars affected by
Friendship Necklace have a unique orbit ring just around ring 3. Its familiars orbit clockwise faster.
Pickup Generation Familiars
Familiars that generate pickups when certain conditions are met.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Bomb Bag | 5.100.131 | ![]() |
Gives bombs | Spawns a familiar that drops a ![]() |
![]() ![]() |
Bum Friend | 5.100.144 | ![]() |
He's greedy | Spawns a familiar that picks up ![]() ![]() |
1 |
Dark Bum | 5.100.278 | ![]() |
He wants to take your life | Spawns a familiar that follows Isaac around and collects ![]() |
3 |
Little C.H.A.D. | 5.100.96 | ![]() |
Gives kisses | Spawns a familiar who drops a ![]() |
2 |
Mystery Sack | 5.100.271 | ![]() |
? | Spawns a familiar that drops a Heart, coin, ![]() ![]() |
2 |
Sack of Pennies | 5.100.94 | ![]() |
Gives money | Spawns a familiar that drops a ![]() |
1 |
The Relic | 5.100.98 | ![]() |
Soul generator | Spawns a cross familiar that drops a ![]() |
3 |
![]() |
5.100.385 | ![]() |
Bumbo want coin! | Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. | 1 |
![]() |
5.100.372 | ![]() |
Bbbzzzzzt! | Spawns a familiar that occasionally drops a ![]() |
![]() ![]() |
![]() |
5.100.388 | ![]() |
He wants your keys! | Spawns a familiar that follows Isaac and collects ![]() ![]() |
0 |
![]() |
5.100.362 | ![]() |
What's in the box? | Spawns a chest familiar that spawns a random pickup (25% chance) or trinket (10% chance) upon clearing a room. | 2 |
![]() |
5.100.389 | ![]() |
Rune generator | Spawns a familiar that drops a random rune after clearing enough rooms. | 3 |
![]() |
5.100.403 | ![]() |
Mod buddy! | Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a ![]() |
1 |
![]() |
5.100.363 | ![]() |
Protective friend | Spawns an orbital familiar which does ![]() ![]() ![]() |
![]() ![]() |
![]() |
5.100.491 | ![]() |
Pills pills pills! | Spawns a familiar that drops a random pill every 3 rooms. Upon using a pill, all enemies in the room are poisoned. | 2 |
![]() |
5.100.500 | ![]() |
Gives sacks | Spawns a familiar that drops a ![]() |
![]() ![]() |
![]() |
5.100.565 | ![]() |
What a cute little thing! | Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac. Dealing enough damage to it returns it to normal. | 1 |
![]() |
5.100.612 | ![]() |
Protect him | Creates a ghostly familiar that closely follows behind Isaac. It dies in one hit, but respawns at the start of the next floor. Each time it survives until the next floor, it rewards Isaac with ![]() ![]() |
![]() ![]() |
Note: Only the second, third, and fourth stages of
Bumbo generate pickups.
Note: Only the second and third stages of
Blood Puppy generate pickups.
Shooting Familiars
Familiars that attack with their own tears or other ranged effects. Most shooting familiars only shoot as long as Isaac is attacking or charging a shot, though there are others that target and fire automatically.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Scissors | 5.100.325 | ![]() |
Lose your head | Turns Isaac's head into a stationary familiar for the current room which fires tears automatically. ![]() |
![]() ![]() |
![]() |
5.100.504 | ![]() |
Friendly fly | Spawns a stationary fly turret that lasts for the current room and fires tears at nearby enemies. | 0 |
![]() |
5.100.703 | ![]() |
Lost brother | Swaps between the current character and Esau Jr., who has +2 flat damage and flight. Characters have independent items and health. Dying as either character ends the run. | ![]() ![]() |
![]() |
5.100.728 | ![]() |
Demonic gestation | Spawns a demon familiar for the current room attached to Isaac that moves and fires in the direction Isaac shoots, using Isaac's damage, tears, range, shot speed, and special tear effects. | 3 |
![]() |
5.100.713 | ![]() |
Blood to blood | Removes half a heart and creates a Clot familiar that mimics Isaac's movements and tear effects. As ![]() |
3 |
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Abel | 5.100.188 | ![]() |
Mirrored buddy | ![]() ![]() |
0 |
Ball of Bandages | 5.100.207 | ![]() |
Gotta lick 'em all! | Creates an orbital familiar. Collecting additional copies gives it the ability to shoot Charm tears, then chase enemies to deal contact damage, then deal even more contact damage. | ![]() ![]() |
Brother Bobby | 5.100.8 | ![]() |
Friends 'till the end | Spawns a familiar that follows Isaac around shooting tears that deal 3.5 damage. ![]() |
1 |
Cain's Other Eye | 5.100.319 | ![]() |
Near-sighted friend | ![]() ![]() |
2 |
Cube of Meat | 5.100.73 | ![]() |
Gotta meat 'em all! | Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage. | ![]() ![]() |
Demon Baby | 5.100.113 | ![]() |
Auto-turret friend | Spawns a familiar that follows Isaac and automatically fires at enemies in its reach. | ![]() ![]() |
Ghost Baby | 5.100.163 | ![]() |
Spectral buddy | Spawns a familiar that follows Isaac around and fires spectral tears. | 1 |
Harlequin Baby | 5.100.167 | ![]() |
Double shot buddy | Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern. | 1 |
Lil Brimstone | 5.100.275 | ![]() |
Evil friend | Grants a familiar that charges a thin ![]() |
2 |
Little Gish | 5.100.99 | ![]() |
Sticky friend | Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed. | ![]() ![]() |
Little Steven | 5.100.100 | ![]() |
Psychic friend | Spawns a familiar who follows Isaac around and fires homing tears. | 2 |
Mongo Baby | 5.100.322 | ![]() |
Mongo friend | Spawns a familiar that copies the tears of Isaac's other familiars. | 2 |
Rainbow Baby | 5.100.174 | ![]() |
Random buddy | Spawns a familiar that follows Isaac around and fires tears with random effects. | 1 |
Robo-Baby | 5.100.95 | ![]() |
Friends 'till the bbbbzzzt | Spawns a familiar that shoots ![]() |
1 |
Robo-Baby 2.0 | 5.100.267 | ![]() |
We worked out all the kinks | Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears. | 1 |
Rotten Baby | 5.100.268 | ![]() |
Infested friend | Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time. | 3 |
Sister Maggy | 5.100.67 | ![]() |
Friends 'till the end | ![]() ![]() |
1 |
![]() |
5.100.385 | ![]() |
Bumbo want coin! | Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. | 1 |
![]() |
5.100.361 | ![]() |
Your fate beside you | A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage. | 2 |
![]() |
5.100.360 | ![]() |
Dark friend | Spawns a demonic familiar that shoots tears identical to Isaac's in terms of damage, tears, and tear effects. | 4 |
![]() |
5.100.435 | ![]() |
4-way buddy! | Spawns a Loki familiar that follows Isaac and fires 4 tears in a cross pattern. | 1 |
![]() |
5.100.430 | ![]() |
Turret follower | Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies. | 1 |
![]() |
5.100.390 | ![]() |
Sworn friend | Spawns an angel familiar who follows Isaac and fires homing tears which deal 10 damage and have 75% shot speed. | 3 |
![]() |
5.100.518 | ![]() |
What could it be?! | Spawns a familiar with a random tear effect. The familiar is randomized at the start of each floor. | 2 |
![]() |
5.100.471 | ![]() |
Ain't he cute? | Spawns a familiar that fires clusters of tears. Must be charged before shooting. | 2 |
![]() |
5.100.537 | ![]() |
Puking buddy | Drops a random pill, and spawns a familiar that charges up and fires creep. Using pills changes the creep type. | 1 |
![]() |
5.100.607 | ![]() |
Messy friend | Gives Isaac a familiar that fires chaotic bursts of tears in all directions. | 1 |
![]() |
5.100.629 | ![]() |
Defense drone | Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles. | 3 |
![]() |
5.100.608 | ![]() |
Iced iced baby | Spawns a shooting familiar that has a chance to petrify enemies, and freezes monsters upon killing them. | 2 |
![]() |
5.100.658 | ![]() |
Micro friends | Causes Isaac to spawn Minisaac familiars when he takes damage, which chase and shoot at nearby enemies. | 1 |
![]() |
5.100.679 | ![]() |
Abyssal friend | Spawns a familiar that charges a miniature ![]() |
2 |
![]() |
5.100.661 | ![]() |
They lurk inside | The first five enemies killed in a room will spawn stationary shooting familiars where they died. | 2 |
![]() |
5.100.575 | ![]() |
Invasive friend | A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. | ![]() ![]() |
![]() |
5.100.698 | ![]() |
Double trouble! | Spawns two familiars that float on either side of Isaac and fire tears that use his tears, range, shot speed, and tear effects, and scale with damage. | 4 |
![]() |
5.100.276 | ![]() |
Protect it | Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. ![]() |
0 |
![]() |
5.100.470 | ![]() |
Lil hush! | Spawns a ![]() ![]() |
0 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
???'s Soul | 5.350.57 | ![]() |
Imaginary Friend | Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to ![]() |
Isaac's Head | 5.350.54 | ![]() |
Dead friend | Spawns Isaac's severed head as a tear-firing familiar. Fires piercing tears. |
Umbilical Cord | 5.350.33 | ![]() |
Fetal Protection | When brought down to only a ![]() ![]() ![]() ![]() |
![]() |
5.350.180 | ![]() |
Finally! | Spawns a familiar that copies Isaac's movements and scales with damage and tears. If it takes damage, it will die and respawn on the next floor. |
![]() |
5.350.176 | ![]() |
Mini friend | Spawns a clot familiar that mimics Isaac's movements and tears. It dies for the current room after taking too much damage. |
Note: Only second stage Cube of Meat and
Ball of Bandages shoot tears.
Note: Only third stage
Bumbo fires tears.
Note: Most shooting familiars that follow Isaac take 5th priority along the familiar line. This is the second to last priority with the last being non-combat familiars. There are some exceptions such as
Incubus which has 2nd priority,
Lil Brimstone and
Lil Monstro which have 3rd priority, and
Boiled Baby which has 6th priority.
Note: Using five or more different copies of
Esau Jr. will destroy the item and spawn a familiar that behaves the same way as
Abel.
Wandering Familiars
Familiars that move around the room sporadically.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Punching Bag | 5.100.281 | ![]() |
Scape goat | Spawns a ![]() |
1 |
Sissy Longlegs | 5.100.280 | ![]() |
She loves you | Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. ![]() |
1 |
![]() |
5.100.403 | ![]() |
Mod buddy! | Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a ![]() |
1 |
![]() |
5.100.526 | ![]() |
Lil harbingers! | Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. | 2 |
![]() |
5.100.492 | ![]() |
Yo listen! | +1 luck. Spawns a fairy familiar that points out ![]() ![]() |
2 |
Note: The
Spider Baby transformation grants a familiar nearly identical to
Spider Mod with the only difference being the lack of ability to see enemy HP bars.
Note: Only
Famine,
Pestilence, and
Conquest in
7 Seals wander randomly.
Bouncing Familiars
Familiars that bounce around the room in a zig-zag pattern, changing directions when hitting a wall.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
![]() |
5.100.605 | ![]() |
Plop! | Summons ![]() |
![]() ![]() |
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
BBF | 5.100.272 | ![]() |
Big Beautiful Fly | Spawns a familiar that flies around the room in a zig-zag pattern and explodes on contact with an enemy. Respawns after ten seconds. | ![]() ![]() |
The Peeper | 5.100.155 | ![]() |
Plop! | Spawns a familiar that slowly floats around the room in a zig-zag pattern, damaging enemies it passes through. ![]() |
2 |
![]() |
5.100.417 | ![]() |
Damage booster | Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5× tear damage multiplier. | 3 |
![]() |
5.100.470 | ![]() |
Lil hush! | Spawns a ![]() ![]() |
0 |
![]() |
5.100.319 | ![]() |
Near-sighted friend | ![]() ![]() |
|
![]() |
5.100.405 | ![]() |
Double tap glitch | ![]() ![]() |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
???'s Soul | 5.350.57 | ![]() |
Imaginary Friend | Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to ![]() |
Mimicking Familiars 
Familiars that copy Isaac's movements after a certain delay.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Multidimensional Baby | 5.100.431 | ![]() |
ydduB Buddy | Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed. | 2 |
Obsessed Fan | 5.100.426 | ![]() |
Follows my every move... | Spawns a familiar that follows Isaac's movements on a delay and deals 30 contact damage per second to enemies. | 0 |
Papa Fly | 5.100.430 | ![]() |
Turret follower | Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies. | 1 |
![]() |
5.100.468 | ![]() |
It follows | Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly ![]() |
0 |
![]() |
5.100.433 | ![]() |
Me! And my shaaaadow! | ![]() ![]() ![]() ![]() |
![]() ![]() |
Throwable Familiars
Familiars that are thrown by Isaac by shooting and can return to him after awhile.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
![]() |
5.100.706 | ![]() |
Come forth from the depths | Destroys all items in the room and gives Isaac a unique locust familiar for each item destroyed. Many items generate locusts with special effects. | ![]() ![]() |
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Bob's Brain | 5.100.273 | ![]() |
Explosive thoughts | Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds. | ![]() ![]() |
Little Chubby | 5.100.88 | ![]() |
Attack buddy | Spawns a ![]() |
![]() ![]() |
![]() |
5.100.473 | ![]() |
Chub chub | Spawns a familiar that follows Isaac and charges across the room when Isaac fires, blocking shots and dealing 40.5 damage per second on contact. | 1 |
![]() |
5.100.548 | ![]() |
Fetch! | Spawns a familiar that flies through the room while firing, dealing a flat 7 contact damage to enemies and retrieving pickups. | 1 |
![]() |
5.100.626 | ![]() |
??? | Combined with ![]() ![]() |
0 |
![]() |
5.100.627 | ![]() |
??? | Combined with ![]() ![]() |
0 |
![]() |
5.100.681 | ![]() |
It hungers | Spawns a familiar that flies forward, consuming pickups in its path and dealing damage to enemies. Each pickup increases its size and damage and spawns a Blue Fly. ![]() ![]() 1 + (stage number) pickups, opens a portal which leads to a special room with contents that persist between floors.
|
![]() ![]() |
![]() |
5.100.405 | ![]() |
Double tap glitch | ![]() ![]() |
1 |
![]() |
5.100.178 | ![]() |
Splash! | ![]() ![]() |
3 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
![]() |
5.350.186 | ![]() |
Attack buddy | Spawns an attack locust familiar which will fly forward while Isaac shoots. |
Note:
Knife Piece 1 and
Knife Piece 2 are only throwable when combined.
Controlled Familiars
Familiars that move in the direction Isaac is shooting.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
![]() |
5.100.635 | ![]() |
Bait and switch | Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar. | 1 |
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
???'s Only Friend | 5.100.320 | ![]() |
Controlled friend | Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys | 1 |
Robo-Baby 2.0 | 5.100.267 | ![]() |
We worked out all the kinks | Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears. | 1 |
Others
Familiars that don't fit into any of the above categories or that produce multiple effects.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Monster Manual | 5.100.123 | ![]() |
Temporary buddy generator | ![]() ![]() |
1 |
![]() |
5.100.516 | ![]() |
Sprinkles. | Creates a stationary sprinkler for the current room that rotates and fires tears in 8 directions. The tears copy Isaac's stats and most tear effects. | ![]() ![]() |
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
1up! | 5.100.11 | ![]() |
Extra life | Gives Isaac an extra life. Upon death, he will respawn in the previous room with full health, after which 1up! will disappear. | 2 |
Dead Cat | 5.100.81 | ![]() |
9 lives | Sets Isaac's Red Heart Containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container. | 3 |
Dry Baby | 5.100.265 | ![]() |
Immortal friend | Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering ![]() |
3 |
Guppy's Hairball | 5.100.187 | ![]() |
Swing it | Spawns a familiar that loosely follows behind Isaac, which blocks shots and can be swung like a flail to damage enemies. Grows bigger by killing enemies. | 1 |
Headless Baby | 5.100.269 | ![]() |
Bloody friend | Spawns a familiar that follows Isaac, leaving blood creep on the ground. | 1 |
Holy Water | 5.100.178 | ![]() |
Splash! | ![]() ![]() |
3 |
Isaac's Heart | 5.100.276 | ![]() |
Protect it | Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. ![]() |
0 |
Juicy Sack | 5.100.266 | ![]() |
Sticky babies | Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. | 2 |
Key Piece 1 | 5.100.238 | ![]() |
??? | Combined with ![]() ![]() ![]() ![]() |
0 |
Key Piece 2 | 5.100.239 | ![]() |
??? | Combined with ![]() ![]() ![]() ![]() |
0 |
Samson's Chains | 5.100.321 | ![]() |
The ol' ball and chain | Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most Obstacles. | 1 |
![]() |
5.100.412 | ![]() |
Feed them hate | After taking damage a certain amount of times, a permanent demonic familiar spawns. | ![]() ![]() |
![]() |
5.100.387 | ![]() |
Peace be with you | Spawns a familiar which creates a circular aura that slows down enemies and enemy shots inside. | ![]() ![]() |
![]() |
5.100.404 | ![]() |
He farts! | Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which charms, poisons, or knocks back nearby enemies. | 1 |
![]() |
5.100.413 | ![]() |
Feed them love | Upon picking up a certain amount of health, spawn a permanent angelic familiar. | 1 |
![]() |
5.100.384 | ![]() |
A gurd of your own! | A ![]() |
![]() ![]() |
![]() |
5.100.365 | ![]() |
Lost protector | Spawns a fly familiar that moves in a straight line and circles around the first wall or obstacle it hits. ![]() ![]() |
2 |
![]() |
5.100.436 | ![]() |
Don't cry over it... | ![]() ![]() ![]() |
1 |
![]() |
5.100.511 | ![]() |
He's violent | Spawns a fly familiar that orbits around a random enemy and deals 30 damage per second to enemies it comes in contact with. | 1 |
![]() |
5.100.469 | ![]() |
:( | Spawns a familiar that leaves a trail of creep that damages enemies at 6 damage per second. Has a chance to spawn damaging beams of light onto enemies that touch the cloud. | 1 |
![]() |
5.100.467 | ![]() |
Watch where you point that! | Spawns a finger familiar that faces in the same direction as Isaac, rapidly damaging enemies it points at for 10% of Isaac's damage. | 1 |
![]() |
5.100.543 | ![]() |
Portable sanctuary | Spawns a white poop familiar, which turns into a ![]() ![]() |
1 |
![]() |
5.100.472 | ![]() |
Hail to the king baby | Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, other familiars stop moving. | 1 |
![]() |
5.100.519 | ![]() |
Delirious friend | Grants a familiar that transforms into another random familiar every 10 seconds. | ![]() ![]() |
![]() |
5.100.539 | ![]() |
Sacrificial insemination | Spawns an egg familiar, which hatches a random friendly monster when Isaac is hurt once per room. The power of the monster improves for each consecutive room cleared without taking damage. | ![]() ![]() |
![]() |
5.100.544 | ![]() |
Stabbing time | Spawns a bone familiar that hovers back and forth in front of Isaac, dealing damage equal to Isaac's damage. | ![]() ![]() |
![]() |
5.100.569 | ![]() |
Bleed me dry | Stabs Isaac at the beginning of each floor, draining his ![]() |
1 |
![]() |
5.100.652 | ![]() |
Kick it! | Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills. | 1 |
![]() |
5.100.649 | ![]() |
Bouncy friend | Gives Isaac a miniature ![]() |
1 |
![]() |
5.100.658 | ![]() |
Micro friends | Causes Isaac to spawn Minisaac familiars when he takes damage, which chase and shoot at nearby enemies. | 1 |
![]() |
5.100.626 | ![]() |
??? | Combined with ![]() ![]() |
0 |
![]() |
5.100.627 | ![]() |
??? | Combined with ![]() ![]() |
0 |
![]() |
5.100.615 | ![]() |
Puffy buddy | Spawns a Dumpy familiar that pushes away nearby enemies and projectiles just before Isaac is about to be hit, then falls asleep. He can be awoken by walking to him. | 3 |
![]() |
5.100.567 | ![]() |
Keep the flame burning | Gives Isaac a familiar that grants +0.4 Fire Rate for each consecutive room he's cleared without taking damage. The bonus stacks up to five times. | 3 |
![]() |
5.100.651 | ![]() |
Follow the light | Spawns a star familiar that slowly travels towards the ![]() |
3 |
![]() |
5.100.697 | ![]() |
He wants revenge | Spawns a familiar that becomes a weaker clone of the floor's boss when entering the ![]() |
![]() ![]() |
![]() |
5.100.682 | ![]() |
Clingy buddy | Gives Isaac a ![]() |
3 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
![]() |
5.350.97 | ![]() |
Sick... | When hit, there is a small chance to spawn a permanent tonsil familiar that blocks enemy shots. This can happen twice, after which the trinket is destroyed. |
Name | ID | Icon | Message | Description |
---|---|---|---|---|
![]() |
5.300.92 | ![]() |
Motherhood | Grants one permanent familiar from the Baby Shop pool. Can give familiars that Isaac already has. |
Unlockable Achievements
![]() ![]() |
---|