Chapter 4 (Bosses)

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Bosses
Normal mode only Normal / Hard mode only Hard
(except in Rebirth) Greed mode only Greed / (except in Rebirth and Afterbirth) Greedier mode only Greedier
Others

WombWomb

Boss Blastocyst portrait.png
Boss Lokii portrait.png
Boss Mama Gurdy portrait.png
Boss Mr. Fred portrait.png
Blastocyst Lokii Mama Gurdy Mr. Fred
Boss Scolex portrait.png
Boss The Bloat portrait.png
Boss Daddy Long Legs portrait.png
Boss Triachnid portrait.png
Scolex The Bloat (except in Repentance and Repentance+) Daddy Long Legs (except in Repentance and Repentance+) Triachnid (except in Repentance and Repentance+) Needs to be unlocked
Boss Teratoma portrait.png
Boss Death portrait.png
Boss Conquest portrait.png
Boss Headless Horseman portrait.png
Teratoma (except in Repentance and Repentance+) Death Needs to be unlocked Conquest Needs to be unlocked Headless Horseman Needs to be unlocked
Boss The Fallen portrait.png
Boss The Matriarch portrait.png
Boss Sisters Vis portrait.png
The Fallen Devil Room Icon.png The Matriarch (except in Rebirth and Afterbirth) Needs to be unlocked Sisters Vis (in Afterbirth †) Needs to be unlocked

Double Trouble

Double Trouble Bosses
Boss Dingle portrait.png
Boss The Cage portrait.png
Boss The Fallen portrait.png
Boss The Gate portrait.png
(Double Trouble)
Dingle 		(Double Trouble)
The Cage 		(Double Trouble)
The Fallen 		(Double Trouble)
The Gate
Boss Gurdy portrait.png
Boss Dangle portrait.png
Boss Little Horn portrait.png
(Double Trouble)
Gurdy 		(Double Trouble)
Dangle (except in Rebirth) Needs to be unlocked 		(Double Trouble)
Little Horn (except in Rebirth) Needs to be unlocked

UteroUtero

Boss Lokii portrait.png
Boss The Bloat portrait.png
Boss Daddy Long Legs portrait.png
Boss Triachnid portrait.png
Lokii The Bloat Daddy Long Legs Triachnid Needs to be unlocked
Boss Teratoma portrait.png
Boss Mr. Fred portrait.png
Boss Mama Gurdy portrait.png
Boss Blastocyst portrait.png
Teratoma Mr. Fred (except in Repentance and Repentance+) Mama Gurdy (except in Repentance and Repentance+) Blastocyst (except in Repentance and Repentance+)
Boss Death portrait.png
Boss Conquest portrait.png
Boss Headless Horseman portrait.png
Boss The Fallen portrait.png
Death Needs to be unlocked Conquest Needs to be unlocked Headless Horseman Needs to be unlocked The Fallen Devil Room Icon.png
Boss Sisters Vis portrait.png
Boss The Matriarch portrait.png
Sisters Vis (in Afterbirth †) Needs to be unlocked The Matriarch (in Afterbirth †) Needs to be unlocked

Double Trouble

Double Trouble Bosses
Boss The Cage portrait.png
Boss The Fallen portrait.png
Boss The Gate portrait.png
(Double Trouble)
The Cage 		(Double Trouble)
The Fallen 		(Double Trouble)
The Gate
Boss Gurdy portrait.png
Boss Loki portrait.png
Boss Little Horn portrait.png
(Double Trouble)
Gurdy 		(Double Trouble)
Loki 		(Double Trouble)
Little Horn (except in Rebirth) Needs to be unlocked

(except in Rebirth) Scarred WombScarred Womb

Boss Blastocyst portrait.png
Boss Mama Gurdy portrait.png
Boss Scolex portrait.png
Boss Triachnid portrait.png
Blastocyst Mama Gurdy Scolex Triachnid Needs to be unlocked
Boss Daddy Long Legs portrait.png
Boss Teratoma portrait.png
Boss The Bloat portrait.png
Boss Death portrait.png
Daddy Long Legs (except in Repentance and Repentance+) Teratoma (except in Repentance and Repentance+) The Bloat (except in Repentance and Repentance+) Death Needs to be unlocked
Boss Conquest portrait.png
Boss Headless Horseman portrait.png
Boss The Fallen portrait.png
Boss The Matriarch portrait.png
Conquest Needs to be unlocked Headless Horseman Needs to be unlocked The Fallen Devil Room Icon.png The Matriarch (except in Rebirth and Afterbirth) Needs to be unlocked
Boss Sisters Vis portrait.png
Boss Lokii portrait.png
Boss Mr. Fred portrait.png
Sisters Vis (in Afterbirth †) Needs to be unlocked Lokii (in Repentance and Repentance+) Mr. Fred (in Repentance and Repentance+)

Double Trouble

Double Trouble Bosses
Boss Gurdy portrait.png
(Double Trouble)
Gurdy

Final Boss

Boss Mom's Heart ingame.pngMom's Heart will always appear in the second floor of this chapter or in the last boss room if Curse of the Labyrinth.pngCurse of the Labyrinth is active. Once Boss It Lives! ingame.pngIt Lives! is unlocked, it will appear instead of Mom's Heart.

Boss Mom's Heart portrait.png
Boss It Lives! portrait.png
Mom's Heart It Lives! Needs to be unlocked

Notes


Boss Monstro portrait.png Bosses Boss Monstro portrait.png
Chapter 1
Stage Basement icon.pngStage Cellar icon.pngStage Burning Basement icon.png 		Boss Monstro ingame.pngMonstro • Boss Gemini ingame.pngGemini • Boss Steven ingame.pngSteven • Boss Dingle ingame.pngDingle • Gurgling.pngGurglings • Boss Larry Jr. ingame.pngLarry Jr. • Boss The Duke of Flies ingame.pngThe Duke of Flies • Boss Widow ingame.pngWidow • Boss Blighted Ovum ingame.pngBlighted Ovum • Boss The Haunt ingame.pngThe Haunt • Boss Pin ingame.pngPin • Boss Famine ingame.pngFamine • Boss The Fallen ingame.pngThe Fallen • Boss Headless Horseman ingame.pngHeadless Horseman
(except in Rebirth) Boss Dangle ingame.pngDangle • Boss Turdlings ingame.pngTurdlings • Boss Little Horn ingame.pngLittle Horn • Boss Rag Man ingame.pngRag Man
(in Repentance and Repentance+) Boss Baby Plum ingame.pngBaby Plum
(in Repentance and Repentance+) Chapter 1.5
Stage Downpour icon.pngStage Dross icon.png 		(in Repentance and Repentance+) Boss The Rainmaker ingame.pngThe Rainmaker • Boss Min-Min ingame.pngMin-Min • Boss Lil Blub (Downpour) ingame.pngLil Blub • Boss Wormwood (Downpour) ingame.pngWormwood • Boss Clog ingame.pngClog • Boss Colostomia ingame.pngColostomia • Boss Turdlet ingame.pngTurdlet
Chapter 2
Stage Caves icon.pngStage Catacombs icon.pngStage Flooded Caves icon.png 		Boss Fistula ingame.pngFistula • Boss Chub ingame.pngChub • Boss C.H.A.D. ingame.pngC.H.A.D. • Boss Gurdy ingame.pngGurdy • Boss Mega Fatty ingame.pngMega Fatty • Boss Mega Maw ingame.pngMega Maw • Boss Gurdy Jr. ingame.pngGurdy Jr. • Boss Peep ingame.pngPeep • Boss The Husk ingame.pngThe Husk • Boss The Hollow ingame.pngThe Hollow • Boss Carrion Queen ingame.pngCarrion Queen • Boss Dark One ingame.pngDark One • Boss Polycephalus ingame.pngPolycephalus • Boss The Wretched ingame.pngThe Wretched • Boss Pestilence ingame.pngPestilence • Boss The Fallen ingame.pngThe Fallen • Boss Headless Horseman ingame.pngHeadless Horseman
(except in Rebirth) Boss The Stain ingame.pngThe Stain • Boss The Frail ingame.pngThe Frail • Boss The Forsaken ingame.pngThe Forsaken
(except in Rebirth and Afterbirth) Boss Big Horn ingame.pngBig Horn • Boss Rag Mega ingame.pngRag Mega
(in Repentance and Repentance+) Boss Bumbino ingame.pngBumbino
(in Repentance and Repentance+) Chapter 2.5
Stage Mines icon.pngStage Ashpit icon.png 		(in Repentance and Repentance+) Boss Reap Creep ingame.pngReap Creep • Boss Tuff Twins ingame.pngTuff Twins • Boss Hornfel ingame.pngHornfel • Boss Great Gideon ingame.pngGreat Gideon • Boss The Pile ingame.pngThe Pile • Boss The Shell ingame.pngThe Shell • Boss Singe ingame.pngSinge • Boss Clutch ingame.pngClutch
Chapter 3
Stage Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png 		Boss Monstro II ingame.pngMonstro II • Boss Gish ingame.pngGish • Boss The Cage ingame.pngThe Cage • Boss The Gate ingame.pngThe Gate • Boss Loki ingame.pngLoki • Boss The Adversary ingame.pngThe Adversary • Boss The Bloat ingame.pngThe Bloat • Boss Mask of Infamy ingame.pngMask of Infamy • Boss War ingame.pngWar • Boss The Fallen ingame.pngThe Fallen • Boss Headless Horseman ingame.pngHeadless Horseman • Boss Mom ingame.pngMom
(except in Rebirth) Boss Brownie ingame.pngBrownie
(except in Rebirth and Afterbirth) Boss Sisters Vis ingame.pngSisters Vis
(in Repentance and Repentance+) Boss Reap Creep ingame.pngReap Creep • Boss The Pile ingame.pngThe Pile
(in Repentance and Repentance+) Chapter 3.5
Stage Mausoleum icon.pngStage Gehenna icon.png 		(in Repentance and Repentance+) Boss The Siren ingame.pngThe Siren • Boss The Heretic ingame.pngThe Heretic • Boss The Visage ingame.pngThe Visage • Boss The Horny Boys ingame.pngThe Horny Boys • Boss Mom ingame.pngMom • Boss Mom's Heart ingame.pngMom's Heart
Chapter 4
Stage Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png 		Boss Blastocyst ingame.pngBlastocyst • Boss Mama Gurdy ingame.pngMama Gurdy • Boss Scolex ingame.pngScolex • Boss Mr. Fred ingame.pngMr. Fred • Boss Lokii ingame.pngLokii • Boss The Bloat ingame.pngThe Bloat • Boss Daddy Long Legs ingame.pngDaddy Long Legs • Boss Triachnid ingame.pngTriachnid • Boss Teratoma ingame.pngTeratoma • Boss Death ingame.pngDeath • Boss Conquest ingame.pngConquest • Boss The Fallen ingame.pngThe Fallen • Boss Headless Horseman ingame.pngHeadless Horseman • Boss Mom's Heart ingame.pngMom's Heart • Boss It Lives! ingame.pngIt Lives!
(except in Rebirth and Afterbirth) Boss The Matriarch ingame.pngThe Matriarch
(except in Rebirth) ???
??? 		(except in Rebirth) Boss Hush ingame.pngHush
(in Repentance and Repentance+) Corpse
Stage Corpse icon.png 		(in Repentance and Repentance+) Boss Chimera ingame.pngChimera • Boss The Scourge ingame.pngThe Scourge • Boss Rotgut ingame.pngRotgut • Boss Mother secondphase ingame.pngMother
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png 		Boss Satan ingame.pngSatan • Boss Isaac ingame.pngIsaac
Chapter 6
Stage Dark Room icon.pngChest 		Boss ??? ingame.png??? • Boss The Lamb ingame.pngThe Lamb • Mega Satan Head ingame.pngMega Satan
(except in Rebirth and Afterbirth) The Void
Stage The Void icon.png 		(except in Rebirth and Afterbirth) Boss Delirium ingame.pngDelirium
(in Repentance and Repentance+) Home
Stage Home icon.png 		(in Repentance and Repentance+) Boss Dogma ingame.pngDogma • Boss Ultra Famine ingame.pngUltra Famine • Boss Ultra Pestilence ingame.pngUltra Pestilence • Boss Ultra War ingame.pngUltra War • Boss Ultra Death ingame.pngUltra Death • Boss The Beast ingame.pngThe Beast
(except in Rebirth) Greed Mode
Ultra Greed 		(except in Rebirth) Boss Ultra Greed ingame.pngUltra Greed
(except in Rebirth and Afterbirth) Boss Ultra Greedier ingame.pngUltra Greedier
SmallIsaac.pngThe Binding of Isaac: RebirthSmallIsaac.png
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