Chapter 2 (Bosses)

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Bosses
Normal mode only Normal / Hard mode only Hard
(except in Rebirth) Greed mode only Greed / (except in Rebirth and Afterbirth) Greedier mode only Greedier
Others

CavesCaves

Boss Chub portrait.png
Boss C.H.A.D. portrait.png
Boss Gurdy portrait.png
 Boss Gurdy Jr. portrait.png
Chub C.H.A.D. Needs to be unlocked Gurdy Gurdy Jr.
Boss Mega Fatty portrait.png
Boss Mega Maw portrait.png
Boss Peep portrait.png
Boss Dark One portrait.png
Mega Fatty Mega Maw Peep Dark One (except in Repentance and Repentance+)
Boss Pestilence portrait.png
Boss Headless Horseman portrait.png
Boss The Fallen portrait.png
Boss The Stain portrait.png
Pestilence Needs to be unlocked Headless Horseman Needs to be unlocked The Fallen Devil Room Icon.png The Stain (except in Rebirth) Needs to be unlocked
Boss The Frail portrait.png
Boss The Forsaken portrait.png
Boss Big Horn portrait.png
Boss Rag Mega portrait.png
The Frail (in Afterbirth and Afterbirth †) Needs to be unlocked The Forsaken (in Afterbirth and Afterbirth †) Needs to be unlocked Big Horn (except in Rebirth and Afterbirth) Needs to be unlocked Rag Mega (except in Rebirth and Afterbirth) Needs to be unlocked
Boss Fistula portrait.png
Boss Bumbino portrait.png
Fistula (in Repentance and Repentance+) Bumbino (in Repentance and Repentance+) Needs to be unlocked

Double Trouble

Double Trouble Bosses
Boss Dingle portrait.png
Boss The Duke of Flies portrait.png
 Boss Gemini portrait.png
Boss Larry Jr. portrait.png
(Double Trouble)
Dingle 		(Double Trouble)
The Duke of Flies 		(Double Trouble)
Gemini 		(Double Trouble)
Larry Jr.
Boss Monstro portrait.png
Boss Pin portrait.png
Boss Polycephalus portrait.png
Boss Rag Man portrait.png
(Double Trouble)
Monstro 		(Double Trouble)
Pin 		(Double Trouble)
Polycephalus 		(Double Trouble)
Rag Man (except in Rebirth) Needs to be unlocked

CatacombsCatacombs

Boss Carrion Queen portrait.png
Boss Dark One portrait.png
 Boss Gurdy Jr. portrait.png
Boss The Hollow portrait.png
Carrion Queen Dark One Gurdy Jr. The Hollow
Boss The Husk portrait.png
Boss Peep portrait.png
Boss Polycephalus portrait.png
Boss The Wretched portrait.png
The Husk Peep Polycephalus The Wretched
Boss Pestilence portrait.png
Boss Headless Horseman portrait.png
Boss The Fallen portrait.png
Boss The Forsaken portrait.png
Pestilence Needs to be unlocked Headless Horseman Needs to be unlocked The Fallen Devil Room Icon.png The Forsaken (except in Rebirth) Needs to be unlocked
Boss The Frail portrait.png
Boss The Stain portrait.png
Boss Big Horn portrait.png
Boss Rag Mega portrait.png
The Frail (except in Rebirth) Needs to be unlocked The Stain (in Afterbirth and Afterbirth †) Needs to be unlocked Big Horn (except in Rebirth and Afterbirth) Needs to be unlocked Rag Mega (except in Rebirth and Afterbirth) Needs to be unlocked
Boss Bumbino portrait.png
Bumbino (in Repentance and Repentance+) Needs to be unlocked

Double Trouble

Double Trouble Bosses
Boss Dingle portrait.png
Boss The Duke of Flies portrait.png
 Boss Gemini portrait.png
Boss Larry Jr. portrait.png
(Double Trouble)
Dingle 		(Double Trouble)
The Duke of Flies 		(Double Trouble)
Gemini 		(Double Trouble)
Larry Jr.
Boss Monstro portrait.png
Boss Pin portrait.png
Boss Rag Man portrait.png
Boss Gurglings portrait.png
(Double Trouble)
Monstro 		(Double Trouble)
Pin 		(Double Trouble)
Rag Man (except in Rebirth) Needs to be unlocked 		(Double Trouble)
Gurglings (in Repentance and Repentance+)

(except in Rebirth) Flooded CavesFlooded Caves

Boss Chub portrait.png
Boss C.H.A.D. portrait.png
Boss Gurdy portrait.png
 Boss Gurdy Jr. portrait.png
Chub C.H.A.D. Needs to be unlocked Gurdy Gurdy Jr.
Boss Peep portrait.png
Boss Polycephalus portrait.png
Boss Dark One portrait.png
Boss Pestilence portrait.png
Peep Polycephalus (except in Repentance and Repentance+) Dark One (except in Repentance and Repentance+) Pestilence Needs to be unlocked
Boss Headless Horseman portrait.png
Boss The Fallen portrait.png
Boss The Forsaken portrait.png
Boss The Frail portrait.png
Headless Horseman Needs to be unlocked The Fallen Devil Room Icon.png The Forsaken Needs to be unlocked The Frail Needs to be unlocked
Boss The Stain portrait.png
Boss Big Horn portrait.png
Boss Rag Mega portrait.png
Boss Fistula portrait.png
The Stain Needs to be unlocked Big Horn (except in Rebirth and Afterbirth) Needs to be unlocked Rag Mega (except in Rebirth and Afterbirth) Needs to be unlocked Fistula (in Repentance and Repentance+)
Boss Mega Maw portrait.png
Boss Mega Fatty portrait.png
Boss Bumbino portrait.png
Mega Maw (in Repentance and Repentance+) Mega Fatty (in Repentance and Repentance+) Bumbino (in Repentance and Repentance+) Needs to be unlocked

Double Trouble

Double Trouble Bosses
Boss The Duke of Flies portrait.png
 Boss Monstro portrait.png
Boss Rag Man portrait.png
 Boss Pin portrait.png
(Double Trouble)
The Duke of Flies 		(Double Trouble)
Monstro 		(Double Trouble)
Rag Man Needs to be unlocked 		(Double Trouble)
Pin (in Repentance and Repentance+)

Notes


Boss Monstro portrait.png Bosses Boss Monstro portrait.png
Chapter 1
Stage Basement icon.pngStage Cellar icon.pngStage Burning Basement icon.png 		Boss Monstro ingame.pngMonstro • Boss Gemini ingame.pngGemini • Boss Steven ingame.pngSteven • Boss Dingle ingame.pngDingle • Gurgling.pngGurglings • Boss Larry Jr. ingame.pngLarry Jr. • Boss The Duke of Flies ingame.pngThe Duke of Flies • Boss Widow ingame.pngWidow • Boss Blighted Ovum ingame.pngBlighted Ovum • Boss The Haunt ingame.pngThe Haunt • Boss Pin ingame.pngPin • Boss Famine ingame.pngFamine • Boss The Fallen ingame.pngThe Fallen • Boss Headless Horseman ingame.pngHeadless Horseman
(except in Rebirth) Boss Dangle ingame.pngDangle • Boss Turdlings ingame.pngTurdlings • Boss Little Horn ingame.pngLittle Horn • Boss Rag Man ingame.pngRag Man
(in Repentance and Repentance+) Boss Baby Plum ingame.pngBaby Plum
(in Repentance and Repentance+) Chapter 1.5
Stage Downpour icon.pngStage Dross icon.png 		(in Repentance and Repentance+) Boss The Rainmaker ingame.pngThe Rainmaker • Boss Min-Min ingame.pngMin-Min • Boss Lil Blub (Downpour) ingame.pngLil Blub • Boss Wormwood (Downpour) ingame.pngWormwood • Boss Clog ingame.pngClog • Boss Colostomia ingame.pngColostomia • Boss Turdlet ingame.pngTurdlet
Chapter 2
Stage Caves icon.pngStage Catacombs icon.pngStage Flooded Caves icon.png 		Boss Fistula ingame.pngFistula • Boss Chub ingame.pngChub • Boss C.H.A.D. ingame.pngC.H.A.D. • Boss Gurdy ingame.pngGurdy • Boss Mega Fatty ingame.pngMega Fatty • Boss Mega Maw ingame.pngMega Maw • Boss Gurdy Jr. ingame.pngGurdy Jr. • Boss Peep ingame.pngPeep • Boss The Husk ingame.pngThe Husk • Boss The Hollow ingame.pngThe Hollow • Boss Carrion Queen ingame.pngCarrion Queen • Boss Dark One ingame.pngDark One • Boss Polycephalus ingame.pngPolycephalus • Boss The Wretched ingame.pngThe Wretched • Boss Pestilence ingame.pngPestilence • Boss The Fallen ingame.pngThe Fallen • Boss Headless Horseman ingame.pngHeadless Horseman
(except in Rebirth) Boss The Stain ingame.pngThe Stain • Boss The Frail ingame.pngThe Frail • Boss The Forsaken ingame.pngThe Forsaken
(except in Rebirth and Afterbirth) Boss Big Horn ingame.pngBig Horn • Boss Rag Mega ingame.pngRag Mega
(in Repentance and Repentance+) Boss Bumbino ingame.pngBumbino
(in Repentance and Repentance+) Chapter 2.5
Stage Mines icon.pngStage Ashpit icon.png 		(in Repentance and Repentance+) Boss Reap Creep ingame.pngReap Creep • Boss Tuff Twins ingame.pngTuff Twins • Boss Hornfel ingame.pngHornfel • Boss Great Gideon ingame.pngGreat Gideon • Boss The Pile ingame.pngThe Pile • Boss The Shell ingame.pngThe Shell • Boss Singe ingame.pngSinge • Boss Clutch ingame.pngClutch
Chapter 3
Stage Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png 		Boss Monstro II ingame.pngMonstro II • Boss Gish ingame.pngGish • Boss The Cage ingame.pngThe Cage • Boss The Gate ingame.pngThe Gate • Boss Loki ingame.pngLoki • Boss The Adversary ingame.pngThe Adversary • Boss The Bloat ingame.pngThe Bloat • Boss Mask of Infamy ingame.pngMask of Infamy • Boss War ingame.pngWar • Boss The Fallen ingame.pngThe Fallen • Boss Headless Horseman ingame.pngHeadless Horseman • Boss Mom ingame.pngMom
(except in Rebirth) Boss Brownie ingame.pngBrownie
(except in Rebirth and Afterbirth) Boss Sisters Vis ingame.pngSisters Vis
(in Repentance and Repentance+) Boss Reap Creep ingame.pngReap Creep • Boss The Pile ingame.pngThe Pile
(in Repentance and Repentance+) Chapter 3.5
Stage Mausoleum icon.pngStage Gehenna icon.png 		(in Repentance and Repentance+) Boss The Siren ingame.pngThe Siren • Boss The Heretic ingame.pngThe Heretic • Boss The Visage ingame.pngThe Visage • Boss The Horny Boys ingame.pngThe Horny Boys • Boss Mom ingame.pngMom • Boss Mom's Heart ingame.pngMom's Heart
Chapter 4
Stage Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png 		Boss Blastocyst ingame.pngBlastocyst • Boss Mama Gurdy ingame.pngMama Gurdy • Boss Scolex ingame.pngScolex • Boss Mr. Fred ingame.pngMr. Fred • Boss Lokii ingame.pngLokii • Boss The Bloat ingame.pngThe Bloat • Boss Daddy Long Legs ingame.pngDaddy Long Legs • Boss Triachnid ingame.pngTriachnid • Boss Teratoma ingame.pngTeratoma • Boss Death ingame.pngDeath • Boss Conquest ingame.pngConquest • Boss The Fallen ingame.pngThe Fallen • Boss Headless Horseman ingame.pngHeadless Horseman • Boss Mom's Heart ingame.pngMom's Heart • Boss It Lives! ingame.pngIt Lives!
(except in Rebirth and Afterbirth) Boss The Matriarch ingame.pngThe Matriarch
(except in Rebirth) ???
??? 		(except in Rebirth) Boss Hush ingame.pngHush
(in Repentance and Repentance+) Corpse
Stage Corpse icon.png 		(in Repentance and Repentance+) Boss Chimera ingame.pngChimera • Boss The Scourge ingame.pngThe Scourge • Boss Rotgut ingame.pngRotgut • Boss Mother secondphase ingame.pngMother
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png 		Boss Satan ingame.pngSatan • Boss Isaac ingame.pngIsaac
Chapter 6
Stage Dark Room icon.pngChest 		Boss The Lamb ingame.pngThe Lamb • Boss ??? ingame.png??? • Mega Satan Head ingame.pngMega Satan
(except in Rebirth and Afterbirth) The Void
Stage The Void icon.png 		(except in Rebirth and Afterbirth) Boss Delirium ingame.pngDelirium
(in Repentance and Repentance+) Home
Stage Home icon.png 		(in Repentance and Repentance+) Boss Dogma ingame.pngDogma • Boss Ultra Famine ingame.pngUltra Famine • Boss Ultra Pestilence ingame.pngUltra Pestilence • Boss Ultra War ingame.pngUltra War • Boss Ultra Death ingame.pngUltra Death • Boss The Beast ingame.pngThe Beast
(except in Rebirth) Greed Mode
Ultra Greed 		(except in Rebirth) Boss Ultra Greed ingame.pngUltra Greed
(except in Rebirth and Afterbirth) Boss Ultra Greedier ingame.pngUltra Greedier
SmallIsaac.pngThe Binding of Isaac: RebirthSmallIsaac.png
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