Blank Rune

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(except in Rebirth)

Blank Rune is an unlockable rune added in The Binding of Isaac: Afterbirth.

Effects

  • Grants a random rune effect.
  • Has a 25% chance to drop another Blank Rune on the ground upon use.

Notes

  • The random rune effect can be from a rune that hasn't been unlocked yet.
  • (in Repentance and Repentance+) Blank Rune cannot replicate the effects of Soul Stones.

Strategy

  • The two most valuable rune effects from Blank Rune are PerthroPerthro for a re-roll, or EhwazEhwaz for a Crawl SpaceCrawl Space- which has a high chance of containing a free item. Therefore, the best use of Blank Rune is in a room with an item pedestal while also standing over a tile with a special graphic. (in Repentance and Repentance+) Using Blank Rune in a room with an item pedestal also has the chance to activate Black RuneBlack Rune, exchanging the item for stats.

Synergies

  • (except in Repentance and Repentance+)Tarot ClothTarot Cloth: Activates two random rune effects. Attempts to spawn additional Blank Rune twice.

In-game Footage

  • TBA