All Bosses (Bosses)

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Bosses
Normal mode only Normal / Hard mode only Hard
(except in Rebirth) Greed mode only Greed / (except in Rebirth and Afterbirth) Greedier mode only Greedier
Others

Bosses

Boss Monstro portrait.png
Boss Gemini portrait.png
Boss Steven portrait.png
 Boss Dingle portrait.png
Monstro Gemini Steven Needs to be unlocked Dingle
Boss Gurglings portrait.png
Boss Larry Jr. portrait.png
Boss The Duke of Flies portrait.png
 Boss Widow portrait.png
Gurglings Larry Jr. The Duke of Flies Widow
Boss Blighted Ovum portrait.png
Boss The Haunt portrait.png
 Boss Pin portrait.png
Boss Famine portrait.png
Blighted Ovum The Haunt Pin Famine Needs to be unlocked
Boss Fistula portrait.png
Boss Chub portrait.png
Boss C.H.A.D. portrait.png
Boss Gurdy portrait.png
Fistula Chub C.H.A.D. Needs to be unlocked Gurdy
Boss Mega Fatty portrait.png
 Boss Mega Maw portrait.png
Boss Gurdy Jr. portrait.png
Boss Peep portrait.png
Mega Fatty Mega Maw Gurdy Jr. Peep
Boss The Husk portrait.png
Boss The Hollow portrait.png
Boss Carrion Queen portrait.png
Boss Dark One portrait.png
The Husk The Hollow Carrion Queen Dark One
Boss Polycephalus portrait.png
Boss The Wretched portrait.png
Boss Pestilence portrait.png
Boss Monstro II portrait.png
Polycephalus The Wretched Pestilence Needs to be unlocked Monstro II
Boss Gish portrait.png
Boss The Cage portrait.png
Boss The Gate portrait.png
Boss Loki portrait.png
Gish Needs to be unlocked The Cage The Gate Loki
Boss The Adversary portrait.png
Boss The Bloat portrait.png
Boss Mask of Infamy portrait.png
Boss War portrait.png
The Adversary The Bloat Mask Of Infamy War Needs to be unlocked
Boss Blastocyst portrait.png
Boss Mama Gurdy portrait.png
Boss Scolex portrait.png
Boss Mr. Fred portrait.png
Blastocyst Mama Gurdy Scolex Mr. Fred
Boss Lokii portrait.png
Boss Daddy Long Legs portrait.png
Boss Triachnid portrait.png
Boss Teratoma portrait.png
Lokii Daddy Long Legs Triachnid Needs to be unlocked Teratoma
Boss Death portrait.png
Boss Conquest portrait.png
Boss Headless Horseman portrait.png
Boss The Fallen portrait.png
Death Needs to be unlocked Conquest Needs to be unlocked Headless Horseman Needs to be unlocked The Fallen Devil Room Icon.png

Afterbirth (except in Rebirth)

Boss Dangle portrait.png
Boss Turdlings portrait.png
Boss Little Horn portrait.png
Boss Rag Man portrait.png
Dangle Needs to be unlocked Turdlings Needs to be unlocked Little Horn Needs to be unlocked Rag Man Needs to be unlocked
Boss The Stain portrait.png
Boss The Forsaken portrait.png
Boss The Frail portrait.png
Boss Brownie portrait.png
The Stain Needs to be unlocked The Forsaken Needs to be unlocked The Frail Needs to be unlocked Brownie Needs to be unlocked

Afterbirth+ (except in Rebirth and Afterbirth)

Boss Big Horn portrait.png
Boss Rag Mega portrait.png
Boss Sisters Vis portrait.png
Boss The Matriarch portrait.png
Big Horn Needs to be unlocked Rag Mega Needs to be unlocked Sisters Vis Needs to be unlocked The Matriarch Needs to be unlocked

Repentance (in Repentance and Repentance+)

Boss Baby Plum portrait.png
Boss Bumbino portrait.png
Boss Reap Creep portrait.png
Boss The Pile portrait.png
Baby Plum Needs to be unlocked Bumbino Needs to be unlocked Reap Creep Needs to be unlocked The Pile Needs to be unlocked
Boss The Rainmaker portrait.png
Boss Min-Min portrait.png
Boss Lil Blub (Downpour) portrait.png
Boss Wormwood (Downpour) portrait.png
The Rainmaker Needs to be unlocked Min-Min Needs to be unlocked Lil Blub Needs to be unlocked Wormwood Needs to be unlocked
Boss Clog portrait.png
Boss Colostomia portrait.png
Boss Turdlet portrait.png
Boss Tuff Twins portrait.png
Clog Needs to be unlocked Colostomia Needs to be unlocked Turdlet Needs to be unlocked Tuff Twins Needs to be unlocked
Boss Hornfel portrait.png
Boss Great Gideon portrait.png
Boss Singe portrait.png
Boss The Shell portrait.png
Hornfel Needs to be unlocked Great Gideon Needs to be unlocked Singe Needs to be unlocked The Shell Needs to be unlocked
Boss Clutch portrait.png
Boss The Siren portrait.png
Boss The Heretic portrait.png
Boss The Visage portrait.png
Clutch Needs to be unlocked The Siren Needs to be unlocked The Heretic Needs to be unlocked The Visage Needs to be unlocked
Boss The Horny Boys portrait.png
Boss Chimera portrait.png
Boss The Scourge portrait.png
Boss Rotgut portrait.png
The Horny Boys Needs to be unlocked Chimera Needs to be unlocked The Scourge Needs to be unlocked Rotgut Needs to be unlocked
Boss Ultra Famine ingame.png
Boss Ultra Pestilence ingame.png
Boss Ultra War ingame.png
Boss Ultra Death ingame.png
Ultra Famine Needs to be unlocked Ultra Pestilence Needs to be unlocked Ultra War Needs to be unlocked Ultra Death Needs to be unlocked
Boss Dogma portrait.png
Dogma (in Repentance and Repentance+) Needs to be unlocked

Final Bosses

Boss Mom portrait.png
Boss Mom's Heart portrait.png
Boss It Lives! portrait.png
Boss Satan portrait.png
Mom Mom's Heart Needs to be unlocked It Lives! Needs to be unlocked Satan Needs to be unlocked
Boss Isaac portrait.png
Boss The Lamb portrait.png
???
Boss Mega Satan portrait.png
Isaac Needs to be unlocked The Lamb Needs to be unlocked ??? Needs to be unlocked Mega Satan Needs to be unlocked
Boss Hush portrait.png
Boss Delirium portrait.png
Boss Mother portrait.png
Hush (except in Rebirth) Needs to be unlocked Delirium (except in Rebirth and Afterbirth) Needs to be unlocked Mother (in Repentance and Repentance+) Needs to be unlocked
Boss The Beast ingame.png
Boss Ultra Greed portrait.png
Boss Ultra Greedier ingame.png
The Beast (in Repentance and Repentance+) Needs to be unlocked Ultra Greed (except in Rebirth) Ultra Greedier (except in Rebirth and Afterbirth) Needs to be unlocked


Boss Monstro portrait.png Bosses Boss Monstro portrait.png
Chapter 1
Stage Basement icon.pngStage Cellar icon.pngStage Burning Basement icon.png 		Boss Monstro ingame.pngMonstro • Boss Gemini ingame.pngGemini • Boss Steven ingame.pngSteven • Boss Dingle ingame.pngDingle • Gurgling.pngGurglings • Boss Larry Jr. ingame.pngLarry Jr. • Boss The Duke of Flies ingame.pngThe Duke of Flies • Boss Widow ingame.pngWidow • Boss Blighted Ovum ingame.pngBlighted Ovum • Boss The Haunt ingame.pngThe Haunt • Boss Pin ingame.pngPin • Boss Famine ingame.pngFamine • Boss The Fallen ingame.pngThe Fallen • Boss Headless Horseman ingame.pngHeadless Horseman
(except in Rebirth) Boss Dangle ingame.pngDangle • Boss Turdlings ingame.pngTurdlings • Boss Little Horn ingame.pngLittle Horn • Boss Rag Man ingame.pngRag Man
(in Repentance and Repentance+) Boss Baby Plum ingame.pngBaby Plum
(in Repentance and Repentance+) Chapter 1.5
Stage Downpour icon.pngStage Dross icon.png 		(in Repentance and Repentance+) Boss The Rainmaker ingame.pngThe Rainmaker • Boss Lil Blub (Downpour) ingame.pngLil Blub • Boss Min-Min ingame.pngMin-Min • Boss Wormwood (Downpour) ingame.pngWormwood • Boss Clog ingame.pngClog • Boss Colostomia ingame.pngColostomia • Boss Turdlet ingame.pngTurdlet
Chapter 2
Stage Caves icon.pngStage Catacombs icon.pngStage Flooded Caves icon.png 		Boss Fistula ingame.pngFistula • Boss Chub ingame.pngChub • Boss C.H.A.D. ingame.pngC.H.A.D. • Boss Gurdy ingame.pngGurdy • Boss Mega Fatty ingame.pngMega Fatty • Boss Mega Maw ingame.pngMega Maw • Boss Gurdy Jr. ingame.pngGurdy Jr. • Boss Peep ingame.pngPeep • Boss The Husk ingame.pngThe Husk • Boss The Hollow ingame.pngThe Hollow • Boss Carrion Queen ingame.pngCarrion Queen • Boss Dark One ingame.pngDark One • Boss Polycephalus ingame.pngPolycephalus • Boss The Wretched ingame.pngThe Wretched • Boss Pestilence ingame.pngPestilence • Boss The Fallen ingame.pngThe Fallen • Boss Headless Horseman ingame.pngHeadless Horseman
(except in Rebirth) Boss The Stain ingame.pngThe Stain • Boss The Frail ingame.pngThe Frail • Boss The Forsaken ingame.pngThe Forsaken
(except in Rebirth and Afterbirth) Boss Big Horn ingame.pngBig Horn • Boss Rag Mega ingame.pngRag Mega
(in Repentance and Repentance+) Boss Bumbino ingame.pngBumbino
(in Repentance and Repentance+) Chapter 2.5
Stage Mines icon.pngStage Ashpit icon.png 		(in Repentance and Repentance+) Boss Reap Creep ingame.pngReap Creep • Boss Tuff Twins ingame.pngTuff Twins • Boss Hornfel ingame.pngHornfel • Boss Great Gideon ingame.pngGreat Gideon • Boss The Pile ingame.pngThe Pile • Boss The Shell ingame.pngThe Shell • Boss Singe ingame.pngSinge • Boss Clutch ingame.pngClutch
Chapter 3
Stage Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png 		Boss Monstro II ingame.pngMonstro II • Boss Gish ingame.pngGish • Boss The Cage ingame.pngThe Cage • Boss The Gate ingame.pngThe Gate • Boss Loki ingame.pngLoki • Boss The Adversary ingame.pngThe Adversary • Boss The Bloat ingame.pngThe Bloat • Boss Mask of Infamy ingame.pngMask of Infamy • Boss War ingame.pngWar • Boss The Fallen ingame.pngThe Fallen • Boss Headless Horseman ingame.pngHeadless Horseman • Boss Mom ingame.pngMom
(except in Rebirth) Boss Brownie ingame.pngBrownie
(except in Rebirth and Afterbirth) Boss Sisters Vis ingame.pngSisters Vis
(in Repentance and Repentance+) Boss Reap Creep ingame.pngReap Creep • Boss The Pile ingame.pngThe Pile
(in Repentance and Repentance+) Chapter 3.5
Stage Mausoleum icon.pngStage Gehenna icon.png 		(in Repentance and Repentance+) Boss The Siren ingame.pngThe Siren • Boss The Heretic ingame.pngThe Heretic • Boss The Visage ingame.pngThe Visage • Boss The Horny Boys ingame.pngThe Horny Boys • Boss Mom ingame.pngMom • Boss Mom's Heart ingame.pngMom's Heart
Chapter 4
Stage Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png 		Boss Blastocyst ingame.pngBlastocyst • Boss Mama Gurdy ingame.pngMama Gurdy • Boss Scolex ingame.pngScolex • Boss Mr. Fred ingame.pngMr. Fred • Boss Lokii ingame.pngLokii • Boss The Bloat ingame.pngThe Bloat • Boss Daddy Long Legs ingame.pngDaddy Long Legs • Boss Triachnid ingame.pngTriachnid • Boss Teratoma ingame.pngTeratoma • Boss Death ingame.pngDeath • Boss Conquest ingame.pngConquest • Boss The Fallen ingame.pngThe Fallen • Boss Headless Horseman ingame.pngHeadless Horseman • Boss Mom's Heart ingame.pngMom's Heart • Boss It Lives! ingame.pngIt Lives!
(except in Rebirth and Afterbirth) Boss The Matriarch ingame.pngThe Matriarch
(except in Rebirth) ???
??? 		(except in Rebirth) Boss Hush ingame.pngHush
(in Repentance and Repentance+) Corpse
Stage Corpse icon.png 		(in Repentance and Repentance+) Boss Chimera ingame.pngChimera • Boss The Scourge ingame.pngThe Scourge • Boss Rotgut ingame.pngRotgut • Boss Mother secondphase ingame.pngMother
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png 		Boss Satan ingame.pngSatan • Boss Isaac ingame.pngIsaac
Chapter 6
Stage Dark Room icon.pngChest 		Boss ??? ingame.png??? • Boss The Lamb ingame.pngThe Lamb • Mega Satan Head ingame.pngMega Satan
(except in Rebirth and Afterbirth) The Void
Stage The Void icon.png 		(except in Rebirth and Afterbirth) Boss Delirium ingame.pngDelirium
(in Repentance and Repentance+) Home
Stage Home icon.png 		(in Repentance and Repentance+) Boss Dogma ingame.pngDogma • Boss Ultra Famine ingame.pngUltra Famine • Boss Ultra Pestilence ingame.pngUltra Pestilence • Boss Ultra War ingame.pngUltra War • Boss Ultra Death ingame.pngUltra Death • Boss The Beast ingame.pngThe Beast
(except in Rebirth) Greed Mode
Ultra Greed 		(except in Rebirth) Boss Ultra Greed ingame.pngUltra Greed
(except in Rebirth and Afterbirth) Boss Ultra Greedier ingame.pngUltra Greedier
SmallIsaac.pngThe Binding of Isaac: RebirthSmallIsaac.png
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