Achievements

For tips and strategies on completing achievements, see achievement tips.

Achievements are unlocked after completing Challenges, reaching certain milestones, achieving hidden goals, or unlocking certain items. In the PC version, every Steam achievement exactly corresponds to one secret in-game, whereas only a handful of secrets are represented by PSN trophies in the PlayStation version of the game.

If Isaac is unable to unlock achievements, a small icon of a crossed-out trophy will be displayed below the Key's counter. Conditions which can disable the ability to unlock achievements include:

• Using a pre-determined seed. Certain cosmetic and difficulty-increasing special seeds will still allow unlocks.
• During a Challenge, although the achievement for completing the challenge is unaffected.
• During a Daily Challenge, although the achievements associated with this game mode are unaffected.
• Playing with any enabled mod (unless Mom has been beaten).
• During Victory Laps.
• If the Debug Console is enabled (unless Mom has been beaten).

Rebirth has a total of 178 unlockable secrets. Afterbirth added 98 new secrets, for a total of 276. Afterbirth † added 63 new secrets, for a total of 339. Booster Pack #5 added 64 new secrets, for a total of 403. Repentance added 234 new secrets, for a total of 637. Repentance+ added 3 new secrets, for a total of 640.

Inside the stats menu, while having the "secrets" menu open, pressing Alt + F2 will sync unlocks with Steam achievements. If you have Steam achievements for secrets that haven't been unlocked in-game, they will be unlocked by doing this. NOTE: using this on a second file will take your first file and copy it (because Steam achievements don't consider the file you have unlocked it in).

All Achievements

Rebirth

Name	Image	Description	Unlock	In Game Secret Number
Magdalene		Unlocked a new character.	Have 7 or more Red Heart Containers at one time	1
Cain		Unlocked a new character.	Hold 55 Coins at one time	2
Judas		Unlocked a new character.	Defeat Satan	3
The Womb		Chapter 4 - The Womb unlocked.	Defeat Mom	4
The Harbingers		The horsemen are loose.	Defeat Mom	5
A Cube of Meat		Unlocked a new item. (Also unlocks the Ball of Bandages)	Defeat Mom	6
The Book of Revelations		Unlocked a new item.	Defeat a Harbinger	7
A Noose		Unlocked a new item.	Defeat Mom's Heart 3 times	8
The Nail		Unlocked a new item.	Complete the Boss Rush as Azazel	9
A Quarter		Unlocked a new item.	Defeat Mom's Heart 8 times	10
A Fetus in a Jar		Unlocked a new item.	Defeat Mom's Heart 9 times	11
A Small Rock		Unlocked a new item.	Destroy 100 Tinted Rocks	12
Monstro's Tooth		Unlocked a new item.	Beat Chapter 1	13
Lil' Chubby		Unlocked a new item.	Beat Chapter 2	14
Loki's Horns		Unlocked a new item.	Defeat Lokii	15
Something From The Future		New boss in the basement!	Beat Basement 40 times	16
Something Cute		New boss in the caves!	Beat Chapter 2 30 times	17
Something Sticky		New boss in the depths!	Beat Chapter 3 20 times	18
A Bandage		Unlocked a new item.	Make a Super Bandage Girl by picking up 4 copies of Ball of Bandages in one run; see Unlocking Super Meat Boy & Super Bandage Girl	19
A Cross		Unlocked a new item.	Defeat Isaac as Magdalene	20
A Bag of Pennies		Unlocked a new item.	Defeat Isaac as Cain	21
The Book of Sin		Unlocked a new item.	Defeat all 7 Deadly Sins	22
Little Gish		Unlocked a new item.	Defeat Gish	23
Little Steven		Unlocked a new item.	Defeat Steven	24
Little C.H.A.D.		Unlocked a new item.	Defeat C.H.A.D.	25
A Gamekid		Unlocked a new item.	Visit 10 Arcades	26
A Halo		Unlocked a new item.	Defeat Mom, Mom's Heart, or It Lives! using The Bible or XV - The Devil?	27
Mr. Mega		Unlocked a new item.	Destroy 10 Tinted Rocks	28
The D6		Isaac now holds the D6!	Defeat Isaac as ???	29
The Scissors		Unlocked a new item.	Die 100 times	30
The Parasite		Unlocked a new item.	Pick up any 2 of the following items in a single run: Bob's Rotten Head, Dead Cat, Cricket's Head, and Tammy's Head ( Any 2 items that have the 'dead' item tag)	31
???		Unlocked a new character.	Defeat Mom's Heart 10 times	32
Everything Is Terrible!!!		The game just got harder!	Defeat Mom's Heart 5 times	33
It Lives!		Your future's past waits.	Defeat Mom's Heart 11 times	34
Mom's Contact		Unlocked a new item.	Obtain three Yes Mother? items in one run	35
The Necronomicon		Unlocked a new item.	Use XIII - Death 4 times	36
Basement Boy		Beat basement without taking damage.	Beat Chapter 1 without taking damage	37
Spelunker Boy		Beat caves without taking damage.	Beat Chapter 2 without taking damage	38
Dark Boy		Beat depths without taking damage.	Beat Chapter 3 without taking damage	39
Mama's Boy		Beat womb without taking damage.	Beat Chapter 4 without taking damage	40
Golden God!		You are the best!!	Defeat ??? and The Lamb	41
Eve		Unlocked a new character.	Don't pick up any Hearts for 2 floors in a row	42
Mom's Knife		Unlocked a new item.	Defeat Satan as Isaac	43
The Razor		Unlocked a new item.	Defeat Satan as Eve	44
Guardian Angel		Unlocked a new item.	Defeat Satan as Magdalene	45
A Bag of Bombs		Unlocked a new item.	Defeat Satan as Cain	46
Demon Baby		Unlocked a new item.	Defeat The Lamb as Azazel	47
Forget Me Now		Unlocked a new item.	Defeat Satan as ???	48
The D20		Unlocked a new item.	Defeat ??? as Isaac	49
Celtic Cross		Unlocked a new item.	Defeat ??? as Magdalene	50
Abel		Unlocked a new item.	Defeat The Lamb as Cain	51
Curved Horn		Unlocked a new item.	Defeat The Lamb as Judas	52
Sacrificial Dagger		Unlocked a new item.	Defeat ??? as Eve	53
Bloody Lust		Unlocked a new item.	Defeat Isaac as Samson	54
Blood Penny		Unlocked a new item.	Defeat ??? as Samson	55
Blood Rights		Unlocked a new item.	Defeat Satan as Samson	56
The Polaroid		Unlocked a new item.	Defeat Isaac 5 times	57
Dad's Key		Unlocked a new item.	Pick up both Key Pieces from the Angels in one run	58
Blue Candle		Unlocked a new item.	Donate 900 coins to the Donation Machine	59
Burnt Penny		Unlocked a new item.	Complete Beans! (challenge #13)	60
Lucky Toe		Unlocked a new item.	Blow up 20 Shopkeepers	61
Epic Fetus		Unlocked a new item.	Complete The Family Man (challenge #19)	62
SMB Super Fan		Unlocked a new item.	Complete It's in the Cards (challenge #14)	63
Counterfeit Coin		Unlocked a new item.	Play either Shell Game or Hell Game 100 times	64
Guppy's Hairball		Unlocked a new item.	Become Guppy	65
A Forgotten Horseman		Unlocked a new boss!	Take 10 Angel Room items	66
Samson		Unlocked a new character.	Complete 2 floors in a row without taking damage	67
Something Icky		New boss in the womb!	Defeat Isaac 10 times	68
!Platinum God!		OMG!	Collect all non-DLC items in the game, and unlock all of the secrets and endings (minus The Lost and his 6 unlockable items)	69
Isaac's Head		Unlocked a new item.	Complete the Boss Rush as Isaac	70
Maggy's Faith		Unlocked a new item.	Defeat The Lamb as Magdalene	71
Judas' Tongue		Unlocked a new item.	Defeat Satan as Judas	72
???'s Soul		Unlocked a new item.	Defeat The Lamb as ???	73
Samson's Lock		Unlocked a new item.	Defeat The Lamb as Samson	74
Cain's Eye		Unlocked a new item.	Defeat ??? as Cain	75
Eve's Bird Foot		Unlocked a new item.	Defeat Isaac as Eve	76
The Left Hand		Unlocked a new item.	Defeat Ultra Pride as any character, or ??? as Judas	77
The Negative		Unlocked a new item.	Defeat Satan 5 times	78
Azazel		Unlocked a new character.	Make 3 Deals with the Devil in one run	79
Lazarus		Unlocked a new character.	Have 4 or more Soul Hearts at one time	80
Eden		Unlocked a new character.	Complete Chapter 4	81
The Lost		Unlocked a new character.	It's complicated Die in a Sacrifice Room while holding Missing Poster	82
Dead Boy		Beat Chest or Dark Room without taking damage.	Complete Chapter 6 without taking damage	83
The Real Platinum God		111% now stop playing!	Collect every non-DLC item, and unlock every secret and ending.	84
Lucky Rock		Destroy 100 rocks.	Destroy 100 rocks	85
The Cellar		Alt stage to the basement.	Beat all Basement bosses ( except Baby Plum) (not restricted to beating bosses in The Basement)	86
The Catacombs		Alt stage to the caves.	Beat all Caves bosses ( except Bumbino) (not restricted to beating bosses in The Caves)	87
The Necropolis		Alt stage to the depths.	Beat all Depths bosses ( except Reap Creep) (not restricted to beating bosses in The Depths)	88
Rune of Hagalaz		Unlocked a new item.	Complete Pitch Black (challenge #1)	89
Rune of Jera		Unlocked a new item.	Complete High Brow (challenge #2)	90
Rune of Ehwaz		Unlocked a new item.	Complete Head Trauma (challenge #3)	91
Rune of Dagaz		Unlocked a new item.	Complete Darkness Falls (challenge #4)	92
Rune of Ansuz		Unlocked a new item.	Complete The Tank (challenge #5)	93
Rune of Perthro		Unlocked a new item.	Complete Solar System (challenge #6)	94
Rune of Berkano		Unlocked a new item.	Complete Purist (challenge #20)	95
Rune of Algiz		Unlocked a new item.	Complete Cat Got Your Tongue (challenge #8)	96
Chaos Card		Unlocked a new item.	Complete Demo Man (challenge #9)	97
Credit Card		Unlocked a new item.	Complete Cursed! (challenge #10)	98
Rules Card		Unlocked a new item.	Complete Glass Cannon (challenge #11)	99
Card Against Humanity		Unlocked a new item.	Complete When Life Gives You Lemons (challenge #12)	100
Swallowed Penny		Unlocked a new item.	Complete Slow Roll (challenge #15)	101
Robo-Baby 2.0		Unlocked a new item.	Complete Computer Savvy (challenge #16)	102
Death's Touch		Unlocked a new item.	Complete Waka Waka (challenge #17)	103
Technology .5		Unlocked a new item.	Complete The Host (challenge #18)	104
Missing No.		Unlocked a new item.	Complete the Boss Rush as Lazarus	105
Isaac's Tears		Unlocked a new item.	Defeat Isaac as Isaac	106
Guillotine		Unlocked a new item.	Defeat Isaac as Judas	107
Judas' Shadow		Unlocked a new item.	Complete the Boss Rush as Judas	108
Maggy's Bow		Unlocked a new item.	Complete the Boss Rush as Magdalene	109
Cain's Other Eye		Unlocked a new item.	Complete the Boss Rush as Cain	110
Black Lipstick		Unlocked a new item.	Defeat The Lamb as Eve	111
Eve's Mascara		Unlocked a new item.	Complete the Boss Rush as Eve	112
Fate		Unlocked a new item.	Defeat ??? as ???	113
???'s Only Friend		Unlocked a new item.	Complete the Boss Rush as ???	114
Samson's Chains		Unlocked a new item.	Complete the Boss Rush as Samson	115
Lazarus' Rags		Unlocked a new item.	Defeat Isaac as Lazarus	116
Broken Ankh		Unlocked a new item.	Defeat Satan as Lazarus	117
Store Credit		Unlocked a new item.	Defeat ??? as Lazarus	118
Pandora's Box		Unlocked a new item.	Defeat The Lamb as Lazarus	119
Suicide King		Unlocked a new item.	Complete Suicide King (challenge #7)	120
Blank Card		Unlocked a new item.	Defeat Isaac as Eden	121
Book of Secrets		Unlocked a new item.	Defeat Satan as Eden	122
Mysterious Paper		Unlocked a new item.	Defeat ??? as Eden	123
Mystery Sack		Unlocked a new item.	Defeat The Lamb as Eden	124
Undefined		Unlocked a new item.	Complete the Boss Rush as Eden	125
Satanic Bible		Unlocked a new item.	Defeat Isaac as Azazel	126
Daemon's Tail		Unlocked a new item.	Defeat Satan as Azazel	127
Abaddon		Unlocked a new item.	Defeat ??? as Azazel	128
Isaac's Heart		Unlocked a new item.	Defeat Isaac as The Lost	129
The Mind		Unlocked a new item.	Defeat Satan as The Lost	130
The Body		Unlocked a new item.	Defeat ??? as The Lost	131
The Soul		Unlocked a new item.	Defeat The Lamb as The Lost	132
The D100		Unlocked a new item.	Complete the Boss Rush as The Lost	133
Blue Map		Unlocked a new item.	Donate 10 Coins to the Donation Machine	134
There's Options		Unlocked a new item.	Donate 50 Coins to the Donation Machine	135
Black Candle		Unlocked a new item	Donate 150 Coins to the Donation Machine	136
Red Candle		Unlocked a new item.	Donate 400 Coins to the Donation Machine	137
Stop Watch		Unlocked a new item	Donate 999 Coins to the Donation Machine	138
Wire Coat Hanger		Unlocked a new item.	Defeat Mom's Heart 4 times	139
Ipecac		Unlocked a new item.	Defeat Mom's Heart 6 times	140
Experimental Treatment		Unlocked a new item.	Defeat Mom's Heart 7 times	141
Krampus		Unlocked another miniboss!	Take 20 items from Devil Rooms	142
Head of Krampus		Unlocked a new item.	Defeat Krampus	143
Super Meat Boy		Built him out of meat cubes.	Make a Super Meat Boy by picking up 4 copies of Cube of Meat in one run; see Unlocking Super Meat Boy & Super Bandage Girl	144
Butter Bean		Unlocked a new item.	Destroy 100 Poops	145
Little Baggy		Unlocked a new item.	Pick up any 2 of the following items in a single run: Roid Rage, The Virus, Growth Hormones, Experimental Treatment, and Speed Ball ( Any 2 items that have the 'syringe' item tag)	146
Blood Bag		Unlocked a new item.	Use the Blood Donation Machine 30 times	147
The D4		Unlocked a new item.	Blow up 30 Slot Machine	148
Missing Poster		Unlocked a new item.	Defeat The Lamb as Isaac	149
Rubber Cement		Unlocked a new item.	Defeat Mom's Heart 2 times	150
Store Upgrade lv.1		Donated 20 pennies to the shop.	Donate 20 Coins to the Donation Machine	151
Store Upgrade lv.2		Donated 100 pennies to the shop.	Donate 100 Coins to the Donation Machine	152
Store Upgrade lv.3		Donated 200 pennies to the shop.	Donate 200 Coins to the Donation Machine	153
Store Upgrade lv.4		Donated 600 pennies to the shop.	Donate 600 Coins to the Donation Machine	154
Angels		They are waiting.	Complete Chapter 6	155
Godhead		Unlocked a new item.	Earn all 6 / 9 / 10 / 12 Completion Marks on Hard mode as The Lost	156
Darkness Falls		Unlocked Challenge #4.	Defeat Mom's Heart 11 times and unlock Eve Defeat Mom's Heart 11 times and defeat ??? as Eve	157
The Tank		Unlocked Challenge #5.	Have 7 or more Red Heart Containers at one time	158
Solar System		Unlocked Challenge #6.	Defeat Mom's Heart 3 times	159
Suicide King		Unlocked Challenge #7.	Defeat Mom's Heart 11 times and unlock Lazarus	160
Cat Got Your Tongue		Unlocked Challenge #8.	Become Guppy	161
Demo Man		Unlocked Challenge #9.	Defeat Mom's Heart 9 times	162
Cursed!		Unlocked Challenge #10.	Have 7 or more Red Heart Containers at one time	163
Glass Cannon		Unlocked Challenge #11.	Beat The Family Man (challenge #19), defeat Lokii, and unlock Judas	164
The Family Man		Unlocked Challenge #19.	Pick up both Key Pieces from the Angels in one run	165
Purist		Unlocked Challenge #20.	Defeat Mom	166
Lost Baby		Unlocked a new co-player baby.	Defeat Mom's Heart on Hard mode as Isaac	167
Cute Baby		Unlocked a new co-player baby.	Defeat Mom's Heart on Hard mode as Magdalene	168
Crow Baby		Unlocked a new co-player baby.	Defeat Mom's Heart on Hard mode as Eve	169
Shadow Baby		Unlocked a new co-player baby.	Defeat Mom's Heart on Hard mode as Judas	170
Glass Baby		Unlocked a new co-player baby.	Defeat Mom's Heart on Hard mode as Cain	171
Wrapped Baby		Unlocked a new co-player baby.	Defeat Mom's Heart on Hard mode as Azazel Defeat Mom's Heart on Hard mode as Lazarus	172
Begotten Baby		Unlocked a new co-player baby.	Defeat Mom's Heart on Hard mode as Lazarus Defeat Mom's Heart on Hard mode as Azazel	173
Dead Baby		Unlocked a new co-player baby.	Defeat Mom's Heart on Hard mode as ???	174
-0- Baby		Unlocked a new co-player baby.	Defeat Mom's Heart on Hard mode as The Lost	175
Glitch Baby		Unlocked a new co-player baby.	Defeat Mom's Heart on Hard mode as Eden	176
Fighting Baby		Unlocked a new co-player baby.	Defeat Mom's Heart on Hard mode as Samson	177
Lord of the Flies		You became Lord of the Flies.	Become Beelzebub	178

Afterbirth

Name	Image	Description	Unlock	In Game Secret Number
Fart Baby		Unlocked a new item.	Defeat Hush as Isaac	179
Purity		Unlocked a new item.	Defeat Hush as Magdalene	180
D12		Unlocked a new item.	Defeat Hush as Cain	181
Betrayal		Unlocked a new item.	Defeat Hush as Judas	182
Fate's Reward		Unlocked a new item.	Defeat Hush as ???	183
Athame		Unlocked a new item.	Defeat Hush as Eve	184
Blind Rage		Unlocked a new item.	Defeat Hush as Samson	185
Maw of the Void		Unlocked a new item.	Defeat Hush as Azazel	186
Empty Vessel		Unlocked a new item.	Defeat Hush as Lazarus	187
Eden's Blessing		Unlocked a new item.	Defeat Hush as Eden	188
Sworn Protector		Unlocked a new item.	Defeat Hush as The Lost	189
Incubus		Unlocked a new item.	Defeat Hush as Lilith	190
Keeper now holds... A Penny!		Unlocked a new item.	Defeat Hush as Keeper	191
Lil' Chest		Unlocked a new item.	Defeat Ultra Greed as Isaac	192
Censer		Unlocked a new item.	Defeat Ultra Greed as Magdalene	193
Evil Eye		Unlocked a new item.	Defeat Ultra Greed as Cain	194
My Shadow		Unlocked a new item.	Defeat Ultra Greed as Judas	195
Cracked Dice		Unlocked a new item.	Defeat Ultra Greed as ???	196
Black Feather		Unlocked a new item.	Defeat Ultra Greed as Eve	197
Lusty Blood		Unlocked a new item.	Defeat Ultra Greed as Samson	198
Lilith		Unlocked a new character.	Defeat Ultra Greed as Azazel	199
Key Bum		Unlocked a new item.	Defeat Ultra Greed as Lazarus	200
GB Bug		Unlocked a new item.	Defeat Ultra Greed as Eden	201
Zodiac		Unlocked a new item.	Defeat Ultra Greed as The Lost	202
Box of Friends		Unlocked a new item.	Defeat Ultra Greed as Lilith	203
Rib of Greed		Unlocked a new item.	Defeat Ultra Greed as Keeper	204
Cry Baby		Unlocked a new co-player baby.	Defeat Mega Satan as Isaac	205
Red Baby		Unlocked a new co-player baby.	Defeat Mega Satan as Magdalene	206
Green Baby		Unlocked a new co-player baby.	Defeat Mega Satan as Cain	207
Brown Baby		Unlocked a new co-player baby.	Defeat Mega Satan as Judas	208
Blue Baby		Unlocked a new co-player baby.	Defeat Mega Satan as ???	209
Lil' Baby		Unlocked a new co-player baby.	Defeat Mega Satan as Eve	210
Rage Baby		Unlocked a new co-player baby.	Defeat Mega Satan as Samson	211
Black Baby		Unlocked a new co-player baby.	Defeat Mega Satan as Azazel	212
Long Baby		Unlocked a new co-player baby.	Defeat Mega Satan as Lazarus	213
Yellow Baby		Unlocked a new co-player baby.	Defeat Mega Satan as Eden	214
White Baby		Unlocked a new co-player baby.	Defeat Mega Satan as The Lost	215
Big Baby		Unlocked a new co-player baby.	Defeat Mega Satan as Lilith	216
Noose Baby		Unlocked a new co-player baby.	Defeat Mega Satan as Keeper	217
Rune Bag		Unlocked a new item.	Defeat Isaac as Lilith	218
Cambion Conception		Unlocked a new item.	Defeat ??? as Lilith	219
Serpent's Kiss		Unlocked a new item.	Defeat Satan as Lilith	220
Succubus		Unlocked a new item.	Defeat The Lamb as Lilith	221
Immaculate Conception		Unlocked a new item.	Complete the Boss Rush as Lilith	222
Goat Head Baby		Unlocked a new co-player baby.	Defeat Mom's Heart on Hard mode as Lilith	223
Gold Heart		Unlocked a new item.	Complete XXXXXXXXL (challenge #21)	224
Get out of Jail Free Card		Unlocked a new item.	Complete SPEED! (challenge #22)	225
Gold Bomb		Unlocked a new item.	Complete Blue Bomber (challenge #23)	226
2 new pills		Unlocked a new item.	Complete PAY TO PLAY (challenge #24)	227
2 new pills		Unlocked a new item.	Complete Have a Heart (challenge #25)	228
Poker Chip		Unlocked a new item.	Complete I RULE! (challenge #26)	229
Stud Finder		Unlocked a new item.	Complete BRAINS! (challenge #27)	230
D8		Unlocked a new item.	Complete PRIDE DAY! (challenge #28)	231
Kidney Stone		Unlocked a new item.	Complete The Guardian (challenge #30) Complete Onan's Streak (challenge #29)	232
Blank Rune		Unlocked a new item.	Complete Onan's Streak (challenge #29) Complete The Guardian (challenge #30)	233
Blue Womb		Unlocked a hidden chapter.	Defeat Mom's Heart 10 times	234
1001%		Nerd x 1000000	Unlock all secrets and endings, and collect every item in the game Unlock as many of the previously mentioned things as there were in Afterbirth (Ex: Unlocking items that were not in Afterbirth, like Red Key, count towards this achievement, meaning you do not need to unlock items like Mega Blast to gain this achievement)	235
Keeper holds Wooden Nickel		Unlocked a new starting item.	Defeat Isaac as Keeper	236
Keeper holds Store Key		Unlocked a new starting item.	Defeat Satan as Keeper	237
Deep Pockets		Unlocked a new item.	Defeat ??? as Keeper	238
Karma		Unlocked a new item.	Defeat The Lamb as Keeper	239
Sticky Nickels		Unlocked a new item.	Complete the Boss Rush as Keeper	240
Super Greed Baby		Unlocked a new co-player baby.	Defeat Mom's Heart on Hard mode as Keeper	241
Lucky Pennies		Unlocked a new item.	Donate 2 Coins to the Greed Donation Machine	242
Special Hanging Shopkeepers		Unlocked a secret.	Donate 14 Coins to the Greed Donation Machine	243
Wooden Nickel		Unlocked a new item.	Donate 33 Coins to the Greed Donation Machine	244
Cain holds Paperclip		Unlocked a new starting item.	Donate 68 Coins to the Greed Donation Machine	245
Everything is Terrible 2!!!		Greed just got harder!	Donate 111 Coins to the Greed Donation Machine	246
Special Shopkeepers		Unlocked a secret.	Donate 234 Coins to the Greed Donation Machine	247
Eve now holds Razor Blade		Unlocked a new starting item.	Donate 439 Coins to the Greed Donation Machine	248
Store Key		Unlocked a new item.	Donate 666 Coins to the Greed Donation Machine	249
Lost holds Holy Mantle		Unlocked a new starting item.	Donate 879 Coins to the Greed Donation Machine	250
Keeper		Unlocked a new character.	Donate 1000 Coins to the Greed Donation Machine	251
Hive Baby		Unlocked a new co-player baby.	Earn all Hard mode Completion Marks as ???	252
Buddy Baby		Unlocked a new co-player baby.	Earn all Hard mode Completion Marks as Isaac	253
Colorful Baby		Unlocked a new co-player baby.	Earn all Hard mode Completion Marks as Magdalene	254
Whore Baby		Unlocked a new co-player baby.	Earn all Hard mode Completion Marks as Eve	255
Cracked Baby		Unlocked a new co-player baby.	Earn all Hard mode Completion Marks as Eden	256
Dripping Baby		Unlocked a new co-player baby.	Earn all Hard mode Completion Marks as Lazarus	257
Blinding Baby		Unlocked a new co-player baby.	Use Blank Card while holding XIX - The Sun	258
Sucky Baby		Unlocked a new co-player baby.	Earn all Hard mode Completion Marks as Azazel	259
Dark Baby		Unlocked a new co-player baby.	Earn all Hard mode Completion Marks as Lilith	260
Picky Baby		Unlocked a new co-player baby.	Earn all Hard mode Completion Marks as Cain	261
Revenge Baby		Unlocked a new co-player baby.	Earn all Hard mode Completion Marks as Samson	262
Belial Baby		Unlocked a new co-player baby.	Earn all Hard mode Completion Marks as Judas	263
Sale Baby		Unlocked a new co-player baby.	Earn all Hard mode Completion Marks as Keeper	264
XXXXXXXXL		Unlocked Challenge #21.	Defeat Mom	265
SPEED!		Unlocked Challenge #22.	Defeat Mom	266
Blue Bomber		Unlocked Challenge #23.	Destroy 10 Tinted Rocks and defeat Mom's Heart 11 times	267
PAY TO PLAY		Unlocked Challenge #24.	Defeat Isaac as Cain and destroy 10 Tinted Rocks	268
Have a Heart		Unlocked Challenge #25.	Defeat Mom	269
I RULE!		Unlocked Challenge #26.	Defeat ??? or The Lamb, defeat Satan as Isaac, and unlock The Negative Defeat ??? or The Lamb, and defeat Satan as Isaac Defeat Mega Satan and unlock The Negative	270
BRAINS!		Unlocked Challenge #27.	Defeat Isaac 5 times	271
PRIDE DAY!		Unlocked Challenge #28.	Defeat Mom	272
Onan's Streak		Unlocked Challenge #29.	Defeat Mom Unlock Judas and It Lives.	273
The Guardian		Unlocked Challenge #30.	Defeat Mom	274
Generosity		If only everyone was as generous as you are...	Donate 999 Coins to the Greed Donation Machine	275
Mega		Unlocked...	Defeat Mega Satan as every character ( except Tainted characters)	276

Afterbirth †

Name	Image	Description	Unlock	In Game Secret Number
Backasswards		Unlocked a new challenge.	Defeat ??? or The Lamb Defeat Mega Satan and unlock The Negative	277
Aprils fool		Unlocked a new challenge.	Defeat Mom	278
Pokey Mans		Unlocked a new challenge.	Defeat Mom's Heart 11 times	279
Ultra Hard		Unlocked a new challenge.	Defeat ??? or The Lamb. Possession of The Polaroid / The Negative is required, barring getting to Dark Room through a Sacrifice Room. Defeat Mega Satan and unlock The Negative	280
PONG		Unlocked a new challenge.	Defeat Isaac 5 times	281
D infinity		Unlocked a new item.	Defeat Delirium as Isaac	282
Eucharist		Unlocked a new item.	Defeat Delirium as Magdalene	283
Silver Dollar		Unlocked a new item.	Defeat Delirium as Cain	284
Shade		Unlocked a new item.	Defeat Delirium as Judas	285
King Baby		Unlocked a new co-player baby.	Defeat Delirium as ???	286
Bloody Crown		Unlocked a new item.	Defeat Delirium as Samson	287
Dull Razor		Unlocked a new item.	Defeat Delirium as Eve	288
Eden's Soul		Unlocked a new item.	Defeat Delirium as Eden	289
Dark Prince's Crown		Unlocked a new item.	Defeat Delirium as Azazel	290
Compound Fracture		Unlocked a new item.	Defeat Delirium as Lazarus	291
Euthanasia		Unlocked a new item.	Defeat Delirium as Lilith	292
Holy Card		Unlocked a new item.	Defeat Delirium as The Lost	293
Crooked Penny		Unlocked a new item.	Defeat Delirium as Keeper	294
Void		Unlocked a new item.	Defeat Delirium as Apollyon	295
D1		Unlocked a new item.	Defeat Ultra Greedier as Isaac	296
Glyph of Balance		Unlocked a new item.	Defeat Ultra Greedier as Magdalene	297
Sack of Sacks		Unlocked a new item.	Defeat Ultra Greedier as Cain	298
Eye of Belial		Unlocked a new item.	Defeat Ultra Greedier as Judas	299
Meconium		Unlocked a new item.	Defeat Ultra Greedier as ???	300
Stem Cell		Unlocked a new item.	Defeat Ultra Greedier as Samson	301
Crow Heart		Unlocked a new item.	Defeat Ultra Greedier as Eve	302
Metronome		Unlocked a new item.	Defeat Ultra Greedier as Eden	303
Bat Wing		Unlocked a new item.	Defeat Ultra Greedier as Azazel	304
Plan C		Unlocked a new item.	Defeat Ultra Greedier as Lazarus	305
Duality		Unlocked a new item.	Defeat Ultra Greedier as Lilith	306
Dad's Lost Coin		Unlocked a new item.	Defeat Ultra Greedier as The Lost	307
Eye of Greed		Unlocked a new item.	Defeat Ultra Greedier as Keeper	308
Black Rune		Unlocked a new item.	Defeat Ultra Greedier as Apollyon	309
Locust of Wrath		Unlocked a new item.	Defeat Isaac as Apollyon	310
Locust of Pestilence		Unlocked a new item.	Defeat Satan as Apollyon	311
Locust of Famine		Unlocked a new item.	Defeat ??? as Apollyon	312
Locust of Death		Unlocked a new item.	Defeat The Lamb as Apollyon	313
Locust of Conquest		Unlocked a new item.	Complete the Boss Rush as Apollyon	314
Hushy		Unlocked a new item.	Defeat Hush as Apollyon	315
Brown Nugget		Unlocked a new item.	Defeat Ultra Greed as Apollyon	316
Mort Baby		Unlocked a new co-player baby.	Defeat Mega Satan as Apollyon	317
Smelter		Unlocked a new item.	Defeat Mom's Heart or It Lives! on Hard mode as Apollyon	318
Apollyon Baby		Unlocked a new co-player baby.	Earn all Hard mode Completion Marks as Apollyon	319
New Area		Unlocked a new area.	Defeat Hush	320
Once More with Feeling!		Unlocked a new item.	Complete a Victory Lap by defeating The Lamb	321
Hat trick!		Unlocked a new item.	Get a 3-win streak	322
5 Nights at Mom's		Unlocked super special rocks.	Get a 5-win streak, using a different character each time ( this number can be reduced to 3, see the notes section)	323
Sin collector		Unlocked a new item.	Collect every entry in the Bestiary (bugged v190 - Mobs that don't exist in the bestiary are being counted. This allows Sin Collector to be unlocked without a complete bestiary)	324
Dedication		Unlocked a new item.	Participate in 31 Daily Challenges (they don't have to be consecutive; it will still count if Isaac dies in the first room)	325
ZIP!		Unlocked a new item.	Defeat The Lamb in under 20 minutes	326
It's the Key		Unlocked a new item.	Defeat The Lamb without taking Hearts, Coins, or Bombs through the entire run. Letting certain familiars (e.g. Bum Friend, Dark Bum, Bumbo or Lil Portal) or bosses (e.g. Bumbino) pick up the consumables fails this condition as well.	327
Mr. Resetter!		Unlocked a new item.	Reset 7 times in a row Switch PS4 Get a minus 10-win streak	328
Living on the edge		Unlocked a new item.	Complete a Chapter (floors I and II) after Basement, start-to-finish, with only half a Heart total (can use The Lost)	329
U Broke It!		Unlocked a new item.	Obtain 50 items in a run (duplicate passive items/familiars count towards the total, e.g., multiple Breakfast)	330
Laz Bleeds More!		Unlocked a new starting item.	Complete Backasswards (challenge #31)	331
Maggy Now Holds a Pill!		Unlocked a new starting item.	Complete Aprils Fool (challenge #32)	332
Charged Key		Unlocked a new item.	Complete Pokey Mans (challenge #33)	333
Samson Feels Healthy!		Unlocked a new starting item.	Complete Ultra Hard (challenge #34)	334
Greed's Gullet		Unlocked a new item.	Complete Pong (challenge #35)	335
The Marathon		Unlocked a new item.	Get a 5-win streak in the Daily Challenges (they don't have to be consecutive days, only the runs you play are counted)	336
RERUN		Unlocked the power of RERUN.	Complete 3 Victory Laps by defeating The Lamb	337
Delirious		Unlocked a new item.	Defeat Delirium	338
1000000%		Just Stop!	Collect every item in the game, unlock all secrets and endings, and complete the Bestiary	339
Apollyon		Unlocked a new character.	Defeat Mega Satan	340
Greedier!		New mode unlocked!	Donate 500 Coins to the Greed Donation Machine	341
Burning Basement		Alt stage to the basement.	Defeat Mom's Heart 11 times	342
Flooded Caves		Alt stage to the caves.	Defeat It Lives! 16 times	343
Dank Depths		Alt stage to the depths.	Defeat It Lives! 21 times	344
Scarred Womb		Alt stage to the womb.	Defeat It Lives! 30 times	345
Something wicked this way comes!		Unlocked new bosses!	Defeat ??? as 3 different Characters	346
Something wicked this way comes+!		Unlocked even more bosses!	Defeat ??? as 6 different Characters	347
The gate is open!		Unlocked new enemies!	Defeat The Lamb	348
Black Hole		Unlocked a new item.	Defeat 20 Portals	349 PS4 340
Mystery Gift		Unlocked a new item.	Destroy 500 rocks	350 PS4 341
Sprinkler		Unlocked a new item.	Beat Chapter 1 without taking damage	351 PS4 342
Angry Fly		Unlocked a new item.	Become Beelzebub	352 PS4 343
Bozo		Unlocked a new item.	Destroy 5 rainbow poops	353 PS4 344
Broken Modem		Unlocked a new item.	Complete 7 Daily Challenges (by touching the trophy at the end)	354 PS4 345
Buddy in a Box		Unlocked a new item.	Pick up 5 familiars in a single run	355 PS4 346
Fast Bombs		Unlocked a new item.	Defeat Little Horn 20 times	356 PS4 347
Lil Delirium		Unlocked a new item.	Defeat Delirium for the 1st time	357 PS4 348
Hairpin		Unlocked a new item.	Recharge using Lil' Batteries 20 times	358 PS4 349
Wooden Cross		Unlocked a new item.	Sleep in a bed	359 PS4 350
Butter!		Unlocked a new item.	Complete 2 Victory Laps by defeating The Lamb	360 PS4 351
Huge Growth		Unlocked a new item.	Increase in size 5 times in a single run via Magic Mushroom, "One makes you larger" pills, XI - Strength, etc.	361 PS4 352
Ancient Recall		Unlocked a new item.	Use Cards and Runes 20 times	362 PS4 353
Era Walk		Unlocked a new item.	Add both the Broken Watch and the Stop Watch to your collection	363 PS4 354
Coupon		Unlocked a new item.	Purchase anything from Shops, Devil Rooms, and/or Black Markets 50 times	364 PS4 355
Telekinesis		Unlocked a new item.	Beat Chapter 2 without taking damage	365 PS4 356
Moving Box		Unlocked a new item.	Use Pandora's Box in Dark Room	366 PS4 357
Jumper Cables		Unlocked a new item.	Pick up any 2 of the following items/trinkets in a single run: 9 Volt, The Battery, Car Battery, AAA Battery, and Watch Battery ( Any 2 items that have the 'battery' item tag)	367 PS4 358
Leprosy		Unlocked a new item.	Beat Chapter 3 without taking damage	368 PS4 359
Technology Zero		Unlocked a new item.	Pick up any 2 technology items in a single run ( Any 2 items that have the 'tech' item tag)	369 PS4 360
Filigree Feather		Unlocked a new item.	Acquire both Key Piece 1 and Key Piece 2	370 PS4 361
Mr. ME!		Unlocked a new item.	Open 20 Locked Chests	371 PS4 362
7 Seals		Unlocked a new item.	Defeat all 5 Harbingers	372 PS4 363
Angelic Prism		Unlocked a new item.	Defeat an Angel 10 times	373 PS4 364
Pop!		Unlocked a new item.	Beat Chapter 4 without taking damage	374 PS4 365
Door Stop		Unlocked a new item.	Blow up doors and Secret Room walls 50 times	375 PS4 366
Death's List		Unlocked a new item.	Take 25 Deals with the Devil	376
Haemolacria		Unlocked a new item.	Acquire Blood Clot 10 times	377
Lachryphagy		Unlocked a new item.	Collect 10 "Tears Up" items or pills in one run	378
Schoolbag		Unlocked a new item.	Enter 6 Shops in one run	379
Trisagion		Unlocked a new item.	Take 25 Angel Rooms items	380
Extension Cord		Unlocked a new item.	Have The Battery, 9 Volt, and Car Battery in Isaac's collection	381
Flat Stone		Unlocked a new item.	Acquire Rubber Cement 5 times	382
Sacrificial Altar		Unlocked a new item.	Take 50 Deals with the Devil	383
Lil Spewer		Unlocked a new item.	Have Isaac die to his own explosion from Ipecac, Bob's Rotten Head, or a Horf! pill	384
Blanket		Unlocked a new item.	Sleep in 10 beds	385
Marbles		Unlocked a new item.	Use 5 Gulp! pills in one run (Placebo uses count)	386
Mystery Egg		Unlocked a new item.	Spawn three charmed enemies in the same room	387
Rotten Penny		Unlocked a new item.	Have 20 Blue Flies at the same time	388
Baby-Bender		Unlocked a new item.	Use I - The Magician or Telepathy For Dummies while already having homing tears	389
The Forgotten		Unlocked a new character.	It's complicated	390
Bone Heart		Unlocked a new item.	It's complicated	391
Marrow		Unlocked a new item.	Defeat Mom's Heart or It Lives! on Hard mode as The Forgotten	392
Slipped Rib		Unlocked a new item.	Defeat Isaac as The Forgotten	393
Pointy Rib		Unlocked a new item.	Defeat Satan as The Forgotten	394
Jaw Bone		Unlocked a new item.	Defeat ??? as The Forgotten	395
Brittle Bones		Unlocked a new item.	Defeat The Lamb as The Forgotten	396
Divorce Papers		Unlocked a new item.	Complete the Boss Rush as The Forgotten	397
Hallowed Ground		Unlocked a new item.	Defeat Hush as The Forgotten	398
Finger Bone		Unlocked a new item.	Defeat Ultra Greed as The Forgotten	399
Dad's Ring		Unlocked a new item.	Defeat Ultra Greedier as The Forgotten	400
Book of the Dead		Unlocked a new item.	Defeat Delirium as The Forgotten	401
Bone Baby		Unlocked a new co-player baby.	Earn all Hard mode Completion Marks as The Forgotten	402
Bound Baby		Unlocked a new co-player baby.	Defeat Mega Satan as The Forgotten	403

Repentance

Name	Image	Description	Unlock	In Game Secret Number
Bethany		Beat Hard mode as Lazarus without losing a life	Defeat Mom's Heart/It Lives! on hard mode as Lazarus, without dying at all	404
Jacob and Esau		You are just like your father...	Defeat Mother	405
The Planetarium		Kids shouldn't believe in fortunes...	Collect any 3 items with the 'stars' item tag in a single run	406
A Secret Exit		Complete ??? 3 times.	Defeat Hush 3 times	407
Forgotten Lullaby		Get that song out of her head.	Blow up The Siren's skull after defeating her	408
Fruity Plum		Defeat Baby Plum 10 times.	Defeat Baby Plum 10 times	409
Plum Flute		Make a new friend!	Allow Baby Plum to escape instead of defeating her	410
Rotten Heart		Enter the Corpse...	Enter Corpse for the first time	411
Dross		Defeat all bosses in Downpour.	Defeat all bosses in Downpour	412
Ashpit		Defeat all bosses in the Mines.	Defeat all bosses in Mines	413
Gehenna		Defeat all bosses in the Mausoleum.	Defeat all bosses in Mausoleum	414
Red Key		The other side is calling...	Open Mom's Chest in Home	415
Wisp Baby		Beat the game in Hard mode with Bethany.	Defeat Mom's Heart or It Lives! on Hard mode as Bethany	416
Book of Virtues		Complete the Cathedral with Bethany.	Defeat Isaac as Bethany	417
Urn of Souls		Complete Sheol with Bethany.	Defeat Satan as Bethany	418
Blessed Penny		Complete the Chest with Bethany.	Defeat ??? as Bethany	419
Alabaster Box		Complete the Dark Room with Bethany.	Defeat The Lamb as Bethany	420
Beth's Faith		Complete Boss Rush with Bethany.	Complete the Boss Rush as Bethany	421
Soul Locket		Beat Greed mode with Bethany.	Defeat Ultra Greed as Bethany	422
Divine Intervention		Complete ??? with Bethany.	Defeat Hush as Bethany	423
Vade Retro		Beat Greedier mode with Bethany.	Defeat Ultra Greedier as Bethany	424
Star of Bethlehem		Beat the Void with Bethany.	Defeat Delirium as Bethany	425
Hope Baby		Beat everything in Hard mode with Bethany.	Earn all Hard mode Completion Marks as Bethany	426
Glowing Baby		Defeat Mega Satan with Bethany.	Defeat Mega Satan as Bethany	427
Double Baby		Beat the game in Hard mode with Jacob and Esau.	Defeat Mom's Heart or It Lives! on Hard mode as Jacob and Esau	428
The Stairway		Complete the Cathedral with Jacob and Esau.	Defeat Isaac as Jacob and Esau	429
Red Stew		Complete Sheol with Jacob and Esau.	Defeat Satan as Jacob and Esau	430
Birthright		Complete the Chest with Jacob and Esau.	Defeat ??? as Jacob and Esau	431
Damocles		Complete the Dark Room with Jacob and Esau.	Defeat The Lamb as Jacob and Esau	432
Rock Bottom		Complete Boss Rush with Jacob and Esau.	Complete Boss Rush as Jacob and Esau	433
Inner Child		Beat Greed mode with Jacob and Esau.	Defeat Ultra Greed as Jacob and Esau	434
Vanishing Twin		Complete ??? with Jacob and Esau.	Defeat Hush as Jacob and Esau	435
Genesis		Beat Greedier mode with Jacob and Esau.	Defeat Ultra Greedier as Jacob and Esau	436
Suplex!		Complete the Void with Jacob and Esau.	Defeat Delirium as Jacob and Esau	437
Solomon's Baby		Beat everything in Hard mode with Jacob and Esau.	Earn all Hard mode Completion Marks as Jacob and Esau	438
Illusion Baby		Defeat Mega Satan with Jacob and Esau.	Defeat Mega Satan as Jacob and Esau	439
Meat Cleaver		Complete the Corpse with Isaac.	Defeat Mother as Isaac	440
Options?		Complete the final chapter with Isaac.	Defeat The Beast as Isaac	441
Yuck Heart		Complete the Corpse with Magdalene.	Defeat Mother as Magdalene	442
Candy Heart		Complete the final chapter with Magdalene.	Defeat The Beast as Magdalene	443
Guppy's Eye		Complete the Corpse with Cain.	Defeat Mother as Cain	444
A Pound of Flesh		Complete the final chapter with Cain.	Defeat The Beast as Cain	445
Akeldama		Complete the Corpse with Judas.	Defeat Mother as Judas	446
Redemption		Complete the final chapter with Judas.	Defeat The Beast as Judas	447
Eternal D6		Complete the Corpse with ???.	Defeat Mother as ???	448
Montezuma's Revenge		Complete the final chapter with ???.	Defeat The Beast as ???	449
Bird Cage		Complete the Corpse with Eve.	Defeat Mother as Eve	450
Cracked Orb		Complete the final chapter with Eve.	Defeat The Beast as Eve	451
Bloody Gust		Complete the Corpse with Samson.	Defeat Mother as Samson	452
Empty Heart		Complete the final chapter with Samson.	Defeat The Beast as Samson	453
Devil's Crown		Complete the Corpse with Azazel.	Defeat Mother as Azazel	454
Lil Abaddon		Complete the final chapter with Azazel.	Defeat The Beast as Azazel	455
Tinytoma		Complete the Corpse with Lazarus.	Defeat Mother as Lazarus	456
Astral Projection		Complete the final chapter with Lazarus.	Defeat The Beast as Lazarus	457
'M		Complete the Corpse with Eden.	Defeat Mother as Eden	458
Everything Jar		Complete the final chapter with Eden.	Defeat The Beast as Eden	459
Lost Soul		Complete the Corpse with the Lost.	Defeat Mother as The Lost	460
Hungry Soul		Complete the final chapter with the Lost.	Defeat The Beast as The Lost	461
Blood Puppy		Complete the Corpse with Lilith.	Defeat Mother as Lilith	462
C Section		Complete the final chapter with Lilith.	Defeat The Beast as Lilith	463
Keeper's Sack		Complete the Corpse with Keeper.	Defeat Mother as Keeper	464
Keeper's Box		Complete the final chapter with Keeper.	Defeat The Beast as Keeper	465
Lil Portal		Complete the Corpse with Apollyon.	Defeat Mother as Apollyon	466
Worm Friend		Complete the final chapter with Apollyon.	Defeat The Beast as Apollyon	467
Bone Spurs		Complete the Corpse with the Forgotten.	Defeat Mother as The Forgotten	468
Spirit Shackles		Complete the final chapter with the Forgotten.	Defeat The Beast as The Forgotten	469
Revelation		Complete the Corpse with Bethany.	Defeat Mother as Bethany	470
Jar of Wisps		Complete the final chapter with Bethany.	Defeat The Beast as Bethany	471
Magic Skin		Complete the Corpse with Jacob and Esau.	Defeat Mother as Jacob and Esau	472
Friend Finder		Complete the final chapter with Jacob and Esau.	Defeat The Beast as Jacob and Esau	473
The Broken		???	Use Red Key (etc.) to open the hidden closet in Home as Isaac	474
The Dauntless		???	Use Red Key (etc.) to open the hidden closet in Home as Magdalene	475
The Hoarder		???	Use Red Key (etc.) to open the hidden closet in Home as Cain	476
The Deceiver		???	Use Red Key (etc.) to open the hidden closet in Home as Judas	477
The Soiled		???	Use Red Key (etc.) to open the hidden closet in Home as ???	478
The Curdled		???	Use Red Key (etc.) to open the hidden closet in Home as Eve	479
The Savage		???	Use Red Key (etc.) to open the hidden closet in Home as Samson	480
The Benighted		???	Use Red Key (etc.) to open the hidden closet in Home as Azazel	481
The Enigma		???	Use Red Key (etc.) to open the hidden closet in Home as Lazarus	482
The Capricious		???	Use Red Key (etc.) to open the hidden closet in Home as Eden	483
The Baleful		???	Use Red Key (etc.) to open the hidden closet in Home as The Lost	484
The Harlot		???	Use Red Key (etc.) to open the hidden closet in Home as Lilith	485
The Miser		???	Use Red Key (etc.) to open the hidden closet in Home as Keeper	486
The Empty		???	Use Red Key (etc.) to open the hidden closet in Home as Apollyon	487
The Fettered		???	Use Red Key (etc.) to open the hidden closet in Home as The Forgotten	488
The Zealot		???	Use Red Key (etc.) to open the hidden closet in Home as Bethany	489
The Deserter		???	Use Red Key (etc.) to open the hidden closet in Home as Jacob and Esau	490
Glitched Crown		???	Defeat The Beast as Tainted Isaac	491
Belly Jelly		???	Defeat The Beast as Tainted Magdalene	492
Blue Key		???	Defeat The Beast as Tainted Cain	493
Sanguine Bond		???	Defeat The Beast as Tainted Judas	494
The Swarm		???	Defeat The Beast as Tainted ???	495
Heartbreak		???	Defeat The Beast as Tainted Eve	496
Larynx		???	Defeat The Beast as Tainted Samson	497
Azazel's Rage		???	Defeat The Beast as Tainted Azazel	498
Salvation		???	Defeat The Beast as Tainted Lazarus	499
TMTRAINER		???	Defeat The Beast as Tainted Eden	500
Sacred Orb		???	Defeat The Beast as Tainted Lost	501
Twisted Pair		???	Defeat The Beast as Tainted Lilith	502
Strawman		???	Defeat The Beast as Tainted Keeper	503
Echo Chamber		???	Defeat The Beast as Tainted Apollyon	504
Isaac's Tomb		???	Defeat The Beast as Tainted Forgotten	505
Vengeful Spirit		???	Defeat The Beast as Tainted Bethany	506
Esau Jr.		???	Defeat The Beast as Tainted Jacob	507
Bloody Mary		Unlocked a new challenge.	Unlock Bethany, Blood Bag, and It Lives!	508
Baptism by Fire		Unlocked a new challenge.	Defeat Satan as Bethany, defeat Mom's Heart 11 times, and unlock Maggy's Faith	509
Isaac's Awakening		Unlocked a new challenge.	Defeat Mother	510
Seeing Double		Unlocked a new challenge.	Defeat Mother	511
Pica Run		Unlocked a new challenge.	Defeat Mom's Heart 11 times and unlock Marbles	512
Hot Potato		Unlocked a new challenge.	Unlock Tainted Forgotten	513
Cantripped!		Unlocked a new challenge.	Unlock Tainted Cain	514
Red Redemption		Unlocked a new challenge.	Unlock Tainted Jacob	515
DELETE THIS		TODO: remove this achievement	Unlock Tainted Eden	516
Dirty Mind		Complete Challenge 36.	Complete Scat Man (challenge #36)	517
Sigil of Baphomet		Complete Challenge 37.	Complete Bloody Mary (challenge #37)	518
Purgatory		Complete Challenge 38.	Complete Baptism by Fire (challenge #38)	519
Spirit Sword		Complete Challenge 39.	Complete Isaac's Awakening (challenge #39)	520
Broken Glasses		Complete Challenge 40.	Complete Seeing Double (challenge #40)	521
Ice Cube		Complete Challenge 41.	Complete Pica Run (challenge #41)	522
Charged Penny		They will charge you up... for a small fee.	Donate to Battery Bums until they pay out with an item 5 times	523
The Fool		???	Defeat Ultra Greedier as Tainted Lost	524
The Magician		???	Defeat Ultra Greedier as Tainted Judas	525
The High Priestess		???	Defeat Ultra Greedier as Tainted Lilith	526
The Empress		???	Defeat Ultra Greedier as Tainted Eve	527
The Emperor		???	Defeat Ultra Greedier as Tainted ???	528
The Hierophant		???	Defeat Ultra Greedier as Tainted Bethany	529
The Lovers		???	Defeat Ultra Greedier as Tainted Magdalene	530
The Chariot		Complete Challenge 42.	Complete Hot Potato (challenge #42)	531
Justice		Complete Challenge 43.	Complete Cantripped (challenge #43)	532
The Hermit		Complete Challenge 44.	Complete Red Redemption (challenge #44)	533
Wheel of Fortune		???	Defeat Ultra Greedier as Tainted Cain	534
Strength		???	Defeat Ultra Greedier as Tainted Samson	535
The Hanged Man		???	Defeat Ultra Greedier as Tainted Keeper	536
Death		???	Defeat Ultra Greedier as Tainted Forgotten	537
Temperance		INVALID_DESCRIPTION	Complete DELETE THIS (challenge #45)	538
The Devil		???	Defeat Ultra Greedier as Tainted Azazel	539
The Tower		???	Defeat Ultra Greedier as Tainted Apollyon	540
The Stars		???	Defeat Ultra Greedier as Tainted Isaac	541
The Sun and the Moon		???	Defeat Ultra Greedier as Tainted Jacob	542
Judgement		???	Defeat Ultra Greedier as Tainted Lazarus	543
The World		???	Defeat Ultra Greedier as Tainted Eden	544
Old Capacitor		Kill 10 Battery Bums.	Kill 10 Battery Bums	545
Brimstone Bombs		Kill Hornfel before he escapes!	After breaking Hornfel's minecart, kill him before he can escape	546
Mega Mush		Beat everything in Hard Mode as every character.	Earn all Hard mode Completion Marks for all non-Tainted characters	547
Mom's Lock		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Isaac	548
Dice Bag		???	Defeat Mother as Tainted Isaac	549
Holy Crown		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Magdalene	550
Mother's Kiss		???	Defeat Mother as Tainted Magdalene	551
Gilded Key		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Cain	552
Lucky Sack		???	Defeat Mother as Tainted Cain	553
Your Soul		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Judas	554
Number Magnet		???	Defeat Mother as Tainted Judas	555
Dingle Berry		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted ???	556
Ring Cap		???	Defeat Mother as Tainted ???	557
Strange Key		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Eve	558
Lil Clot		???	Defeat Mother as Tainted Eve	559
Temporary Tattoo		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Samson	560
Swallowed M80		???	Defeat Mother as Tainted Samson	561
Wicked Crown		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Azazel	562
Azazel's Stump		???	Defeat Mother as Tainted Azazel	563
Torn Pocket		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Lazarus	564
Torn Card		???	Defeat Mother as Tainted Lazarus	565
Nuh Uh!		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Eden	566
Modeling Clay		???	Defeat Mother as Tainted Eden	567
Kid's Drawing		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Lost	568
Crystal Key		???	Defeat Mother as Tainted Lost	569
The Twins		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Lilith	570
Adoption Papers		???	Defeat Mother as Tainted Lilith	571
Keeper's Bargain		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Keeper	572
Cursed Penny		???	Defeat Mother as Tainted Keeper	573
Cricket Leg		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Apollyon	574
Apollyon's Best Friend		???	Defeat Mother as Tainted Apollyon	575
Polished Bone		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Forgotten	576
Hollow Heart		???	Defeat Mother as Tainted Forgotten	577
Expansion Pack		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Bethany	578
Beth's Essence		???	Defeat Mother as Tainted Bethany	579
RC Remote		???	Defeat Isaac, ???, Satan, and The Lamb as Tainted Jacob	580
Found Soul		???	Defeat Mother as Tainted Jacob	581
Member Card		Spend 40+ pennies in a single shop.	Spend 40+ coins in a single Shop	582
Golden Razor		Obtain 99 pennies. Then spend every single one of them.	In a single run, obtain 99 Coins, then spend all of them	583
Spindown Dice		???	Defeat Delirium as Tainted Isaac	584
Hypercoagulation		???	Defeat Delirium as Tainted Magdalene	585
Bag of Crafting		???	Defeat Delirium as Tainted Cain	586
Dark Arts		???	Defeat Delirium as Tainted Judas	587
IBS		???	Defeat Delirium as Tainted ???	588
Sumptorium		???	Defeat Delirium as Tainted Eve	589
Berserk!		???	Defeat Delirium as Tainted Samson	590
Hemoptysis		???	Defeat Delirium as Tainted Azazel	591
Flip		???	Defeat Delirium as Tainted Lazarus	592
Corrupted Data		???	Defeat Delirium as Tainted Eden	593
Ghost Bombs		???	Defeat Delirium as Tainted Lost	594
Gello		???	Defeat Delirium as Tainted Lilith	595
Keeper's Kin		???	Defeat Delirium as Tainted Keeper	596
Abyss		???	Defeat Delirium as Tainted Apollyon	597
Decap Attack		???	Defeat Delirium as Tainted Forgotten	598
Lemegeton		???	Defeat Delirium as Tainted Bethany	599
Anima Sola		???	Defeat Delirium as Tainted Jacob	600
Mega Chest		???	Defeat Mega Satan as Tainted Isaac	601
Queen of Hearts		???	Defeat Mega Satan as Tainted Magdalene	602
Gold Pill		???	Defeat Mega Satan as Tainted Cain	603
Black Sack		???	Defeat Mega Satan as Tainted Judas	604
Charming Poop		???	Defeat Mega Satan as Tainted ???	605
Horse Pill		???	Defeat Mega Satan as Tainted Eve	606
Crane Game		???	Defeat Mega Satan as Tainted Samson	607
Hell Game		???	Defeat Mega Satan as Tainted Azazel	608
Wooden Chest		???	Defeat Mega Satan as Tainted Lazarus	609
Wild Card		???	Defeat Mega Satan as Tainted Eden	610
Haunted Chest		???	Defeat Mega Satan as Tainted Lost	611
Fool's Gold		???	Defeat Mega Satan as Tainted Lilith	612
Golden Penny		???	Defeat Mega Satan as Tainted Keeper	613
Rotten Beggar		???	Defeat Mega Satan as Tainted Apollyon	614
Golden Battery		???	Defeat Mega Satan as Tainted Forgotten	615
Confessional		???	Defeat Mega Satan as Tainted Bethany	616
Golden Trinket		???	Defeat Mega Satan as Tainted Jacob	617
Soul of Isaac		???	Defeat Hush and Boss Rush as Tainted Isaac	618
Soul of Magdalene		???	Defeat Hush and Boss Rush as Tainted Magdalene	619
Soul of Cain		???	Defeat Hush and Boss Rush as Tainted Cain	620
Soul of Judas		???	Defeat Hush and Boss Rush as Tainted Judas	621
Soul of ???		???	Defeat Hush and Boss Rush as Tainted ???	622
Soul of Eve		???	Defeat Hush and Boss Rush as Tainted Eve	623
Soul of Samson		???	Defeat Hush and Boss Rush as Tainted Samson	624
Soul of Azazel		???	Defeat Hush and Boss Rush as Tainted Azazel	625
Soul of Lazarus		???	Defeat Hush and Boss Rush as Tainted Lazarus	626
Soul of Eden		???	Defeat Hush and Boss Rush as Tainted Eden	627
Soul of the Lost		???	Defeat Hush and Boss Rush as Tainted Lost	628
Soul of Lilith		???	Defeat Hush and Boss Rush as Tainted Lilith	629
Soul of the Keeper		???	Defeat Hush and Boss Rush as Tainted Keeper	630
Soul of Apollyon		???	Defeat Hush and Boss Rush as Tainted Apollyon	631
Soul of the Forgotten		???	Defeat Hush and Boss Rush as Tainted Forgotten	632
Soul of Bethany		???	Defeat Hush and Boss Rush as Tainted Bethany	633
Soul of Jacob and Esau		???	Defeat Hush and Boss Rush as Tainted Jacob	634
A Strange Door		Where could it lead to?	Defeat Mother	635
Death Certificate		...	Earn all Hard mode Completion Marks for all characters, including tainted ones	636
Dead God			Unlock all the other achievements and collect every item in the game	637

Repentance+

Name	Image	Description	Unlock	In Game Secret Number
Play Online		Played Online	Play an Online game	638
Win Online		Won Online	Win an Online run	639
Win Online Daily		Won Online Daily	Win an Online Daily run	640

PlayStation Trophies

Name	Image	Unlock
Platinum		Obtain all trophies
Isaac's Tears		Kill Isaac with Isaac
Mom's Knife		Kill Satan with Isaac
Isaac's Heart		Kill Isaac with The Lost
The Mind		Kill Satan with The Lost
Magdalene		Have 7 or more heart containers at one time
The Relic		Kill Isaac with Maggy
Guardian Angel		Kill Satan with Maggy
Cain		Hold 55 coins at one time
The Coin Bag		Kill Isaac with Cain
The Bomb Bag		Kill Satan with Cain
Judas		Kill Satan for the 1st time
The Guillotine		Kill Isaac with Judas
Judas' Tongue		Kill Satan with Judas
Eve		Don't pick up any hearts for 2 floors in a row
Eve's Bird Foot		Kill Isaac with Eve
The Razor		Kill Satan with Eve
Samson		Beat 2 floors in a row without taking damage
Bloody Lust		Kill Isaac with Samson
Blood Rights		Kill Satan with Samson
Azazel		Make 3 deals with the devil in one run
Satanic Bible		Kill Isaac with Azazel
Daemon's Tail		Kill Satan with Azazel
Lazarus		Have 4 or more soul hearts at one time
Lazarus' Rags		Kill Isaac with Lazarus
Broken Ankh		Kill Satan with Lazarus
Eden		Beat Chapter 4 for the 1st time
Blank Card		Kill Isaac with Eden
The Book of Secrets		Kill Satan with Eden
Something From The Future		Beat The Basement 40 times.
Something Cute		Beat Chapter 2 30 times
Something Sticky		Beat Chapter 3 20 times
Basement Boy		Beat Chapter 1 without taking damage
Spelunker Boy		Beat Chapter 2 without taking damage
Dark Boy		Beat Chapter 3 without taking damage
Mama's Boy		Beat Chapter 4 without taking damage
Dead Boy		Beat The Chest or Dark Room without taking damage
Challenges		Beat all 20 Challenges
Boss Rush		Beat the Boss Rush
Dark Room		Beat the Dark Room
The Chest		Beat The Chest
Lost Poster		Beat Dark Room with Isaac
Little Baggy		Collect 2 of either roid rage, the virus, growth hormones, experimental treatment or speed ball
The Womb		Kill Mom for the 1st time
The Halo		Kill Mom using The Bible
Transcendence		Kill Mom's Heart 3 times
Everything is Terrible		Kill Mom's Heart 5 times
A Quarter		Kill Mom's Heart 8 times
A Fetus in a Jar		Kill Mom's Heart 9 times
Blue Baby		Kill Mom's Heart 10 times
It Lives		Kill Mom's Heart 11 times
Forget Me Now		Kill Satan with ???
The Book of Sin		Kill all 7 Sins
The Polaroid		Kill Isaac 5 times
The Negative		Kill Satan 5 times
Golden God		Kill ??? and The Lamb
Platinum God		Collect all items in the game, unlock all of the secrets and Endings minus The Lost and his 7 unlockable items
The Lost		Unlock The Lost
Real Platinum God		Collect every Item and unlock every ending.

Notes

• The 5 Nights at Mom's achievement is bugged in various ways:
  • Because the game uses 32-bit architecture and has 41 characters, the game counts one of the first 9 characters as two wins. That means if in your streak you play once with a character from Isaac to Lazarus, you will get the achievement with 4 wins. If you play with two characters from Isaac to Lazarus, you will get the achievement with 3 wins. Since the game uses 64-bit architecture on consoles, this bug is PC-only.
  • Using normal Characters to get a win and then using its tainted counterpart won't work, only one of them will work for obtaining the achievement.
    • Additionally, due to integer overflow, some tainted characters share the same bitmask with some normal characters. The game resets the achievement streak counter if two runs are done with characters with the same bitmask. Tainted Lilith has the same bitmask as Isaac. Here are the pairs of characters that have the same bitmask : Tainted Keeper and Magdalene, Tainted Apollyon and Cain, Tainted Forgotten and Lazarus, Tainted Bethany and ???, Tainted Jacob and Eve, Tainted Dead Lazarus and Samson, Tainted Jacob in Lost form and Azazel. If you did a run with Isaac or Lilith, do not finish a run with Tainted Lilith or the counter will reset. Not confirmed yet but by the same logic as the bug above, this one is likely pc only too.
  • The achievement does not unlock in Co-op Repentance, even if the five wins were done with different characters for each player.
  • Modded characters do not interfere with the streaks, and do not reset nor increment the counter.

Trivia

• Each achievement is color-coded based on the requirements for unlocking their respective secrets:
  • Tan: Miscellaneous unlocks
  • Tan with blood stain: Mom's Heart/It Lives! Hard Mode unlocks
  • Olive-Green: Character unlocks
  • Dark Red: Mom's Heart/Womb ending unlocks
  • Grey: Isaac unlocks
  • Black: Satan unlocks
  • Dark Blue: ??? unlocks
  • Purple: The Lamb unlocks
  • Pale Green: Boss Rush unlocks
  • Pale Blue: Hush unlocks
  • Orange Yellow: Greed Mode unlocks
  • Orange Yellow with blood stain: Greedier mode unlocks
  • White: Delirium unlocks
  • Red: Mega Satan unlocks
  • Bright Yellow: All Hard Mode marks (most are tan)/Damageless floor/100% unlocks
  • Brighter Yellow: Greed Donation Machine unlocks
  • Bluish Purple: Challenge unlocks
  • Dark Green with bloodstain: Mother unlocks
  • Orange: The Beast unlocks
  • Bright Purple: Tainted Character unlocks
• Despite being a Boss Rush unlock for Lazarus, Missing No.'s achievement color is bluish purple, a color normally used for challenge-related unlocks.
• Achievements 37-41 and 83 have a typo on their pop-ups, and read "achieveved".
• Despite unlocking Locust of War, achievement 310 is named "Locust of Wrath".
• Although not technically an achievement, getting 1000000% on all 3 save files will result in a special 3,000,000%!!! graphic on the save file selection screen.
  • In Repentance, something similar happens when achieving Dead God on all 3 save files.
• The 5 Nights at Mom's achievement is a reference to Five Nights at Freddy's.
• The Mr. Resetter achievement may be a reference to Mr. Resetti from the Animal Crossing series.
• The Something Wicked This Way Comes quote is most likely a reference to the same quote from one of the witches from Shakespeare's play "Macbeth."
• Booster Pack #5 added 64 secrets. Interestingly, this is a single secret more than Afterbirth+'s original count of 63 secrets. Thus, this update more than doubled the amount of secrets added to the game.

PS4 Achievements 340-348 don't exist in the PS4 version, resulting in the content already being "unlocked" even on new save files.

• Achievements 638 to 640 are currently part of the Online Co-op beta and are not available in the base game and are not yet added to Steam. Achievement 640 is not even implemented and not obtainable in the beta.

• Despite having no achievement description normally, if the player attempts to showcase the Dead God achievement on their Steam Profile using the Achievement Showcase element, a small description will pop up that reads "NEW_ACHIEVEMENT_22_16_DESC".
• Like Monster Manual, the achievement Dead God is a reference to the Dead Gods adventure module for the second edition of wikipedia:Advanced Dungeons & Dragons.

Bugs

Bug!	Clear Rune must be unlocked and collected to attain !Platinum God! and The Real Platinum God despite being a Repentance item. This is due to its ID being unused in Rebirth, thus being in the ID range of Rebirth items.

Bug!	PS4 If installed, before unlocking it, the 'Challenges' trophy will require completing all the challenges available on the current DLC played instead of the original 20 Challenges.

References

The Binding of Isaac: Rebirth
Achievements Challenges Completion Marks Items Trinkets Characters Chapters Rooms Transformations Attributes Bosses Monsters Pickups Modes Curses Objects Seeds Effects Endings
Collection Item Pools Version History Modding Music